Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor
Johnson, Douglas S, Stiff, Cory, Lazerwith, Scott E, Kesten, Suzanne R, Fay, Lorraine K, Morris, Mark, Beidler, David, Liimatta, Marya B, Smith, Sarah E, Dudley, David T, Sadagopan, Nalini, Bhattachar, Shobha N, Kesten, Stephen J, Nomanbhoy, Tyzoon K, Cravatt, Benjamin F, Ahn, Kay
Published in ACS medicinal chemistry letters (10.02.2011)
Published in ACS medicinal chemistry letters (10.02.2011)
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Journal Article
Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase
FENAUX, Martijn, ENG, Stacey, LAZERWITH, Scott E, LEW, Willard, QI LIU, MERTZMAN, Michael, MORGANELLI, Philip, LIANHONG XU, HONG YE, JENNIFER ZHANG, MATLES, Mike, MURRAY, Bernard P, LEAVITT, Stephanie A, MWANGI, Judy, JINGYU ZHANG, HASHASH, Ahmad, KRAWCZYK, Steve H, BIDGOOD, Alison M, APPLEBY, Todd C, WATKINS, William J, LEE, Yu-Jen, MABERY, Eric M, YANG TIAN, BYUN, Daniel, CANALES, Eda, CLARKE, Michael O, DOERFFLER, Edward
Published in Antimicrobial Agents and Chemotherapy (01.02.2013)
Published in Antimicrobial Agents and Chemotherapy (01.02.2013)
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A Small-Molecule Inhibitor of Hepatitis C Virus Infectivity
BUSH, Caroline O, POKROVSKII, Maria V, PAGRATIS, Nikos, WEIDONG ZHONG, DELANEY, William E, PAULSON, Matthew S, BERAN, Rudolf K. F, SAITO, Roland, MORGANELLI, Philip, CANALES, Eda, CLARKE, Michael O, LAZERWITH, Scott E, GOLDE, Justin, REID, Brian G, BABAOGLU, Kerim
Published in Antimicrobial Agents and Chemotherapy (01.01.2014)
Published in Antimicrobial Agents and Chemotherapy (01.01.2014)
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Bio-orthogonal Affinity Purification of Direct Kinase Substrates
Allen, Jasmina J, Lazerwith, Scott E, Shokat, Kevan M
Published in Journal of the American Chemical Society (20.04.2005)
Published in Journal of the American Chemical Society (20.04.2005)
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Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile
Tsiang, Manuel, Jones, Gregg S, Goldsmith, Joshua, Mulato, Andrew, Hansen, Derek, Kan, Elaine, Tsai, Luong, Bam, Rujuta A, Stepan, George, Stray, Kirsten M, Niedziela-Majka, Anita, Yant, Stephen R, Yu, Helen, Kukolj, George, Cihlar, Tomas, Lazerwith, Scott E, White, Kirsten L, Jin, Haolun
Published in Antimicrobial agents and chemotherapy (01.12.2016)
Published in Antimicrobial agents and chemotherapy (01.12.2016)
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Long Dissociation of Bictegravir from HIV-1 Integrase-DNA Complexes
White, Kirsten L, Osman, Nathan, Cuadra-Foy, Ernesto, Brenner, Bluma G, Shivakumar, Devleena, Campigotto, Federico, Tsiang, Manuel, Morganelli, Philip A, Novikov, Nikolai, Lazerwith, Scott E, Jin, Haolun, Niedziela-Majka, Anita
Published in Antimicrobial agents and chemotherapy (19.04.2021)
Published in Antimicrobial agents and chemotherapy (19.04.2021)
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Journal Article
Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection
Lazerwith, Scott E., Lew, Willard, Zhang, Jennifer, Morganelli, Philip, Liu, Qi, Canales, Eda, Clarke, Michael O., Doerffler, Edward, Byun, Daniel, Mertzman, Michael, Ye, Hong, Chong, Lee, Xu, Lianhong, Appleby, Todd, Chen, Xiaowu, Fenaux, Martijn, Hashash, Ahmad, Leavitt, Stephanie A., Mabery, Eric, Matles, Mike, Mwangi, Judy W., Tian, Yang, Lee, Yu-Jen, Zhang, Jingyu, Zhu, Christine, Murray, Bernard P., Watkins, William J.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)
Johnson, Douglas S., Ahn, Kay, Kesten, Suzanne, Lazerwith, Scott E., Song, Yuntao, Morris, Mark, Fay, Lorraine, Gregory, Tracy, Stiff, Cory, Dunbar, James B., Liimatta, Marya, Beidler, David, Smith, Sarah, Nomanbhoy, Tyzoon K., Cravatt, Benjamin F.
