Versatile Synthetic Approach for Selective Diversification of Bicyclic Aza-Diketopiperazines
Péron, Florent, Riché, Stéphanie, Lesur, Brigitte, Hibert, Marcel, Breton, Philippe, Fourquez, Jean-Marie, Girard, Nicolas, Bonnet, Dominique
Published in ACS omega (30.11.2018)
Published in ACS omega (30.11.2018)
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Productive Syntheses of Privileged Scaffolds Inspired by the Recognition of a Diels–Alder Pattern Common to Three Classes of Natural Products
Badarau, Eduard, Reddy, K. Harsha Vardhan, Loudet, Aurore, Simon, Charles, Trembleau, Laurent, Claerhout, Stijn, Pair, Etienne, Massip, Stéphane, Breton, Philippe, Lesur, Brigitte, Goldstein, Solo, Fourquez, Jean‐Marie, Henlin, Jean Michel, Ghosez, Léon
Published in Chemistry : a European journal (01.12.2020)
Published in Chemistry : a European journal (01.12.2020)
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IMI European Lead Factory — democratizing access to high-throughput screening
Jones, Philip S., Boucharens, Sylviane, McElroy, Stuart P., Morrison, Angus, Honarnejad, Saman, van Boeckel, Stan, van den Hurk, Helma, Basting, Daniel, Hüser, Jörg, Jaroch, Stefan, Ottow, Eckhard, Benningshof, Jorg, Folmer, Rutger H. A., Leemhuis, Frank, Kramer-Verhulst, Patricia M., Nies, Vera J. M., Orrling, Kristina M., Rijnders, Ton, Pfander, Claudia, Engkvist, Ola, Pairaudeau, Garry, Simpson, Peter B., Ortholand, Jean-Yves, Roche, Didier, Dömling, Alexander, Kühnert, Sven M., Roevens, Peter W. M., van Vlijmen, Herman, van Wanrooij, Eva J. A., Verbruggen, Christophe, Nussbaumer, Peter, Ovaa, Huib, van der Stelt, Mario, Simonsen, Klaus Baek, Tagmose, Lena, Waldmann, Herbert, Duffy, James, Finsinger, Dirk, Jurzak, Mirek, Burgess-Brown, Nicola A., Lee, Wen H., Rutjes, Floris P. J. T., Haag, Hubert, Kallus, Christopher, Mors, Hartmut, Dorval, Thierry, Lesur, Brigitte, Ramon Olayo, Fernando, Hamza, Daniel, Jones, Geraint, Pearce, Christopher, Piechot, Alexander, Tzalis, Dimitrios, Clausen, Mads H., Davis, Jeremy, Derouane, Daphné, Vermeiren, Céline, Kaiser, Markus, Stockman, Robert A., Barrault, Denise V., Pannifer, Andrew D., Swedlow, Jason R., Nelson, Adam S., Orru, Romano V. A., Ruijter, Eelco, van Helden, Steven P., Li, Volkhart M., Vries, Ton, de Vlieger, Jon S. B.
