Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve
Klein, Rebecca M., Layton, Mark E., Regan, Hillary, Regan, Christopher P., Li, Yuxing, Filzen, Tracey, Cato, Matt, Clements, Michelle K., Wang, Jixin, Sanoja, Raul, Greshock, Thomas J., Roecker, Anthony J., Pero, Joseph E., Kim, Ron, Burgey, Christopher, John, Christopher T., Wang, Ying-Hong, Bhandari, Neetesh, Struyk, Arie, Kraus, Richard L., Henze, Darrell A., Houghton, Andrea K.
Published in Channels (Austin, Tex.) (31.12.2022)
Published in Channels (Austin, Tex.) (31.12.2022)
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Biomimetic Synthesis of (−)-Longithorone A
Layton, Mark E, Morales, Carl A, Shair, Matthew D
Published in Journal of the American Chemical Society (06.02.2002)
Published in Journal of the American Chemical Society (06.02.2002)
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3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts
Brnardic, Edward J., Fraley, Mark E., Garbaccio, Robert M., Layton, Mark E., Sanders, John M., Culberson, Chris, Jacobson, Marlene A., Magliaro, Brian C., Hutson, Pete H., O’Brien, Julie A., Huszar, Sarah L., Uslaner, Jason M., Fillgrove, Kerry L., Tang, Cuyue, Kuo, Yuhsin, Sur, Sylvie M., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia
Layton, Mark E., Kern, Jeffrey C., Hartingh, Timothy J., Shipe, William D., Raheem, Izzat, Kandebo, Monika, Hayes, Robert P., Huszar, Sarah, Eddins, Donnie, Ma, Bennett, Fuerst, Joy, Wollenberg, Gordon K., Li, Jing, Fritzen, Jeff, McGaughey, Georgia B., Uslaner, Jason M., Smith, Sean M., Coleman, Paul J., Cox, Christopher D.
Published in Journal of medicinal chemistry (26.01.2023)
Published in Journal of medicinal chemistry (26.01.2023)
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Synthesis of Cyclooctenones Using Intramolecular Hydroacylation
Aloise, Allen D, Layton, Mark E, Shair, Matthew D
Published in Journal of the American Chemical Society (20.12.2000)
Published in Journal of the American Chemical Society (20.12.2000)
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Journal Article
Analgesia and peripheral c-fiber modulation by selective Nav1.8 inhibition in rhesus
Vardigan, Joshua D, Pall, Parul S, McDevitt, Dillon S, Huang, ChienJung, Clements, Michelle K, Li, Yuxing, Kraus, Richard L, Breslin, Michael J, Bungard, Christopher J, Nemenov, Mikhail I, Klukinov, Mikhail, Burgey, Chritopher S, Layton, Mark E, Stachel, Shawn J, Lange, Henry S, Savitz, Alan T, Santarelli, Vincent P, Henze, Darrell A, Uslaner, Jason M
Published in Pain (Amsterdam) (08.10.2024)
Published in Pain (Amsterdam) (08.10.2024)
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Journal Article
Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists
Layton, Mark E., Kelly, Michael J., Rodzinak, Kevin J., Sanderson, Philip E., Young, Steven D., Bednar, Rodney A., DiLella, Anthony G., Mcdonald, Terrence P., Wang, Hao, Mosser, Scott D., Fay, John F., Cunningham, Michael E., Reiss, Duane R., Fandozzi, Christine, Trainor, Nicole, Liang, Annie, Lis, Edward V., Seabrook, Guy R., Urban, Mark O., Yergey, James, Koblan, Kenneth S.
