Inhibition of endothelin-B receptor signaling synergizes with MAPK pathway inhibitors in BRAF mutated melanoma
Schäfer, Alexander, Haenig, Benedicte, Erupathil, Julie, Strickner, Panja, Sabato, Daniela, Welford, Richard W. D., Klaeylé, Lhéanna, Simon, Elise, Krepler, Clemens, Brafford, Patricia, Xiao, Min, Herlyn, Meenhard, Gstaiger, Matthias, Lehembre, Francois, Renz, Imke
Published in Oncogene (04.03.2021)
Published in Oncogene (04.03.2021)
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Macitentan, a Dual Endothelin Receptor Antagonist, in Combination with Temozolomide Leads to Glioblastoma Regression and Long-term Survival in Mice
Kim, Sun-Jin, Lee, Ho Jeong, Kim, Mark Seungwook, Choi, Hyun Jin, He, Junqin, Wu, Qiuyu, Aldape, Kenneth, Weinberg, Jeffrey S, Yung, W K Alfred, Conrad, Charles A, Langley, Robert R, Lehembre, François, Regenass, Urs, Fidler, Isaiah J
Published in Clinical cancer research (15.10.2015)
Published in Clinical cancer research (15.10.2015)
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Journal Article
NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin
Lehembre, Francois, Yilmaz, Mahmut, Wicki, Andreas, Schomber, Tibor, Strittmatter, Karin, Ziegler, Dominik, Kren, Angelika, Went, Phillip, Derksen, Patrick WB, Berns, Anton, Jonkers, Jos, Christofori, Gerhard
Published in The EMBO journal (08.10.2008)
Published in The EMBO journal (08.10.2008)
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Journal Article
Elucidating essential kinases of endothelin signalling by logic modelling of phosphoproteomics data
Schäfer, Alexander, Gjerga, Enio, Welford, Richard WD, Renz, Imke, Lehembre, Francois, Groenen, Peter MA, Saez‐Rodriguez, Julio, Aebersold, Ruedi, Gstaiger, Matthias
Published in Molecular systems biology (01.08.2019)
Published in Molecular systems biology (01.08.2019)
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Journal Article
Macitentan (ACT-064992), a Tissue-Targeting Endothelin Receptor Antagonist, Enhances Therapeutic Efficacy of Paclitaxel by Modulating Survival Pathways in Orthotopic Models of Metastatic Human Ovarian Cancer
Kim, Sun-Jin, Kim, Jang Seong, Kim, Seung Wook, Brantley, Emily, Yun, Seok Joong, He, Junqin, Maya, Marva, Zhang, Fahao, Wu, Qiuyu, Lehembre, François, Regenass, Urs, Fidler, Isaiah J
Published in Neoplasia (New York, N.Y.) (01.02.2011)
Published in Neoplasia (New York, N.Y.) (01.02.2011)
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Journal Article
Discovery of the Potent, Selective, Orally Available CXCR7 Antagonist ACT-1004-1239
Richard-Bildstein, Sylvia, Aissaoui, Hamed, Pothier, Julien, Schäfer, Gabriel, Gnerre, Carmela, Lindenberg, Eleanor, Lehembre, François, Pouzol, Laetitia, Guerry, Philippe
Published in Journal of medicinal chemistry (24.12.2020)
Published in Journal of medicinal chemistry (24.12.2020)
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Journal Article
Distinct mechanisms of tumor invasion and metastasis
Yilmaz, Mahmut, Christofori, Gerhard, Lehembre, François
Published in Trends in molecular medicine (01.12.2007)
Published in Trends in molecular medicine (01.12.2007)
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Journal Article
The SUMO Pathway Is Essential for Nuclear Integrity and Chromosome Segregation in Mice
Nacerddine, Karim, Lehembre, François, Bhaumik, Mantu, Artus, Jérôme, Cohen-Tannoudji, Michel, Babinet, Charles, Pandolfi, Pier Paolo, Dejean, Anne
Published in Developmental cell (01.12.2005)
Published in Developmental cell (01.12.2005)
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CXCR7 Antagonism Reduces Acute Lung Injury Pathogenesis
Pouzol, Laetitia, Sassi, Anna, Baumlin, Nadège, Tunis, Mélanie, Strasser, Daniel S., Lehembre, François, Martinic, Marianne M.
