Discovery of (2 S )-8-[(3 R )-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2 H -pyrimido[1,2- a ]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors
Pasquier, Benoit, El-Ahmad, Youssef, Filoche-Rommé, Bruno, Dureuil, Christine, Fassy, Florence, Abecassis, Pierre-Yves, Mathieu, Magali, Bertrand, Thomas, Benard, Tsiala, Barrière, Cédric, El Batti, Samira, Letallec, Jean-Philippe, Sonnefraud, Véronique, Brollo, Maurice, Delbarre, Laurence, Loyau, Véronique, Pilorge, Fabienne, Bertin, Luc, Richepin, Patrick, Arigon, Jérôme, Labrosse, Jean-Robert, Clément, Jacques, Durand, Florence, Combet, Romain, Perraut, Pierre, Leroy, Vincent, Gay, Frédéric, Lefrançois, Dominique, Bretin, François, Marquette, Jean-Pierre, Michot, Nadine, Caron, Anne, Castell, Christelle, Schio, Laurent, McCort, Gary, Goulaouic, Hélène, Garcia-Echeverria, Carlos, Ronan, Baptiste
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Journal Article
Mapping the kinase domain of janus kinase 3
Adams, Christopher, Aldous, David J., Amendola, Shelley, Bamborough, Paul, Bright, Colin, Crowe, Sarah, Eastwood, Paul, Fenton, Garry, Foster, Martyn, Harrison, Trevor K.P., King, Sue, Lai, Justine, Lawrence, Christopher, Letallec, Jean-Philippe, McCarthy, Clive, Moorcroft, Neil, Page, Kenneth, Rao, Sudha, Redford, Jane, Sadiq, Shazia, Smith, Keith, Souness, John E., Thurairatnam, Sukanthini, Vine, Mark, Wyman, Barry
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
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Journal Article
NOVEL 2,3-DIHYDRO-1H-IMIDAZO[1,2-A]PYRIMIDIN-5-ONE AND THIS 1,2,3,4-TETRAHYDROPYRIMIDO[1,2-A]PYRIMIDIN-6-ONE DERIVATIVES COMPRISING A SUBSTITUTED MORPHOLINE, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF
FILOCHE ROMME BRUNO, EL AHMAD YOUSSEF, VIVET BERTRAND, MARCINIAK GILBERT, LETALLEC JEAN PHILIPPE, RONAN BAPTISTE, BROLLO MAURICE
Year of Publication 05.03.2015
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Year of Publication 05.03.2015
Patent
2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one and this 1,2,3,4-tetrahydropyrimido{1,2-a}pyrimidin-6-one derivatives comprising a substituted morpholine, preparation thereof and pharmaceutical use thereof
Brollo, Maurice, Marciniak, Gilbert, El-Ahmad, Youssef, Vivet, Bertrand, Letallec, Jean-Philippe, Ronan, Baptiste, Filoche-Romme, Bruno
Year of Publication 29.08.2023
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Year of Publication 29.08.2023
Patent
Novel 2,3-Dihydro-1h-imidazo{1,2-a}pyrimidin-5-one and this 1,2,3,4-tetrahydropyrimido{1,2-a}pyrimidin-6-one Derivatives Comprising a Substituted Morpholine, Preparation Thereof and Pharmaceutical Use Thereof
Brollo, Maurice, Marciniak, Gilbert, El-Ahmad, Youssef, Vivet, Bertrand, Letallec, Jean-Philippe, Ronan, Baptiste, Filoche-Romme, Bruno
Year of Publication 26.09.2019
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Year of Publication 26.09.2019
Patent
Mapping the kinase domain of Janus Kinase 3: Recent advances in the design of kinase inhibitors as novel therapeutic agents
ADAMS, Christopher, ALDOUS, David J, KING, Sue, LAI, Justine, LAWRENCE, Christopher, LETALLEC, Jean-Philippe, MCCARTHY, Clive, MOORCROFT, Neil, PAGE, Kenneth, RAO, Sudha, REDFORD, Jane, SADIQ, Shazia, AMENDOLA, Shelley, SMITH, Keith, SOUNESS, John E, THURAIRATNAM, Sukanthini, VINE, Mark, WYMAN, Barry, BAMBOROUGH, Paul, BRIGHT, Colin, CROWE, Sarah, EASTWOOD, Paul, FENTON, Garry, FOSTER, Martyn, HARRISON, Trevor K. P
