Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1 H -pyrazol-1-yl)methyl)phosphonate (BMS-820132)
Shi, Yan, Wang, Ying, Meng, Wei, Brigance, Robert P, Ryono, Denis E, Bolton, Scott, Zhang, Hao, Chen, Sean, Smirk, Rebecca, Tao, Shiwei, Tino, Joseph A, Williams, Kristin N, Sulsky, Richard, Nielsen, Laura, Ellsworth, Bruce, Wong, Michael K Y, Sun, Jung-Hui, Leith, Leslie W, Sun, Dawn, Wu, Dauh-Rurng, Gupta, Anuradha, Rampulla, Richard, Mathur, Arvind, Chen, Bang-Chi, Wang, Aiying, Fuentes-Catanio, Helen G, Kunselman, Lori, Cap, Michael, Zalaznick, Jacob, Ma, Xiaohui, Liu, Heng, Taylor, Joseph R, Zebo, Rachel, Jones, Beverly, Kalinowski, Stephen, Swartz, Joann, Staal, Ada, O'Malley, Kevin, Kopcho, Lisa, Muckelbauer, Jodi K, Krystek, Jr, Stanley R, Spronk, Steven A, Marcinkeviciene, Jovita, Everlof, Gerry, Chen, Xue-Qing, Xu, Carrie, Li, Yi-Xin, Langish, Robert A, Yang, Yanou, Wang, Qi, Behnia, Kamelia, Fura, Aberra, Janovitz, Evan B, Pannacciulli, Nicola, Griffen, Steven, Zinker, Bradley A, Krupinski, John, Kirby, Mark, Whaley, Jean, Zahler, Robert, Barrish, Joel C, Robl, Jeffrey A, Cheng, Peter T W
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
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Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)‑1H‑pyrazol-1-yl)methyl)phosphonate (BMS-820132)
Shi, Yan, Wang, Ying, Meng, Wei, Brigance, Robert P, Ryono, Denis E, Bolton, Scott, Zhang, Hao, Chen, Sean, Smirk, Rebecca, Tao, Shiwei, Tino, Joseph A, Williams, Kristin N, Sulsky, Richard, Nielsen, Laura, Ellsworth, Bruce, Wong, Michael K. Y, Sun, Jung-Hui, Leith, Leslie W, Sun, Dawn, Wu, Dauh-Rurng, Gupta, Anuradha, Rampulla, Richard, Mathur, Arvind, Chen, Bang-Chi, Wang, Aiying, Fuentes-Catanio, Helen G, Kunselman, Lori, Cap, Michael, Zalaznick, Jacob, Ma, Xiaohui, Liu, Heng, Taylor, Joseph R, Zebo, Rachel, Jones, Beverly, Kalinowski, Stephen, Swartz, Joann, Staal, Ada, O’Malley, Kevin, Kopcho, Lisa, Muckelbauer, Jodi K, Krystek, Stanley R, Spronk, Steven A, Marcinkeviciene, Jovita, Everlof, Gerry, Chen, Xue-Qing, Xu, Carrie, Li, Yi-Xin, Langish, Robert A, Yang, Yanou, Wang, Qi, Behnia, Kamelia, Fura, Aberra, Janovitz, Evan B, Pannacciulli, Nicola, Griffen, Steven, Zinker, Bradley A, Krupinski, John, Kirby, Mark, Whaley, Jean, Zahler, Robert, Barrish, Joel C, Robl, Jeffrey A, Cheng, Peter T. W
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
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The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists
Balog, Aaron, Salvati, Mark E., Shan, Weifang, Mathur, Arvind, Leith, Leslie W., Wei, Donna D., Attar, Ricardo M., Geng, Jieping, Rizzo, Cheryl A., Wang, Chihuei, Krystek, Stanley R., Tokarski, John S., Hunt, John T., Gottardis, Marco, Weinmann, Roberto
Published in Bioorganic & medicinal chemistry letters (20.12.2004)
Published in Bioorganic & medicinal chemistry letters (20.12.2004)
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Radial patterns of bitumen dykes around Quaternary volcanoes, provinces of northern Neuquén and southernmost Mendoza, Argentina
Cobbold, Peter R., Ruffet, Gilles, Leith, Leslie, Loseth, Helge, Rodrigues, Nuno, Leanza, Hector A., Zanella, Alain
Published in Journal of South American earth sciences (01.12.2014)
Published in Journal of South American earth sciences (01.12.2014)
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Discovery and Preclinical Studies of (R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an In Vivo Active Potent VEGFR-2 Inhibitor
Bhide, Rajeev S, Cai, Zhen-Wei, Zhang, Yong-Zheng, Qian, Ligang, Wei, Donna, Barbosa, Stephanie, Lombardo, Louis J, Borzilleri, Robert M, Zheng, Xiaoping, Wu, Laurence I, Barrish, Joel C, Kim, Soong-Hoon, Leavitt, Kenneth, Mathur, Arvind, Leith, Leslie, Chao, Sam, Wautlet, Barri, Mortillo, Steven, Jeyaseelan, Robert, Kukral, Daniel, Hunt, John T, Kamath, Amrita, Fura, Aberra, Vyas, Viral, Marathe, Punit, D'Arienzo, Celia, Derbin, George, Fargnoli, Joseph
Published in Journal of medicinal chemistry (06.04.2006)
Published in Journal of medicinal chemistry (06.04.2006)
