The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites
Delves, Michael, Plouffe, David, Scheurer, Christian, Meister, Stephan, Wittlin, Sergio, Winzeler, Elizabeth A, Sinden, Robert E, Leroy, Didier
Published in PLoS medicine (01.02.2012)
Published in PLoS medicine (01.02.2012)
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A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria
Phillips, Margaret A, Lotharius, Julie, Marsh, Kennan, White, John, Dayan, Anthony, White, Karen L, Njoroge, Jacqueline W, El Mazouni, Farah, Lao, Yanbin, Kokkonda, Sreekanth, Tomchick, Diana R, Deng, Xiaoyi, Laird, Trevor, Bhatia, Sangeeta N, March, Sandra, Ng, Caroline L, Fidock, David A, Wittlin, Sergio, Lafuente-Monasterio, Maria, Benito, Francisco Javier Gamo, Alonso, Laura Maria Sanz, Martinez, Maria Santos, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Haselden, John N, Louttit, James, Cui, Yi, Sridhar, Arun, Zeeman, Anna-Marie, Kocken, Clemens, Sauerwein, Robert, Dechering, Koen, Avery, Vicky M, Duffy, Sandra, Delves, Michael, Sinden, Robert, Ruecker, Andrea, Wickham, Kristina S, Rochford, Rosemary, Gahagen, Janet, Iyer, Lalitha, Riccio, Ed, Mirsalis, Jon, Bathhurst, Ian, Rueckle, Thomas, Ding, Xavier, Campo, Brice, Leroy, Didier, Rogers, M John, Rathod, Pradipsinh K, Burrows, Jeremy N, Charman, Susan A
Published in Science translational medicine (15.07.2015)
Published in Science translational medicine (15.07.2015)
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Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence "transmission blocking" assay
Lelièvre, Joël, Almela, Maria Jesus, Lozano, Sonia, Miguel, Celia, Franco, Virginia, Leroy, Didier, Herreros, Esperanza
Published in PloS one (13.04.2012)
Published in PloS one (13.04.2012)
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Defining the next generation of severe malaria treatment: a target product profile
Achan, Jane, Barry, Aïssata, Leroy, Didier, Kamara, George, Duparc, Stephan, Kaszubska, Wiweka, Gandhi, Preetam, Buffet, Bénédicte, Tshilab, Patrick, Ogutu, Bernhards, Taylor, Terrie, Krishna, Sanjeev, Richardson, Naomi, Ramachandruni, Hanu, Rietveld, Hans
Published in Malaria journal (05.06.2024)
Published in Malaria journal (05.06.2024)
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The relevance of non-human primate and rodent malaria models for humans
Langhorne, Jean, Buffet, Pierre, Galinski, Mary, Good, Michael, Harty, John, Leroy, Didier, Mota, Maria M, Pasini, Erica, Renia, Laurent, Riley, Eleanor, Stins, Monique, Duffy, Patrick
Published in Malaria journal (02.02.2011)
Published in Malaria journal (02.02.2011)
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Fueling Open Innovation for Malaria Transmission-Blocking Drugs: Hundreds of Molecules Targeting Early Parasite Mosquito Stages
Delves, Michael, Lafuente-Monasterio, M Jose, Upton, Leanna, Ruecker, Andrea, Leroy, Didier, Gamo, Francisco-Javier, Sinden, Robert
Published in Frontiers in microbiology (13.09.2019)
Published in Frontiers in microbiology (13.09.2019)
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The biology of sexual development of Plasmodium: the design and implementation of transmission-blocking strategies
Sinden, Robert E, Carter, Richard, Drakeley, Chris, Leroy, Didier
Published in Malaria journal (16.03.2012)
Published in Malaria journal (16.03.2012)
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Conference Proceeding
Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination
Reader, Janette, Botha, Mariëtte, Theron, Anjo, Lauterbach, Sonja B, Rossouw, Claire, Engelbrecht, Dewaldt, Wepener, Melanie, Smit, Annél, Leroy, Didier, Mancama, Dalu, Coetzer, Theresa L, Birkholtz, Lyn-Marie
Published in Malaria journal (22.05.2015)
Published in Malaria journal (22.05.2015)
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A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria
