Intestinal P-gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications
Zamek-Gliszczynski, Maciej J, Patel, Mitesh, Yang, Xinning, Lutz, Justin D, Chu, Xiaoyan, Brouwer, Kim L R, Lai, Yurong, Lee, Caroline A, Neuhoff, Sibylle, Paine, Mary F, Sugiyama, Yuichi, Taskar, Kunal S, Galetin, Aleksandra
Published in Clinical pharmacology and therapeutics (01.01.2021)
Published in Clinical pharmacology and therapeutics (01.01.2021)
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Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs
Di, Li, Breen, Christopher, Chambers, Rob, Eckley, Sean T., Fricke, Robert, Ghosh, Avijit, Harradine, Paul, Kalvass, J. Cory, Ho, Stacy, Lee, Caroline A., Marathe, Punit, Perkins, Everett J., Qian, Mark, Tse, Susanna, Yan, Zhengyin, Zamek-Gliszczynski, Maciej J.
Published in Journal of pharmaceutical sciences (01.12.2017)
Published in Journal of pharmaceutical sciences (01.12.2017)
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Journal Article
Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design
Lee, Caroline A, O'Connor, Meeghan A, Ritchie, Tasha K, Galetin, Aleksandra, Cook, Jack A, Ragueneau-Majlessi, Isabelle, Ellens, Harma, Feng, Bo, Taub, Mitchell E, Paine, Mary F, Polli, Joseph W, Ware, Joseph A, Zamek-Gliszczynski, Maciej J
Published in Drug metabolism and disposition (01.04.2015)
Published in Drug metabolism and disposition (01.04.2015)
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Journal Article
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity
Lee, Caroline A, Jones, 3rd, J P, Katayama, Jonathan, Kaspera, Rüdiger, Jiang, Ying, Freiwald, Sascha, Smith, Evan, Walker, Gregory S, Totah, Rheem A
Published in Drug metabolism and disposition (01.05.2012)
Published in Drug metabolism and disposition (01.05.2012)
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Journal Article
Identification of Novel Substrates for Human Cytochrome P450 2J2
LEE, Caroline A, NEUL, David, CLOUSER-ROCHE, Andrea, DALVIE, Deepak, WESTER, Michael R, YING JIANG, JONES, J. P, FREIWALD, Sascha, ZIENTEK, Michael, TOTAH, Rheem A
Published in Drug metabolism and disposition (01.02.2010)
Published in Drug metabolism and disposition (01.02.2010)
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Journal Article
Metabolism and disposition of lesinurad, a uric acid reabsorption inhibitor, in humans
Shah, Vishal, Yang, Chun, Shen, Zancong, Kerr, Bradley M., Tieu, Kathy, Wilson, David M., Hall, Jesse, Gillen, Michael, Lee, Caroline A.
Published in Xenobiotica (03.07.2019)
Published in Xenobiotica (03.07.2019)
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EVALUATION OF TIME-DEPENDENT INACTIVATION OF CYP3A IN CRYOPRESERVED HUMAN HEPATOCYTES
Zhao, Ping, Kunze, Kent L, Lee, Caroline A
Published in Drug metabolism and disposition (01.06.2005)
Published in Drug metabolism and disposition (01.06.2005)
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S959 A Phase 1 Drug Interaction Study Evaluating the Effects of Itraconazole on the Pharmacokinetics, Safety, and Tolerability of Etrasimod in Healthy Volunteers
Lee, Caroline A., Ramaiya, Atulkumar, Tang, Yong, Sapone, Anna, Gilder, Kye, Randle, Andrenika, Grundy, John S.
Published in The American journal of gastroenterology (01.10.2022)
Published in The American journal of gastroenterology (01.10.2022)
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Journal Article
S759 Model-Predicted Lymphocyte Response and Recovery Profiles for the Sphingosine 1-Phosphate Receptor Modulators Ozanimod and Etrasimod
Lee, Caroline A., Waterhouse, Timothy, Heathman, Michael, Oh, D. Alex, Komori, H. Kiyomi, Grundy, John S.
