Discovery of (R)‑1-(3-((2-Chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1′-Biphenyl]-2-ylcarbamate (TD-5959, GSK961081, Batefenterol): First-in-Class Dual Pharmacology Multivalent Muscarinic Antagonist and β2 Agonist (MABA) for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)
Hughes, Adam D, Chen, Yan, Hegde, Sharath S, Jasper, Jeffrey R, Jaw-Tsai, Sarah, Lee, Tae-Weon, McNamara, Alexander, Pulido-Rios, M. Teresa, Steinfeld, Tod, Mammen, Mathai
Published in Journal of medicinal chemistry (26.03.2015)
Published in Journal of medicinal chemistry (26.03.2015)
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Functionally Different Agonists Induce Distinct Conformations in the G Protein Coupling Domain of the β2Adrenergic Receptor
Ghanouni, Pejman, Gryczynski, Zygmunt, Steenhuis, Jacqueline J., Lee, Tae Weon, Farrens, David L., Lakowicz, Joseph R., Kobilka, Brian K.
Published in The Journal of biological chemistry (01.01.2001)
Published in The Journal of biological chemistry (01.01.2001)
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Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties
Hegde, Sharath S, Hughes, Adam D, Chen, Yan, Steinfeld, Tod, Jasper, Jeffrey R, Lee, Tae-Weon, McNamara, Alexander, Martin, William J, Pulido-Rios, M Teresa, Mammen, Mathai
Published in The Journal of pharmacology and experimental therapeutics (01.10.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2014)
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Journal Article
Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules
Hughes, Adam D., Chin, Kay H., Dunham, Sarah L., Jasper, Jeffrey R., King, Kristin E., Lee, Tae Weon, Mammen, Mathai, Martin, Jerri, Steinfeld, Tod
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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Identification of an Allosteric Binding Site for Zn2+on the β2 Adrenergic Receptor
Swaminath, Gayathri, Lee, Tae Weon, Kobilka, Brian
Published in The Journal of biological chemistry (01.01.2003)
Published in The Journal of biological chemistry (01.01.2003)
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Sequential Binding of Agonists to the β2 Adrenoceptor
Swaminath, Gayathri, Xiang, Yang, Lee, Tae Weon, Steenhuis, Jacqueline, Parnot, Charles, Kobilka, Brian K.
Published in The Journal of biological chemistry (01.01.2004)
Published in The Journal of biological chemistry (01.01.2004)
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Solution Structure of YKR049C, a Putative Redox Protein from Saccharomyces cerevisiae
Jung, J.W. (Yonsei University, Seoul, Republic of Korea), Yee, Adelinda; Wu, Bin; Arrowsmith, Cheryl H. (University of Toronto, Toronto, ON, Canada), Lee, W.T. (Yonsei University, Seoul, Republic of Korea), E-mail: wlee@spin.yonsei.ac.kr
Published in BMB reports (30.09.2005)
Published in BMB reports (30.09.2005)
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Why Do SGLT2 Inhibitors Inhibit Only 30―50% of Renal Glucose Reabsorption in Humans?
