Structural Basis for the Synthesis of Indirubins as Potent and Selective Inhibitors of Glycogen Synthase Kinase-3 and Cyclin-Dependent Kinases
Polychronopoulos, Panagiotis, Magiatis, Prokopios, Skaltsounis, Alexios-Leandros, Myrianthopoulos, Vassilios, Mikros, Emmanuel, Tarricone, Aldo, Musacchio, Andrea, Roe, S. Mark, Pearl, Laurence, Leost, Maryse, Greengard, Paul, Meijer, Laurent
Published in Journal of medicinal chemistry (12.02.2004)
Published in Journal of medicinal chemistry (12.02.2004)
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Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
Gompel, Marie, Leost, Maryse, De Kier Joffe, Elisa Bal, Puricelli, Lydia, Franco, Laura Hernandez, Palermo, Jorge, Meijer, Laurent
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
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Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases
Eisenbrand, Gerhard, Endicott, Jane A, Lawrie, Alison, Meijer, Laurent, Damiens, Eve, Marie, Dominique, Tunnah, Paul, Leclerc, Sophie, Tang, Weici, Niederberger, Ellen, Leost, Maryse, Hoessel, Ralph, Marko, Doris, Nobel, Martin E. M
Published in Nature cell biology (01.05.1999)
Published in Nature cell biology (01.05.1999)
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Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins
KNOCKAERT, Marie, BLONDEL, Marc, RYAN, Xiaozhou P, MAGIATIS, Prokopios, POLYCHRONOPOULOS, Panos, GREENGARD, Paul, SKALTSOUNIS, Leandros, MEIJER, Laurent, BACH, Stéphane, LEOST, Maryse, ELBI, Cem, HAGER, Gordon L, NAGY, Scott R, HAN, Dalho, DENISON, Michael, FFRENCH, Martine
Published in Oncogene (27.05.2004)
Published in Oncogene (27.05.2004)
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Journal Article
GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins
Meijer, Laurent, Skaltsounis, Alexios-Leandros, Magiatis, Prokopios, Polychronopoulos, Panagiotis, Knockaert, Marie, Leost, Maryse, Ryan, Xiaozhou P., Vonica, Claudia Alin, Brivanlou, Ali, Dajani, Rana, Crovace, Claudia, Tarricone, Cataldo, Musacchio, Andrea, Roe, S.Mark, Pearl, Laurence, Greengard, Paul
Published in Chemistry & biology (01.12.2003)
Published in Chemistry & biology (01.12.2003)
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Polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase CDC25A
Erdogan-Orhan, Ilkay, Sener, Bilge, De Rosa, Salvatore, Perez-Baz, Julia, Lozach, Olivier, Leost, Maryse, Rakhilin, Sergei, Meijer, Laurent
Published in Natural product research (01.02.2004)
Published in Natural product research (01.02.2004)
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Intracellular Targets of Paullones
Knockaert, Marie, Wieking, Karen, Schmitt, Sophie, Leost, Maryse, Grant, Karen M., Mottram, Jeremy C., Kunick, Conrad, Meijer, Laurent
Published in The Journal of biological chemistry (12.07.2002)
Published in The Journal of biological chemistry (12.07.2002)
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Journal Article
1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3β
Kunick, Conrad, Lauenroth, Kathrin, Leost, Maryse, Meijer, Laurent, Lemcke, Thomas
Published in Bioorganic & medicinal chemistry letters (19.01.2004)
Published in Bioorganic & medicinal chemistry letters (19.01.2004)
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Journal Article
Paullones, a Series of Cyclin-Dependent Kinase Inhibitors: Synthesis, Evaluation of CDK1/Cyclin B Inhibition, and in Vitro Antitumor Activity
Schultz, Christiane, Link, Andreas, Leost, Maryse, Zaharevitz, Daniel W, Gussio, Rick, Sausville, Edward A, Meijer, Laurent, Kunick, Conrad
Published in Journal of medicinal chemistry (29.07.1999)
Published in Journal of medicinal chemistry (29.07.1999)
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Journal Article
Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors
Chang, Young-Tae, Gray, Nathanael S, Rosania, Gustavo R, Sutherlin, Daniel P, Kwon, Soojin, Norman, Thea C, Sarohia, Radhika, Leost, Maryse, Meijer, Laurent, Schultz, Peter G
Published in Chemistry & biology (01.06.1999)
Published in Chemistry & biology (01.06.1999)