Published in Frontiers in pharmacology (05.11.2021)
Published in Frontiers in pharmacology (05.11.2021)
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Journal Article
Design of Dual EP2/EP4 Antagonists through Scaffold Merging of Selective Inhibitors
Corminboeuf, Olivier, Diethelm, Stefan, Zumbrunn, Cornelia, Lyothier, Isabelle, Niggli, Nadja, Gnerre, Carmela, Jeay, Sébastien, Lehembre, François, Boss, Christoph
Published in ChemMedChem (15.01.2024)
Published in ChemMedChem (15.01.2024)
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Journal Article
Tumor invasion in the absence of epithelial-mesenchymal transition: Podoplanin-mediated remodeling of the actin cytoskeleton
Wicki, Andreas, Lehembre, François, Wick, Nikolaus, Hantusch, Brigitte, Kerjaschki, Dontscho, Christofori, Gerhard
Published in Cancer cell (01.04.2006)
Published in Cancer cell (01.04.2006)
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Treatment of experimental human breast cancer and lung cancer brain metastases in mice by macitentan, a dual antagonist of endothelin receptors, combined with paclitaxel
Lee, Ho Jeong, Hanibuchi, Masaki, Kim, Sun-Jin, Yu, Hyunkyung, Kim, Mark Seungwook, He, Junqin, Langley, Robert R, Lehembre, François, Regenass, Urs, Fidler, Isaiah J
Published in Neuro-oncology (Charlottesville, Va.) (01.04.2016)
Published in Neuro-oncology (Charlottesville, Va.) (01.04.2016)
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Journal Article
Transcription factor Dlx2 protects from TGFβ-induced cell-cycle arrest and apoptosis
Yilmaz, Mahmut, Maaß, Dorothea, Tiwari, Neha, Waldmeier, Lorenz, Schmidt, Petra, Lehembre, François, Christofori, Gerhard
Published in The EMBO journal (02.11.2011)
Published in The EMBO journal (02.11.2011)
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Journal Article
Increased tumor cell dissemination and cellular senescence in the absence of β1-integrin function
Kren, Angelika, Baeriswyl, Vanessa, Lehembre, François, Wunderlin, Christoph, Strittmatter, Karin, Antoniadis, Helena, Fässler, Reinhard, Cavallaro, Ugo, Christofori, Gerhard
Published in The EMBO journal (20.06.2007)
Published in The EMBO journal (20.06.2007)
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Journal Article
A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor
Lotz-Jenne, Carina, Lüthi, Urs, Ackerknecht, Sabine, Lehembre, François, Fink, Tobias, Stritt, Manuel, Wirth, Matthias, Pavan, Simona, Bill, Ruben, Regenass, Urs, Christofori, Gerhard, Meyer-Schaller, Nathalie
Published in Oncotarget (03.05.2016)
Published in Oncotarget (03.05.2016)
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Journal Article
Antivascular Therapy for Multidrug-Resistant Ovarian Tumors by Macitentan, a Dual Endothelin Receptor Antagonist
Kim, Sun-Jin, Kim, Jang Seong, Kim, Seung Wook, Yun, Seok Joong, He, Junqin, Brantley, Emily, Fan, Dominic, Strickner, Panja, Lehembre, François, Regenass, Urs, Fidler, Isaiah J
Published in Translational oncology (01.02.2012)
Published in Translational oncology (01.02.2012)
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Journal Article
Regulation of Pax3 transcriptional activity by SUMO-1-modified PML
LEHEMBRE, Francois, MÜLLER, Stefan, PANDOLFI, Pier Paolo, DEJEAN, Anne
Published in Oncogene (04.01.2001)
Published in Oncogene (04.01.2001)
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Journal Article
Abstract 1809: ACT-1002-4391 - A novel potent antagonist of the prostaglandin E2 receptors EP2 and EP4 with excellent duality
Jeay, Sébastien, Diethelm, Stefan, Knopf, Agnes, Goxe, Marie, Daugan, Marie, Erupathil, Julie, Pothier, Julien, Pozzi, Davide, Sifferlen, Thierry, Wyder, Lorenza, Lyothier, Isabelle, Corminboeuf, Olivier, Lehembre, Francois, Renz, Imke, Meyer, Dominique
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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