Published in Bioorganic & medicinal chemistry letters (2003)
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Published in Bioorganic & medicinal chemistry letters (2003)
Journal Article
2,3-dihydro-1H-imidazo{1,2-a}pyrimidin-5-one and this 1,2,3,4-tetrahydropyrimido{1,2-a}pyrimidin-6-one derivatives comprising a substituted morpholine, preparation thereof and pharmaceutical use thereof
Brollo, Maurice, Marciniak, Gilbert, El-Ahmad, Youssef, Vivet, Bertrand, Letallec, Jean-Philippe, Ronan, Baptiste, Filoche-Romme, Bruno
Year of Publication 09.04.2019
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Year of Publication 09.04.2019
Patent
NOVEL 2,3-DIHYDRO-1H-IMIDAZO{1,2-a}PYRIMIDIN-5-ONE and this1,2,3,4-TETRAHYDROPYRIMIDO{1,2-a}PYRIMIDIN-6-ONE DERIVATIVES COMPRISING A SUBSTITUTED MORPHOLINE, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF
VIVET, BERTRAND, LETALLEC, JEAN-PHILIPPE, FILOCHE-ROMME, BRUNO, RONAN, BAPTISTE, MARCINIAK, GILBERT, EL-AHMAD, YOUSSEF, BROLLO, MAURICE
Year of Publication 29.06.2018
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Year of Publication 29.06.2018
Patent
HIDTIL UKENDT 2,3-DIHYDRO-1H-IMIDAZO{1,2-A}PYRIMIDIN-5-ON OG THIS1,2,3,4-TETRAHYDROPYRIMIDO{1,2-A}PYRIMIDIN-6-ONDERIVATER, DER OMFATTER EN SUBSTITUERET MORPHOLIN, FREMSTILING OG FARMACEUTISK ANVENDELSE DERAF
RONAN, Baptiste, FILOCHE-ROMME, Bruno, MARCINIAK, Gilbert, EL-AHMAD, Youssef, VIVET, Bertrand, BROLLO, Maurice, LETALLEC, Jean-Philippe
Year of Publication 19.03.2018
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Year of Publication 19.03.2018
Patent
NOVEL 2,3-DIHYDRO-1H-IMIDAZO{1,2-A}PYRIMIDIN-5-ONE AND THIS1,2,3,4-TETRAHYDROPYRIMIDO{1,2-A}PYRIMIDIN-6-ONE DERIVATIVES COMPRISING A SUBSTITUTED MORPHOLINE, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF
YOUSSEF EL-AHMAD, BAPTISTE RONAN, BRUNO FILOCHE-ROMME, GILBERT MARCINIAK, JEAN-PHILIPPE LETALLEC, BERTRAND VIVET, MAURICE BROLLO
Year of Publication 15.03.2018
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Year of Publication 15.03.2018
Patent
NOVEL 2,3-DIHYDRO-1H-IMIDAZO{1,2-a}PYRIMIDIN-5-ONE and this1,2,3,4-TETRAHYDROPYRIMIDO{1,2-a}PYRIMIDIN-6-ONE DERIVATIVES COMPRISING A SUBSTITUTED MORPHOLINE, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF
RONAN, Baptiste, FILOCHE-ROMME, Bruno, MARCINIAK, Gilbert, EL-AHMAD, Youssef, VIVET, Bertrand, BROLLO, Maurice, LETALLEC, Jean-Philippe
Year of Publication 13.12.2017
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Year of Publication 13.12.2017
Patent
2,3-diidro-1h-imidazo{1,2-a}pirimidin-5-ona e estes derivados de 1,2,3,4-tetraidropirimido{1,2-a}pirimidin-6-ona compreendendo uma morfolina substituída, preparação da mesma e uso farmacêutico da mesma
YOUSSEF EL-AHMAD, BAPTISTE RONAN, BRUNO FILOCHE-ROMME, GILBERT MARCINIAK, JEAN-PHILIPPE LETALLEC, BERTRAND VIVET, MAURICE BROLLO
Year of Publication 27.06.2017
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Year of Publication 27.06.2017
Patent
Novel 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one and this1,2,3,4-tetrahydropyrimido{1,2-a}pyrimidin-6-one derivatives comprising a substituted morpholine, preparation thereof and pharmaceutical use thereof
