Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial
Falchook, Gerald S, Dr, Lewis, Karl D, MD, Infante, Jeffrey R, MD, Gordon, Michael S, MD, Vogelzang, Nicholas J, MD, DeMarini, Douglas J, PhD, Sun, Peng, PhD, Moy, Christopher, MS, Szabo, Stephen A, BA, Roadcap, Lori T, MS, Peddareddigari, Vijay GR, MD, Lebowitz, Peter F, MD, Le, Ngocdiep T, MD, Burris, Howard A, MD, Messersmith, Wells A, MD, O'Dwyer, Peter J, Prof, Kim, Kevin B, MD, Flaherty, Keith, MD, Bendell, Johanna C, MD, Gonzalez, Rene, Prof, Kurzrock, Razelle, Prof, Fecher, Leslie A, MD
Published in The lancet oncology (01.08.2012)
Published in The lancet oncology (01.08.2012)
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Phase II Study of the MEK1/MEK2 Inhibitor Trametinib in Patients With Metastatic BRAF-Mutant Cutaneous Melanoma Previously Treated With or Without a BRAF Inhibitor
KIM, Kevin B, KEFFORD, Richard, GONZALEZ, Rene, OTT, Patrick A, LONG, Georgina V, GARDNER, Olivia S, OUELLET, Daniele, YANMEI XU, DEMARINI, Douglas J, LE, Ngocdiep T, PATEL, Kiran, LEWIS, Karl D, PAVLICK, Anna C, INFANTE, Jeffrey R, RIBAS, Antoni, SOSMAN, Jeffrey A, FECHER, Leslie A, MILLWARD, Michael, MCARTHUR, GrantA, HWU, Patrick
Published in Journal of clinical oncology (01.02.2013)
Published in Journal of clinical oncology (01.02.2013)
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Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma
Long, Georgina V, Stroyakovskiy, Daniil, Gogas, Helen, Levchenko, Evgeny, de Braud, Filippo, Larkin, James, Garbe, Claus, Jouary, Thomas, Hauschild, Axel, Grob, Jean Jacques, Chiarion Sileni, Vanna, Lebbe, Celeste, Mandalà, Mario, Millward, Michael, Arance, Ana, Bondarenko, Igor, Haanen, John B.A.G, Hansson, Johan, Utikal, Jochen, Ferraresi, Virginia, Kovalenko, Nadezhda, Mohr, Peter, Probachai, Volodymyr, Schadendorf, Dirk, Nathan, Paul, Robert, Caroline, Ribas, Antoni, DeMarini, Douglas J, Irani, Jhangir G, Casey, Michelle, Ouellet, Daniele, Martin, Anne-Marie, Le, Ngocdiep, Patel, Kiran, Flaherty, Keith
Published in The New England journal of medicine (13.11.2014)
Published in The New England journal of medicine (13.11.2014)
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Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial
Infante, Jeffrey R, Dr, Fecher, Leslie A, MD, Falchook, Gerald S, MD, Nallapareddy, Sujatha, MD, Gordon, Michael S, MD, Becerra, Carlos, MD, DeMarini, Douglas J, PhD, Cox, Donna S, PhD, Xu, Yanmei, MS, Morris, Shannon R, MD, Peddareddigari, Vijay GR, MD, Le, Ngocdiep T, MD, Hart, Lowell, MD, Bendell, Johanna C, MD, Eckhardt, Gail, MD, Kurzrock, Razelle, Prof, Flaherty, Keith, MD, Burris, Howard A, MD, Messersmith, Wells A, MD
Published in The lancet oncology (01.08.2012)
Published in The lancet oncology (01.08.2012)
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Safety, Pharmacokinetics, and Antitumor Activity of AMG 386, a Selective Angiopoietin Inhibitor, in Adult Patients With Advanced Solid Tumors
HERBST, Roy S, HONG, David, EVELHOCH, Jeffrey L, OLINER, Jonathan D, LE, Ngocdiep, ROSEN, Lee S, LINNEA CHAP, KURZROCK, Razelle, JACKSON, Edward, SILVERMAN, Jeffrey M, RASMUSSEN, Erik, SUN, Yu-Nien, DON ZHONG, HWANG, Yuying C
Published in Journal of clinical oncology (20.07.2009)
Published in Journal of clinical oncology (20.07.2009)
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A phase 1b study of trametinib, an oral Mitogen-activated protein kinase kinase (MEK) inhibitor, in combination with gemcitabine in advanced solid tumours
