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Published in Journal of medicinal chemistry (22.11.2017)
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Robey, Robert W., Robinson, Andrea N., Ali-Rahmani, Fatima, Huff, Lyn M., Lusvarghi, Sabrina, Vahedi, Shahrooz, Hotz, Jordan M., Warner, Andrew C., Butcher, Donna, Matta, Jennifer, Edmondson, Elijah F., Lee, Tobie D., Roth, Jacob S., Lee, Olivia W., Shen, Min, Tanner, Kandice, Hall, Matthew D., Ambudkar, Suresh V., Gottesman, Michael M.
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Savage, Sara R., Yi, Xinpei, Lei, Jonathan T., Wen, Bo, Zhao, Hongwei, Liao, Yuxing, Jaehnig, Eric J., Somes, Lauren K., Shafer, Paul W., Lee, Tobie D., Fu, Zile, Dou, Yongchao, Shi, Zhiao, Gao, Daming, Hoyos, Valentina, Gao, Qiang, Zhang, Bing
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Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen–Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design
Eron, Scott J, Huang, Hongwei, Agafonov, Roman V, Fitzgerald, Mark E, Patel, Joe, Michael, Ryan E, Lee, Tobie D, Hart, Ashley A, Shaulsky, Jodi, Nasveschuk, Christopher G, Phillips, Andrew J, Fisher, Stewart L, Good, Andrew
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Published in ACS chemical biology (19.11.2021)
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A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein
Lee, Tobie D, Lee, Olivia W, Brimacombe, Kyle R, Chen, Lu, Guha, Rajarshi, Lusvarghi, Sabrina, Tebase, Bethilehem G, Klumpp-Thomas, Carleen, Robey, Robert W, Ambudkar, Suresh V, Shen, Min, Gottesman, Michael M, Hall, Matthew D
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Discovery and Optimization of 2H‑1λ2‑Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer
Rohde, Jason M, Karavadhi, Surendra, Pragani, Rajan, Liu, Li, Fang, Yuhong, Zhang, Weihe, McIver, Andrew, Zheng, Hongchao, Liu, Qingyang, Davis, Mindy I, Urban, Daniel J, Lee, Tobie D, Cheff, Dorian M, Hollingshead, Melinda, Henderson, Mark J, Martinez, Natalia J, Brimacombe, Kyle R, Yasgar, Adam, Zhao, Wei, Klumpp-Thomas, Carleen, Michael, Sam, Covey, Joseph, Moore, William J, Stott, Gordon M, Li, Zhuyin, Simeonov, Anton, Jadhav, Ajit, Frye, Stephen, Hall, Matthew D, Shen, Min, Wang, Xiaodong, Patnaik, Samarjit, Boxer, Matthew B
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties
Rai, Ganesha, Urban, Daniel J, Mott, Bryan T, Hu, Xin, Yang, Shyh-Ming, Benavides, Gloria A, Johnson, Michelle S, Squadrito, Giuseppe L, Brimacombe, Kyle R, Lee, Tobie D, Cheff, Dorian M, Zhu, Hu, Henderson, Mark J, Pohida, Katherine, Sulikowski, Gary A, Dranow, David M, Kabir, Md, Shah, Pranav, Padilha, Elias, Tao, Dingyin, Fang, Yuhong, Christov, Plamen P, Kim, Kwangho, Jana, Somnath, Muttil, Pavan, Anderson, Tamara, Kunda, Nitesh K, Hathaway, Helen J, Kusewitt, Donna F, Oshima, Nobu, Cherukuri, Murali, Davies, Douglas R, Norenberg, Jeffrey P, Sklar, Larry A, Moore, William J, Dang, Chi V, Stott, Gordon M, Neckers, Leonard, Flint, Andrew J, Darley-Usmar, Victor M, Simeonov, Anton, Waterson, Alex G, Jadhav, Ajit, Hall, Matthew D, Maloney, David J
Published in Journal of medicinal chemistry (08.10.2020)
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Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors
Rohde, Jason M., Brimacombe, Kyle R., Liu, Li, Pacold, Michael E., Yasgar, Adam, Cheff, Dorian M., Lee, Tobie D., Rai, Ganesha, Baljinnyam, Bolormaa, Li, Zhuyin, Simeonov, Anton, Hall, Matthew D., Shen, Min, Sabatini, David M., Boxer, Matthew B.
Published in Bioorganic & medicinal chemistry (01.05.2018)
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Urban, Daniel J., Martinez, Natalia J., Davis, Mindy I., Brimacombe, Kyle R., Cheff, Dorian M., Lee, Tobie D., Henderson, Mark J., Titus, Steven A., Pragani, Rajan, Rohde, Jason M., Liu, Li, Fang, Yuhong, Karavadhi, Surendra, Shah, Pranav, Lee, Olivia W., Wang, Amy, McIver, Andrew, Zheng, Hongchao, Wang, Xiaodong, Xu, Xin, Jadhav, Ajit, Simeonov, Anton, Shen, Min, Boxer, Matthew B., Hall, Matthew D.
