Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma
Hansen, Joshua D, Correa, Matthew, Nagy, Mark A, Alexander, Matt, Plantevin, Veronique, Grant, Virginia, Whitefield, Brandon, Huang, Dehua, Kercher, Timothy, Harris, Roy, Narla, Rama Krishna, Leisten, Jim, Tang, Yang, Moghaddam, Mehran, Ebinger, Katalin, Piccotti, Joseph, Havens, Courtney G, Cathers, Brian, Carmichael, James, Daniel, Thomas, Vessey, Rupert, Hamann, Lawrence G, Leftheris, Katerina, Mendy, Derek, Baculi, Frans, LeBrun, Laurie A, Khambatta, Gody, Lopez-Girona, Antonia
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex
Matyskiela, Mary E., Clayton, Thomas, Zheng, Xinde, Mayne, Christopher, Tran, Eileen, Carpenter, Aaron, Pagarigan, Barbra, McDonald, Joseph, Rolfe, Mark, Hamann, Lawrence G., Lu, Gang, Chamberlain, Philip P.
Published in Nature structural & molecular biology (01.04.2020)
Published in Nature structural & molecular biology (01.04.2020)
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Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron‑2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA)
Cheung, Atwood K, Hurley, Brian, Kerrigan, Ryan, Shu, Lei, Chin, Donovan N, Shen, Yiping, O’Brien, Gary, Sung, Moo Je, Hou, Ying, Axford, Jake, Cody, Emma, Sun, Robert, Fazal, Aleem, Tomlinson, Ronald C, Jain, Monish, Deng, Lin, Hoffmaster, Keith, Song, Cheng, Van Hoosear, Mailin, Shin, Youngah, Servais, Rebecca, Towler, Christopher, Hild, Marc, Curtis, Daniel, Dietrich, William F, Hamann, Lawrence G, Briner, Karin, Chen, Karen S, Kobayashi, Dione, Sivasankaran, Rajeev, Dales, Natalie A
Published in Journal of medicinal chemistry (27.12.2018)
Published in Journal of medicinal chemistry (27.12.2018)
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Intermolecular Crossed [2 + 2] Cycloaddition Promoted by Visible-Light Triplet Photosensitization: Expedient Access to Polysubstituted 2‑Oxaspiro[3.3]heptanes
Murray, Philip R. D, Bussink, Willem M. M, Davies, Geraint H. M, van der Mei, Farid W, Antropow, Alyssa H, Edwards, Jacob T, D’Agostino, Laura Akullian, Ellis, J. Michael, Hamann, Lawrence G, Romanov-Michailidis, Fedor, Knowles, Robert R
Published in Journal of the American Chemical Society (17.03.2021)
Published in Journal of the American Chemical Society (17.03.2021)
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Evolution of Cereblon-Mediated Protein Degradation as a Therapeutic Modality
Chamberlain, Philip P, D’Agostino, Laura A, Ellis, J. Michael, Hansen, Joshua D, Matyskiela, Mary E, McDonald, Joseph J, Riggs, Jennifer R, Hamann, Lawrence G
Published in ACS medicinal chemistry letters (12.12.2019)
Published in ACS medicinal chemistry letters (12.12.2019)
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Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo
Saenz, Steven A, Local, Andrea, Carr, Tiffany, Shakya, Arvind, Koul, Shivsmriti, Hu, Haiqing, Chourb, Lisa, Stedman, Justin, Malley, Jenna, D'Agostino, Laura Akullian, Shanmugasundaram, Veerabahu, Malona, John, Schwartz, C Eric, Beebe, Lisa, Clements, Meghan, Rajaraman, Ganesh, Cho, John, Jiang, Lan, Dubrovskiy, Alex, Kreilein, Matt, Shimanovich, Roman, Hamann, Lawrence G, Escoubet, Laure, Ellis, J Michael
Published in PloS one (09.11.2021)
Published in PloS one (09.11.2021)
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Non-Directed Allylic C-H Acetoxylation in the Presence of Lewis Basic Heterocycles
Malik, Hasnain A, Taylor, Buck L H, Kerrigan, John R, Grob, Jonathan E, Houk, K N, Du Bois, J, Hamann, Lawrence G, Patterson, Andrew W
Published in Chemical science (Cambridge) (01.01.2014)
Published in Chemical science (Cambridge) (01.01.2014)
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Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
Augeri, David J, Robl, Jeffrey A, Betebenner, David A, Magnin, David R, Khanna, Ashish, Robertson, James G, Wang, Aiying, Simpkins, Ligaya M, Taunk, Prakash, Huang, Qi, Han, Song-Ping, Abboa-Offei, Benoni, Cap, Michael, Xin, Li, Tao, Li, Tozzo, Effie, Welzel, Gustav E, Egan, Donald M, Marcinkeviciene, Jovita, Chang, Shu Y, Biller, Scott A, Kirby, Mark S, Parker, Rex A, Hamann, Lawrence G
