S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab
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Published in Molecular cancer therapeutics (01.09.2013)
Published in Molecular cancer therapeutics (01.09.2013)
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Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells
Sancier, Florence, Dumont, Aurélie, Sirvent, Audrey, Paquay de Plater, Ludmilla, Edmonds, Thomas, David, Géraldine, Jan, Michel, de Montrion, Catherine, Cogé, Francis, Léonce, Stéphane, Burbridge, Michael, Bruno, Alain, Boutin, Jean A, Lockhart, Brian, Roche, Serge, Cruzalegui, Francisco
Published in PloS one (24.02.2011)
Published in PloS one (24.02.2011)
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Antiproliferative and iron chelating efficiency of the new bis-8-hydroxyquinoline benzylamine chelator S1 in hepatocyte cultures
Lescoat, Gérard, Léonce, Stéphane, Pierré, Alain, Gouffier, Lucie, Gaboriau, François
Published in Chemico-biological interactions (25.01.2012)
Published in Chemico-biological interactions (25.01.2012)
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Synthesis, Cytotoxic Activity, and Mechanism of Action of Furo[2,3-c]acridin-6-one and Benzo[b]furo[3,2-h]acridin-6-one Analogues of Psorospermin and Acronycine
Boutefnouchet, Sabrina, Gaboriaud-Kolar, Nicolas, Minh, Nguyen Tuan, Depauw, Sabine, David-Cordonnier, Marie-Hélène, Pfeiffer, Bruno, Léonce, Stéphane, Pierré, Alain, Tillequin, François, Lallemand, Marie-Christine, Michel, Sylvie
Published in Journal of medicinal chemistry (27.11.2008)
Published in Journal of medicinal chemistry (27.11.2008)
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Synthesis and Biological Evaluation of Novel Naphthocarbazoles as Potential Anticancer Agents
Routier, Sylvain, Peixoto, Paul, Mérour, Jean-Yves, Coudert, Gérard, Dias, Nathalie, Bailly, Christian, Pierré, Alain, Léonce, Stéphane, Caignard, Daniel-Henry
Published in Journal of medicinal chemistry (10.03.2005)
Published in Journal of medicinal chemistry (10.03.2005)
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An unusual DNA binding compound, S23906, induces mitotic catastrophe in cultured human cells
Cahuzac, Nathalie, Studény, Aurélie, Marshall, Kris, Versteege, Isabella, Wetenhall, Kate, Pfeiffer, Bruno, Léonce, Stéphane, Hickman, John A, Pierré, Alain, Golsteyn, Roy M
Published in Cancer letters (28.03.2010)
Published in Cancer letters (28.03.2010)
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Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of dipyrrolo[3,4- a:3,4- c]carbazole-triones
Conchon, Elisabeth, Anizon, Fabrice, Golsteyn, Roy M., Léonce, Stéphane, Pfeiffer, Bruno, Prudhomme, Michelle
Published in Tetrahedron (27.11.2006)
Published in Tetrahedron (27.11.2006)
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Journal Article
Synthesis, biological evaluation and docking studies of 4-amino-tetrahydroquinazolino[3,2- e]purine derivatives
Verones, Valerie, Flouquet, Nathalie, Farce, Amaury, Carato, Pascal, Leonce, Stephane, Pfeiffer, Bruno, Berthelot, Pascal, Lebegue, Nicolas
Published in European journal of medicinal chemistry (01.12.2010)
Published in European journal of medicinal chemistry (01.12.2010)
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Journal Article
Synthesis and biological evaluation of aristolactams
Couture, Axel, Deniau, Eric, Grandclaudon, Pierre, Rybalko-Rosen, Hélène, Léonce, Stéphane, Pfeiffer, Bruno, Renard, Pierre
Published in Bioorganic & medicinal chemistry letters (16.12.2002)
Published in Bioorganic & medicinal chemistry letters (16.12.2002)
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Journal Article
Novel 5-azaindolocarbazoles as cytotoxic agents and Chk1 inhibitors
Lefoix, Myriam, Coudert, Gérard, Routier, Sylvain, Pfeiffer, Bruno, Caignard, Daniel-Henri, Hickman, John, Pierré, Alain, Golsteyn, Roy M., Léonce, Stéphane, Bossard, Céline, Mérour, Jean-Yves
Published in Bioorganic & medicinal chemistry (01.05.2008)
Published in Bioorganic & medicinal chemistry (01.05.2008)
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Cytotoxic turrianes of Kermadecia elliptica from the New Caledonian rainforest
Jolly, Claire, Thoison, Odile, Martin, Marie-Thérèse, Dumontet, Vincent, Gilbert, Aline, Pfeiffer, Bruno, Léonce, Stéphane, Sévenet, Thierry, Guéritte, Françoise, Litaudon, Marc
Published in Phytochemistry (Oxford) (2008)
Published in Phytochemistry (Oxford) (2008)
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Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of indolylpyrazolones and indolylpyridazinedione
