Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine
Dempsey, Daniel R., Nichols, Derek A., Battistini, Matthew R., Pemberton, Orville, Ospina, Santiago Rodriguez, Zhang, Xiujun, Carpenter, Anne-Marie, O’Flynn, Brian G., Leahy, James W., Kanwar, Ankush, Lewandowski, Eric M., Chen, Yu, Merkler, David J.
Published in Scientific reports (18.10.2017)
Published in Scientific reports (18.10.2017)
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Enantioselective Total Synthesis of the Antitumor Macrolide Rhizoxin D
Lafontaine, Jennifer A, Provencal, David P, Gardelli, Cristina, Leahy, James W
Published in Journal of organic chemistry (30.05.2003)
Published in Journal of organic chemistry (30.05.2003)
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Enantioselective Total Synthesis of CannabinoidsA Route for Analogue Development
Shultz, Zachary P, Lawrence, Grant A, Jacobson, Jeffrey M, Cruz, Emmanuel J, Leahy, James W
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Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome
Mansfield, Christopher R., Quan, Baiyi, Chirgwin, Michael E., Eduful, Benjamin, Hughes, Philip F., Neveu, Gaëlle, Sylvester, Kayla, Ryan, Daniel H., Kafsack, Björn F.C., Haystead, Timothy A.J., Leahy, James W., Fitzgerald, Michael C., Derbyshire, Emily R.
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Published in Cell chemical biology (18.04.2024)
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Alkyne modified purines for assessment of activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp
Botnar, Alona, Lawrence, Grant, Maher, Steven P., Vantaux, Amélie, Witkowski, Benoît, Shiau, Justine C., Merino, Emilio F., De Vore, David, Yang, Christian, Murray, Cameron, Cassera, Maria B., Leahy, James W., Kyle, Dennis E.
Published in International journal for parasitology (01.10.2022)
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Benzothiazole Substitution Analogs of Rhodacyanine Hsp70 Inhibitors Modulate Tau Accumulation
Hill, Shannon E., Beaulieu-Abdelahad, David, Lemus, Andrea, Webster, Jack M., Ospina, Santiago Rodriguez, Darling, April L., Martin, Mackenzie D., Patel, Shreya, Bridenstine, Liznair, Swonger, Ronald, Paul, Steven, Blackburn, Roy, Calcul, Laurent, Dickey, Chad A., Leahy, James W., Blair, Laura J.
Published in ACS chemical biology (19.05.2023)
Published in ACS chemical biology (19.05.2023)
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Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba
Tillery, Logan, Barrett, Kayleigh, Goldstein, Jenna, Lassner, Jared W, Osterhout, Bram, Tran, Nathan L, Xu, Lily, Young, Ryan M, Craig, Justin, Chun, Ian, Dranow, David M, Abendroth, Jan, Delker, Silvia L, Davies, Douglas R, Mayclin, Stephen J, Calhoun, Brandy, Bolejack, Madison J, Staker, Bart, Subramanian, Sandhya, Phan, Isabelle, Lorimer, Donald D, Myler, Peter J, Edwards, Thomas E, Kyle, Dennis E, Rice, Christopher A, Morris, James C, Leahy, James W, Manetsch, Roman, Barrett, Lynn K, Smith, Craig L, Van Voorhis, Wesley C
Published in PloS one (24.03.2021)
Published in PloS one (24.03.2021)
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Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD
Sabbagh, Jonathan J, Cordova, Ricardo A, Zheng, Dali, Criado-Marrero, Marangelie, Lemus, Andrea, Li, Pengfei, Baker, Jeremy D, Nordhues, Bryce A, Darling, April L, Martinez-Licha, Carlos, Rutz, Daniel A, Patel, Shreya, Buchner, Johannes, Leahy, James W, Koren, John, Dickey, Chad A, Blair, Laura J
Published in ACS chemical biology (17.08.2018)
Published in ACS chemical biology (17.08.2018)
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Discovery of a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR)