Published in ACS chemical neuroscience (20.07.2011)
Published in ACS chemical neuroscience (20.07.2011)
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Journal Article
Invention of MK-7845, a SARS-CoV‑2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic
Shurtleff, Valerie W., Layton, Mark E., Parish, Craig A., Perkins, James J., Schreier, John D., Wang, Yunyi, Adam, Gregory C., Alvarez, Nadine, Bahmanjah, Soheila, Bahnck-Teets, Carolyn M., Boyce, Christopher W., Burlein, Christine, Cabalu, Tamara D., Campbell, Brian T., Carroll, Steven S., Chang, Wonsuk, de Lera Ruiz, Manuel, Dolgov, Enriko, Fay, John F., Fox, Nicholas G., Goh, Shih Lin, Hartingh, Timothy J., Hurzy, Danielle M., Kelly, Michael J., Klein, Daniel J., Klingler, Franca-Maria, Krishnamurthy, Harini, Kudalkar, Shalley, Mayhood, Todd W., McKenna, Philip M., Murray, Edward M., Nahas, Debbie, Nawrat, Christopher C., Park, Steven, Qian, Dongming, Roecker, Anthony J., Sharma, Vijeta, Shipe, William D., Su, Jing, Taggart, Robert V., Truong, Quang, Wu, Yin, Zhou, Xiaoyan, Zhuang, Ningning, Perlin, David S., Olsen, David B., Howe, John A., McCauley, John A.
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Journal Article
Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice
Roecker, Anthony J., Egbertson, Melissa, Jones, Kristen L.G., Gomez, Robert, Kraus, Richard L., Li, Yuxing, Koser, Amy Jo, Urban, Mark O., Klein, Rebecca, Clements, Michelle, Panigel, Jacqueline, Daley, Christopher, Wang, Jixin, Finger, Eleftheria N., Majercak, John, Santarelli, Vincent, Gregan, Irene, Cato, Matthew, Filzen, Tracey, Jovanovska, Aneta, Wang, Ying-Hong, Wang, Deping, Joyce, Leo A., Sherer, Edward C., Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Coleman, Paul J., Houghton, Andrea K., Layton, Mark E.
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
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Journal Article
Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model
Pero, Joseph E., Rossi, Michael A., Lehman, Hannah D.G.F., Kelly, Michael J., Mulhearn, James J., Wolkenberg, Scott E., Cato, Matthew J., Clements, Michelle K., Daley, Christopher J., Filzen, Tracey, Finger, Eleftheria N., Gregan, Yun, Henze, Darrell A., Jovanovska, Aneta, Klein, Rebecca, Kraus, Richard L., Li, Yuxing, Liang, Annie, Majercak, John M., Panigel, Jacqueline, Urban, Mark O., Wang, Jixin, Wang, Ying-Hong, Houghton, Andrea K., Layton, Mark E.
Published in Bioorganic & medicinal chemistry letters (15.06.2017)
Published in Bioorganic & medicinal chemistry letters (15.06.2017)
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Journal Article
Na v 1.7 target modulation and efficacy can be measured in nonhuman primate assays
Kraus, Richard L, Zhao, Fuqiang, Pall, Parul S, Zhou, Dan, Vardigan, Joshua D, Danziger, Andrew, Li, Yuxing, Daley, Christopher, Ballard, Jeanine E, Clements, Michelle K, Klein, Rebecca M, Holahan, Marie A, Greshock, Thomas J, Kim, Ronald M, Layton, Mark E, Burgey, Christopher S, Serra, Jordi, Henze, Darrell A, Houghton, Andrea K
Published in Science translational medicine (19.05.2021)
Published in Science translational medicine (19.05.2021)
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Journal Article
Novel Pan-Coronavirus 3CL Protease Inhibitor MK-7845: Biological and Pharmacological Profiling
Alvarez, Nadine, Adam, Gregory C, Howe, John A, Sharma, Vijeta, Zimmerman, Matthew D, Dolgov, Enriko, Rasheed, Risha, Nizar, Fatima, Sahay, Khushboo, Nelson, Andrew M, Park, Steven, Zhou, Xiaoyan, Burlein, Christine, Fay, John F, Iwamoto, Daniel V, Bahnck-Teets, Carolyn M, Getty, Krista L, Lin Goh, Shih, Salhab, Imad, Smith, Keith, Boyce, Christopher W, Cabalu, Tamara D, Murgolo, Nicholas, Fox, Nicholas G, Mayhood, Todd W, Shurtleff, Valerie W, Layton, Mark E, Parish, Craig A, McCauley, John A, Olsen, David B, Perlin, David S
