Targeting Metabolism of Extracellular Nucleotides via Inhibition of Ectonucleotidases CD73 and CD39
Jeffrey, Jenna L, Lawson, Kenneth V, Powers, Jay P
Published in Journal of medicinal chemistry (25.11.2020)
Published in Journal of medicinal chemistry (25.11.2020)
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Journal Article
Discovery of AB680: A Potent and Selective Inhibitor of CD73
Lawson, Kenneth V, Kalisiak, Jaroslaw, Lindsey, Erick A, Newcomb, Eric T, Leleti, Manmohan Reddy, Debien, Laurent, Rosen, Brandon R, Miles, Dillon H, Sharif, Ehesan U, Jeffrey, Jenna L, Tan, Joanne B. L, Chen, Ada, Zhao, Sharon, Xu, Guifen, Fu, Lijuan, Jin, Lixia, Park, Tim W, Berry, Wade, Moschütz, Susanne, Scaletti, Emma, Sträter, Norbert, Walker, Nigel P, Young, Stephen W, Walters, Matthew J, Schindler, Uli, Powers, Jay P
Published in Journal of medicinal chemistry (22.10.2020)
Published in Journal of medicinal chemistry (22.10.2020)
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Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73
Beatty, Joel W, Lindsey, Erick A, Thomas-Tran, Rhiannon, Debien, Laurent, Mandal, Debashis, Jeffrey, Jenna L, Tran, Anh T, Fournier, Jeremy, Jacob, Steven D, Yan, Xuelei, Drew, Samuel L, Ginn, Elaine, Chen, Ada, Pham, Amber T, Zhao, Sharon, Jin, Lixia, Young, Stephen W, Walker, Nigel P, Leleti, Manmohan Reddy, Moschütz, Susanne, Sträter, Norbert, Powers, Jay P, Lawson, Kenneth V
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
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Journal Article
Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors
Sharif, Ehesan U., Kalisiak, Jaroslaw, Lawson, Kenneth, Miles, Dillon H., Newcomb, Eric, Lindsey, Erick A., Rosen, Brandon R., Debien, Laurent P. P., Chen, Ada, Zhao, Xiaoning, Young, Stephen W., Walker, Nigel P., Straeter, Norbert, Scaletti, Emma R., Jin, Lixia, Xu, Guifen, Leleti, Manmohan R., Powers, Jay P.
Published in Journal of medicinal chemistry (14.01.2021)
Published in Journal of medicinal chemistry (14.01.2021)
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Journal Article
Discovery of Potent and Selective PI3Kγ Inhibitors
Drew, Samuel L, Thomas-Tran, Rhiannon, Beatty, Joel W, Fournier, Jeremy, Lawson, Kenneth V, Miles, Dillon H, Mata, Guillaume, Sharif, Ehesan U, Yan, Xuelei, Mailyan, Artur K, Ginn, Elaine, Chen, Jie, Wong, Kent, Soni, Divyank, Dhanota, Puja, Chen, Pei-Yu, Shaqfeh, Stefan G, Meleza, Cesar, Pham, Amber T, Chen, Ada, Zhao, Xiaoning, Banuelos, Jesus, Jin, Lixia, Schindler, Ulrike, Walters, Matthew J, Young, Stephen W, Walker, Nigel P, Leleti, Manmohan Reddy, Powers, Jay P, Jeffrey, Jenna L
Published in Journal of medicinal chemistry (08.10.2020)
Published in Journal of medicinal chemistry (08.10.2020)
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Design, Synthesis, and Structure-Activity Relationship Optimization of Pyrazolopyrimidine Amide Inhibitors of Phosphoinositide 3-Kinase γ (PI3Kγ)
Mata, Guillaume, Miles, Dillon H, Drew, Samuel L, Fournier, Jeremy, Lawson, Kenneth V, Mailyan, Artur K, Sharif, Ehesan U, Yan, Xuelei, Beatty, Joel W, Banuelos, Jesus, Chen, Jie, Ginn, Elaine, Chen, Ada, Gerrick, Kimberline Y, Pham, Amber T, Wong, Kent, Soni, Divyank, Dhanota, Puja, Shaqfeh, Stefan G, Meleza, Cesar, Narasappa, Nell, Singh, Hema, Zhao, Xiaoning, Jin, Lixia, Schindler, Ulrike, Walters, Matthew J, Young, Stephen W, Walker, Nigel P, Leleti, Manmohan Reddy, Powers, Jay P, Jeffrey, Jenna L
Published in Journal of medicinal chemistry (27.01.2022)
Published in Journal of medicinal chemistry (27.01.2022)
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Journal Article
Large ring-forming alkylations provide facile access to composite macrocycles
Rose, Tristan E, Lawson, Kenneth V, Harran, Patrick G
Published in Chemical science (Cambridge) (16.04.2015)
Published in Chemical science (Cambridge) (16.04.2015)
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Journal Article
Discovery of Potent and Selective 7‑Azaindole Isoindolinone-Based PI3Kγ Inhibitors
Miles, Dillon H, Yan, Xuelei, Thomas-Tran, Rhiannon, Fournier, Jeremy, Sharif, Ehesan U, Drew, Samuel L, Mata, Guillaume, Lawson, Kenneth V, Ginn, Elaine, Wong, Kent, Soni, Divyank, Dhanota, Puja, Shaqfeh, Stefan G, Meleza, Cesar, Chen, Ada, Pham, Amber T, Park, Timothy, Swinarski, Debbie, Banuelos, Jesus, Schindler, Ulrike, Walters, Matthew J, Walker, Nigel P, Zhao, Xiaoning, Young, Stephen W, Chen, Jie, Jin, Lixia, Leleti, Manmohan Reddy, Powers, Jay P, Jeffrey, Jenna L
Published in ACS medicinal chemistry letters (12.11.2020)
Published in ACS medicinal chemistry letters (12.11.2020)
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Synthesis of a designed sesquiterpenoid that forms useful composites with peptides and related oligomers
Lawson, Kenneth V., Rose, Tristan E., Harran, Patrick G.
