The role of ligand efficiency metrics in drug discovery
Hopkins, Andrew L, Keserü, György M, Leeson, Paul D, Rees, David C, Reynolds, Charles H
Published in Nature reviews. Drug discovery (01.02.2014)
Published in Nature reviews. Drug discovery (01.02.2014)
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Book Review
An analysis of the attrition of drug candidates from four major pharmaceutical companies
Waring, Michael J, Arrowsmith, John, Leach, Andrew R, Leeson, Paul D, Mandrell, Sam, Owen, Robert M, Pairaudeau, Garry, Pennie, William D, Pickett, Stephen D, Wang, Jibo, Wallace, Owen, Weir, Alex
Published in Nature reviews. Drug discovery (01.07.2015)
Published in Nature reviews. Drug discovery (01.07.2015)
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A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs
Wenlock, Mark C, Austin, Rupert P, Barton, Patrick, Davis, Andrew M, Leeson, Paul D
Published in Journal of medicinal chemistry (27.03.2003)
Published in Journal of medicinal chemistry (27.03.2003)
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From ATP to AZD6140 : The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis
SPRINGTHORPE, Brian, BAILEY, Andrew, HUNT, Simon F, INCE, Francis, INGALL, Anthony H, KIRK, Ian P, LEESON, Paul D, LEFF, Paul, LEWIS, Richard J, MARTIN, Barrie P, MCGINNITY, Dermot F, MORTIMORE, Michael P, BARTON, Patrick, PAINE, Stuart W, PAIRAUDEAU, Garry, PATEL, Anil, RIGBY, Aaron J, RILEY, Robert J, TEOBALD, Barry J, TOMLINSON, Wendy, WEBBORN, Peter J. H, WILLIS, Paul A, BIRKINSHAW, Timothy N, BONNERT, Roger V, BROWN, Roger C, CHAPMAN, David, DIXON, John, GUILE, Simon D, HUMPHRIES, Robert G
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
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Target-Based Evaluation of “Drug-Like” Properties and Ligand Efficiencies
Leeson, Paul D, Bento, A. Patricia, Gaulton, Anna, Hersey, Anne, Manners, Emma J, Radoux, Chris J, Leach, Andrew R
Published in Journal of medicinal chemistry (10.06.2021)
Published in Journal of medicinal chemistry (10.06.2021)
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The Time and Place for Nature in Drug Discovery
Young, Robert J., Flitsch, Sabine L., Grigalunas, Michael, Leeson, Paul D., Quinn, Ronald J., Turner, Nicholas J., Waldmann, Herbert
Published in JACS Au (28.11.2022)
Published in JACS Au (28.11.2022)
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Validity of Ligand Efficiency Metrics
Murray, Christopher W, Erlanson, Daniel A, Hopkins, Andrew L, Keserü, György M, Leeson, Paul D, Rees, David C, Reynolds, Charles H, Richmond, Nicola J
Published in ACS medicinal chemistry letters (12.06.2014)
Published in ACS medicinal chemistry letters (12.06.2014)
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Effect of Plasma Protein Binding on in Vivo Activity and Brain Penetration of Glycine/NMDA Receptor Antagonists
Rowley, Michael, Kulagowski, Janusz J, Watt, Alan P, Rathbone, Denise, Stevenson, Graeme I, Carling, Robert W, Baker, Raymond, Marshall, George R, Kemp, John A, Foster, Alan C, Grimwood, Sarah, Hargreaves, Richard, Hurley, Catherine, Saywell, Kay L, Tricklebank, Mark D, Leeson, Paul D
Published in Journal of medicinal chemistry (05.12.1997)
Published in Journal of medicinal chemistry (05.12.1997)
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Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules
Luker, Tim, Alcaraz, Lilian, Chohan, Kamaldeep K., Blomberg, Niklas, Brown, Dearg S., Butlin, Roger J., Elebring, Thomas, Griffin, Andrew M., Guile, Simon, St-Gallay, Stephen, Swahn, Britt-Marie, Swallow, Steve, Waring, Michael J., Wenlock, Mark C., Leeson, Paul D.
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
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