The folate receptor as a rational therapeutic target for personalized cancer treatment
Assaraf, Yehuda G, Leamon, Christopher P, Reddy, Joseph A
Published in Drug resistance updates (01.10.2014)
Published in Drug resistance updates (01.10.2014)
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Journal Article
Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters
Lee, Yong Gu, Chu, Haiyan, Lu, Yingjuan, Leamon, Christopher P., Srinivasarao, Madduri, Putt, Karson S., Low, Philip S.
Published in Nature communications (18.06.2019)
Published in Nature communications (18.06.2019)
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Journal Article
Vintafolide: a novel targeted therapy for the treatment of folate receptor expressing tumors
Vergote, Ignace, Leamon, Christopher P.
Published in Therapeutic Advances in Medical Oncology (01.07.2015)
Published in Therapeutic Advances in Medical Oncology (01.07.2015)
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Book Review
Journal Article
Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases
Frigerio, Barbara, Bizzoni, Claudia, Jansen, Gerrit, Leamon, Christopher P, Peters, Godefridus J, Low, Philip S, Matherly, Larry H, Figini, Mariangela
Published in Journal of experimental & clinical cancer research (12.03.2019)
Published in Journal of experimental & clinical cancer research (12.03.2019)
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Journal Article
PRECEDENT: A Randomized Phase II Trial Comparing Vintafolide (EC145) and Pegylated Liposomal Doxorubicin (PLD) in Combination Versus PLD Alone in Patients With Platinum-Resistant Ovarian Cancer
NAUMANN, R. Wendel, COLEMAN, Robert L, GERSH, Robert H, TENERIELLO, Michael G, HARB, Wael A, KONSTANTINOPOULOS, Panagiotis A, PENSON, Richard T, SYMANOWSKI, James T, LOVEJOY, Chandra D, LEAMON, Christopher P, MORGENSTERN, David E, MESSMANN, Richard A, BURGER, Robert A, SAUSVILLE, Edward A, KUTARSKA, Elzbieta, GHAMANDE, Sharad A, GABRAIL, Nashat Y, DEPASQUALE, Stephen E, NOWARA, Elzbieta, GILBERT, Lucy
Published in Journal of clinical oncology (10.12.2013)
Published in Journal of clinical oncology (10.12.2013)
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Journal Article
Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
Parker, Nikki, Turk, Mary Jo, Westrick, Elaine, Lewis, Jeffrey D., Low, Philip S., Leamon, Christopher P.
Published in Analytical biochemistry (15.03.2005)
Published in Analytical biochemistry (15.03.2005)
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Journal Article
Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic
Reddy, Joseph A., Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Dircksen, Christina, Vetzel, Marilynn, Kleindl, Paul, Santhapuram, Hari, Vlahov, Iontcho R., Leamon, Christopher P.
Published in Scientific reports (12.06.2018)
Published in Scientific reports (12.06.2018)
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Journal Article
Phase I Study of Folate Conjugate EC145 (Vintafolide) in Patients With Refractory Solid Tumors
LORUSSO, Patricia M, EDELMAN, Martin J, LEAMON, Christopher P, MESSMANN, Richard A, SAUSVILLE, Edward A, BEVER, Susan L, FORMAN, Karen M, PILAT, Maryjo, QUINN, Mary F, JING LI, HEATH, Elisabeth I, MALBURG, Lisa M, KLEIN, Patrick J
Published in Journal of clinical oncology (10.11.2012)
Published in Journal of clinical oncology (10.11.2012)
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Journal Article
Preclinical Evaluation of Bispecific Adaptor Molecule Controlled Folate Receptor CAR-T Cell Therapy With Special Focus on Pediatric Malignancies
Lu, Yingjuan J, Chu, Haiyan, Wheeler, Leroy W, Nelson, Melissa, Westrick, Elaine, Matthaei, James F, Cardle, Ian I, Johnson, Adam, Gustafson, Joshua, Parker, Nikki, Vetzel, Marilynn, Xu, Le-Cun, Wang, Emilia Z, Jensen, Michael C, Klein, Patrick J, Low, Philip S, Leamon, Christopher P
Published in Frontiers in oncology (19.03.2019)
Published in Frontiers in oncology (19.03.2019)
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Journal Article
Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent
Reddy, Joseph A., Nelson, Melissa, Dircksen, Christina, Vetzel, Marilynn, Johnson, Theresa, Cross, Vicky, Westrick, Elaine, Qi, LongWu, Hahn, Spencer, Santhapuram, Hari Krishna, Parham, Garth, Wang, Kevin, Vaughn, Jeremy F., Felten, Albert, Pugh, Michael, Lu, June, Klein, Patrick, Vlahov, Iontcho R., Leamon, Christopher P.
