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Inman, Gareth J., Wang, Jun, Nagano, Ai, Alexandrov, Ludmil B., Purdie, Karin J., Taylor, Richard G., Sherwood, Victoria, Thomson, Jason, Hogan, Sarah, Spender, Lindsay C., South, Andrew P., Stratton, Michael, Chelala, Claude, Harwood, Catherine A., Proby, Charlotte M., Leigh, Irene M.
Published in Nature communications (10.09.2018)
Published in Nature communications (10.09.2018)
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Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England
Venables, Zoë C, Autier, Philippe, Nijsten, Tamar, Wong, Kwok F, Langan, Sinéad M, Rous, Brian, Broggio, John, Harwood, Catherine, Henson, Katherine, Proby, Charlotte M, Rashbass, Jem, Leigh, Irene M
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Published in JAMA dermatology (Chicago, Ill.) (01.03.2019)
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NOTCH1 Mutations Occur Early during Cutaneous Squamous Cell Carcinogenesis
South, Andrew P., Purdie, Karin J., Watt, Stephen A., Haldenby, Sam, den Breems, Nicoline Y., Dimon, Michelle, Arron, Sarah T., Kluk, Michael J., Aster, Jon C., McHugh, Angela, Xue, Dylan J., Dayal, Jasbani H.S., Robinson, Kim S., Hasan Rizvi, S.M., Proby, Charlotte M., Harwood, Catherine A., Leigh, Irene M.
Published in Journal of investigative dermatology (01.10.2014)
Published in Journal of investigative dermatology (01.10.2014)
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Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression
Bailey, Peter, Ridgway, Rachel A., Cammareri, Patrizia, Treanor-Taylor, Mairi, Bailey, Ulla-Maja, Schoenherr, Christina, Bone, Max, Schreyer, Daniel, Purdie, Karin, Thomson, Jason, Rickaby, William, Jackstadt, Rene, Campbell, Andrew D., Dimonitsas, Emmanouil, Stratigos, Alexander J., Arron, Sarah T., Wang, Jun, Blyth, Karen, Proby, Charlotte M., Harwood, Catherine A., Sansom, Owen J., Leigh, Irene M., Inman, Gareth J.
Published in Nature communications (25.08.2023)
Published in Nature communications (25.08.2023)
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Mutations in AQP5, Encoding a Water-Channel Protein, Cause Autosomal-Dominant Diffuse Nonepidermolytic Palmoplantar Keratoderma
Blaydon, Diana C., Lind, Lisbet K., Plagnol, Vincent, Linton, Kenneth J., Smith, Francis J.D., Wilson, Neil J., McLean, W.H. Irwin, Munro, Colin S., South, Andrew P., Leigh, Irene M., O’Toole, Edel A., Lundström, Anita, Kelsell, David P.
Published in American journal of human genetics (08.08.2013)
Published in American journal of human genetics (08.08.2013)
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Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expression
Li Mow Chee, Frederic, Beernaert, Bruno, Griffith, Billie G. C., Loftus, Alexander E. P., Kumar, Yatendra, Wills, Jimi C., Lee, Martin, Valli, Jessica, Wheeler, Ann P., Armstrong, J. Douglas, Parsons, Maddy, Leigh, Irene M., Proby, Charlotte M., von Kriegsheim, Alex, Bickmore, Wendy A., Frame, Margaret C., Byron, Adam
Published in Nature communications (23.03.2023)
Published in Nature communications (23.03.2023)
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Potential of Fibroblast Cell Therapy for Recessive Dystrophic Epidermolysis Bullosa
Wong, Tracy, Gammon, Luke, Liu, Lu, Mellerio, Jemima E., Dopping-Hepenstal, Patricia J.C., Pacy, John, Elia, George, Jeffery, Rosemary, Leigh, Irene M., Navsaria, Harshad, McGrath, John A.
Published in Journal of investigative dermatology (01.09.2008)
Published in Journal of investigative dermatology (01.09.2008)
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RHBDF2 Mutations Are Associated with Tylosis, a Familial Esophageal Cancer Syndrome
Blaydon, Diana C., Etheridge, Sarah L., Risk, Janet M., Hennies, Hans-Christian, Gay, Laura J., Carroll, Rebecca, Plagnol, Vincent, McRonald, Fiona E., Stevens, Howard P., Spurr, Nigel K., Bishop, D. Timothy, Ellis, Anthony, Jankowski, Janusz, Field, John K., Leigh, Irene M., South, Andrew P., Kelsell, David P.
Published in American journal of human genetics (10.02.2012)
Published in American journal of human genetics (10.02.2012)
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Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16
Maruthappu, Thiviyani, Chikh, Anissa, Fell, Benjamin, Delaney, Paul J., Brooke, Matthew A., Levet, Clemence, Moncada-Pazos, Angela, Ishida-Yamamoto, Akemi, Blaydon, Diana, Waseem, Ahmad, Leigh, Irene M., Freeman, Matthew, Kelsell, David P.