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Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N‑[(1R)‑1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311)
Qiao, Jennifer X, Wang, Tammy C, Adam, Leonard P, Chen, Alice Ye A, Taylor, David S, Yang, Richard Z, Zhuang, Shaobin, Sleph, Paul G, Li, Julia P, Li, Danshi, Yin, Xiaohong, Chang, Ming, Chen, Xue-Qing, Shen, Hong, Li, Jianqing, Smith, Daniel, Wu, Dauh-Rurng, Leith, Leslie, Harikrishnan, Lalgudi S, Kamau, Muthoni G, Miller, Michael M, Bilder, Donna, Rampulla, Richard, Li, Yi-Xin, Xu, Carrie, Lawrence, R. Michael, Poss, Michael A, Levesque, Paul, Gordon, David A, Huang, Christine S, Finlay, Heather J, Wexler, Ruth R, Salvati, Mark E
Published in Journal of medicinal chemistry (25.11.2015)
Published in Journal of medicinal chemistry (25.11.2015)
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Source rock heterogeneity of the Upper Jurassic Draupne Formation, North Viking Graben, and its relevance to petroleum generation studies
Keym, Matthias, Dieckmann, Volker, Horsfield, Brian, Erdmann, Michael, Galimberti, Roberto, Kua, Lung-Chuan, Leith, Leslie, Podlaha, Olaf
Published in Organic geochemistry (01.02.2006)
Published in Organic geochemistry (01.02.2006)
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Discovery and Development of 5-[(5S,9R)-9- (4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1- methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non- 7-yl-methyl]-3-thiophenecarboxylic Acid (BMS-587101)A Small Molecule Antagonist of Leukocyte Function Associated Antigen-1
Potin, Dominique, Launay, Michele, Monatlik, Francoise, Malabre, Patrice, Fabreguettes, Maud, Fouquet, Andre, Maillet, Magali, Nicolai, Eric, Dorgeret, Loïc, Chevallier, François, Besse, Dominique, Dufort, Monique, Caussade, François, Ahmad, Syed Z, Stetsko, Dawn K, Skala, Stacey, Davis, Patricia M, Balimane, Praveen, Patel, Karishma, Yang, Zheng, Marathe, Punit, Postelneck, Jennifer, Townsend, Robert M, Goldfarb, Valentina, Sheriff, Steven, Einspahr, Howard, Kish, Kevin, Malley, Mary F, DiMarco, John D, Gougoutas, Jack Z, Kadiyala, Pathanjali, Cheney, Daniel L, Tejwani, Ravindra W, Murphy, Denette K, Mcintyre, Kim W, Yang, Xiaoxia, Chao, Sam, Leith, Leslie, Xiao, Zili, Mathur, Arvind, Chen, Bang-Chi, Wu, Daugh-Rurng, Traeger, Sarah C, McKinnon, Murray, Barrish, Joel C, Robl, Jeffrey A, Iwanowicz, Edwin J, Suchard, Suzanne J, Dhar, T. G. Murali
Published in Journal of medicinal chemistry (30.11.2006)
Published in Journal of medicinal chemistry (30.11.2006)
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Design and Synthesis of a G-Protein-Coupled Receptor Antagonist Library of Aryloxyalkanolamines Using a Polymer-Supported Acyclic Acetal Linker
Roberge, Jacques Y, Harikrishnan, Lalgudi S, Kamau, Muthoni G, Ruan, Zheming, Van Kirk, Katy, Liu, Yalei, Cooper, Christopher B, Poss, Michael A, Dickson, John K, Gavai, Ashvinikumar V, Chao, Sam T, Leith, Leslie W, Bednarz, Mark S, Mathur, Arvind, Kakarla, Ramesh, Schnur, Dora M, Vaz, Roy, Lawrence, R. Michael
Published in Journal of combinatorial chemistry (12.01.2009)
Published in Journal of combinatorial chemistry (12.01.2009)
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Thio- and Oxoflavopiridols, Cyclin-Dependent Kinase 1-Selective Inhibitors: Synthesis and Biological Effects
Kim, Kyoung Soon, Sack, John S, Tokarski, John S, Qian, Ligang, Chao, Sam T, Leith, Leslie, Kelly, Yolanda F, Misra, Raj N, Hunt, John T, Kimball, S. David, Humphreys, William G, Wautlet, Barris S, Mulheron, Janet G, Webster, Kevin R
Published in Journal of medicinal chemistry (02.11.2000)
Published in Journal of medicinal chemistry (02.11.2000)
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Biphenylsulfonamide Endothelin Receptor Antagonists. 4. Discovery of N-[[2‘-[[(4,5-Dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1‘-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), A Highly Potent and Orally Active ETA Selective Antagonist
Murugesan, Natesan, Gu, Zhengxiang, Spergel, Steven, Young, Marian, Chen, Ping, Mathur, Arvind, Leith, Leslie, Hermsmeier, Mark, Liu, Eddie C.-K, Zhang, Rongan, Bird, Eileen, Waldron, Tom, Marino, Anthony, Koplowitz, Barry, Humphreys, W. Griffith, Chong, Saeho, Morrison, Richard A, Webb, Maria L, Moreland, Suzanne, Trippodo, Nick, Barrish, Joel C