Published in Nature reviews. Drug discovery (01.04.2022)
Published in Nature reviews. Drug discovery (01.04.2022)
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Hit finding: towards ‘smarter’ approaches
Langer, Thierry, Hoffmann, Rémy, Bryant, Sharon, Lesur, Brigitte
Published in Current opinion in pharmacology (01.10.2009)
Published in Current opinion in pharmacology (01.10.2009)
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Synthesis and Antitumor Characterization of Pyrazolic Analogues of the Marine Pyrroloquinoline Alkaloids: Wakayin and Tsitsikammamines
Legentil, Laurent, Benel, Laurent, Bertrand, Viviane, Lesur, Brigitte, Delfourne, Evelyne
Published in Journal of medicinal chemistry (18.05.2006)
Published in Journal of medicinal chemistry (18.05.2006)
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A convenient synthesis of 5-arylamino-4H-pyran-4-ones using palladium-catalyzed amination
Farard, Julien, Loge, Cedric, Pfeiffer, Bruno, Lesur, Brigitte, Duflos, Muriel
Published in Tetrahedron letters (14.10.2009)
Published in Tetrahedron letters (14.10.2009)
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Synthesis of 5-(4-aryl)-2-phenyl-5,6-dihydrobenzo[b][1,5]oxazocin-4-ones
Davion, Y, Guillaumet, G, Leger, JM, Jarry, C, Lesur, B, Merour, JY
Published in Heterocycles (01.08.2003)
Published in Heterocycles (01.08.2003)
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Journal Article
3-Aryl-2-Quinolone Derivatives: Synthesis and Characterization of In Vitro and In Vivo Antitumor Effects with Emphasis on a New Therapeutical Target Connected with Cell Migration
Joseph, Benoît, Darro, Francis, Béhard, Aurélie, Lesur, Brigitte, Collignon, Françoise, Decaestecker, Christine, Frydman, Armand, Guillaumet, Gérald, Kiss, Robert
Published in Journal of medicinal chemistry (06.06.2002)
Published in Journal of medicinal chemistry (06.06.2002)
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Wake-promoting agents: Search for next generation modafinil: Part IV
Louvet, Philippe, Schweizer, Dominique, Gourdel, Marie-Edith, Riguet, Eric, Yue, Christoph, Marcy, Val R., Lin, Yin Guo, Gruner, John, Lesur, Brigitte, Bacon, Edward R., Chatterjee, Sankar
Published in European journal of medicinal chemistry (01.08.2012)
Published in European journal of medicinal chemistry (01.08.2012)
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Journal Article
Novel morpholine ketone analogs as potent histamine H3 receptor inverse agonists with wake activity
Sundar, Babu G., Bailey, Thomas R., Dunn, Derek, Hostetler, Greg A., Chatterjee, Sankar, Bacon, Edward R., Yue, Christoph, Schweizer, Dominique, Aimone, Lisa D., Gruner, John A., Lyons, Jacquelyn, Raddatz, Rita, Lesur, Brigitte
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
Aryl-Heteroaryl Derivatives as Novel Wake-Promoting Agents
Lesur, Brigitte, Lin, Yin G., Marcy, Val R., Aimone, Lisa D., Gruner, John, Bacon, Edward R., Chatterjee, Sankar
Published in Chemical biology & drug design (01.03.2013)
Published in Chemical biology & drug design (01.03.2013)
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Chemoinformatics and virtual screening of molecules for therapeutic use
Vayer, Philippe, Arrault, Alban, Lesur, Brigitte, Bertrand, Marc, Walther, Bernard
Published in M.S. Médecine sciences (01.10.2009)
Published in M.S. Médecine sciences (01.10.2009)
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Synthesis and in vitro antitumor activity of ring C and D-substituted phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine
Delfourne, Evelyne, Kiss, Robert, Le Corre, Laurent, Dujols, Frederic, Bastide, Jean, Collignon, Françoise, Lesur, Brigitte, Frydman, Armand, Darro, Francis
Published in Bioorganic & medicinal chemistry (01.08.2004)
Published in Bioorganic & medicinal chemistry (01.08.2004)
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Journal Article
Synthesis and in Vitro Antitumor Activity of Phenanthrolin-7-one Derivatives, Analogues of the Marine Pyridoacridine Alkaloids Ascididemin and Meridine: Structure−Activity Relationship
Delfourne, Evelyne, Kiss, Robert, Corre, Laurent Le, Dujols, Frederic, Bastide, Jean, Collignon, Françoise, Lesur, Brigitte, Frydman, Armand, Darro, Francis
Published in Journal of medicinal chemistry (31.07.2003)
Published in Journal of medicinal chemistry (31.07.2003)
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Journal Article
Synthesis and In Vitro Antitumor Activity of Novel Ring D Analogues of the Marine Pyridoacridine Ascididemin: Structure−Activity Relationship
Delfourne, Evelyne, Darro, Francis, Portefaix, Philippe, Galaup, Chantal, Bayssade, Sylvie, Bouteillé, Anne, Le Corre, Laurent, Bastide, Jean, Collignon, Françoise, Lesur, Brigitte, Frydman, Armand, Kiss, Robert
Published in Journal of medicinal chemistry (15.08.2002)
Published in Journal of medicinal chemistry (15.08.2002)
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