Infante, Jeffrey R, Papadopoulos, Kyriakos P, Bendell, Johanna C, Patnaik, Amita, Burris, Howard A, Rasco, Drew, Jones, Suzanne F, Smith, Lon, Cox, Donna S, Durante, Michael, Bellew, Kevin M, Park, Joohyun (Jennifer), Le, Ngocdiep T, Tolcher, Anthony W
Published in European journal of cancer (1990) (01.06.2013)
Published in European journal of cancer (1990) (01.06.2013)
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408 Preliminary biomarker and clinical ata of a phase 2a study of NT-I7, a long-acting interleukin-7, plus pembrolizumab: cohort of subjects with checkpoint inhibitor-naïve advanced pancreatic cancer
Naing, Aung, Kim, Richard, Barve, Minal, Johnson, Melissa, Lee, Byung Ha, Ferrando-Martinez, Sara, Pant, Shubham, Wolff, Robert, Haymaker, Cara, Chaney, Marya, Kim, Dae Won, Fan, Jean, Le, NgocDiep, Mamdani, Hirva
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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396 NT-I7, a long-acting interleukin-7, promotes expansion of CD8 T cells and NK cells and immune activation in patients with newly diagnosed high-grade gliomas after chemoradiation
Zhou, Alice, Rettig, Michael, Foltz, Jennifer, Luo, Jingqin, Butt, Omar, Avvaru, Chai, Katumba, Ruth, Kim, Albert, Dunn, Gavin, Abraham, Christopher, Yang, Se Hwan, Fan, Jean, Lee, Byung Ha, Le, NgocDiep, Ansstas, George, Johanns, Tanner, Huang, Jiayi, Chheda, Milan, Fehniger, Todd, Campian, Jian
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse
Chen, Benny J., Deoliveira, Divino, Cui, Xiuyu, Le, Ngocdiep T., Son, Jessica, Whitesides, John F., Chao, Nelson J.
Published in Blood (01.04.2007)
Published in Blood (01.04.2007)
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A phase Ib dose-escalation study of the oral pan-PI3K inhibitor buparlisib (BKM120) in combination with the oral MEK1/2 inhibitor trametinib (GSK1120212) in patients with selected advanced solid tumors
Bedard, Philippe L, Tabernero, Josep, Janku, Filip, Wainberg, Zev A, Paz-Ares, Luis, Vansteenkiste, Johan, Van Cutsem, Eric, Pérez-García, José, Stathis, Anastasios, Britten, Carolyn D, Le, Ngocdiep, Carter, Kirsten, Demanse, David, Csonka, Denes, Peters, Malte, Zubel, Angela, Nauwelaerts, Heidi, Sessa, Cristiana
Published in Clinical cancer research (15.02.2015)
Published in Clinical cancer research (15.02.2015)
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A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas
Infante, Jeffrey R, Somer, Bradley G, Park, Joon Oh, Li, Chung-Pin, Scheulen, Max E, Kasubhai, Saifuddin M, Oh, Do-Youn, Liu, Yuan, Redhu, Suman, Steplewski, Klaudia, Le, Ngocdiep
Published in European journal of cancer (1990) (01.08.2014)
Published in European journal of cancer (1990) (01.08.2014)
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DYNAMO: A Phase II Study of Duvelisib (IPI-145) in Patients With Refractory Indolent Non-Hodgkin Lymphoma
Flinn, Ian W, Miller, Carole B, Ardeshna, Kirit M, Tetreault, Scott, Assouline, Sarit E, Mayer, Jiri, Merli, Michele, Lunin, Scott D, Pettitt, Andrew R, Nagy, Zoltan, Tournilhac, Olivier, Abou-Nassar, Karem-Etienne, Crump, Michael, Jacobsen, Eric D, de Vos, Sven, Kelly, Virginia M, Shi, Weiliang, Steelman, Lori, Le, NgocDiep, Weaver, David T, Lustgarten, Stephanie, Wagner-Johnston, Nina D, Zinzani, Pier Luigi
Published in Journal of clinical oncology (10.04.2019)
Published in Journal of clinical oncology (10.04.2019)
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Rapamycin Induces Tolerance by Increasing Regulatory T Cells in Chronic Graft Versus Host Disease Model