Published in Journal of medicinal chemistry (02.01.2003)
Published in Journal of medicinal chemistry (02.01.2003)
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Synthesis of lead LFA-1 antagonist [14C]spyrocyclic hydantoin
Tran, Scott B., Maxwell, Brad D., Chen, Shiang-Yuan, Bonacorsi, Samuel J., Leith, Leslie, Ogan, Marc, Rinehart, J. Kent, Balasubramanian, Balu
Published in Journal of labelled compounds & radiopharmaceuticals (30.05.2009)
Published in Journal of labelled compounds & radiopharmaceuticals (30.05.2009)
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Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors
Chen, Ping, Norris, Derek, Das, Jagabandhu, Spergel, Steven H, Wityak, John, Leith, Leslie, Zhao, Rulin, Chen, Bang-Chi, Pitt, Sidney, Pang, Suhong, Shen, Ding Ren, Zhang, Rosemary, De Fex, Henry F, Doweyko, Arthur M, McIntyre, Kim W, Shuster, David J, Behnia, Kamelia, Schieven, Gary L, Barrish, Joel C
Published in Bioorganic & medicinal chemistry letters (20.12.2004)
Published in Bioorganic & medicinal chemistry letters (20.12.2004)
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Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl- 1H-indol-5-yloxy)-5-methylpyrrolo[2,1-/][1,2,4]triazin-6-yloxy)propan2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor
BHIDE, Rajeev S, CAI, Zhen-Wei, BARRISH, Joel C, KIM, Soong-Hoon, LEAVITT, Kenneth, MATHUR, Arvind, LEITH, Leslie, CHAO, Sam, WAUTLET, Barri, MORTILLO, Steven, JEYASEELAN, Robert, KUKRAL, Daniel, ZHANG, Yong-Zheng, HUNT, John T, KAMATH, Amrita, FURA, Aberra, VYAS, Viral, MARATHE, Punit, D'ARIENZO, Celia, DERBIN, George, FARGNOLI, Joseph, LIGANG QIAN, WEI, Donna, BARBOSA, Stephanie, LOMBARDO, Louis J, BORZILLERI, Robert M, XIAOPING ZHENG, WU, Laurence I
Published in Journal of medicinal chemistry (2006)
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Published in Journal of medicinal chemistry (2006)
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Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists
Murugesan, N, Gu, Z, Stein, P D, Spergel, S, Mathur, A, Leith, L, Liu, E C, Zhang, R, Bird, E, Waldron, T, Marino, A, Morrison, R A, Webb, M L, Moreland, S, Barrish, J C
Published in Journal of medicinal chemistry (10.08.2000)
Published in Journal of medicinal chemistry (10.08.2000)
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Biphenylsulfonamide Endothelin Receptor Antagonists. 2. Discovery of 4‘-Oxazolyl Biphenylsulfonamides as a New Class of Potent, Highly Selective ETA Antagonists
Murugesan, Natesan, Gu, Zhengxiang, Stein, Philip D, Spergel, Steven, Mathur, Arvind, Leith, Leslie, Liu, Eddie C.-K, Zhang, Rongan, Bird, Eileen, Waldron, Tom, Marino, Anthony, Morrison, Richard A, Webb, Maria L, Moreland, Suzanne, Barrish, Joel C
Published in Journal of medicinal chemistry (10.08.2000)
Published in Journal of medicinal chemistry (10.08.2000)
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Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56Lck inhibitors
PING CHEN, NORRIS, Derek, DING REN SHEN, ZHANG, Rosemary, DE FEX, Henry F, DOWEYKO, Arthur M, MCINTYRE, Kim W, SHUSTER, David J, BEHNIA, Kamelia, SCHIEVEN, Gary L, BARRISH, Joel C, DAS, Jagabandhu, SPERGEL, Steven H, WITYAK, John, LEITH, Leslie, RULIN ZHAO, CHEN, Bang-Chi, PITT, Sidney, SUHONG PANG
Published in Bioorganic & medicinal chemistry letters (01.12.2004)
Published in Bioorganic & medicinal chemistry letters (01.12.2004)
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Journal Article
Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56 Lck inhibitors
Chen, Ping, Norris, Derek, Das, Jagabandhu, Spergel, Steven H., Wityak, John, Leith, Leslie, Zhao, Rulin, Chen, Bang-Chi, Pitt, Sidney, Pang, Suhong, Shen, Ding Ren, Zhang, Rosemary, De Fex, Henry F., Doweyko, Arthur M., McIntyre, Kim W., Shuster, David J., Behnia, Kamelia, Schieven, Gary L., Barrish, Joel C.
Published in Bioorganic & medicinal chemistry letters (2004)
Published in Bioorganic & medicinal chemistry letters (2004)
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