Adoke, Yeka, Zoleko-Manego, Rella, Ouoba, Serge, Tiono, Alfred B, Kaguthi, Grace, Bonzela, Juvêncio Eduardo, Duong, Tran Thanh, Nahum, Alain, Bouyou-Akotet, Marielle, Ogutu, Bernhards, Ouedraogo, Alphonse, Macintyre, Fiona, Jessel, Andreas, Laurijssens, Bart, Cherkaoui-Rbati, Mohammed H, Cantalloube, Cathy, Marrast, Anne Claire, Bejuit, Raphaël, White, David, Wells, Timothy N C, Wartha, Florian, Leroy, Didier, Kibuuka, Afizi, Mombo-Ngoma, Ghyslain, Ouattara, Daouda, Mugenya, Irène, Phuc, Bui Quang, Bohissou, Francis, Mawili-Mboumba, Denise P, Olewe, Fredrick, Soulama, Issiaka, Tinto, Halidou
Published in Malaria journal (19.05.2021)
Published in Malaria journal (19.05.2021)
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Host-directed therapy, an untapped opportunity for antimalarial intervention
Wei, Ling, Adderley, Jack, Leroy, Didier, Drewry, David H., Wilson, Danny W., Kaushansky, Alexis, Doerig, Christian
Published in Cell reports. Medicine (19.10.2021)
Published in Cell reports. Medicine (19.10.2021)
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Tetrahydro-2-naphthyl and 2‑Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity
Kokkonda, Sreekanth, Deng, Xiaoyi, White, Karen L, Coteron, Jose M, Marco, Maria, de las Heras, Laura, White, John, El Mazouni, Farah, Tomchick, Diana R, Manjalanagara, Krishne, Rudra, Kakali Rani, Chen, Gong, Morizzi, Julia, Ryan, Eileen, Kaminsky, Werner, Leroy, Didier, Martínez-Martínez, María Santos, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Waterson, David, Burrows, Jeremy N, Matthews, Dave, Charman, Susan A, Phillips, Margaret A, Rathod, Pradipsinh K
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
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Cation ATPase (ATP4) Orthologue Replacement in the Malaria Parasite Plasmodium knowlesi Reveals Species-Specific Responses to ATP4-Targeting Drugs
Mohring, Franziska, van Schalkwyk, Donelly A, Henrici, Ryan C, Blasco, Benjamin, Leroy, Didier, Sutherland, Colin J, Moon, Robert W
Published in mBio (26.10.2022)
Published in mBio (26.10.2022)
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A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria
Macintyre, Fiona, Adoke, Yeka, Tiono, Alfred B, Duong, Tran Thanh, Mombo-Ngoma, Ghyslain, Bouyou-Akotet, Marielle, Tinto, Halidou, Bassat, Quique, Issifou, Saadou, Adamy, Marc, Demarest, Helen, Duparc, Stephan, Leroy, Didier, Laurijssens, Bart E, Biguenet, Sophie, Kibuuka, Afizi, Tshefu, Antoinette Kitoto, Smith, Melnick, Foster, Chanelle, Leipoldt, Illse, Kremsner, Peter G, Phuc, Bui Quang, Ouedraogo, Alphonse, Ramharter, Michael
Published in BMC medicine (09.10.2017)
Published in BMC medicine (09.10.2017)
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The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of Plasmodium falciparum Viability after Antimalarial Treatment In Vitro
Walz, Annabelle, Duffey, Maëlle, Aljayyoussi, Ghaith, Sax, Sibylle, Leroy, Didier, Besson, Dominique, Burrows, Jeremy N, Cherkaoui-Rbati, Mohammed H, Gobeau, Nathalie, Westwood, Marie-Anne, Siethoff, Christoph, Gamo, Francisco-Javier, Mäser, Pascal, Wittlin, Sergio
Published in Pharmaceuticals (Basel, Switzerland) (23.01.2023)
Published in Pharmaceuticals (Basel, Switzerland) (23.01.2023)
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Mouse Model of Respiratory Tract Infection Induced by Waddlia chondrophila
Pilloux, Ludovic, LeRoy, Didier, Brunel, Christophe, Roger, Thierry, Greub, Gilbert
Published in PloS one (07.03.2016)
Published in PloS one (07.03.2016)
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African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker
Leroy, Didier, Macintyre, Fiona, Adoke, Yeka, Ouoba, Serge, Barry, Aissata, Mombo-Ngoma, Ghyslain, Ndong Ngomo, Jacques Mari, Varo, Rosauro, Dossou, Yannelle, Tshefu, Antoinette Kitoto, Duong, Tran Thanh, Phuc, Bui Quang, Laurijssens, Bart, Klopper, Roland, Khim, Nimol, Legrand, Eric, Ménard, Didier
Published in Malaria journal (10.04.2019)
Published in Malaria journal (10.04.2019)
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