The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K
Gauthier, Jacques Yves, Chauret, Nathalie, Cromlish, Wanda, Desmarais, Sylvie, Duong, Le T., Falgueyret, Jean-Pierre, Kimmel, Donald B., Lamontagne, Sonia, Léger, Serge, LeRiche, Tammy, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Nicoll-Griffith, Deborah A., Oballa, Renata M., Palmer, James T., Percival, M. David, Riendeau, Denis, Robichaud, Joel, Rodan, Gideon A., Rodan, Sevgi B., Seto, Carmai, Thérien, Michel, Truong, Vouy-Linh, Venuti, Michael C., Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Black, W. Cameron
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Journal Article
Novel pyridone EP4 agonists featuring allylic alcohol ω-chains
Dorich, Stéphane, Cox, Jennifer H., Burch, Jason D., Chagnon, Félix, Chen, Bin, Léger, Serge, St-Onge, Miguel, Fader, Lee D.
Published in Bioorganic & medicinal chemistry letters (15.05.2020)
Published in Bioorganic & medicinal chemistry letters (15.05.2020)
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On the Learning Curve Attrition Bias in Additive Factor Modeling
Goutte, Cyril, Durand, Guillaume, Léger, Serge
Published in Artificial Intelligence in Education (2018)
Published in Artificial Intelligence in Education (2018)
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Book Chapter
Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)
Léger, Serge, Black, W. Cameron, Deschenes, Denis, Dolman, Sarah, Falgueyret, Jean-Pierre, Gagnon, Marc, Guiral, Sébastien, Huang, Zheng, Guay, Jocelyne, Leblanc, Yves, Li, Chun-Sing, Massé, Frédéric, Oballa, Renata, Zhang, Lei
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K
Black, W. Cameron, Bayly, Christopher I., Davis, Dana E., Desmarais, Sylvie, Falgueyret, Jean-Pierre, Léger, Serge, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Palmer, James T., Percival, M. David, Robichaud, Joël, Tsou, Nancy, Zamboni, Robert
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
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Journal Article
Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series
Lachance, Nicolas, Gareau, Yves, Guiral, Sébastien, Huang, Zheng, Isabel, Elise, Leclerc, Jean-Philippe, Léger, Serge, Martins, Evelyn, Nadeau, Christian, Oballa, Renata M., Ouellet, Stéphane G., Powell, David A., Ramtohul, Yeeman K., Tranmer, Geoffrey K., Trinh, Thao, Wang, Hao, Zhang, Lei
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Journal Article
Identification of a Nonbasic, Nitrile-Containing Cathepsin K Inhibitor (MK-1256) that is Efficacious in a Monkey Model of Osteoporosis
Robichaud, Jöel, Black, W. Cameron, Thérien, Michel, Paquet, Julie, Oballa, Renata M, Bayly, Christopher I, McKay, Daniel J, Wang, Qingping, Isabel, Elise, Léger, Serge, Mellon, Christophe, Kimmel, Donald B, Wesolowski, Gregg, Percival, M. David, Massé, Fréderic, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Crane, Sheldon N
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
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Journal Article
Identification of a potent and selective non-basic cathepsin K inhibitor
Li, Chun Sing, Deschenes, Denis, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Kimmel, Donald. B., Léger, Serge, Massé, Frédéric, McGrath, Mary E., McKay, Daniel J., Percival, M. David, Riendeau, Denis, Rodan, Sevgi B., Thérien, Michel, Truong, Vouy-Linh, Wesolowski, Gregg, Zamboni, Robert, Black, W. Cameron
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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Journal Article
스플라이싱을 조절하기 위한 화합물 및 방법
REYNOLDS DOMINIC, VAILLANCOURT FREDERIC, AGRAWAL ANANT A, SEILER MICHAEL W, SMITH PETER, PRAJAPATI SUDEEP, LEGER SERGE
Year of Publication 09.01.2023
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Year of Publication 09.01.2023
Patent
스플라이싱을 조절하기 위한 화합물 및 방법
REYNOLDS DOMINIC, VAILLANCOURT FREDERIC, AGRAWAL ANANT A, SEILER MICHAEL W, SMITH PETER, LEGER SERGE
Year of Publication 06.01.2023
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Year of Publication 06.01.2023
Patent
Difluoroethylamines as an amide isostere in inhibitors of cathepsin K
Isabel, Elise, Mellon, Christophe, Boyd, Michael J., Chauret, Nathalie, Deschênes, Denis, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Khougaz, Karine, Lau, Cheuk K., Léger, Serge, Levorse, Dorothy A., Li, Chun Sing, Massé, Frédéric, David Percival, M., Roy, Bruno, Scheigetz, John, Thérien, Michel, Truong, Vouy Linh, Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Cameron Black, W.
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
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Journal Article
The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor
Isabel, Elise, Bateman, Kevin P., Chauret, Nathalie, Cromlish, Wanda, Desmarais, Sylvie, Duong, Le T., Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Lamontagne, Sonia, Lau, Cheuk K., Léger, Serge, LeRiche, Tammy, Lévesque, Jean-François, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Mellon, Christophe, Nicoll-Griffith, Deborah A., Oballa, Renata M., Percival, M. David, Riendeau, Denis, Robichaud, Joël, Rodan, Gideon A., Rodan, Sevgi B., Seto, Carmai, Thérien, Michel, Truong, Vouy Linh, Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Black, W. Cameron
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article
Primary amides as selective inhibitors of cathepsin K
Léger, Serge, Bayly, Christopher I., Black, W. Cameron, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Massé, Frédéric, Percival, M. David, Truchon, Jean-François
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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Journal Article