Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
Singh, Rumani, Letai, Anthony, Sarosiek, Kristopher
Published in Nature reviews. Molecular cell biology (01.03.2019)
Published in Nature reviews. Molecular cell biology (01.03.2019)
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iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry
Ryan, Jeremy, Montero, Joan, Rocco, James, Letai, Anthony
Published in Biological chemistry (01.07.2016)
Published in Biological chemistry (01.07.2016)
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Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia
DiNardo, Courtney D, Jonas, Brian A, Pullarkat, Vinod, Thirman, Michael J, Garcia, Jacqueline S, Wei, Andrew H, Konopleva, Marina, Döhner, Hartmut, Letai, Anthony, Fenaux, Pierre, Koller, Elizabeth, Havelange, Violaine, Leber, Brian, Esteve, Jordi, Wang, Jianxiang, Pejsa, Vlatko, Hájek, Roman, Porkka, Kimmo, Illés, Árpád, Lavie, David, Lemoli, Roberto M, Yamamoto, Kazuhito, Yoon, Sung-Soo, Jang, Jun-Ho, Yeh, Su-Peng, Turgut, Mehmet, Hong, Wan-Jen, Zhou, Ying, Potluri, Jalaja, Pratz, Keith W
Published in The New England journal of medicine (13.08.2020)
Published in The New England journal of medicine (13.08.2020)
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Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia
Pan, Rongqing, Hogdal, Leah J, Benito, Juliana M, Bucci, Donna, Han, Lina, Borthakur, Gautam, Cortes, Jorge, DeAngelo, Daniel J, Debose, Lakeisha, Mu, Hong, Döhner, Hartmut, Gaidzik, Verena I, Galinsky, Ilene, Golfman, Leonard S, Haferlach, Torsten, Harutyunyan, Karine G, Hu, Jianhua, Leverson, Joel D, Marcucci, Guido, Müschen, Markus, Newman, Rachel, Park, Eugene, Ruvolo, Peter P, Ruvolo, Vivian, Ryan, Jeremy, Schindela, Sonja, Zweidler-McKay, Patrick, Stone, Richard M, Kantarjian, Hagop, Andreeff, Michael, Konopleva, Marina, Letai, Anthony G
Published in Cancer discovery (01.03.2014)
Published in Cancer discovery (01.03.2014)
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Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies
Guièze, Romain, Liu, Vivian M., Rosebrock, Daniel, Jourdain, Alexis A., Hernández-Sánchez, María, Martinez Zurita, Aina, Sun, Jing, Ten Hacken, Elisa, Baranowski, Kaitlyn, Thompson, Philip A., Heo, Jin-Mi, Cartun, Zachary, Aygün, Ozan, Iorgulescu, J. Bryan, Zhang, Wandi, Notarangelo, Giulia, Livitz, Dimitri, Li, Shuqiang, Davids, Matthew S., Biran, Anat, Fernandes, Stacey M., Brown, Jennifer R., Lako, Ana, Ciantra, Zoe B., Lawlor, Matthew A., Keskin, Derin B., Udeshi, Namrata D., Wierda, William G., Livak, Kenneth J., Letai, Anthony G., Neuberg, Donna, Harper, J. Wade, Carr, Steven A., Piccioni, Federica, Ott, Christopher J., Leshchiner, Ignaty, Johannessen, Cory M., Doench, John, Mootha, Vamsi K., Getz, Gad, Wu, Catherine J.
Published in Cancer cell (14.10.2019)
Published in Cancer cell (14.10.2019)
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PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells
Kahn, Josephine D., Miller, Peter G., Silver, Alexander J., Sellar, Rob S., Bhatt, Shruti, Gibson, Christopher, McConkey, Marie, Adams, Dylan, Mar, Brenton, Mertins, Philipp, Fereshetian, Shaunt, Krug, Karsten, Zhu, Haoling, Letai, Anthony, Carr, Steven A., Doench, John, Jaiswal, Siddhartha, Ebert, Benjamin L.
Published in Blood (13.09.2018)
Published in Blood (13.09.2018)
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Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax
Leverson, Joel D, Sampath, Deepak, Souers, Andrew J, Rosenberg, Saul H, Fairbrother, Wayne J, Amiot, Martine, Konopleva, Marina, Letai, Anthony
Published in Cancer discovery (01.12.2017)
Published in Cancer discovery (01.12.2017)
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BH3 Profiling Identifies Three Distinct Classes of Apoptotic Blocks to Predict Response to ABT-737 and Conventional Chemotherapeutic Agents
Deng, Jing, Carlson, Nicole, Takeyama, Kunihiko, Dal Cin, Paola, Shipp, Margaret, Letai, Anthony
Published in Cancer cell (01.08.2007)
Published in Cancer cell (01.08.2007)
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Drug-Induced Death Signaling Strategy Rapidly Predicts Cancer Response to Chemotherapy
Montero, Joan, Sarosiek, Kristopher A., DeAngelo, Joseph D., Maertens, Ophélia, Ryan, Jeremy, Ercan, Dalia, Piao, Huiying, Horowitz, Neil S., Berkowitz, Ross S., Matulonis, Ursula, Jänne, Pasi A., Amrein, Philip C., Cichowski, Karen, Drapkin, Ronny, Letai, Anthony
Published in Cell (26.02.2015)
Published in Cell (26.02.2015)
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Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition
Burger, Jan A, Landau, Dan A, Taylor-Weiner, Amaro, Bozic, Ivana, Zhang, Huidan, Sarosiek, Kristopher, Wang, Lili, Stewart, Chip, Fan, Jean, Hoellenriegel, Julia, Sivina, Mariela, Dubuc, Adrian M, Fraser, Cameron, Han, Yulong, Li, Shuqiang, Livak, Kenneth J, Zou, Lihua, Wan, Youzhong, Konoplev, Sergej, Sougnez, Carrie, Brown, Jennifer R, Abruzzo, Lynne V, Carter, Scott L, Keating, Michael J, Davids, Matthew S, Wierda, William G, Cibulskis, Kristian, Zenz, Thorsten, Werner, Lillian, Dal Cin, Paola, Kharchencko, Peter, Neuberg, Donna, Kantarjian, Hagop, Lander, Eric, Gabriel, Stacey, O'Brien, Susan, Letai, Anthony, Weitz, David A, Nowak, Martin A, Getz, Gad, Wu, Catherine J
Published in Nature communications (20.05.2016)
Published in Nature communications (20.05.2016)
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The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism
Anderson, Mary Ann, Deng, Jing, Seymour, John F., Tam, Constantine, Kim, Su Young, Fein, Joshua, Yu, Lijian, Brown, Jennifer R., Westerman, David, Si, Eric G., Majewski, Ian J., Segal, David, Heitner Enschede, Sari L., Huang, David C.S., Davids, Matthew S., Letai, Anthony, Roberts, Andrew W.
Published in Blood (23.06.2016)
Published in Blood (23.06.2016)
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