Published in The American journal of gastroenterology (01.10.2022)
Published in The American journal of gastroenterology (01.10.2022)
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Journal Article
S774 Pharmacokinetics, Safety, and Tolerability of Etrasimod: Results From a Phase 1 Drug-Drug Interaction Study in Healthy Volunteers
Lee, Caroline A., Tang, Yong, Villa-Caballero, Leonel, Shan, Kevin, Randle, Andrenika, Grundy, John S.
Published in The American journal of gastroenterology (01.10.2022)
Published in The American journal of gastroenterology (01.10.2022)
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Journal Article
Transporter-dependent cytotoxicity of antiviral drugs in primary cultures of human proximal tubular cells
Lash, Lawrence H., Lee, Caroline A., Wilker, Clynn, Shah, Vishal
Published in Toxicology (Amsterdam) (01.07.2018)
Published in Toxicology (Amsterdam) (01.07.2018)
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Journal Article
In Vitro Assessment of the Drug-Drug Interaction Potential of Verinurad and Its Metabolites as Substrates and Inhibitors of Metabolizing Enzymes and Drug Transporters
Gopaul, V Sashi, Vildhede, Anna, Andersson, Tommy B, Erlandsson, Fredrik, Lee, Caroline A, Johansson, Susanne, Hilgendorf, Constanze
Published in The Journal of pharmacology and experimental therapeutics (01.08.2021)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2021)
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Membrane transporters in drug development
Giacomini, Kathleen M, Huang, Shiew-Mei, Tweedie, Donald J, Benet, Leslie Z, Brouwer, Kim L R, Chu, Xiaoyan, Dahlin, Amber, Evers, Raymond, Fischer, Volker, Hillgren, Kathleen M, Hoffmaster, Keith A, Ishikawa, Toshihisa, Keppler, Dietrich, Kim, Richard B, Lee, Caroline A, Niemi, Mikko, Polli, Joseph W, Sugiyama, Yuichi, Swaan, Peter W, Ware, Joseph A, Wright, Stephen H, Yee, Sook Wah, Zamek-Gliszczynski, Maciej J, Zhang, Lei
Published in Nature reviews. Drug discovery (01.03.2010)
Published in Nature reviews. Drug discovery (01.03.2010)
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Journal Article
S928 Effect of Etrasimod on Circulating Lymphocytes in Patients With Moderately to Severely Active Ulcerative Colitis: Data From the Phase 3 ELEVATE UC 52 and ELEVATE UC 12 Trials
Danese, Silvio, Komori, H. Kiyomi, Ryan, Rathi D., Cataldi, Fabio, Lee, Caroline A., Goetsch, Martina, Siegmund, Britta
Published in The American journal of gastroenterology (01.10.2022)
Published in The American journal of gastroenterology (01.10.2022)
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Journal Article
Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics
Billington, Sarah, Ray, Adrian S, Salphati, Laurent, Xiao, Guangqing, Chu, Xiaoyan, Humphreys, W Griffith, Liao, Mingxiang, Lee, Caroline A, Mathias, Anita, Hop, Cornelis E C A, Rowbottom, Christopher, Evers, Raymond, Lai, Yurong, Kelly, Edward J, Prasad, Bhagwat, Unadkat, Jashvant D
Published in Drug metabolism and disposition (01.02.2018)
Published in Drug metabolism and disposition (01.02.2018)
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Journal Article
ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision
Zamek-Gliszczynski, Maciej J, Chu, Xiaoyan, Cook, Jack A, Custodio, Joseph M, Galetin, Aleksandra, Giacomini, Kathleen M, Lee, Caroline A, Paine, Mary F, Ray, Adrian S, Ware, Joseph A, Wittwer, Matthias B, Zhang, Lei
Published in Clinical pharmacology and therapeutics (01.11.2018)
Published in Clinical pharmacology and therapeutics (01.11.2018)
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Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers
Yang, Chun, Zhou, Dongmei, Shen, Zancong, Wilson, David M, Renner, Matthew, Miner, Jeffrey N, Girardet, Jean-Luc, Lee, Caroline A
Published in Drug metabolism and disposition (01.02.2019)
Published in Drug metabolism and disposition (01.02.2019)
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