A new antibiotic kills pathogens without detectable resistance
Ling, Losee L, Schneider, Tanja, Peoples, Aaron J, Spoering, Amy L, Engels, Ina, Conlon, Brian P, Mueller, Anna, Schäberle, Till F, Hughes, Dallas E, Epstein, Slava, Jones, Michael, Lazarides, Linos, Steadman, Victoria A, Cohen, Douglas R, Felix, Cintia R, Fetterman, K Ashley, Millett, William P, Nitti, Anthony G, Zullo, Ashley M, Chen, Chao, Lewis, Kim
Published in Nature (London) (22.01.2015)
Published in Nature (London) (22.01.2015)
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Synthesis and evaluation of novel α-amino cyclic boronates as inhibitors of HCV NS3 protease
Li, Xianfeng, Zhang, Yong-Kang, Liu, Yang, Ding, Charles Z., Li, Qun, Zhou, Yasheen, Plattner, Jacob J., Baker, Stephen J., Qian, Xuelei, Fan, Dazhong, Liao, Liang, Ni, Zhi-Jie, White, Gemma V., Mordaunt, Jackie E., Lazarides, Linos X., Slater, Martin J., Jarvest, Richard L., Thommes, Pia, Ellis, Malcolm, Edge, Colin M., Hubbard, Julia A., Somers, Don, Rowland, Paul, Nassau, Pamela, McDowell, Bill, Skarzynski, Tadeusz J., Kazmierski, Wieslaw M., Grimes, Richard M., Wright, Lois L., Smith, Gary K., Zou, Wuxin, Wright, Jon, Pennicott, Lewis E.
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle
Mackman, Richard L, Steadman, Victoria A, Dean, David K, Jansa, Petr, Poullennec, Karine G, Appleby, Todd, Austin, Carol, Blakemore, Caroline A, Cai, Ruby, Cannizzaro, Carina, Chin, Gregory, Chiva, Jean-Yves C, Dunbar, Neil A, Fliri, Hans, Highton, Adrian J, Hui, Hon, Ji, Mingzhe, Jin, Haolun, Karki, Kapil, Keats, Andrew J, Lazarides, Linos, Lee, Yu-Jen, Liclican, Albert, Mish, Michael, Murray, Bernard, Pettit, Simon B, Pyun, Peter, Sangi, Michael, Santos, Rex, Sanvoisin, Jonathan, Schmitz, Uli, Schrier, Adam, Siegel, Dustin, Sperandio, David, Stepan, George, Tian, Yang, Watt, Gregory M, Yang, Hai, Schultz, Brian E
Published in Journal of medicinal chemistry (08.11.2018)
Published in Journal of medicinal chemistry (08.11.2018)
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Journal Article
Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A
Steadman, Victoria A, Pettit, Simon B, Poullennec, Karine G, Lazarides, Linos, Keats, Andrew J, Dean, David K, Stanway, Steven J, Austin, Carol A, Sanvoisin, Jonathan A, Watt, Gregory M, Fliri, Hans G, Liclican, Albert C, Jin, Debi, Wong, Melanie H, Leavitt, Stephanie A, Lee, Yu-Jen, Tian, Yang, Frey, Christian R, Appleby, Todd C, Schmitz, Uli, Jansa, Petr, Mackman, Richard L, Schultz, Brian E
Published in Journal of medicinal chemistry (09.02.2017)
Published in Journal of medicinal chemistry (09.02.2017)
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Journal Article
Erratum: A new antibiotic kills pathogens without detectable resistance
Ling, Losee L, Schneider, Tanja, Peoples, Aaron J, Spoering, Amy L, Engels, Ina, Conlon, Brian P, Mueller, Anna, Schäberle, Till F, Hughes, Dallas E, Epstein, Slava, Jones, Michael, Lazarides, Linos, Steadman, Victoria A, Cohen, Douglas R, Felix, Cintia R, Fetterman, K Ashley, Millett, William P, Nitti, Anthony G, Zullo, Ashley M, Chen, Chao, Lewis, Kim
Published in Nature (London) (16.04.2015)
Published in Nature (London) (16.04.2015)
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Discovery of 6‑Amino-2-{[(1S)‑1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro‑8H‑purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma
Biggadike, Keith, Ahmed, Mahbub, Ball, Doug I, Coe, Diane M, Dalmas Wilk, Deidre A, Edwards, Chris D, Gibbon, Bob H, Hardy, Charlotte J, Hermitage, Stephen A, Hessey, Joanne O, Hillegas, Aimee E, Hughes, Stephen C, Lazarides, Linos, Lewell, Xiao Q, Lucas, Amanda, Mallett, David N, Price, Mark A, Priest, Fiona M, Quint, Diana J, Shah, Poonam, Sitaram, Anesh, Smith, Stephen A, Stocker, Richard, Trivedi, Naimisha A, Tsitoura, Daphne C, Weller, Victoria
Published in Journal of medicinal chemistry (10.03.2016)
Published in Journal of medicinal chemistry (10.03.2016)
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Journal Article
Discovery of 6-Amino-2-{[(1 S )-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8 H -purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma
