An updated patent review of autotaxin inhibitors (2017-present)
Tan, Zehui, Lei, Hongrui, Guo, Ming, Chen, Yuxiang, Zhai, Xin
Published in Expert opinion on therapeutic patents (04.05.2021)
Published in Expert opinion on therapeutic patents (04.05.2021)
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Journal Article
Recent advances and challenges of revolutionizing drug-resistant tuberculosis treatment
Wei, Xiujian, Yue, Lingfeng, Zhao, Bing, Jiang, Nan, Lei, Hongrui, Zhai, Xin
Published in European journal of medicinal chemistry (05.11.2024)
Published in European journal of medicinal chemistry (05.11.2024)
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Journal Article
Discovery of Novel Non-nucleoside DOT1LR231Q Inhibitors with Improved Pharmacokinetic Properties and Anti-lung Cancer Efficacy
Tan, Zehui, Guo, Ning, Liu, Shuyu, Li, Jiandong, Chen, Yu, Cui, Jianming, Lei, Hongrui, Jiang, Nan, Wang, Lihui, Zhai, Xin
Published in Journal of medicinal chemistry (26.09.2024)
Published in Journal of medicinal chemistry (26.09.2024)
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Journal Article
Discovery of Novel Non-nucleoside DOT1L R231Q Inhibitors with Improved Pharmacokinetic Properties and Anti-lung Cancer Efficacy
Tan, Zehui, Guo, Ning, Liu, Shuyu, Li, Jiandong, Chen, Yu, Cui, Jianming, Lei, Hongrui, Jiang, Nan, Wang, Lihui, Zhai, Xin
Published in Journal of medicinal chemistry (26.09.2024)
Published in Journal of medicinal chemistry (26.09.2024)
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Journal Article
Discovery of Novel Indole-Based Allosteric Highly Potent ATX Inhibitors with Great In Vivo Efficacy in a Mouse Lung Fibrosis Model
Lei, Hongrui, Guo, Ming, Li, Xiaopeng, Jia, Fang, Li, Changtao, Yang, Yu, Cao, Meng, Jiang, Nan, Ma, Enlong, Zhai, Xin
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Journal Article
Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects
Lei, Hongrui, Li, Changtao, Yang, Yu, Jia, Fang, Guo, Ming, Zhu, Minglin, Jiang, Nan, Zhai, Xin
Published in European journal of medicinal chemistry (01.09.2020)
Published in European journal of medicinal chemistry (01.09.2020)
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Journal Article
Design, synthesis and anti-fibrosis evaluation of imidazo[1,2–a]pyridine derivatives as potent ATX inhibitors
Chen, Yuxiang, Lei, Hongrui, Li, Tong, Cui, Youbao, Wang, Xinyu, Cao, Zhi, Wu, Huinan, Zhai, Xin
Published in Bioorganic & medicinal chemistry (15.09.2021)
Published in Bioorganic & medicinal chemistry (15.09.2021)
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Journal Article
Design, synthesis and promising anti-tumor efficacy of novel imidazo[1,2-a]pyridine derivatives as potent autotaxin allosteric inhibitors
Lei, Hongrui, Wang, Xinyu, Zhao, Guolong, Li, Tong, Cui, Youbao, Wu, Huinan, Yang, Jing, Jiang, Nan, Zhai, Xin
Published in European journal of medicinal chemistry (05.06.2022)
Published in European journal of medicinal chemistry (05.06.2022)
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Journal Article
Precise engineering of disulfide bond-bridged prodrug nanoassemblies to balance antitumor efficacy and safety
Sun, Yixin, Wang, Simeng, Li, Yaqi, Wang, Danping, Zhang, Yu, Zhang, Haotian, Lei, Hongrui, Liu, Xiaohong, Sun, Jin, Sun, Bingjun, He, Zhonggui
Published in Acta biomaterialia (01.02.2023)
Published in Acta biomaterialia (01.02.2023)
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Journal Article
Structure-based linker exploration: Discovery of 1-ethyl-1H-indole analogs as novel ATX inhibitors
Jia, Fang, Lei, Hongrui, Chen, Yuxiang, Li, Tong, Xing, Lingyun, Cao, Zhi, Zhai, Xin
Published in Bioorganic & medicinal chemistry (15.11.2020)
Published in Bioorganic & medicinal chemistry (15.11.2020)
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Journal Article
