Efficacy of the novel tubulin polymerization inhibitor PTC‐028 for myelodysplastic syndrome
Zhong, Cheng, Kayamori, Kensuke, Koide, Shuhei, Shinoda, Daisuke, Oshima, Motohiko, Nakajima‐Takagi, Yaeko, Nagai, Yurie, Mimura, Naoya, Sakaida, Emiko, Yamazaki, Satoshi, Iwano, Satoshi, Miyawaki, Atsushi, Ito, Ryoji, Tohyama, Kaoru, Yamaguchi, Kiyoshi, Furukawa, Yoichi, Lennox, William, Sheedy, Josephine, Weetall, Marla, Iwama, Atsushi
Published in Cancer science (01.12.2020)
Published in Cancer science (01.12.2020)
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Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform
Cao, Liangxian, Weetall, Marla, Bombard, Jenelle, Qi, Hongyan, Arasu, Tamil, Lennox, William, Hedrick, Jean, Sheedy, Josephine, Risher, Nicole, Brooks, Peter C, Trifillis, Panayiota, Trotta, Christopher, Moon, Young-Choon, Babiak, John, Almstead, Neil G, Colacino, Joseph M, Davis, Thomas W, Peltz, Stuart W
Published in PloS one (16.12.2016)
Published in PloS one (16.12.2016)
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Structure–Activity Relationship (SAR) Optimization of 6‑(Indol-2-yl)pyridine-3-sulfonamides: Identification of Potent, Selective, and Orally Bioavailable Small Molecules Targeting Hepatitis C (HCV) NS4B
Zhang, Nanjing, Zhang, Xiaoyan, Zhu, Jin, Turpoff, Anthony, Chen, Guangming, Morrill, Christie, Huang, Song, Lennox, William, Kakarla, Ramesh, Liu, Ronggang, Li, Chunshi, Ren, Hongyu, Almstead, Neil, Venkatraman, Srikanth, Njoroge, F. George, Gu, Zhengxian, Clausen, Valerie, Graci, Jason, Jung, Stephen P., Zheng, Yingcong, Colacino, Joseph M., Lahser, Fred, Sheedy, Josephine, Mollin, Anna, Weetall, Marla, Nomeir, Amin, Karp, Gary M.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Discovery of novel HCV inhibitors: Synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B
Zhang, Xiaoyan, Zhang, Nanjing, Chen, Guangming, Turpoff, Anthony, Ren, Hongyu, Takasugi, James, Morrill, Christie, Zhu, Jin, Li, Chunshi, Lennox, William, Paget, Steven, Liu, Yalei, Almstead, Neil, George Njoroge, F., Gu, Zhengxian, Komatsu, Takashi, Clausen, Valerie, Espiritu, Christine, Graci, Jason, Colacino, Joseph, Lahser, Fred, Risher, Nicole, Weetall, Marla, Nomeir, Amin, Karp, Gary M.
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
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Discovery of 5-Arylsulfonamido-3- (pyrrolidin-2-ylmethyl)-1H-indole Derivatives as Potent, Selective 5-HT6 Receptor Agonists and Antagonists
Cole, Derek C, Lennox, William J, Lombardi, Sabrina, Ellingboe, John W, Bernotas, Ronald C, Tawa, Gregory J, Mazandarani, Hossein, Smith, Deborah L, Zhang, Guoming, Coupet, Joseph, Schechter, Lee E
Published in Journal of medicinal chemistry (27.01.2005)
Published in Journal of medicinal chemistry (27.01.2005)
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Discovery of N1-(6-Chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT6 Receptor Agonist
Cole, Derek C, Stock, Joseph R, Lennox, William J, Bernotas, Ronald C, Ellingboe, John W, Boikess, Steve, Coupet, Joseph, Smith, Deborah L, Leung, Louis, Zhang, Guo-Ming, Feng, Xidong, Kelly, Michael F, Galante, Rocco, Huang, Pingzhong, Dawson, Lee A, Marquis, Karen, Rosenzweig-Lipson, Sharon, Beyer, Chad E, Schechter, Lee E
Published in Journal of medicinal chemistry (15.11.2007)
Published in Journal of medicinal chemistry (15.11.2007)
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Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists
COLE, Derek C, LENNOX, William J, STOCK, Joseph R, ELLINGBOE, John W, MAZANDARANI, Hossein, SMITH, Deborah L, GUOMING ZHANG, TAWA, Gregory J, SCHECHTER, Lee E
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
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Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
Cao, Liangxian, Weetall, Marla, Trotta, Christopher, Cintron, Katherine, Ma, Jiyuan, Kim, Min Jung, Furia, Bansri, Romfo, Charles, Graci, Jason D, Li, Wencheng, Du, Joshua, Sheedy, Josephine, Hedrick, Jean, Risher, Nicole, Yeh, Shirley, Qi, Hongyan, Arasu, Tamil, Hwang, Seongwoo, Lennox, William, Kong, Ronald, Petruska, Janet, Moon, Young-Choon, Babiak, John, Davis, Thomas W, Jacobson, Allan, Almstead, Neil G, Branstrom, Art, Colacino, Joseph M, Peltz, Stuart W
Published in Molecular cancer therapeutics (01.01.2019)
Published in Molecular cancer therapeutics (01.01.2019)
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Comparison of pharmaceutical properties and biological activities of prednisolone, deflazacort, and vamorolone in DMD disease models