Biggadike, Keith, Ahmed, Mahbub, Ball, Doug I., Coe, Diane M., Dalmas Wilk, Deidre A., Edwards, Chris D., Gibbon, Bob H., Hardy, Charlotte J., Hermitage, Stephen A., Hessey, Joanne O., Hillegas, Aimee E., Hughes, Stephen C., Lazarides, Linos, Lewell, Xiao Q., Lucas, Amanda, Mallett, David N., Price, Mark A., Priest, Fiona M., Quint, Diana J., Shah, Poonam, Sitaram, Anesh, Smith, Stephen A., Stocker, Richard, Trivedi, Naimisha A., Tsitoura, Daphne C., Weller, Victoria
Published in Journal of medicinal chemistry (10.03.2016)
Published in Journal of medicinal chemistry (10.03.2016)
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O-Directed Free-Radical Hydrostannations of Propargyl Ethers, Acetals, and Alcohols with Ph3SnH and Et3B
Dimopoulos, Paschalis, Athlan, Audrey, Manaviazar, Soraya, George, Jonathan, Walters, Marcus, Lazarides, Linos, Aliev, Abil E, Hale, Karl J
Published in Organic letters (24.11.2005)
Published in Organic letters (24.11.2005)
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NOVEL ADENINE DERIVATIVES
BAZIN LEE HELENE, LAZARIDES LINOS, SMITH STEPHEN ALLAN, COE DIANE MARY, TRIVEDI NAIMISHA, MITCHELL CHARLOTTE JANE
Year of Publication 11.01.2016
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Year of Publication 11.01.2016
Patent
Synthesis of A83586C Analogs with Potent Anticancer and β-Catenin/ TCF4/Osteopontin Inhibitory Effects and Insights Into How A83586C Modulates E2Fs and pRb
Hale, Karl J, Manaviazar, Soraya, Lazarides, Linos, George, Jonathan, Walters, Marcus A, Cai, Jiaqiang, Delisser, Vern M, Bhatia, Gurpreet S, Peak, S. Andrew, Dalby, Stephen M, Lefranc, Amandine, Chen, Ying-Nan P, Wood, Alexander W, Crowe, Paul, Erwin, Pauline, El-Tanani, Mohamed
Published in Organic letters (05.02.2009)
Published in Organic letters (05.02.2009)
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MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES
SANVOISIN JONATHAN, WATT GREGORY M, FLIRI HANS G, LAZARIDES LINOS, KEATS ANDREW J, MACKMAN RICHARD L, APPLEBY TODD, PETTIT SIMON N, STEADMAN VICTORIA A, POULLENNEC KARINE G
Year of Publication 13.03.2014
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Year of Publication 13.03.2014
Patent
O -Directed Free-Radical Hydrostannations of Propargyl Ethers, Acetals, and Alcohols with Ph 3 SnH and Et 3 B
Dimopoulos, Paschalis, Athlan, Audrey, Manaviazar, Soraya, George, Jonathan, Walters, Marcus, Lazarides, Linos, Aliev, Abil E., Hale, Karl J.
Published in Organic letters (01.11.2005)
Published in Organic letters (01.11.2005)
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Synthesis of an l-proline modified mimetic of the A83586C antitumour cyclodepsipeptideElectronic supplementary information (ESI) available: characterisation data. See http://www.rsc.org/suppdata/cc/b2/b204018b
Hale, Karl J., Lazarides, Linos
Published in Chemical communications (Cambridge, England) (21.08.2002)
Published in Chemical communications (Cambridge, England) (21.08.2002)
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Journal Article
NOVEL DEPSIPEPTIDE AND USES THEREOF
LING, Losee, Lucy, SPOERING, Amy, LEWIS, Kim, STEADMAN, Victoria, Alexandra, HUGHES, Dallas, EPSTEIN, Slava, NITTI, Anthony, PEOPLES, Aaron, J, MILLETT, William, POULLENNEC, Karine, Gaelle, CHIVA, Jean-Yves, Christophe, LAZARIDES, Linos, JONES, Michael Kenyon
Year of Publication 14.08.2024
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Year of Publication 14.08.2024
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NOVEL DEPSIPEPTIDE AND USES THEREOF
LING, Losee, Lucy, SPOERING, Amy, LEWIS, Kim, STEADMAN, Victoria, Alexandra, HUGHES, Dallas, EPSTEIN, Slava, NITTI, Anthony, PEOPLES, Aaron, J, MILLETT, William, POULLENNEC, Karine, Gaelle, CHIVA, Jean-Yves, Christophe, LAZARIDES, Linos, JONES, Michael Kenyon
Year of Publication 27.03.2024
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Year of Publication 27.03.2024
Patent
Depsipeptide and uses thereof
Hughes, Dallas, Lewis, Kim, Nitti, Anthony, Chiva, Jean-Yves Christophe, Millett, William, Ling, Losee Lucy, Poullennec, Karine Gaelle, Steadman, Victoria Alexandra, Spoering, Amy, Jones, Michael Kenyon, Lazarides, Linos, Epstein, Slava, Peoples, Aaron J
Year of Publication 26.12.2023
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Year of Publication 26.12.2023
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