Published in Viruses (01.07.2024)
Published in Viruses (01.07.2024)
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Discovery of Arylsulfonamide Nav1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile
Roecker, Anthony J, Layton, Mark E, Pero, Joseph E, Kelly, Michael J, Greshock, Thomas J, Kraus, Richard L, Li, Yuxing, Klein, Rebecca, Clements, Michelle, Daley, Christopher, Jovanovska, Aneta, Ballard, Jeanine E, Wang, Deping, Zhao, Fuqiang, Brunskill, Andrew P. J, Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Houghton, Andrea K, Burgey, Christopher S
Published in ACS medicinal chemistry letters (10.06.2021)
Published in ACS medicinal chemistry letters (10.06.2021)
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Journal Article
Discovery of Arylsulfonamide Na v 1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile
Roecker, Anthony J, Layton, Mark E, Pero, Joseph E, Kelly, 3rd, Michael J, Greshock, Thomas J, Kraus, Richard L, Li, Yuxing, Klein, Rebecca, Clements, Michelle, Daley, Christopher, Jovanovska, Aneta, Ballard, Jeanine E, Wang, Deping, Zhao, Fuqiang, Brunskill, Andrew P J, Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Houghton, Andrea K, Burgey, Christopher S
Published in ACS medicinal chemistry letters (10.06.2021)
Published in ACS medicinal chemistry letters (10.06.2021)
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Journal Article
Benzoxazolinone aryl sulfonamides as potent, selective Na v 1.7 inhibitors with in vivo efficacy in a preclinical pain model
Pero, Joseph E, Rossi, Michael A, Lehman, Hannah D G F, Kelly, 3rd, Michael J, Mulhearn, James J, Wolkenberg, Scott E, Cato, Matthew J, Clements, Michelle K, Daley, Christopher J, Filzen, Tracey, Finger, Eleftheria N, Gregan, Yun, Henze, Darrell A, Jovanovska, Aneta, Klein, Rebecca, Kraus, Richard L, Li, Yuxing, Liang, Annie, Majercak, John M, Panigel, Jacqueline, Urban, Mark O, Wang, Jixin, Wang, Ying-Hong, Houghton, Andrea K, Layton, Mark E
Published in Bioorganic & medicinal chemistry letters (15.06.2017)
Published in Bioorganic & medicinal chemistry letters (15.06.2017)
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Journal Article
Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis
Layton, Mark E., Reif, Alexander J., Hartingh, Timothy J., Rodzinak, Kevin, Dudkin, Vadim, Wang, Cheng, Arrington, Ken, Kelly, Michael J., Garbaccio, Robert M., O’Brien, Julie A., Magliaro, Brian C., Uslaner, Jason M., Huszar, Sarah L., Fillgrove, Kerry L., Tang, Cuyue, Kuo, Yuhsin, Jacobson, Marlene A.
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
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Journal Article
Discovery of selective, orally bioavailable, N-linked arylsulfonamide Na v 1.7 inhibitors with pain efficacy in mice
Roecker, Anthony J, Egbertson, Melissa, Jones, Kristen L G, Gomez, Robert, Kraus, Richard L, Li, Yuxing, Koser, Amy Jo, Urban, Mark O, Klein, Rebecca, Clements, Michelle, Panigel, Jacqueline, Daley, Christopher, Wang, Jixin, Finger, Eleftheria N, Majercak, John, Santarelli, Vincent, Gregan, Irene, Cato, Matthew, Filzen, Tracey, Jovanovska, Aneta, Wang, Ying-Hong, Wang, Deping, Joyce, Leo A, Sherer, Edward C, Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Coleman, Paul J, Houghton, Andrea K, Layton, Mark E
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
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