LIU, Jiwen (jim), LEE, Taeweon, DEFRONZO, Ralph A
Published in Diabetes (New York, N.Y.) (01.09.2012)
Published in Diabetes (New York, N.Y.) (01.09.2012)
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Probing the β2 Adrenoceptor Binding Site with Catechol Reveals Differences in Binding and Activation by Agonists and Partial Agonists
Swaminath, Gayathri, Deupi, Xavier, Lee, Tae Weon, Zhu, Wen, Thian, Foon Sun, Kobilka, Tong Sun, Kobilka, Brian
Published in The Journal of biological chemistry (10.06.2005)
Published in The Journal of biological chemistry (10.06.2005)
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Discovery of (R)-1-(34(2-Chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1 '-Biphenyl]-2-ylcarbamate (TD-5959, GSK961081, Batefenterol): First-in-Class Dual Pharmacology Multivalent Muscarinic Antagonist and beta(2) Agonist (MABA) for the Treatment of Chronic Obstructive Pulmonary Disease (COPD
Hughes, Adam D., Chen, Yan, Hegde, Sharath S., Jasper, Jeffrey R., Jaw-Tsai, Sarah, Lee, Tae-Weon, McNamara, Alexander, Pulido-Rios, M. Teresa, Steinfeld, Tod, Mammen, Mathai
Published in Journal of medicinal chemistry (26.03.2015)
Published in Journal of medicinal chemistry (26.03.2015)
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Targeted Injection of a Truncated Form of Tissue Inhibitor of Metalloproteinase 3 Alters Post-Myocardial Infarction Remodeling
Lobb, David C, Doviak, Heather, Brower, Gregory L, Romito, Eva, O'Neill, Jason W, Smith, Stephen, Shuman, James A, Freels, Parker D, Zellars, Kia N, Freeburg, Lisa A, Khakoo, Aarif Y, Lee, TaeWeon, Spinale, Francis G
Published in The Journal of pharmacology and experimental therapeutics (01.11.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2020)
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Journal Article
Intracoronary delivery of recombinant TIMP-3 after myocardial infarction: effects on myocardial remodeling and function
Barlow, Shayne C, Doviak, Heather, Jacobs, Julia, Freeburg, Lisa A, Perreault, Paige E, Zellars, Kia N, Moreau, Karen, Villacreses, Camila F, Smith, Stephen, Khakoo, Aarif Y, Lee, TaeWeon, Spinale, Francis G
Published in American journal of physiology. Heart and circulatory physiology (01.10.2017)
Published in American journal of physiology. Heart and circulatory physiology (01.10.2017)
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Journal Article
BIPHENYL DERIVATIVES HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY
HUGHES ADAM, DUNHAM SARAH, MAMMEN MATHAI, LEE, TAE WEON, CHEN YAN, STANGELAND ERIC, HUSFELD CRAIG
Year of Publication 08.12.2011
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Year of Publication 08.12.2011
Patent
BIPHENYL DERIVATIVES HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY
HUGHES ADAM, DUNHAM SARAH, MAMMEN MATHAI, LEE, TAE WEON, CHEN YAN, STANGELAND ERIC, HUSFELD CRAIG
Year of Publication 20.05.2011
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Year of Publication 20.05.2011
Patent
Local hydrogel release of recombinant TIMP-3 attenuates adverse left ventricular remodeling after experimental myocardial infarction
Eckhouse, Shaina R, Purcell, Brendan P, McGarvey, Jeremy R, Lobb, David, Logdon, Christina B, Doviak, Heather, O'Neill, Jason W, Shuman, James A, Novack, Craig P, Zellars, Kia N, Pettaway, Sara, Black, Roy A, Khakoo, Aarif, Lee, Taeweon, Mukherjee, Rupak, Gorman, Joseph H, Gorman, Robert C, Burdick, Jason A, Spinale, Francis G
Published in Science translational medicine (12.02.2014)
Published in Science translational medicine (12.02.2014)
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Journal Article
The Effect of pH on β2 Adrenoceptor Function
Ghanouni, Pejman, Schambye, Hans, Seifert, Roland, Lee, Tae Weon, Rasmussen, Søren G.F., Gether, Ulrik, Kobilka, Brian K.
Published in The Journal of biological chemistry (01.02.2000)
Published in The Journal of biological chemistry (01.02.2000)
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Journal Article
Discovery of ( R )-1-(3-((2-Chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1′-Biphenyl]-2-ylcarbamate (TD-5959, GSK961081, Batefenterol): First-in-Class Dual Pharmacology Multivalent Muscarinic Antagonist and β 2 Agonist (MABA) for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)
Hughes, Adam D., Chen, Yan, Hegde, Sharath S., Jasper, Jeffrey R., Jaw-Tsai, Sarah, Lee, Tae-Weon, McNamara, Alexander, Pulido-Rios, M. Teresa, Steinfeld, Tod, Mammen, Mathai
Published in Journal of medicinal chemistry (26.03.2015)
Published in Journal of medicinal chemistry (26.03.2015)
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Journal Article