Published in Journal of medicinal chemistry (28.07.2005)
Published in Journal of medicinal chemistry (28.07.2005)
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Pharmacokinetics of the Dipeptidyl Peptidase 4 Inhibitor Saxagliptin in Rats, Dogs, and Monkeys and Clinical Projections
FURA, Aberra, KHANNA, Ashish, HUMPHREYS, W. Griffith, KIRBY, Mark, VYAS, Viral, KOPLOWITZ, Barry, CHANG, Shu-Ying, CAPORUSCIO, Christian, BOULTON, David W, CHRISTOPHER, Lisa J, CHADWICK, Kristina D, HAMANN, Lawrence G
Published in Drug metabolism and disposition (01.06.2009)
Published in Drug metabolism and disposition (01.06.2009)
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effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization
Qiu, Dike, Lemm, Julie A, O’Boyle, Donald R., II, Sun, Jin-Hua, Nower, Peter T, Nguyen, Van, Hamann, Lawrence G, Snyder, Lawrence B, Deon, Daniel H, Ruediger, Edward, Meanwell, Nicholas A, Belema, Makonen, Gao, Min, Fridell, Robert A
Published in Journal of general virology (01.11.2011)
Published in Journal of general virology (01.11.2011)
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Involvement of DPP‐IV catalytic residues in enzyme–saxagliptin complex formation
Metzler, William J., Yanchunas, Joseph, Weigelt, Carolyn, Kish, Kevin, Klei, Herbert E., Xie, Dianlin, Zhang, Yaqun, Corbett, Martin, Tamura, James K., He, Bin, Hamann, Lawrence G., Kirby, Mark S., Marcinkeviciene, Jovita
Published in Protein science (01.02.2008)
Published in Protein science (01.02.2008)
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Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors
Zhao, Guohua, Kwon, Chet, Wang, Aiying, Robertson, James G., Marcinkeviciene, Jovita, Parker, Rex A., Kirby, Mark S., Hamann, Lawrence G.
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
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Journal Article
Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins
Page, Claire G., Cooper, Simon J., DeHovitz, Jacob S., Oblinsky, Daniel G., Biegasiewicz, Kyle F., Antropow, Alyssa H., Armbrust, Kurt W., Ellis, J. Michael, Hamann, Lawrence G., Horn, Evan J., Oberg, Kevin M., Scholes, Gregory D., Hyster, Todd K.
Published in Journal of the American Chemical Society (13.01.2021)
Published in Journal of the American Chemical Society (13.01.2021)
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Journal Article
SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate
Matyskiela, Mary E., Couto, Suzana, Zheng, Xinde, Lu, Gang, Hui, Julia, Stamp, Katie, Drew, Clifton, Ren, Yan, Wang, Maria, Carpenter, Aaron, Lee, Chung-Wein, Clayton, Thomas, Fang, Wei, Lu, Chin-Chun, Riley, Mariko, Abdubek, Polat, Blease, Kate, Hartke, James, Kumar, Gondi, Vessey, Rupert, Rolfe, Mark, Hamann, Lawrence G., Chamberlain, Philip P.
Published in Nature chemical biology (01.10.2018)
Published in Nature chemical biology (01.10.2018)
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Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
Mukherjee, Ranjan, Davies, Peter J. A, Crombie, Diane L, Bischoff, Eric D, Cesario, Rosemary M, Jow, Lily, Hamann, Lawrence G, Boehm, Marcus F, Mondon, Carl E, Nadzan, Alex M, Paterniti, James R, Heyman, Richard A
Published in Nature (London) (27.03.1997)
Published in Nature (London) (27.03.1997)
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Discovery of Potent, Orally-Active, and Muscle-Selective Androgen Receptor Modulators Based on an N-Aryl-hydroxybicyclohydantoin Scaffold
Sun, Chongqing, Robl, Jeffrey A, Wang, Tammy C, Huang, Yanting, Kuhns, Joyce E, Lupisella, John A, Beehler, Blake C, Golla, Rajasree, Sleph, Paul G, Seethala, Ramakrishna, Fura, Aberra, Krystek, Stanley R, An, Yongmi, Malley, Mary F, Sack, John S, Salvati, Mark E, Grover, Gary J, Ostrowski, Jacek, Hamann, Lawrence G
Published in Journal of medicinal chemistry (28.12.2006)
Published in Journal of medicinal chemistry (28.12.2006)
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