Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features
Buisson, Rémi, Langenbucher, Adam, Bowen, Danae, Kwan, Eugene E, Benes, Cyril H, Zou, Lee, Lawrence, Michael S
Published in Science (American Association for the Advancement of Science) (28.06.2019)
Published in Science (American Association for the Advancement of Science) (28.06.2019)
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Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
Cibulskis, Kristian, Lawrence, Michael S, Carter, Scott L, Sivachenko, Andrey, Jaffe, David, Sougnez, Carrie, Gabriel, Stacey, Meyerson, Matthew, Lander, Eric S, Getz, Gad
Published in Nature biotechnology (01.03.2013)
Published in Nature biotechnology (01.03.2013)
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Cell-of-origin chromatin organization shapes the mutational landscape of cancer
Polak, Paz, Karlić, Rosa, Koren, Amnon, Thurman, Robert, Sandstrom, Richard, Lawrence, Michael, Reynolds, Alex, Rynes, Eric, Vlahoviček, Kristian, Stamatoyannopoulos, John A, Sunyaev, Shamil R
Published in Nature (London) (19.02.2015)
Published in Nature (London) (19.02.2015)
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Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair
Haradhvala, Nicholas J., Polak, Paz, Stojanov, Petar, Covington, Kyle R., Shinbrot, Eve, Hess, Julian M., Rheinbay, Esther, Kim, Jaegil, Maruvka, Yosef E., Braunstein, Lior Z., Kamburov, Atanas, Hanawalt, Philip C., Wheeler, David A., Koren, Amnon, Lawrence, Michael S., Getz, Gad
Published in Cell (28.01.2016)
Published in Cell (28.01.2016)
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Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer
Ligorio, Matteo, Sil, Srinjoy, Malagon-Lopez, Jose, Nieman, Linda T., Misale, Sandra, Di Pilato, Mauro, Ebright, Richard Y., Karabacak, Murat N., Kulkarni, Anupriya S., Liu, Ann, Vincent Jordan, Nicole, Franses, Joseph W., Philipp, Julia, Kreuzer, Johannes, Desai, Niyati, Arora, Kshitij S., Rajurkar, Mihir, Horwitz, Elad, Neyaz, Azfar, Tai, Eric, Magnus, Neelima K.C., Vo, Kevin D., Yashaswini, Chittampalli N., Marangoni, Francesco, Boukhali, Myriam, Fatherree, Jackson P., Damon, Leah J., Xega, Kristina, Desai, Rushil, Choz, Melissa, Bersani, Francesca, Langenbucher, Adam, Thapar, Vishal, Morris, Robert, Wellner, Ulrich F., Schilling, Oliver, Lawrence, Michael S., Liss, Andrew S., Rivera, Miguel N., Deshpande, Vikram, Benes, Cyril H., Maheswaran, Shyamala, Haber, Daniel A., Fernandez-Del-Castillo, Carlos, Ferrone, Cristina R., Haas, Wilhelm, Aryee, Martin J., Ting, David T.
Published in Cell (27.06.2019)
Published in Cell (27.06.2019)
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APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition
Buisson, Rémi, Lawrence, Michael S, Benes, Cyril H, Zou, Lee
Published in Cancer research (Chicago, Ill.) (01.09.2017)
Published in Cancer research (Chicago, Ill.) (01.09.2017)
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Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients
van de Wetering, Marc, Francies, Hayley E., Francis, Joshua M., Bounova, Gergana, Iorio, Francesco, Pronk, Apollo, van Houdt, Winan, van Gorp, Joost, Taylor-Weiner, Amaro, Kester, Lennart, McLaren-Douglas, Anne, Blokker, Joyce, Jaksani, Sridevi, Bartfeld, Sina, Volckman, Richard, van Sluis, Peter, Li, Vivian S.W., Seepo, Sara, Sekhar Pedamallu, Chandra, Cibulskis, Kristian, Carter, Scott L., McKenna, Aaron, Lawrence, Michael S., Lichtenstein, Lee, Stewart, Chip, Koster, Jan, Versteeg, Rogier, van Oudenaarden, Alexander, Saez-Rodriguez, Julio, Vries, Robert G.J., Getz, Gad, Wessels, Lodewyk, Stratton, Michael R., McDermott, Ultan, Meyerson, Matthew, Garnett, Mathew J., Clevers, Hans
Published in Cell (07.05.2015)
Published in Cell (07.05.2015)
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Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes
Shukla, Sachet A, Rooney, Michael S, Rajasagi, Mohini, Tiao, Grace, Dixon, Philip M, Lawrence, Michael S, Stevens, Jonathan, Lane, William J, Dellagatta, Jamie L, Steelman, Scott, Sougnez, Carrie, Cibulskis, Kristian, Kiezun, Adam, Hacohen, Nir, Brusic, Vladimir, Wu, Catherine J, Getz, Gad