Published in Tetrahedron letters (09.02.2011)
Published in Tetrahedron letters (09.02.2011)
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비경구적으로 투여된 면역 향상 약물
JIN LIXIA, KARAKUNNEL M.D. JOYSON J, KALISIAK JAROSLAW, JEFFREY JENNA LEIGH, JAEN JUAN CARLOS, LAWSON KENNETH V, LELETI MANMOHAN REDDY, POWERS JAY PATRICK
Year of Publication 20.11.2020
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Year of Publication 20.11.2020
Patent
5'-뉴클레오티다아제, 엑토의 조절제, 및 이의 용도
ROSEN BRANDON REID, LINDSEY ERICK ALLEN, KALISIAK JAROSLAW, SHARIF EHESAN UL, JAEN JUAN CARLOS, LAWSON KENNETH V, MILES DILLON HARDING, DEBIEN LAURENT PIERRE PAUL, LELETI MANMOHAN REDDY, NEWCOMB ERIC, POWERS JAY PATRICK
Year of Publication 11.09.2018
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Year of Publication 11.09.2018
Patent
Abstract 1206: Discovery and characterization of AB521, a novel, potent, and selective hypoxia-inducible factor (HIF)-2α inhibitor
Lawson, Kenneth V., Gauthier, Kelsey E. Sivick, Mailyan, Artur K., Fournier, Jeremy T., Beatty, Joel W., Drew, Samuel L., Kalisiak, Jarek, Gal, Balint, Mata, Guillaume, Wang, Zhang, Yan, Xuelei, Jin, Lixia, Ginn, Elaine, Piovesan, Dana, Au, Jennifer, Meleza, Cesar A., Young, Stephen W., Walters, Matthew J., Leleti, Manmohan, Powers, Jay P.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Development of a Scalable Method for Manufacturing the Central Core of CD73 Inhibitor AB680
Fournier, Jeremy, Yan, Xuelei, Tran, Anh T., Grange, Rebecca L., Jacob, Steven D., Kalisiak, Jaroslaw, Lawson, Kenneth V., Connor, Eric F., Leleti, Manmohan R., Powers, Jay P.
Published in Organic process research & development (15.01.2021)
Published in Organic process research & development (15.01.2021)
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Journal Article
Abstract 1756: Discovery and characterization of AB680, a potent and selective small-molecule CD73 inhibitor for cancer immunotherapy
Lawson, Kenneth V., Jin, Lixia, Jeffrey, Jenna L., Kalisiak, Jarek, Yin, Fangfang, Zhang, Kristen, Chen, Ada, Swinarski, Debbie, Walters, Matt J., Young, Steve, Schindler, Ulrike, Jay, Powers P.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Large ring-forming alkylations provide facile access to composite macrocyclesElectronic supplementary information (ESI) available: Fig. S1-S4, list of macrocycles prepared, experimental procedures, and spectroscopic data. CCDC 1023942. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc03848g
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Large ring-forming alkylations provide facile access to composite macrocycles† †Electronic supplementary information (ESI) available: Fig. S1–S4, list of macrocycles prepared, experimental procedures, and spectroscopic data. CCDC 1023942. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc03848g Click here for additional data file. Click here for additional data file
Rose, Tristan E., Lawson, Kenneth V., Harran, Patrick. G.
Published in Chemical science (Cambridge) (09.02.2015)
Published in Chemical science (Cambridge) (09.02.2015)
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