Search Results - "LEARN KEITH S" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)

Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)

by Ott, Gregory R, Cheng, Mangeng, Learn, Keith S, Wagner, Jason, Gingrich, Diane E, Lisko, Joseph G, Curry, Matthew, Mesaros, Eugen F, Ghose, Arup K, Quail, Matthew R, Wan, Weihua, Lu, Lihui, Dobrzanski, Pawel, Albom, Mark S, Angeles, Thelma S, Wells-Knecht, Kevin, Huang, Zeqi, Aimone, Lisa D, Bruckheimer, Elizabeth, Anderson, Nathan, Friedman, Jay, Fernandez, Sandra V, Ator, Mark A, Ruggeri, Bruce A, Dorsey, Bruce D
Published in Journal of medicinal chemistry (25.08.2016)

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Journal Article

Design of 7-amino-6-chloro-3H-imidazo[4,5-b]pyridine scaffold from 5-chloro-2,4-diaminopyrimidine pharmacophore: identification of potent inhibitors of anaplastic lymphoma kinase

Design of 7-amino-6-chloro-3H-imidazo[4,5-b]pyridine scaffold from 5-chloro-2,4-diaminopyrimidine pharmacophore: identification of potent inhibitors of anaplastic lymphoma kinase

by Learn, Keith S., Wagner, Jason C., Albom, Mark S., Angeles, Thelma S., Huang, Zeqi, Ghose, Arup K., Wan, Weihua, Cheng, Mangeng, Dorsey, Bruce D., Ott, Gregory R.
Published in MedChemComm (01.09.2012)

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Journal Article

pi.-Facially controlled nucleophilic additions of chiral vinylorganometallics to chiral .beta.,.gamma.-unsaturated ketones. 1. Double diastereoselection studies involving 7,7-dimethoxy-5-norbornen-2-one

pi.-Facially controlled nucleophilic additions of chiral vinylorganometallics to chiral .beta.,.gamma.-unsaturated ketones. 1. Double diastereoselection studies involving 7,7-dimethoxy-5-norbornen-2-one

by Paquette, Leo A, Learn, Keith S
Published in Journal of the American Chemical Society (01.11.1986)

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Journal Article

Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 4. Addition of chromone moiety enhances leukotriene D4 receptor binding affinity

Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 4. Addition of chromone moiety enhances leukotriene D4 receptor binding affinity

by Huang, Fu Chih, Galemmo, Robert A, Poli, Gregory B, Learn, Keith S, Morrissette, Mathew M, Johnson, William H, Dankulich, William P, Campbell, Henry F, Carnathan, Gilbert W, Van Inwegen, Richard G
Published in Journal of medicinal chemistry (01.05.1991)

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Journal Article

Construction of a kinase inhibitor library via parallel synthesis

Construction of a kinase inhibitor library via parallel synthesis

by Tripathy, Rabindranath, Learn, Keith S, Reddy, Dandu R, Iqbal, Mohamed, Singh, Jasbir, Mallamo, John P
Published in Tetrahedron letters (07.01.2002)

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Journal Article

The development of a novel series of (quinolin-2-ylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 3. Structural variation of the acidic side chain to give antagonists of enhanced potency

The development of a novel series of (quinolin-2-ylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 3. Structural variation of the acidic side chain to give antagonists of enhanced potency

by Galemmo, Robert A, Johnson, William H, Learn, Keith S, Lee, Thomas D. Y, Huang, Fu Chih, Campbell, Henry F, Youssefyeh, Raymond, O'Rourke, Susan V, Schuessler, Glenn
Published in Journal of medicinal chemistry (01.10.1990)

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Journal Article

Design of 7-amino-6-chloro-3H-imidazo[4,5-b]pyridine scaffold from 5-chloro-2,4-diaminopyrimidine pharmacophore: identification of potent inhibitors of anaplastic lymphoma kinaseElectronic supplementary information (ESI) available: Experimental procedures, 1H-NMR and mass spectra data for all compounds. See DOI: 10.1039/c2md20061a

Design of 7-amino-6-chloro-3H-imidazo[4,5-b]pyridine scaffold from 5-chloro-2,4-diaminopyrimidine pharmacophore: identification of potent inhibitors of anaplastic lymphoma kinaseElectronic supplementary information (ESI) available: Experimental procedures, 1H-NMR and mass spectra data for all compounds. See DOI: 10.1039/c2md20061a

by Learn, Keith S, Wagner, Jason C, Albom, Mark S, Angeles, Thelma S, Huang, Zeqi, Ghose, Arup K, Wan, Weihua, Cheng, Mangeng, Dorsey, Bruce D, Ott, Gregory R
Year of Publication 22.08.2012

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Journal Article

THIENOPYRIMIDINE INHIBITORS OF ATYPICAL PROTEIN KINASE C

THIENOPYRIMIDINE INHIBITORS OF ATYPICAL PROTEIN KINASE C

by MORRIS, EMMA L, ROFFEY, JONATHAN R, LEARN, KEITH S, DORSEY, BRUCE D, SOUDY, CHRISTELLE N, WAGNER, JASON C, OTT, GREGORY R
Year of Publication 20.04.2021

