Novel Octahydropyrrolo[3,4‑c]pyrroles Are Selective Orexin‑2 Antagonists: SAR Leading to a Clinical Candidate
Letavic, Michael A., Bonaventure, Pascal, Carruthers, Nicholas I., Dugovic, Christine, Koudriakova, Tatiana, Lord, Brian, Lovenberg, Timothy W., Ly, Kiev S., Mani, Neelakandha S., Nepomuceno, Diane, Pippel, Daniel J., Rizzolio, Michele, Shelton, Jonathan E., Shah, Chandra R., Shireman, Brock T., Young, Lana K., Yun, Sujin
Published in Journal of medicinal chemistry (23.07.2015)
Published in Journal of medicinal chemistry (23.07.2015)
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Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists
Savall, Brad M., Wu, Duncan, De Angelis, Meri, Carruthers, Nicholas I., Ao, Hong, Wang, Qi, Lord, Brian, Bhattacharya, Anindya, Letavic, Michael A.
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
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Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists
Rudolph, Dale A., Alcazar, Jesus, Ameriks, Michael K., Anton, Ana Belen, Ao, Hong, Bonaventure, Pascal, Carruthers, Nicholas I., Chrovian, Christa C., De Angelis, Meri, Lord, Brian, Rech, Jason C., Wang, Qi, Bhattacharya, Anindya, Andres, Jose Ignacio, Letavic, Michael A.
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
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In Vitro Microbiological Characterization of a Novel Azalide, Two Triamilides and an Azalide Ketal against Bovine and Porcine Respiratory Pathogens
NORCIA, LAURA J. L., SILVIA, ANNETTE M., SANTORO, SHERYL L., RETSEMA, JIM, LETAVIC, MICHAEL A., BRONK, BRIAN S., LUNDY, KRISTIN M., YANG, BINGWEI, EVANS, NIGEL A., HAYASHI, SHIGERU F.
Published in Journal of antibiotics (2004)
Published in Journal of antibiotics (2004)
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1 H -Pyrrolo[3,2- b ]pyridine GluN2B-Selective Negative Allosteric Modulators
Chrovian, Christa C, Soyode-Johnson, Akinola, Wall, Jessica L, Rech, Jason C, Schoellerman, Jeff, Lord, Brian, Coe, Kevin J, Carruthers, Nicholas I, Nguyen, Leslie, Jiang, Xiaohui, Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A
Published in ACS medicinal chemistry letters (14.03.2019)
Published in ACS medicinal chemistry letters (14.03.2019)
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1H‑Pyrrolo[3,2‑b]pyridine GluN2B-Selective Negative Allosteric Modulators
Chrovian, Christa C, Soyode-Johnson, Akinola, Wall, Jessica L, Rech, Jason C, Schoellerman, Jeff, Lord, Brian, Coe, Kevin J, Carruthers, Nicholas I, Nguyen, Leslie, Jiang, Xiaohui, Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A
Published in ACS medicinal chemistry letters (14.03.2019)
Published in ACS medicinal chemistry letters (14.03.2019)
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Journal Article
P2X7 Antagonists as Potential Therapeutic Agents for the Treatment of CNS Disorders
Chrovian, Christa C., Rech, Jason C., Bhattacharya, Anindya, Letavic, Michael A.
Published in Progress in Medicinal Chemistry (2014)
Published in Progress in Medicinal Chemistry (2014)
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Novel Phenyl-Substituted 5,6-Dihydro-[1,2,4]triazolo[4,3‑a]pyrazine P2X7 Antagonists with Robust Target Engagement in Rat Brain
Chrovian, Christa C, Soyode-Johnson, Akinola, Ao, Hong, Bacani, Genesis M, Carruthers, Nicholas I, Lord, Brian, Nguyen, Leslie, Rech, Jason C, Wang, Qi, Bhattacharya, Anindya, Letavic, Michael A
Published in ACS chemical neuroscience (20.04.2016)
Published in ACS chemical neuroscience (20.04.2016)
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Journal Article
Substituted 5,6-(Dihydropyrido[3,4‑d]pyrimidin-7(8H)‑yl)-methanones as P2X7 Antagonists
Ziff, Jeannie, Rudolph, Dale A, Stenne, Brice, Koudriakova, Tatiana, Lord, Brian, Bonaventure, Pascal, Lovenberg, Timothy W, Carruthers, Nicholas I, Bhattacharya, Anindya, Letavic, Michael A, Shireman, Brock T
Published in ACS chemical neuroscience (20.04.2016)
Published in ACS chemical neuroscience (20.04.2016)
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Journal Article
Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists
Letavic, Michael A, Lord, Brian, Bischoff, Francois, Hawryluk, Natalie A, Pieters, Serge, Rech, Jason C, Sales, Zachary, Velter, Adriana I, Ao, Hong, Bonaventure, Pascal, Contreras, Victor, Jiang, Xiaohui, Morton, Kirsten L, Scott, Brian, Wang, Qi, Wickenden, Alan D, Carruthers, Nicholas I, Bhattacharya, Anindya
Published in ACS medicinal chemistry letters (11.04.2013)
Published in ACS medicinal chemistry letters (11.04.2013)
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Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [11C]GSK189254 in anesthetized baboon
Logan, Jean, Carruthers, Nicholas I., Letavic, Michael A., Sands, Steven, Jiang, Xiaohui, Shea, Colleen, Muench, Lisa, Xu, Youwen, Carter, Pauline, King, Payton, Fowler, Joanna S.