Published in Bioorganic & medicinal chemistry letters (15.05.2009)
Published in Bioorganic & medicinal chemistry letters (15.05.2009)
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Journal Article
인지질 화합물 및 이의 용도
MEDLEY JONATHAN WILLIAM, STRATTON THOMAS P, MORGANELLI PHILIP A, LAZERWITH SCOTT E, WANG PEIYUAN
Year of Publication 19.06.2023
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Year of Publication 19.06.2023
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인지질 화합물 및 이의 용도
MEDLEY JONATHAN WILLIAM, STRATTON THOMAS P, MORGANELLI PHILIP A, LAZERWITH SCOTT E, NADUTHAMBI DEVAN, WANG PEIYUAN
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Year of Publication 28.04.2023
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HIV 치료용 캡시드 저해제
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Year of Publication 27.02.2023
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Year of Publication 27.02.2023
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티에노피롤 화합물
MITCHELL MICHAEL L, CHANG WENG K, MOAZAMI YASAMIN, SCHROEDER SCOTT D, AMMANN STEPHEN, KINFE HENOK H, SHORE DANIEL G, CANALES EDA Y, LAZERWITH SCOTT E
Year of Publication 30.04.2024
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Year of Publication 30.04.2024
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Optimization of Pharmacokinetics through Manipulation of Physicochemical Properties in a Series of HCV Inhibitors
Lazerwith, Scott E, Bahador, Gina, Canales, Eda, Cheng, Guofeng, Chong, Lee, Clarke, Michael O, Doerffler, Edward, Eisenberg, Eugene J, Hayes, Jaclyn, Lu, Bing, Liu, Qi, Matles, Mike, Mertzman, Michael, Mitchell, Michael L, Morganelli, Philip, Murray, Bernard P, Robinson, Margaret, Strickley, Robert G, Tessler, Megan, Tirunagari, Neeraj, Wang, Jianhong, Wang, Yujin, Zhang, Jennifer R, Zheng, Xubin, Zhong, Weidong, Watkins, William J
Published in ACS medicinal chemistry letters (13.10.2011)
Published in ACS medicinal chemistry letters (13.10.2011)
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티에노피롤 화합물
MITCHELL MICHAEL L, SWANK CHRISTOPHER J, CHANG WENG K, MOAZAMI YASAMIN, AMMANN STEPHEN E, SCHROEDER SCOTT D, KINFE HENOK H, SHORE DANIEL G, CANALES EDA Y, LAZERWITH SCOTT E
Year of Publication 20.12.2023
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Year of Publication 20.12.2023
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티에노피롤 화합물
MITCHELL MICHAEL L, CHANG WENG K, AMMANN STEPHEN E, JIANG LAN, SCHROEDER SCOTT D, KINFE HENOK H, SHORE DANIEL G, CANALES EDA Y, CODELLI JULIAN A, LAZERWITH SCOTT E
Year of Publication 17.10.2023
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Year of Publication 17.10.2023
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MCL-1 MCL-1 INHIBITORS
WATKINS WILLIAM J, HWANG TAE H, HURTLEY ANNA E, SQUIRES NEIL H, TSUI VICKIE H, CHU HANG, NEWBY ZACHARY, KOBAYASHI TETSUYA, LI XIAOFEN, LIN DAVID W, VENKATARAMANI CHANDRASEKAR, LAZERWITH SCOTT E, KATO DARRYL, MITCHELL MICHAEL L, YANG HONG, GUERRERO JUAN A, JIANG LAN, MEDLEY JONATHAN W, KNOX JOHN E, NADUTHAMBI DEVAN
Year of Publication 27.05.2024
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Year of Publication 27.05.2024
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POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
DESAI MANOJ C, TREJO MARTIN TERESA ALEJANDRA, BACON ELIZABETH M, COTTELL JEROMY J, CAI ZHENHONG R, TAYLOR JAMES G, LAZERWITH SCOTT E, JI MINGZHE, PYUN HYUNG JUNG, JIN HAOLUN, MISH MICHAEL R, CHEN XIAOWU, MORGANELLI PHILIP ANTHONY
Year of Publication 08.05.2023
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Year of Publication 08.05.2023
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HBV 복제 억제제로서의 치환된 피롤리진 화합물
GUTIERREZ DAVID ALAN, LEE RICK ANDREW, PYUN HYUNG JUNG, KOBAYASHI TETSUYA, MORGANELLI PHILIP ANTHONY, LAZERWITH SCOTT E
Year of Publication 03.11.2020
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Year of Publication 03.11.2020
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MCL-1 MCL-1 INHIBITORS
WATKINS WILLIAM J, HWANG TAE H, HURTLEY ANNA E, SQUIRES NEIL H, TSUI VICKIE H, CHU HANG, NEWBY ZACHARY, KOBAYASHI TETSUYA, LI XIAOFEN, LIN DAVID W, VENKATARAMANI CHANDRASEKAR, LAZERWITH SCOTT E, KATO DARRYL, MITCHELL MICHAEL L, YANG HONG, GUERRERO JUAN A, JIANG LAN, MEDLEY JONATHAN W, KNOX JOHN E, NADUTHAMBI DEVAN
Year of Publication 18.07.2023
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Year of Publication 18.07.2023
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