Conchon, Elisabeth, Aboab, Bettina, Golsteyn, Roy M., Cruzalegui, Francisco, Edmonds, Thomas, Léonce, Stéphane, Pfeiffer, Bruno, Prudhomme, Michelle
Published in European journal of medicinal chemistry (01.12.2006)
Published in European journal of medicinal chemistry (01.12.2006)
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Journal Article
Synthesis, Cytotoxic Activity, and Mechanism of Action of Furo[2,3-c]acridin-6-one and Benzo[b]furo[3,2-h]acridin-6-one Analogues of Psorospermin and Acronycine
Boutefnouchet, Sabrina, Gaboriaud-Kolar, Nicolas, Minh, Nguyen Tuan, Depauw, Sabine, David-Cordonnier, Marie-Hélène, Pfeiffer, Bruno, Léonce, Stéphane, Pierré, Alain, Tillequin, François, Lallemand, Marie-Christine, Michel, Sylvie
Published in Journal of medicinal chemistry (25.12.2008)
Published in Journal of medicinal chemistry (25.12.2008)
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Novel Stable Camptothecin Derivatives Replacing the E-Ring Lactone by a Ketone Function Are Potent Inhibitors of Topoisomerase I and Promising Antitumor Drugs
Lansiaux, Amélie, Léonce, Stéphane, Kraus-Berthier, Laurence, Bal-Mahieu, Christine, Mazinghien, Romain, Didier, Sébastien, David-Cordonnier, Marie-Hélène, Hautefaye, Patrick, Lavielle, Gilbert, Bailly, Christian, Hickman, John A, Pierré, Alain
Published in Molecular pharmacology (01.08.2007)
Published in Molecular pharmacology (01.08.2007)
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Journal Article
Influence of the Stereoisomeric Position of the Reactive Acetate Groups of the Benzo[b]Acronycine derivative S23906-1 on Its DNA Alkylation, Helix-Opening, Cytotoxic, and Antitumor Activities
Sabine Depauw, Thomas Gaslonde, Stéphane Léonce, Laurence Kraus-Berthier, William Laine, Gaëlle Lenglet, Angèle Chiaroni, Bruno Pfeiffer, Christian Bailly, Sylvie Michel, François Tillequin, Alain PierrÃ, Marie-Hélène David-Cordonnier
Published in Molecular pharmacology (01.12.2009)
Published in Molecular pharmacology (01.12.2009)
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Journal Article
Synthesis, cytotoxic activity, and DNA binding properties of antitumor cis-1,2-dihydroxy-1,2-dihydrobenzo[ b]acronycine cinnamoyl esters
Do, Quyên, Tian, Wen, Yougnia, Rodrigue, Gaslonde, Thomas, Pfeiffer, Bruno, Pierré, Alain, Léonce, Stéphane, Kraus-Berthier, Laurence, David-Cordonnier, Marie-Hélène, Depauw, Sabine, Lansiaux, Amélie, Mazinghien, Romain, Koch, Michel, Tillequin, François, Michel, Sylvie, Dufat, Hanh
Published in Bioorganic & medicinal chemistry (01.03.2009)
Published in Bioorganic & medicinal chemistry (01.03.2009)
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Journal Article
Design, Synthesis, and Antiproliferative Activity of Some New Pyrazole-Fused Amino Derivatives of the Pyranoxanthenone, Pyranothioxanthenone, and Pyranoacridone Ring Systems: A New Class of Cytotoxic Agents
Kostakis, Ioannis K, Magiatis, Prokopios, Pouli, Nicole, Marakos, Panagiotis, Skaltsounis, Alexios-Leandros, Pratsinis, Harris, Léonce, Stephane, Pierré, Alain
Published in Journal of medicinal chemistry (06.06.2002)
Published in Journal of medicinal chemistry (06.06.2002)
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Cellular knock-down of quinone reductase 2: A laborious road to successful inhibition by RNA interference
Chomarat, Pascale, Cogé, Francis, Guénin, Sophie P., Mailliet, François, Vella, Fanny, Mallet, Catherine, Giraudet, Stéphanie, Nagel, Nadine, Leonce, Stéphane, Ferry, Gilles, Delagrange, Philippe, Boutin, Jean A.
Published in Biochimie (01.10.2007)
Published in Biochimie (01.10.2007)
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MYCN Enhances P-gp/ MDR1 Gene Expression in the Human Metastatic Neuroblastoma IGR-N-91 Model
Blanc, Etienne, Goldschneider, David, Ferrandis, Eric, Barrois, Michel, Le Roux, Gwenaëlle, Leonce, Stéphane, Douc-Rasy, Sétha, Bénard, Jean, Raguénez, Gilda
Published in The American journal of pathology (01.07.2003)
Published in The American journal of pathology (01.07.2003)
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Journal Article
Synthesis and Cytotoxic Activity of Dimeric Analogs of Acronycine in the Benzo[b]pyrano[3,2-h]acridin-7-one Series
Gaslonde, Thomas, Michel, Sylvie, Koch, Michel, Pfeiffer, Bruno, Léonce, Stéphane, Pierré, Alain, Tillequin, François
Published in Chemical & Pharmaceutical Bulletin (2007)
Published in Chemical & Pharmaceutical Bulletin (2007)
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