Palmer, Jeanne, Postdoctoral Fellow, Duke University Medical Center, Department of Hematology, Oncology and Cellular Therapy, Durham, NC, Chen, Benny, Assistant Professor of Medicine, Duke University Medical Center, Division of Cellular Therapy/BMT, Durham, NC, Chao, Nelson, Director, Division of Cellular Therapy/BMT, Professor of Medicine and Immunology, Duke University Medical Center, Durham, NC, Le, Ngocdiep, Medical Sciences Director, Amgen Inc., Thousand Oaks, CA
Published in Clinical immunology (Orlando, Fla.) (01.01.2007)
Published in Clinical immunology (Orlando, Fla.) (01.01.2007)
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Safety, pharmacokinetics, pharmacodynamics profiles and preliminary antitumor activity of phase 1b/2a study of NT-I7, a long-acting interleukin-7, plus pembrolizumab in patients with advanced solid tumors: The phase 1b data report
Naing, Aung, Fan, Jean, Lee, Byung Ha, Basudhar, Debashree, Pant, Shubham, Chaney, Marya F., Laviada, Cristina, Rajan, Cynthia, Le, Ngocdiep T., Barve, Minal A.
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
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The PRIMO study: A phase 2 study of duvelisib efficacy and safety in patients with relapsed or refractory peripheral t-cell lymphoma (PTCL)
Horwitz, Steven M., Soto, Jasminder, Youssoufian, Hagop, Lloyd, Deborah, Le, Ngocdiep T.
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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CTIM-07. A PHASE I/II STUDY EVALUATING THE SAFETY AND EFFICACY OF A NOVEL LONG-ACTING INTERLEUKIN-7, NT-I7, FOR PATIENTS WITH NEWLY DIAGNOSED HIGH-GRADE GLIOMAS AFTER CHEMORADIOTHERAPY
Campian, Jian, Butt, Omar, Luo, Jingqin, Avvaru, Chandini, Katumba, Ruth, Zhou, Alice, Kim, Albert, Dunn, Gavin, Abraham, Christopher, Yang, Se Hwan, Fan, Jean, Lee, Byung Ha, Ranjitkar, Sunita, Le, NgocDiep, Ansstas, George, Johanns, Tanner, Rettig, Michael, Chheda, Milan, Huang, Jiayi
Published in Neuro-oncology (Charlottesville, Va.) (12.11.2021)
Published in Neuro-oncology (Charlottesville, Va.) (12.11.2021)
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Characterization of the Long-Term Efficacy and Safety of Duvelisib Monotherapy in Patients with Relapsed/Refractory CLL/SLL on Treatment for > 2 Years across 4 Clinical Studies
Flinn, Ian W., Montillo, Marco, Nagy, Zsolt, Gasztonyi, Zoltán, Davids, Matthew S., Geissler, Klaus, Rifon Roca, Jose J., Berkhan, Leanne, Offner, Fritz, Le, NgocDiep, Lustgarten, Stephanie, Delgado, Julio
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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A phase I/II study to evaluate the safety and efficacy of a novel long-acting interleukin-7, NT-I7, for patients with newly diagnosed high-grade gliomas after chemoradiotherapy: The interim result of the phase I data
Campian, Jian Li, Luo, Jingqin, Avvaru, Chai, Katumba, Ruth, Kim, Albert H, Dunn, Gavin P., Abraham, Christopher, Bhatta, Puspanjali, Yang, Se Hwan, Fan, Jean, Lee, Byung Ha, Ranjitka, Sunita, Le, Ngocdiep T., Ansstas, George, Johanns, Tanner Michael, Chheda, Milan G, Huang, Jiayi
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
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The effect of duvelisib, a dual inhibitor of PI3K-δ,γ, on components of the tumor microenvironment in previously untreated follicular lymphoma
Casulo, Carla, Goy, Andre, Van Eygen, Koen, Sancho, Juan-Manuel, Santiago, Mercadal, Johnson, Rod, Bouabdallah, Kamal, Sprott, Kam, Le, Ngocdiep T., Pachter, Jonathan A., Weaver, David T.
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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