An exploration of solvent-front region high affinity moiety leading to novel potent ALK & ROS1 dual inhibitors with mutant-combating effects
Lei, Hongrui, Jia, Fang, Cao, Meng, Wang, Jie, Guo, Ming, Zhu, Minglin, Zuo, Daiying, Zhai, Xin
Published in Bioorganic & medicinal chemistry (15.10.2019)
Published in Bioorganic & medicinal chemistry (15.10.2019)
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Journal Article
Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model
Lei, Hongrui, Cao, Zhi, Wu, Huinan, Li, Tong, Wang, Xinyu, Chen, Yuxiang, Ma, Enlong, Sun, Lixin, Zhai, Xin
Published in European journal of medicinal chemistry (05.01.2022)
Published in European journal of medicinal chemistry (05.01.2022)
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Journal Article
Catalyst-Free Cyclization- and Curtius Rearrangement-Induced Functional Group Transformation: An Improved Synthetic Strategy of First-in-Class ATX Inhibitor Ziritaxestat (GLPG-1690)
Lei, Hongrui, Yang, Yu, Li, Changtao, Jia, Fang, Jiang, Nan, Gong, Ping, Zhai, Xin
Published in Organic process research & development (19.06.2020)
Published in Organic process research & development (19.06.2020)
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Journal Article
Discovery of novel tetrahydropyrido[4,3-d]pyrimidine analogs as potent autotaxin regulators with impressive tumor suppression effects
Wu, Huinan, Lei, Hongrui, Tan, Zehui, Ma, Deyi, Li, Tong, Wang, Fuyi, Guo, Mengrao, Jiang, Nan, Zhai, Xin
Published in Journal of molecular structure (05.01.2023)
Published in Journal of molecular structure (05.01.2023)
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Journal Article
Discovery and optimization of tetrahydropyrido[4,3-d]pyrimidine derivatives as novel ATX and EGFR dual inhibitors
Jing, Tongfei, Miao, Xiuqi, Jiang, Feng, Guo, Ming, Xing, Lingyun, Zhang, Junlong, Zuo, Daiying, Lei, Hongrui, Zhai, Xin
Published in Bioorganic & medicinal chemistry (01.05.2018)
Published in Bioorganic & medicinal chemistry (01.05.2018)
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Journal Article
Discovery of novel mutant-combating ALK and ROS1 dual inhibitors bearing imidazolidin-2-one moiety with reasonable PK properties
Lei, Hongrui, Jiang, Nan, Miao, Xiuqi, Xing, Lingyun, Guo, Ming, Liu, Yang, Xu, Haowen, Gong, Ping, Zuo, Daiying, Zhai, Xin
Published in European journal of medicinal chemistry (01.06.2019)
Published in European journal of medicinal chemistry (01.06.2019)
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Journal Article
Optimization and evaluation of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as ATX inhibitors for cardiac and hepatic fibrosis
Jiang, Nan, Zhou, Yuhong, Zhu, Minglin, Zhang, Junlong, Cao, Meng, Lei, Hongrui, Guo, Ming, Gong, Ping, Su, Guangyue, Zhai, Xin
Published in European journal of medicinal chemistry (01.02.2020)
Published in European journal of medicinal chemistry (01.02.2020)
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Journal Article
Hybrid imidazo[1,2‐a]pyridine analogs as potent ATX inhibitors with concrete in vivo antifibrosis effect
Li, Tong, Lei, Hongrui, Yang, Juanjuan, Cao, Zhi, Yang, Yu, Liu, Zimeng, Sun, Ruonan, Yang, Xinlian, Zhai, Xin
Published in Archiv der Pharmazie (Weinheim) (01.10.2022)
Published in Archiv der Pharmazie (Weinheim) (01.10.2022)
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Journal Article
Design, synthesis and biological evaluation of novel 4-arylaminopyrimidine derivatives possessing a hydrazone moiety as dual inhibitors of L1196M ALK and ROS1
Wang, Yu, Zhang, Guogang, Hu, Gang, Bu, Yanxin, Lei, Hongrui, Zuo, Daiying, Han, Mengting, Zhai, Xin, Gong, Ping
Published in European journal of medicinal chemistry (10.11.2016)
Published in European journal of medicinal chemistry (10.11.2016)
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