Published in Scientific reports (29.07.2020)
Published in Scientific reports (29.07.2020)
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Journal Article
Preclinical evaluation of EC145, a folate-Vinca alkaloid conjugate
REDDY, Joseph A, DORTON, Ryan, WESTRICK, Elaine, DAWSON, Alicia, SMITH, Terri, XU, Le-Cun, VETZEL, Marilynn, KLEINDL, Paul, VLAHOV, Iontcho R, LEAMON, Christopher P
Published in Cancer research (Chicago, Ill.) (01.05.2007)
Published in Cancer research (Chicago, Ill.) (01.05.2007)
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Journal Article
Impact of High and Low Folate Diets on Tissue Folate Receptor Levels and Antitumor Responses Toward Folate-Drug Conjugates
Leamon, Christopher P, Reddy, Joseph A, Dorton, Ryan, Bloomfield, Alicia, Emsweller, Kristen, Parker, Nikki, Westrick, Elaine
Published in The Journal of pharmacology and experimental therapeutics (01.12.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2008)
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Journal Article
Targeting Folate Receptors to Treat Invasive Urinary Bladder Cancer
DHAWAN, Deepika, RAMOS-VARA, Jose A, REDDY, Joseph A, KOCH, Michael, MURPHY, Linda, FOUREZ, Lindsey M, STEWART, Jane C, KNAPP, Deborah W, NAUGHTON, James F, LIANG CHENG, LOW, Philip S, ROTHENBUHLER, Ryan, LEAMON, Christopher P, PARKER, Nikki, KLEIN, Patrick J, VLAHOV, Lontcho R
Published in Cancer research (Chicago, Ill.) (15.01.2013)
Published in Cancer research (Chicago, Ill.) (15.01.2013)
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Journal Article
Folate-mediated targeting: from diagnostics to drug and gene delivery
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Book Review
Journal Article
High Levels of Expression of P-glycoprotein/Multidrug Resistance Protein Result in Resistance to Vintafolide
Guertin, Amy D, O'Neil, Jennifer, Stoeck, Alexander, Reddy, Joseph A, Cristescu, Razvan, Haines, Brian B, Hinton, Marlene C, Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Vetzel, Marilynn, Lejnine, Serguei, Nebozhyn, Michael, Zhang, Theresa, Loboda, Andrey, Picard, Kristen L, Schmidt, Emmett V, Dussault, Isabelle, Leamon, Christopher P
Published in Molecular cancer therapeutics (01.08.2016)
Published in Molecular cancer therapeutics (01.08.2016)
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Journal Article
Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide
Vlahov, Iontcho R., Santhapuram, Hari Krishna R., Kleindl, Paul J., Howard, Stephen J., Stanford, Katheryn M., Leamon, Christopher P.
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
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Journal Article
Comparative preclinical activity of the folate‐targeted Vinca alkaloid conjugates EC140 and EC145
Leamon, Christopher P., Reddy, Joseph A., Vlahov, Iontcho R., Westrick, Elaine, Parker, Nikki, Nicoson, Jeffrey S., Vetzel, Marilynn
Published in International journal of cancer (01.10.2007)
Published in International journal of cancer (01.10.2007)
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Journal Article
Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes
Lu, Yingjuan J., Wheeler, Leroy W., Chu, Haiyan, Kleindl, Paul J., Pugh, Michael, You, Fei, Rao, Satish, Garcia, Gabriela, Wu, Henry Y., da Cunha, Andre P., Johnson, Richard, Westrick, Elaine, Cross, Vicky, Lloyd, Alex, Dircksen, Christina, Klein, Patrick J., Vlahov, Iontcho R., Low, Philip S., Leamon, Christopher P.
Published in Cell reports. Medicine (19.10.2021)
Published in Cell reports. Medicine (19.10.2021)
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Journal Article