Published in Nature biotechnology (01.11.2015)
Published in Nature biotechnology (01.11.2015)
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Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing
Helman, Elena, Lawrence, Michael S, Stewart, Chip, Sougnez, Carrie, Getz, Gad, Meyerson, Matthew
Published in Genome research (01.07.2014)
Published in Genome research (01.07.2014)
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An extended APOBEC3A mutation signature in cancer
Langenbucher, Adam, Bowen, Danae, Sakhtemani, Ramin, Bournique, Elodie, Wise, Jillian F, Zou, Lee, Bhagwat, Ashok S, Buisson, Rémi, Lawrence, Michael S
Published in Nature communications (11.03.2021)
Published in Nature communications (11.03.2021)
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Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes
Leiserson, Mark D M, Vandin, Fabio, Wu, Hsin-Ta, Dobson, Jason R, Eldridge, Jonathan V, Thomas, Jacob L, Papoutsaki, Alexandra, Kim, Younhun, Niu, Beifang, McLellan, Michael, Lawrence, Michael S, Gonzalez-Perez, Abel, Tamborero, David, Cheng, Yuwei, Ryslik, Gregory A, Lopez-Bigas, Nuria, Getz, Gad, Ding, Li, Raphael, Benjamin J
Published in Nature genetics (01.02.2015)
Published in Nature genetics (01.02.2015)
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Pan-cancer patterns of somatic copy number alteration
Zack, Travis I, Schumacher, Stephen E, Carter, Scott L, Cherniack, Andre D, Saksena, Gordon, Tabak, Barbara, Lawrence, Michael S, Zhsng, Cheng-Zhong, Wala, Jeremiah, Mermel, Craig H, Sougnez, Carrie, Gabriel, Stacey B, Hernandez, Bryan, Shen, Hui, Laird, Peter W, Getz, Gad, Meyerson, Matthew, Beroukhim, Rameen
Published in Nature genetics (01.10.2013)
Published in Nature genetics (01.10.2013)
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Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots
Jalili, Pégah, Bowen, Danae, Langenbucher, Adam, Park, Shinho, Aguirre, Kevin, Corcoran, Ryan B, Fleischman, Angela G, Lawrence, Michael S, Zou, Lee, Buisson, Rémi
Published in Nature communications (12.06.2020)
Published in Nature communications (12.06.2020)
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Comprehensive assessment of cancer missense mutation clustering in protein structures
Kamburov, Atanas, Lawrence, Michael S., Polak, Paz, Leshchiner, Ignaty, Lage, Kasper, Golub, Todd R., Lander, Eric S., Getz, Gad
Published in Proceedings of the National Academy of Sciences - PNAS (06.10.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (06.10.2015)
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A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer
Polak, Paz, Kim, Jaegil, Braunstein, Lior Z, Karlic, Rosa, Haradhavala, Nicholas J, Tiao, Grace, Rosebrock, Daniel, Livitz, Dimitri, Kübler, Kirsten, Mouw, Kent W, Kamburov, Atanas, Maruvka, Yosef E, Leshchiner, Ignaty, Lander, Eric S, Golub, Todd R, Zick, Aviad, Orthwein, Alexandre, Lawrence, Michael S, Batra, Rajbir N, Caldas, Carlos, Haber, Daniel A, Laird, Peter W, Shen, Hui, Ellisen, Leif W, D'Andrea, Alan D, Chanock, Stephen J, Foulkes, William D, Getz, Gad
Published in Nature genetics (01.10.2017)
Published in Nature genetics (01.10.2017)
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Widespread Genetic Heterogeneity in Multiple Myeloma: Implications for Targeted Therapy
Lohr, Jens G., Stojanov, Petar, Carter, Scott L., Cruz-Gordillo, Peter, Lawrence, Michael S., Auclair, Daniel, Sougnez, Carrie, Knoechel, Birgit, Gould, Joshua, Saksena, Gordon, Cibulskis, Kristian, McKenna, Aaron, Chapman, Michael A., Straussman, Ravid, Levy, Joan, Perkins, Louise M., Keats, Jonathan J., Schumacher, Steven E., Rosenberg, Mara, Anderson, Kenneth C., Richardson, Paul, Krishnan, Amrita, Lonial, Sagar, Kaufman, Jonathan, Siegel, David S., Vesole, David H., Roy, Vivek, Rivera, Candido E., Rajkumar, S. Vincent, Kumar, Shaji, Fonseca, Rafael, Ahmann, Greg J., Bergsagel, P. Leif, Stewart, A. Keith, Hofmeister, Craig C., Efebera, Yvonne A., Jagannath, Sundar, Chari, Ajai, Trudel, Suzanne, Reece, Donna, Wolf, Jeffrey, Martin, Thomas, Zimmerman, Todd, Rosenbaum, Cara, Jakubowiak, Andrzej J., Lebovic, Daniel, Vij, Ravi, Stockerl-Goldstein, Keith, Getz, Gad, Golub, Todd R.