Published in Scientific reports (06.10.2017)
Published in Scientific reports (06.10.2017)
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Discovery and Optimization of 2 H -1λ 2 -Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer
Rohde, Jason M, Karavadhi, Surendra, Pragani, Rajan, Liu, Li, Fang, Yuhong, Zhang, Weihe, McIver, Andrew, Zheng, Hongchao, Liu, Qingyang, Davis, Mindy I, Urban, Daniel J, Lee, Tobie D, Cheff, Dorian M, Hollingshead, Melinda, Henderson, Mark J, Martinez, Natalia J, Brimacombe, Kyle R, Yasgar, Adam, Zhao, Wei, Klumpp-Thomas, Carleen, Michael, Sam, Covey, Joseph, Moore, William J, Stott, Gordon M, Li, Zhuyin, Simeonov, Anton, Jadhav, Ajit, Frye, Stephen, Hall, Matthew D, Shen, Min, Wang, Xiaodong, Patnaik, Samarjit, Boxer, Matthew B
Published in Journal of medicinal chemistry (22.04.2021)
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Optimization of ether and aniline based inhibitors of lactate dehydrogenase
Christov, Plamen P., Kim, Kwangho, Jana, Somnath, Romaine, Ian M., Rai, Ganesha, Mott, Bryan T., Allweil, Alexander A., Lamers, Alexander, Brimacombe, Kyle R., Urban, Daniel J., Lee, Tobie D., Hu, Xin, Lukacs, Christine M., Davies, Douglas R., Jadhav, Ajit, Hall, Matthew D., Green, Neal, Moore, William J., Stott, Gordon M., Flint, Andrew J., Maloney, David J., Sulikowski, Gary A., Waterson, Alex G.
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Flickinger, Kyle M, Wilson, Kelli M, Rossiter, Nicholas J, Hunger, Andrea L, Vishwasrao, Paresh V, Lee, Tobie D, Mellado Fritz, Carlos A, Richards, Rebecca M, Hall, Matthew D, Cantor, Jason R
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Shi, Lei, Shen, William, Davis, Mindy I, Kong, Ke, Vu, Phuong, Saha, Supriya K, Adil, Ramzi, Kreuzer, Johannes, Egan, Regina, Lee, Tobie D, Greninger, Patricia, Shrimp, Jonathan H, Zhao, Wei, Wei, Ting-Yu, Zhou, Mi, Eccleston, Jason, Sussman, Jonathan, Manocha, Ujjawal, Weerasekara, Vajira, Kondo, Hiroshi, Vijay, Vindhya, Wu, Meng-Ju, Kearney, Sara E, Ho, Jeffrey, McClanaghan, Joseph, Murchie, Ellen, Crowther, Giovanna S, Patnaik, Samarjit, Boxer, Matthew B, Shen, Min, Ting, David T, Kim, William Y, Stanger, Ben Z, Deshpande, Vikram, Ferrone, Cristina R, Benes, Cyril H, Haas, Wilhelm, Hall, Matthew D, Bardeesy, Nabeel
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Published in Nature cancer (01.03.2023)
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Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening
Lee, Olivia W., Austin, Shelley, Gamma, Madison, Cheff, Dorian M., Lee, Tobie D., Wilson, Kelli M., Johnson, Joseph, Travers, Jameson, Braisted, John C., Guha, Rajarshi, Klumpp-Thomas, Carleen, Shen, Min, Hall, Matthew D.
Published in SLAS discovery (01.01.2020)
Published in SLAS discovery (01.01.2020)
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Keeping It Clean: The Cell Culture Quality Control Experience at the National Center for Advancing Translational Sciences
Roth, Jacob S., Lee, Tobie D., Cheff, Dorian M., Gosztyla, Maya L., Asawa, Rosita R., Danchik, Carina, Michael, Sam, Simeonov, Anton, Klumpp-Thomas, Carleen, Wilson, Kelli M., Hall, Matthew D.
Published in SLAS discovery (01.06.2020)
Published in SLAS discovery (01.06.2020)
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Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy
Oshima, Nobu, Ishida, Ryo, Kishimoto, Shun, Beebe, Kristin, Brender, Jeffrey R., Yamamoto, Kazutoshi, Urban, Daniel, Rai, Ganesha, Johnson, Michelle S., Benavides, Gloria, Squadrito, Giuseppe L., Crooks, Dan, Jackson, Joseph, Joshi, Abhinav, Mott, Bryan T., Shrimp, Jonathan H., Moses, Michael A., Lee, Min-Jung, Yuno, Akira, Lee, Tobie D., Hu, Xin, Anderson, Tamara, Kusewitt, Donna, Hathaway, Helen H., Jadhav, Ajit, Picard, Didier, Trepel, Jane B., Mitchell, James B., Stott, Gordon M., Moore, William, Simeonov, Anton, Sklar, Larry A., Norenberg, Jeffrey P., Linehan, W. Marston, Maloney, David J., Dang, Chi V., Waterson, Alex G., Hall, Matthew, Darley-Usmar, Victor M., Krishna, Murali C., Neckers, Leonard M.
Published in Cell reports (Cambridge) (11.02.2020)
Published in Cell reports (Cambridge) (11.02.2020)
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