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Patent

Thienopyrimidine inhibitors of atypical protein kinase C

Thienopyrimidine inhibitors of atypical protein kinase C

by Ott, Gregory R, Roffey, Jonathan R. A, Dorsey, Bruce D, Morris, Emma L, Wagner, Jason C, Soudy, Christelle N, Learn, Keith S
Year of Publication 23.03.2021

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Patent

THIENOPYRIMIDINE AS INHIBITORS OF ATYPICAL PROTEIN KINASE C

THIENOPYRIMIDINE AS INHIBITORS OF ATYPICAL PROTEIN KINASE C

by ROFFEY, Jonathan R, SOUDY, Christelle N, DORSEY, Bruce D, OTT, Gregory R, WAGNER, Jason C, LEARN, Keith S, MORRIS, Emma L
Year of Publication 06.11.2019

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Patent

THIENOPYRIMIDINE INHIBITORS OF ATYPICAL PROTEIN KINASE C

THIENOPYRIMIDINE INHIBITORS OF ATYPICAL PROTEIN KINASE C

by ROFFEY, Jonathan R.A, SOUDY, Christelle N, DORSEY, Bruce D, OTT, Gregory R, WAGNER, Jason C, LEARN, Keith S, MORRIS, Emma L
Year of Publication 11.04.2019

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Patent

Thienopyrimidine inhibitors of atypical protein kinase C

Thienopyrimidine inhibitors of atypical protein kinase C

by Ott, Gregory R, Dorsey, Bruce D, Morris, Emma L, Wagner, Jason C, Soudy, Christelle N, Learn, Keith S, Roffey, Jonathan R
Year of Publication 28.02.2019

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Patent

Thienopyrimidine inhibitors of atypical protein kinase C

Thienopyrimidine inhibitors of atypical protein kinase C

by Ott, Gregory R, Roffey, Jonathan R. A, Dorsey, Bruce D, Morris, Emma L, Wagner, Jason C, Soudy, Christelle N, Learn, Keith S
Year of Publication 22.01.2019

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Patent

Thienopyrimidine inhibitors of atypical protein kinase C

Thienopyrimidine inhibitors of atypical protein kinase C

by Ott, Gregory R, Dorsey, Bruce D, Morris, Emma L, Wagner, Jason C, Soudy, Christelle N, Learn, Keith S, Roffey, Jonathan R
Year of Publication 22.06.2017

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Patent

THIENOPYRIMIDINE INHIBITORS OF ATYPICAL PROTEIN KINASE C

THIENOPYRIMIDINE INHIBITORS OF ATYPICAL PROTEIN KINASE C

by Learn Keith S, Ott Gregory R, Morris Emma L, Roffey Jonathan R.A, Wagner Jason C, Soudy Christelle N, Dorsey Bruce D
Year of Publication 08.06.2017

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Patent

Thienopyrimidine inhibitors of atypical protein kinase C

Thienopyrimidine inhibitors of atypical protein kinase C

by Learn Keith S, Ott Gregory R, Morris Emma L, Roffey Jonathan R. A, Wagner Jason C, Soudy Christelle N, Dorsey Bruce D
Year of Publication 28.03.2017

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Patent

Thienopyrimidine inhibitors of atypical protein kinase C

Thienopyrimidine inhibitors of atypical protein kinase C

by Ott, Gregory R, Dorsey, Bruce D, Morris, Emma L, Wagner, Jason C, Soudy, Christelle N, Learn, Keith S, Roffey, Jonathan R
Year of Publication 02.03.2017

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Patent

Imidazo[4,5-b]pyridine derivatives as ALK and JAK modulators for the treatment of proliferative disorders

Imidazo[4,5-b]pyridine derivatives as ALK and JAK modulators for the treatment of proliferative disorders

by GINGRICH DIANE E, LEARN KEITH S, OTT GREGORY R, WAGNER JASON C, BRESLIN HENRY J, CURRY MATTHEW A
Year of Publication 19.01.2016

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Patent

IMIDAZO [4, 5 - B]PYRIDINE DERIVATIVES AS ALK AND JAK MODULATORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS

IMIDAZO [4, 5 - B]PYRIDINE DERIVATIVES AS ALK AND JAK MODULATORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS

by CURRY, MATTHEW A, LEARN, KEITH S, BRESLIN, HENRY J, WAGNER, JASON C, OTT, GREGORY R, GINGRICH, DIANE E
Year of Publication 13.01.2016

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Patent

THIENOPYRIMIDINE AS INHIBITORS OF ATYPICAL PROTEIN KINASE C

THIENOPYRIMIDINE AS INHIBITORS OF ATYPICAL PROTEIN KINASE C

by MORRIS, EMMA L, ROFFEY, JONATHAN R, LEARN, KEITH S, DORSEY, BRUCE D, SOUDY, CHRISTELLE N, WAGNER, JASON C, OTT, GREGORY R
Year of Publication 27.07.2016

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Patent