Published in Cancer cell (13.01.2014)
Published in Cancer cell (13.01.2014)
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Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas
Seiwert, Tanguy Y, Zuo, Zhixiang, Keck, Michaela K, Khattri, Arun, Pedamallu, Chandra S, Stricker, Thomas, Brown, Christopher, Pugh, Trevor J, Stojanov, Petar, Cho, Juok, Lawrence, Michael S, Getz, Gad, Brägelmann, Johannes, DeBoer, Rebecca, Weichselbaum, Ralph R, Langerman, Alexander, Portugal, Louis, Blair, Elizabeth, Stenson, Kerstin, Lingen, Mark W, Cohen, Ezra E W, Vokes, Everett E, White, Kevin P, Hammerman, Peter S
Published in Clinical cancer research (01.02.2015)
Published in Clinical cancer research (01.02.2015)
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Punctuated Evolution of Prostate Cancer Genomes
Baca, Sylvan C., Prandi, Davide, Lawrence, Michael S., Mosquera, Juan Miguel, Romanel, Alessandro, Drier, Yotam, Park, Kyung, Kitabayashi, Naoki, MacDonald, Theresa Y., Ghandi, Mahmoud, Van Allen, Eliezer, Kryukov, Gregory V., Sboner, Andrea, Theurillat, Jean-Philippe, Soong, T. David, Nickerson, Elizabeth, Auclair, Daniel, Tewari, Ashutosh, Beltran, Himisha, Onofrio, Robert C., Boysen, Gunther, Guiducci, Candace, Barbieri, Christopher E., Cibulskis, Kristian, Sivachenko, Andrey, Carter, Scott L., Saksena, Gordon, Voet, Douglas, Ramos, Alex H., Winckler, Wendy, Cipicchio, Michelle, Ardlie, Kristin, Kantoff, Philip W., Berger, Michael F., Gabriel, Stacey B., Golub, Todd R., Meyerson, Matthew, Lander, Eric S., Elemento, Olivier, Getz, Gad, Demichelis, Francesca, Rubin, Mark A., Garraway, Levi A.
Published in Cell (25.04.2013)
Published in Cell (25.04.2013)
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Comprehensive identification of mutational cancer driver genes across 12 tumor types
Tamborero, David, Gonzalez-Perez, Abel, Perez-Llamas, Christian, Deu-Pons, Jordi, Kandoth, Cyriac, Reimand, Jüri, Lawrence, Michael S, Getz, Gad, Bader, Gary D, Ding, Li, Lopez-Bigas, Nuria
Published in Scientific reports (02.10.2013)
Published in Scientific reports (02.10.2013)
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The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
Stransky, Nicolas, Egloff, Ann Marie, Tward, Aaron D., Kostic, Aleksandar D., Cibulskis, Kristian, Sivachenko, Andrey, Kryukov, Gregory V., Lawrence, Michael S., Sougnez, Carrie, McKenna, Aaron, Shefler, Erica, Ramos, Alex H., Stojanov, Petar, Carter, Scott L., Voet, Douglas, Cortés, Maria L., Auclair, Daniel, Berger, Michael F., Saksena, Gordon, Guiducci, Candace, Onofrio, Robert C., Parkin, Melissa, Romkes, Marjorie, Weissfeld, Joel L., Seethala, Raja R., Wang, Lin, Rangel-Escareño, Claudia, Fernandez-Lopez, Juan Carlos, Hidalgo-Miranda, Alfredo, Melendez-Zajgla, Jorge, Winckler, Wendy, Ardlie, Kristin, Gabriel, Stacey B., Meyerson, Matthew, Lander, Eric S., Getz, Gad, Golub, Todd R., Garraway, Levi A., Grandis, Jennifer R.
Published in Science (American Association for the Advancement of Science) (26.08.2011)
Published in Science (American Association for the Advancement of Science) (26.08.2011)
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