Published in Psychopharmacologia (01.10.2012)
Published in Psychopharmacologia (01.10.2012)
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In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor
Aluisio, Leah, Lord, Brian, Barbier, Ann J., Fraser, Ian C., Wilson, Sandy J., Boggs, Jamin, Dvorak, Lisa K., Letavic, Michael A., Maryanoff, Bruce E., Carruthers, Nicholas I., Bonaventure, Pascal, Lovenberg, Timothy W.
Published in European journal of pharmacology (10.06.2008)
Published in European journal of pharmacology (10.06.2008)
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Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development
Letavic, Michael A, Aluisio, Leah, Apodaca, Richard, Bajpai, Manoj, Barbier, Ann J, Bonneville, Anne, Bonaventure, Pascal, Carruthers, Nicholas I, Dugovic, Christine, Fraser, Ian C, Kramer, Michelle L, Lord, Brian, Lovenberg, Timothy W, Li, Lilian Y, Ly, Kiev S, Mcallister, Heather, Mani, Neelakandha S, Morton, Kirsten L, Ndifor, Anthony, Nepomuceno, S. Diane, Pandit, Chennagiri R, Sands, Steven B, Shah, Chandra R, Shelton, Jonathan E, Snook, Sandra S, Swanson, Devin M, Xiao, Wei
Published in ACS medicinal chemistry letters (09.04.2015)
Published in ACS medicinal chemistry letters (09.04.2015)
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Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition
Jerome, Kevin D., Rucker, Paul V., Xing, Li, Shieh, Huey S., Baldus, John E., Selness, Shaun R., Letavic, Michael A., Braganza, John F., McClure, Kim F.
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Indole- and benzothiophene-based histamine H3 antagonists
SANTILLAN, Alejandro, MCCLURE, Kelly J, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I, GRICE, Cheryl A, ALLISON, Brett D, LORD, Brian, BOGGS, Jamin D, MORTON, Kirsten L, EVERSON, Anita M, NEPOMUCENO, Diane, LETAVIC, Michael A, LEE-DUTRA, Alice
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
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Theoretical and Experimental Design of Atypical Kinase Inhibitors: Application to p38 MAP Kinase
McClure, Kim F, Abramov, Yuriy A, Laird, Ellen R, Barberia, John T, Cai, Weiling, Carty, Thomas J, Cortina, Santo R, Danley, Dennis E, Dipesa, Alan J, Donahue, Kathleen M, Dombroski, Mark A, Elliott, Nancy C, Gabel, Christopher A, Han, Seungil, Hynes, Thomas R, LeMotte, Peter K, Mansour, Mahmoud N, Marr, Eric S, Letavic, Michael A, Pandit, Jayvardhan, Ripin, David B, Sweeney, Francis J, Tan, Douglas, Tao, Yong
Published in Journal of medicinal chemistry (08.09.2005)
Published in Journal of medicinal chemistry (08.09.2005)
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Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors
LY, Kiev S, LETAVIC, Michael A, DVORAK, Lisa, MILLER, Kirsten L, NEPOMUCENO, Diane, WILSON, Sandy J, CARRUTHERS, Nicholas I, KEITH, John M, MILLER, Jennifer M, STOCKING, Emily M, BARBIER, Ann J, BONAVENTURE, Pascal, LORD, Brian, XIAOHUI JIANG, BOGGS, Jamin D
Published in Bioorganic & medicinal chemistry letters (2008)
Published in Bioorganic & medicinal chemistry letters (2008)
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치환된 피라졸로[4,3-b]피리딘 및 GLUN2B 수용체 조절제로서의 이들의 용도
WALL JESSICA, LETAVIC MICHAEL A, GELIN CHRISTINE, DVORAK CURT, HISCOX AFTON, STENNE BRICE, SAMANT ANDREW
Year of Publication 21.02.2022
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Year of Publication 21.02.2022
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