Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
Popovici-Muller, Janeta, Lemieux, René M, Artin, Erin, Saunders, Jeffrey O, Salituro, Francesco G, Travins, Jeremy, Cianchetta, Giovanni, Cai, Zhenwei, Zhou, Ding, Cui, Dawei, Chen, Ping, Straley, Kimberly, Tobin, Erica, Wang, Fang, David, Muriel D, Penard-Lacronique, Virginie, Quivoron, Cyril, Saada, Véronique, de Botton, Stéphane, Gross, Stefan, Dang, Lenny, Yang, Hua, Utley, Luke, Chen, Yue, Kim, Hyeryun, Jin, Shengfang, Gu, Zhiwei, Yao, Gui, Luo, Zhiyong, Lv, Xiaobing, Fang, Cheng, Yan, Liping, Olaharski, Andrew, Silverman, Lee, Biller, Scott, Su, Shin-San M, Yen, Katharine
Published in ACS medicinal chemistry letters (12.04.2018)
Published in ACS medicinal chemistry letters (12.04.2018)
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Journal Article
Preclinical Drug Metabolism, Pharmacokinetic, and Pharmacodynamic Profiles of Ivosidenib, an Inhibitor of Mutant Isocitrate Dehydrogenase 1 for Treatment of Isocitrate Dehydrogenase 1-Mutant Malignancies
Chen, Yue, Nagaraja, Nelamangala V, Fan, Bin, Utley, Luke, Lemieux, Rene M, Popovici-Muller, Janeta, Dang, Lenny, Kim, Hyeryun, Yan, Liping, Su, Shin-San M, Biller, Scott A, Yang, Hua
Published in Drug metabolism and disposition (01.10.2021)
Published in Drug metabolism and disposition (01.10.2021)
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Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists
Horan, Joshua C., Sanyal, Sulagna, Choi, Younggi, Hill-Drzewi, Melissa, Patnaude, Lori, Anderson, Shawn, Fogal, Steve, Mao, Can, Cook, Brian N., Gueneva-Boucheva, Kristina, Fisher, Michael B., Hickey, Eugene, Pack, Edward, Bannen, Lynne C., Chan, Diva S., Mac, Morrison B., Ng, Stephanie M., Wang, Yong, Xu, Wei, Modis, Louise K., Lemieux, René M.
Published in Bioorganic & medicinal chemistry letters (15.10.2014)
Published in Bioorganic & medicinal chemistry letters (15.10.2014)
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Identification of small molecule inhibitors of G3BP-driven stress granule formation
Freibaum, Brian D, Messing, James, Nakamura, Haruko, Yurtsever, Ugur, Wu, Jinjun, Kim, Hong Joo, Hixon, Jeff, Lemieux, Rene Marc, Duffner, Jay, Huynh, Walter, Wong, Kathy, White, Michael, Lee, Christina, Meyers, Rachel E, Parker, Roy, Taylor, J Paul
Published in The Journal of cell biology (04.03.2024)
Published in The Journal of cell biology (04.03.2024)
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Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists
Horan, Joshua C., Kuzmich, Daniel, Liu, Pingrong, DiSalvo, Darren, Lord, John, Mao, Can, Hopkins, Tamara D., Yu, Hui, Harcken, Christian, Betageri, Raj, Hill-Drzewi, Melissa, Patenaude, Lori, Patel, Monica, Fletcher, Kimberly, Terenzzio, Donna, Linehan, Brian, Xia, Heather, Patel, Mita, Studwell, Debbie, Miller, Craig, Hickey, Eugene, Levin, Jeremy I., Smith, Dustin, Kemper, Raymond A., Modis, Louise K., Bannen, Lynne C., Chan, Diva S., Mac, Morrison B., Ng, Stephanie, Wang, Yong, Xu, Wei, Lemieux, René M.
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
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Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
Yang, Zemin, Johnson, Bryan A., Meliopoulos, Victoria A., Ju, Xiaohui, Zhang, Peipei, Hughes, Michael P., Wu, Jinjun, Koreski, Kaitlin P., Clary, Jemma E., Chang, Ti-Cheng, Wu, Gang, Hixon, Jeff, Duffner, Jay, Wong, Kathy, Lemieux, Rene, Lokugamage, Kumari G., Alvarado, R. Elias, Crocquet-Valdes, Patricia A., Walker, David H., Plante, Kenneth S., Plante, Jessica A., Weaver, Scott C., Kim, Hong Joo, Meyers, Rachel, Schultz-Cherry, Stacey, Ding, Qiang, Menachery, Vineet D., Taylor, J. Paul
Published in Cell reports (Cambridge) (26.03.2024)
Published in Cell reports (Cambridge) (26.03.2024)
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THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
ZHOU DING, LEMIEUX RENE M, CAI ZHENWEI, TRAVINS JEREMY, CUI DAWEI, POPOVICI MULLER JANETA
Year of Publication 08.05.2020
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Year of Publication 08.05.2020
Patent
Abstract 1194: IDH1 mutant inhibitor induces cellular differentiation and offers a combination benefit with Ara-C in a primary human Idh1 mutant AML xenograft model
Ellwood-Yen, Kate, Chen, Yue, Wang, Fang, Lemieux, Rene, Popovici-Muller, Janeta, Yang, Hua, Straley, Kimberly, Choe, Sung, Dorsch, Marion, Agresta, Sam, Schenkein, David, Biller, Scott, Su, Michael
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
ZHOU DING, LEMIEUX RENE M, CAI ZHENWEI, TRAVINS JEREMY, CUI DAWEI, POPOVICI MULLER JANETA
Year of Publication 18.11.2019
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Year of Publication 18.11.2019
Patent