Pharmacological disruption of the Notch transcription factor complex
Lehal, Rajwinder, Zaric, Jelena, Vigolo, Michele, Urech, Charlotte, Frismantas, Viktoras, Zangger, Nadine, Cao, Linlin, Berger, Adeline, Chicote, Irene, Loubéry, Sylvain, Choi, Sung Hee, Koch, Ute, Blacklow, Stephen C., Palmer, Hector G., Bornhauser, Beat, González-Gaitán, Marcos, Arsenijevic, Yvan, Zoete, Vincent, Aster, Jon C., Bourquin, Jean-Pierre, Radtke, Freddy
Published in Proceedings of the National Academy of Sciences - PNAS (14.07.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (14.07.2020)
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Journal Article
Notch Inhibition in Cancer: Challenges and Opportunities
Fabbro, Doriano, Bauer, Michael, Murone, Maximilien, Lehal, Rajwinder
Published in Chimia (01.10.2020)
Published in Chimia (01.10.2020)
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Journal Article
Identification of tumorsphere- and tumor-initiating cells in HER2/Neu-induced mammary tumors
Liu, Jeff C, Deng, Tao, Lehal, Rajwinder S, Kim, Jinny, Zacksenhaus, Eldad
Published in Cancer research (Chicago, Ill.) (15.09.2007)
Published in Cancer research (Chicago, Ill.) (15.09.2007)
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Journal Article
CB‐103: A novel CSL‐NICD inhibitor for the treatment of NOTCH‐driven T‐cell acute lymphoblastic leukemia: A case report of complete clinical response in a patient with relapsed and refractory T‐ALL
Medinger, Michael, Junker, Till, Heim, Dominik, Tzankov, Alexandar, Jermann, Philip M., Bobadilla, Maria, Vigolo, Michele, Lehal, Rajwinder, Vogl, Florian D., Bauer, Michael, Passweg, Jakob
Published in EJHaem (01.08.2022)
Published in EJHaem (01.08.2022)
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Journal Article
Very High Throughput Electrical Cell Lysis and Extraction of Intracellular Compounds Using 3D Carbon Electrodes in Lab-on-a-Chip Devices
Mernier, Guillaume, Martinez-Duarte, Rodrigo, Lehal, Rajwinder, Radtke, Freddy, Renaud, Philippe
Published in Micromachines (Basel) (01.09.2012)
Published in Micromachines (Basel) (01.09.2012)
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Journal Article
Abstract 5799: Characterization and profiling of CB-103, a novel small-molecule protein-protein interaction inhibitor targeting the NOTCH transcription complex
Lehal, Rajwinder, Urech, Charlotte, Vigolo, Michele, Murone, Maximilien, Radtke, Freddy
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 2695: Direct targeting of NOTCH transcription complex by a novel small molecule CB-103 circumvents dose-limiting toxicities associated with pan-NOTCH inhibitors
Lehal, Rajwinder, Zaric, Jelena, Vigolo, Michele, Urech, Charlotte, Murone, Maximilien, Radtke, Freddy
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
In vitro anti‐lymphoma activity of the first‐in‐class pan‐NOTCH transcription inhibitor CB‐103
Spriano, Filippo, Tarantelli, Chiara, Arribas, Alberto J., Gaudio, Eugenio, Cascione, Luciano, Aresu, Luca, Rinaldi, Andrea, Zucca, Emanuele, Rossi, Davide, Stathis, Anastasios, Murone, Maximilien, Radtke, Freddy, Lehal, Rajwinder, Bertoni, Francesco
Published in British journal of haematology (01.03.2023)
Published in British journal of haematology (01.03.2023)
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Journal Article
Gene expression patterns in adenoid cystic carcinoma with and without diffuse NOTCH1 intracellular domain (NICD1) immunohistochemistry staining
Patel, Karan, Manzo, Massimiliano, Hapuarachi, Brindley, Rack, Samuel, Jermann, Philip, Feeney, Laura, Heathcote, Emily, Betts, Guy, Aster, Jon C., Murone, Maximilien, Bobadilla, Maria, Lehal, Rajwinder, Vogl, Florian D., Harrington, Kevin, Metcalf, Robert
Published in Oral oncology (01.11.2023)
Published in Oral oncology (01.11.2023)
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Journal Article
Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity
Sabol, Hayley M, Ferrari, Adam J, Adhikari, Manish, Amorim, Tânia, McAndrews, Kevin, Anderson, Judith, Vigolo, Michele, Lehal, Rajwinder, Cregor, Meloney, Khan, Sharmin, Cuevas, Pedro L, Helms, Jill A, Kurihara, Noriyoshi, Srinivasan, Venkat, Ebetino, Frank H, Boeckman, Jr, Robert K, Roodman, G David, Bellido, Teresita, Delgado-Calle, Jesus
Published in Cancer research (Chicago, Ill.) (01.10.2021)
Published in Cancer research (Chicago, Ill.) (01.10.2021)
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Journal Article
Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production
Dimitrov, Mitko, Alattia, Jean-René, Lemmin, Thomas, Lehal, Rajwinder, Fligier, Andrzej, Houacine, Jemila, Hussain, Ishrut, Radtke, Freddy, Dal Peraro, Matteo, Beher, Dirk, Fraering, Patrick C.
Published in Nature communications (02.08.2013)
Published in Nature communications (02.08.2013)
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Journal Article
The Efficacy of CB-103, a First-in-Class Transcriptional Notch Inhibitor, in Preclinical Models of Breast Cancer
Vigolo, Michele, Urech, Charlotte, Lamy, Sebastien, Monticone, Giulia, Zabaleta, Jovanny, Hossain, Fokhrul, Wyczechowska, Dorota, Del Valle, Luis, O'Regan, Ruth M, Miele, Lucio, Lehal, Rajwinder, Majumder, Samarpan
Published in Cancers (03.08.2023)
Published in Cancers (03.08.2023)
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Journal Article
Abstract 408: Development of a first-in-class notch transcription factor inhibitor CB-103 to overcome resistance to chemotherapy and targeted therapies
Vigolo, Michele, Urech, Charlotte, Lamy, Sebastien, Majumder, Samarpan, Miele, Lucio, Lehal, Rajwinder
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Phase 1 study of CB-103, a novel first-in-class inhibitor of the CSL-NICD gene transcription factor complex in human cancers
Lopez Miranda, Elena, Stathis, Anastasios, Hess, Dagmar, Racca, Fabricio, Quon, Doris, Rodon, Jordi, Saavedra Santa Gadea, Omar, Perez Garcia, Jose Manuel, Nuciforo, Paolo, Vivancos, Ana, Cortes, Javier, Ferrarotto, Renata, Schönborn-Kellenberger, Oliver, Vigolo, Michele, Bobadilla, Maria, Beni, Laura, Lehal, Rajwinder, Bauer, Michael Pascal, Vogl, Florian D., Garralda, Elena
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
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Journal Article
Abstract 1163: Non clinical pharmacology, pharmacokinetics and safety profiling of CB-103: A novel first-in-class small molecule inhibitor of the NOTCH pathway
Lehal, Rajwinder, Frismantas, Viktoras, Urech, Charlotte, Murone, Maximilien, Weber, Dirk, Bauer, Michael, Bourquin, Jean-Pierre, Radtke, Freddy
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 338: A novel small molecule inhibitor of the Notch transcription activation complex
Lehal, Rajwinder, Frismantas, Viktoras, Loubéry, Sylvain, Reinmuller, Viktoria, Turcatti, Gerardo, Gonzalez-Gaitan, Marcos, Bourquin, Jean-Pierre, Radtke, Freddy
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article