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Journal Article
Aloisines, a New Family of CDK/GSK-3 Inhibitors. SAR Study, Crystal Structure in Complex with CDK2, Enzyme Selectivity, and Cellular Effects
Mettey, Yvette, Gompel, Marie, Thomas, Virginie, Garnier, Matthieu, Leost, Maryse, Ceballos-Picot, Irène, Noble, Martin, Endicott, Jane, Vierfond, Jean-michel, Meijer, Laurent
Published in Journal of medicinal chemistry (16.01.2003)
Published in Journal of medicinal chemistry (16.01.2003)
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Journal Article
Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor
Knockaert, Marie, Wieking, Karen, Schmitt, Sophie, Leost, Maryse, Grant, Karen M, Mottram, Jeremy C, Kunick, Conrad, Meijer, Laurent
Published in The Journal of biological chemistry (12.07.2002)
Published in The Journal of biological chemistry (12.07.2002)
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Journal Article
Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases
ZAHAREVITZ, D. W, GUSSIO, R, LEOST, M, SENDEROWICZ, A. M, LAHUSEN, T, KUNICK, C, MEIJER, L, SAUSVILLE, E. A
Published in Cancer research (Chicago, Ill.) (01.06.1999)
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Published in Cancer research (Chicago, Ill.) (01.06.1999)
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Evaluation and Comparison of 3D-QSAR CoMSIA Models for CDK1, CDK5, and GSK-3 Inhibition by Paullones
Kunick, Conrad, Lauenroth, Kathrin, Wieking, Karen, Xie, Xu, Schultz, Christiane, Gussio, Rick, Zaharevitz, Daniel, Leost, Maryse, Meijer, Laurent, Weber, Alexander, Jørgensen, Flemming S, Lemcke, Thomas
Published in Journal of medicinal chemistry (01.01.2004)
Published in Journal of medicinal chemistry (01.01.2004)
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Journal Article
Properties and Potential Applications of Chemical Inhibitors of Cyclin-Dependent Kinases
Meijer, Laurent, Leclerc, Sophie, Leost, Maryse
Published in Pharmacology & therapeutics (Oxford) (01.05.1999)
Published in Pharmacology & therapeutics (Oxford) (01.05.1999)
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Journal Article
Cyclin-Dependent Kinases: Initial Approaches to Exploit a Novel Therapeutic Target
Sausville, Edward A., Zaharevitz, Daniel, Gussio, Robert, Meijer, Laurent, Louarn-Leost, Maryse, Kunick, Conrad, Schultz, Robert, Lahusen, Tyler, Headlee, Donna, Stinson, Sherman, Arbuck, Susan G., Senderowicz, Adrian
Published in Pharmacology & therapeutics (Oxford) (01.05.1999)
Published in Pharmacology & therapeutics (Oxford) (01.05.1999)
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Journal Article
Structure-Aided Optimization of Kinase Inhibitors Derived from Alsterpaullone
Kunick, Conrad, Zeng, Zhihong, Gussio, Rick, Zaharevitz, Daniel, Leost, Maryse, Totzke, Frank, Schächtele, Christoph, Kubbutat, Michael H. G., Meijer, Laurent, Lemcke, Thomas
Published in Chembiochem : a European journal of chemical biology (01.03.2005)
Published in Chembiochem : a European journal of chemical biology (01.03.2005)
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Journal Article
Cyclin-Dependent Kinase Inhibition by New C-2 Alkynylated Purine Derivatives and Molecular Structure of a CDK2−Inhibitor Complex
Legraverend, Michel, Tunnah, Paul, Noble, Martin, Ducrot, Pierre, Ludwig, Odile, Grierson, David S, Leost, Maryse, Meijer, Laurent, Endicott, Jane
Published in Journal of medicinal chemistry (06.04.2000)
Published in Journal of medicinal chemistry (06.04.2000)
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Journal Article
Paullones are potent inhibitors of glycogen synthase kinase‐3β and cyclin‐dependent kinase 5/p25
Leost, Maryse, Schultz, Christiane, Link, Andreas, Wu, Yong‐Zhong, Biernat, Jacek, Mandelkow, Eva‐Maria, Bibb, James A., Snyder, Gretchen L., Greengard, Paul, Zaharevitz, Daniel W., Gussio, Rick, Senderowicz, Adrian M., Sausville, Edward A., Kunick, Conrad, Meijer, Laurent
Published in European journal of biochemistry (01.10.2000)
Published in European journal of biochemistry (01.10.2000)
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