Takeuchi, Craig S, Kim, Byung Gyu, Blazey, Charles M, Ma, Sunghoon, Johnson, Henry W. B, Anand, Neel K, Arcalas, Arlyn, Baik, Tae Gon, Buhr, Chris A, Cannoy, Jonah, Epshteyn, Sergey, Joshi, Anagha, Lara, Katherine, Lee, Matthew S, Wang, Longcheng, Leahy, James W, Nuss, John M, Aay, Naing, Aoyama, Ron, Foster, Paul, Lee, Jae, Lehoux, Isabelle, Munagala, Narsimha, Plonowski, Arthur, Rajan, Sharmila, Woolfrey, John, Yamaguchi, Kyoko, Lamb, Peter, Miller, Nicole
Published in Journal of medicinal chemistry (28.03.2013)
Published in Journal of medicinal chemistry (28.03.2013)
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Characterization of Arylalkylamine N‑Acyltransferase from Tribolium castaneum: An Investigation into a Potential Next-Generation Insecticide Target
O’Flynn, Brian G, Lewandowski, Eric M, Prins, Karin Claire, Suarez, Gabriela, McCaskey, Angelica N, Rios-Guzman, Nasha M, Anderson, Ryan L, Shepherd, Britney A, Gelis, Ioannis, Leahy, James W, Chen, Yu, Merkler, David J
Published in ACS chemical biology (21.02.2020)
Published in ACS chemical biology (21.02.2020)
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Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases
Kassu, Mintesinot, Parvatkar, Prakash T., Milanes, Jillian, Monaghan, Neil P., Kim, Chungsik, Dowgiallo, Matthew, Zhao, Yingzhao, Asakawa, Ami H., Huang, Lili, Wagner, Alicia, Miller, Brandon, Carter, Karissa, Barrett, Kayleigh F., Tillery, Logan M., Barrett, Lynn K., Phan, Isabelle Q., Subramanian, Sandhya, Myler, Peter J., Van Voorhis, Wesley C., Leahy, James W., Rice, Christopher A., Kyle, Dennis E., Morris, James, Manetsch, Roman
Published in ACS infectious diseases (10.11.2023)
Published in ACS infectious diseases (10.11.2023)
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Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase γ Inhibitors
Leahy, James W, Buhr, Chris A, Johnson, Henry W. B, Kim, Byung Gyu, Baik, TaeGon, Cannoy, Jonah, Forsyth, Timothy P, Jeong, Joon Won, Lee, Matthew S, Ma, Sunghoon, Noson, Kevin, Wang, Longcheng, Williams, Matthew, Nuss, John M, Brooks, Eric, Foster, Paul, Goon, Leanne, Heald, Nathan, Holst, Charles, Jaeger, Christopher, Lam, Scott, Lougheed, Julie, Nguyen, Lam, Plonowski, Arthur, Song, Joanne, Stout, Thomas, Wu, Xiang, Yakes, Michael F, Yu, Peiwen, Zhang, Wentao, Lamb, Peter, Raeber, Olivia
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
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A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-Demethoxyrapamycin: Construction of the C(21−42) Perimeters
Smith, Amos B, Condon, Stephen M, McCauley, John A, Leazer, Johnnie L, Leahy, James W, Maleczka, Robert E
Published in Journal of the American Chemical Society (05.02.1997)
Published in Journal of the American Chemical Society (05.02.1997)
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Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries
Giulianotti, Marc A, Vesely, Brian A, Azhari, Ala, Souza, Ashley, LaVoi, Travis, Houghten, Richard A, Kyle, Dennis E, Leahy, James W
Published in ACS medicinal chemistry letters (10.08.2017)
Published in ACS medicinal chemistry letters (10.08.2017)
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A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-Demethoxyrapamycin: Assembly of the Common C(1−20) Perimeter and Final Elaboration
Smith, Amos B, Condon, Stephen M, McCauley, John A, Leazer, Johnnie L, Leahy, James W, Maleczka, Robert E
Published in Journal of the American Chemical Society (05.02.1997)
Published in Journal of the American Chemical Society (05.02.1997)
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Synthesis and Activity of a New Series of Antileishmanial Agents
Kanwar, Ankush, Eduful, Benjamin J, Barbeto, Linda, Carletti Bonomo, Piero, Lemus, Andrea, Vesely, Brian A, Mutka, Tina S, Azhari, Ala, Kyle, Dennis E, Leahy, James W
Published in ACS medicinal chemistry letters (10.08.2017)
Published in ACS medicinal chemistry letters (10.08.2017)
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