Liu, Grace, Lipari, Philip, Mollin, Anna, Jung, Stephen, Teplova, Irina, Li, Wencheng, Ying, Lanqing, More, Vijay, Lennox, William, Yeh, Shirley, McGann, Eric, Moon, Young-Choon, Rice, Cari, Huarte, Eduardo, Gruszka, Barbara, Ray, Balmiki, Goodwin, Elizabeth, Buckendahl, Patricia, Yurkow, Edward, Braughton, Bruce, Narasimhan, Jana, Welch, Ellen, Voronin, Gregory, Weetall, Marla
Published in Human molecular genetics (20.01.2024)
Published in Human molecular genetics (20.01.2024)
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SAR studies toward discovery of emvododstat (PTC299), a potent dihydroorotate dehydrogenase (DHODH) inhibitor
Baiazitov, Ramil Y., Qi, Hongyan, Arasu, Tamil, Lennox, William, Cao, Liangxian, Weetall, Marla, Furia, Bansri, Zhuo, Jin, Choi, Soongyu, Kim, Min Jung, Sheedy, Josephine, Davis, Thomas, Moon, Young-Choon
Published in European journal of medicinal chemistry (15.12.2022)
Published in European journal of medicinal chemistry (15.12.2022)
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Efficacy of Tubulin Polymerization Inhibitor in Myelodysplastic Syndrome
Zhong, Cheng, Kayamori, Kensuke, Koide, Shuhei, Shinoda, Daisuke, Oshima, Motohiko, Nakajima-Takagi, Yaeko, Nagai, Yurie, Mimura, Naoya, Lennox, William, Sheedy, Josephine, Weetall, Marla, Iwama, Atsushi
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Moment operations on random variables, with applications for probabilistic analysis
Kennedy, Christopher A., Lennox, William C.
Published in Probabilistic engineering mechanics (01.07.2001)
Published in Probabilistic engineering mechanics (01.07.2001)
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Synergistic Effect of DHODH Inhibitor PTC299 with DNA Demethylating Agent Decitabine in Myelodysplastic Syndromes
Kayamori, Kensuke, Zhong, Cheng, Shinoda, Daisuke, Koide, Shuhei, Oshima, Motohiko, Nakajima-Takagi, Yaeko, Mimura, Naoya, Ito, Ryoji, Tohyama, Kaoru, Lennox, William, Weetall, Marla, Sheedy, Josephine, Sakaida, Emiko, Yokote, Koutaro, Iwama, Atsushi
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists
COLE, Derek C, ELLINGBOE, John W, LENNOX, William J, MAZANDARANI, Hossein, SMITH, Deborah L, STOCK, Joseph R, GUOMING ZHANG, PING ZHOU, SCHECHTER, Lee E
Published in Bioorganic & medicinal chemistry letters (2005)
Published in Bioorganic & medicinal chemistry letters (2005)
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The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells
Nagai, Yurie, Mimura, Naoya, Rizq, Ola, Isshiki, Yusuke, Oshima, Motohiko, Rizk, Mohamed, Saraya, Atsunori, Koide, Shuhei, Nakajima-Takagi, Yaeko, Miyota, Makiko, Chiba, Tetsuhiro, Oshima-Hasegawa, Nagisa, Muto, Tomoya, Tsukamoto, Shokichi, Mitsukawa, Shio, Takeda, Yusuke, Ohwada, Chikako, Takeuchi, Masahiro, Iseki, Tohru, Nakaseko, Chiaki, Lennox, William, Sheedy, Josephine, Weetall, Marla, Yokote, Koutaro, Iwama, Atsushi, Sakaida, Emiko
Published in Scientific reports (22.01.2021)
Published in Scientific reports (22.01.2021)
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DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes
Kayamori, Kensuke, Nagai, Yurie, Zhong, Cheng, Kaito, Satoshi, Shinoda, Daisuke, Koide, Shuhei, Kuribayashi, Wakako, Oshima, Motohiko, Nakajima-Takagi, Yaeko, Yamashita, Masayuki, Mimura, Naoya, Becker, Hans Jiro, Izawa, Kiyoko, Yamazaki, Satoshi, Iwano, Satoshi, Miyawaki, Atsushi, Ito, Ryoji, Tohyama, Kaoru, Lennox, William, Sheedy, Josephine, Weetall, Marla, Sakaida, Emiko, Yokote, Koutaro, Iwama, Atsushi
Published in Blood advances (26.01.2021)
Published in Blood advances (26.01.2021)
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6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B
Chen, Guangming, Ren, Hongyu, Zhang, Nanjing, Lennox, William, Turpoff, Anthony, Paget, Steven, Li, Chunshi, Almstead, Neil, Njoroge, F. George, Gu, Zhengxian, Graci, Jason, Jung, Stephen P., Colacino, Joseph, Lahser, Fred, Zhao, Xin, Weetall, Marla, Nomeir, Amin, Karp, Gary M.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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Incorporation of Computer Algebra into an Undergraduate Course in Open Channel Hydraulics
KENNEDY, CHRISTOPHER A., LENNOX, WILLIAM C.
Published in European journal of engineering education (01.09.1997)
Published in European journal of engineering education (01.09.1997)
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