Published in Nature communications (27.01.2017)
Published in Nature communications (27.01.2017)
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Genomic analysis of atypical fibroxanthoma
Lai, Kevin, Harwood, Catherine A, Purdie, Karin J, Proby, Charlotte M, Leigh, Irene M, Ravi, Namita, Mully, Thaddeus W, Brooks, Lionel, Sandoval, Priscilla M, Rosenblum, Michael D, Arron, Sarah T
Published in PloS one (15.11.2017)
Published in PloS one (15.11.2017)
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Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry
Kluk, Michael J, Ashworth, Todd, Wang, Hongfang, Knoechel, Birgit, Mason, Emily F, Morgan, Elizabeth A, Dorfman, David, Pinkus, Geraldine, Weigert, Oliver, Hornick, Jason L, Chirieac, Lucian R, Hirsch, Michelle, Oh, David J, South, Andrew P, Leigh, Irene M, Pourreyron, Celine, Cassidy, Andrew J, Deangelo, Daniel J, Weinstock, David M, Krop, Ian E, Dillon, Deborah, Brock, Jane E, Lazar, Alexander J F, Peto, Myron, Cho, Raymond J, Stoeck, Alexander, Haines, Brian B, Sathayanrayanan, Sriram, Rodig, Scott, Aster, Jon C
Published in PloS one (18.06.2013)
Published in PloS one (18.06.2013)
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A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing
Hassan, Sakinah, Purdie, Karin J, Wang, Jun, Harwood, Catherine A, Proby, Charlotte M, Pourreyron, Celine, Mladkova, Nikol, Nagano, Ai, Dhayade, Sandeep, Athineos, Dimitris, Caley, Matthew, Mannella, Viviana, Blyth, Karen, Inman, Gareth J, Leigh, Irene M
Published in International journal of molecular sciences (12.07.2019)
Published in International journal of molecular sciences (12.07.2019)
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Growth and Viability of Cutaneous Squamous Cell Carcinoma Cell Lines Display Different Sensitivities to Isoform-Specific Phosphoinositide 3-Kinase Inhibitors
Mannella, Viviana, Boehm, Kira, Celik, Suheyla, Ali, Tasnim, Mirza, Amnah N, El Hasnaouy, Mariam, Kaffa, Andreas, Lyu, Yanshuang, Kafaei Golahmadi, Donya, Leigh, Irene M, Bergamaschi, Daniele, Harwood, Catherine A, Maffucci, Tania
Published in International journal of molecular sciences (30.03.2021)
Published in International journal of molecular sciences (30.03.2021)
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Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity
McHugh, Angela, Fernandes, Kenneth, South, Andrew P, Mellerio, Jemima E, Salas-Alanís, Julio C, Proby, Charlotte M, Leigh, Irene M, Saville, Mark K
Published in Oncotarget (17.04.2018)
Published in Oncotarget (17.04.2018)
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The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions
Purdie, Karin J, Proby, Charlotte M, Rizvi, Hasan, Griffin, Heather, Doorbar, John, Sommerlad, Mary, Feltkamp, Mariet C, der Meijden, Els Van, Inman, Gareth J, South, Andrew P, Leigh, Irene M, Harwood, Catherine A
Published in Frontiers in microbiology (14.08.2018)
Published in Frontiers in microbiology (14.08.2018)
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Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling
Bose, Amrita, Teh, Muy-Teck, Hutchison, Iain L, Wan, Hong, Leigh, Irene M, Waseem, Ahmad
Published in PloS one (27.06.2012)
Published in PloS one (27.06.2012)
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Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa
Watt, Stephen A, Dayal, Jasbani H S, Wright, Sheila, Riddle, Megan, Pourreyron, Celine, McMillan, James R, Kimble, Roy M, Prisco, Marco, Gartner, Ulrike, Warbrick, Emma, McLean, W H Irwin, Leigh, Irene M, McGrath, John A, Salas-Alanis, Julio C, Tolar, Jakub, South, Andrew P
Published in PloS one (18.09.2015)
Published in PloS one (18.09.2015)
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Tyrosine dephosphorylation is required for Bak activation in apoptosis
Fox, Joanna L, Ismail, Ferina, Azad, Abul, Ternette, Nicola, Leverrier, Sabrina, Edelmann, Mariola J, Kessler, Benedikt M, Leigh, Irene M, Jackson, Sarah, Storey, Alan
Published in The EMBO journal (17.11.2010)
Published in The EMBO journal (17.11.2010)
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Role of a p53 polymorphism in the development of human papilloma-virus-associated cancer
Matlashewski, Greg, Banks, Lawrence, Storey, Alan, Thomas, Miranda, Kalita, Ann, Harwood, Catherine, Gardiol, Daniela, Mantovani, Fiamma, Breuer, Judith, Leigh, Irene M
Published in Nature (London) (21.05.1998)
Published in Nature (London) (21.05.1998)
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