Brollo, Maurice, Marciniak, Gilbert, El-Ahmad, Youssef, Vivet, Bertrand, Letallec, Jean-Philippe, Ronan, Baptiste, Filoche-Romme, Bruno
Year of Publication 15.06.2017
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Year of Publication 15.06.2017
Patent
DERIVADOS DE IMIDAZOLONAS, O PREPARO A TÍTULO DE MEDICAMENTOS, COMPOSIÇÕES FARMACÊUTICAS, UTILIZAÇÃO COMO INIBIDORES DE PROTEÍNAS QUINASES, NOTADAMENTE CDC7
BAPTISTE RONAN, EMMANUEL CONSEILE, ANKE STEINMETZ, ERIC BACQUE, JEAN-PHILIPPE LETALLEC, VINCENT LEROY
Year of Publication 25.11.2014
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Year of Publication 25.11.2014
Patent
NOUVEAUX DERIVES DE 2,3-DIHYDRO-1H-IMIDAZO{1,2-A}PYRIMIDIN-5-ONE ET 1,2,3,4-TETRAHYDRO-PYRIMIDO{1,2-A}PYRIMIDIN-6-ONE COMPORTANT UNE MORPHOLINE SUBSTITUEE, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE
VIVET BERTRAND, LETALLEC JEAN-PHILIPPE, FILOCHE-ROMME BRUNO, MARCINIAK GILBERT, BROLLO MAURICE, RONAN BAPTISTE, EL-AHMAD YOUSSEF
Year of Publication 16.10.2015
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Year of Publication 16.10.2015
Patent
Novel 2,3-Dihydro-1H-imidazopyrimidin-5-one and this 1,2,3,4-tetrahydropyrimidopyrimidin-6-one Derivatives Comprising a Substituted Morpholine, Preparation Thereof and Pharmaceutical Use Thereof
VIVET BERTRAND, LETALLEC JEAN-PHILIPPE, FILOCHE-ROMME BRUNO, MARCINIAK GILBERT, RONAN BAPTISTE, BROLLO MAURICE, EL-AHMAD YOUSSEF
Year of Publication 28.05.2015
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Year of Publication 28.05.2015
Patent
NOVEL 2,3-DIHYDRO-1H-IMIDAZO{1,2 -A}PYRIMIDIN-5-ONE AND THIS1, 2, 3, 4-TETRAHYDROPYRIMIDO{1,2-A}PYRIMIDIN-6-ONE DERIVATIVES COMPRISING A SUBSTITUTED MORPHOLINE, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF
VIVET, BERTRAND, LETALLEC, JEAN-PHILIPPE, FILOCHE-ROMME, BRUNO, RONAN, BAPTISTE, MARCINIAK, GILBERT, EL-AHMAD, YOUSSEF, BROLLO, MAURICE
Year of Publication 08.05.2015
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Year of Publication 08.05.2015
Patent
NOVEL 2,3-DIHYDRO-1H-IMIDAZO{1,2-a}PYRIMIDIN-5-ONE and this1,2,3,4-TETRAHYDROPYRIMIDO{1,2-a}PYRIMIDIN-6-ONE DERIVATIVES COMPRISING A SUBSTITUTED MORPHOLINE, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF
VIVET, BERTRAND, LETALLEC, JEAN-PHILIPPE, FILOCHE-ROMME, BRUNO, RONAN, BAPTISTE, MARCINIAK, GILBERT, EL-AHMAD, YOUSSEF, BROLLO, MAURICE
Year of Publication 29.04.2015
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Year of Publication 29.04.2015
Patent
NOVEL 2,3-DIHYDRO-1H-IMIDAZO{1,2-a}PYRIMIDIN-5-ONE and this1,2,3,4-TETRAHYDROPYRIMIDO{1,2-a}PYRIMIDIN-6-ONE DERIVATIVES COMPRISING A SUBSTITUTED MORPHOLINE, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF
VIVET, BERTRAND, LETALLEC, JEAN-PHILIPPE, FILOCHE-ROMME, BRUNO, RONAN, BAPTISTE, MARCINIAK, GILBERT, EL-AHMAD, YOUSSEF
Year of Publication 29.01.2015
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Year of Publication 29.01.2015
Patent
Novel 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one and this1,2,3,4-tetrahydropyrimido{1,2-a}pyrimidin-6-one derivatives comprising a substituted morpholine, preparation thereof and pharmaceutical use thereof
VIVET, BERTRAND, LETALLEC, JEAN-PHILIPPE, FILOCHE-ROMME, BRUNO, RONAN, BAPTISTE, MARCINIAK, GILBERT, EL-AHMAD, YOUSSEF
Year of Publication 22.01.2015
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Year of Publication 22.01.2015
Patent