mGlu2 Receptor Agonism, but Not Positive Allosteric Modulation, Elicits Rapid Tolerance towards Their Primary Efficacy on Sleep Measures in Rats
Ahnaou, Abdallah, Lavreysen, Hilde, Tresadern, Gary, Cid, Jose M, Drinkenburg, Wilhelmus H
Published in PloS one (11.12.2015)
Published in PloS one (11.12.2015)
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Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782
Lavreysen, Hilde, Langlois, Xavier, Ahnaou, Abdel, Drinkenburg, Wilhelmus, te Riele, Paula, Biesmans, Ilse, Van der Linden, Ilse, Peeters, Luc, Megens, Anton, Wintmolders, Cindy, Cid, Jose Maria, Trabanco, Andrés A, Andrés, Jose Ignacio, Dautzenberg, Frank M, Lütjens, Robert, Macdonald, Gregor, Atack, John R
Published in The Journal of pharmacology and experimental therapeutics (01.09.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2013)
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Discovery of 3‑Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3‑a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor
Cid, Jose María, Tresadern, Gary, Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, Iturrino, Laura, Linares, María Lourdes, Garcia, Aránzazu, Andrés, José Ignacio, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Megens, Anton, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Mackie, Claire, Pype, Stefan, Gallacher, David, Trabanco, Andrés A
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
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Discovery of 8‑Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3‑a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM)
Cid, Jose María, Tresadern, Gary, Vega, Juan Antonio, de Lucas, Ana Isabel, del Cerro, Alcira, Matesanz, Encarnación, Linares, María Lourdes, García, Aránzazu, Iturrino, Laura, Pérez-Benito, Laura, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Peeters, Luc, Ceusters, Marc, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Mackie, Claire, Somers, Marijke, Trabanco, Andrés A
Published in Journal of medicinal chemistry (22.09.2016)
Published in Journal of medicinal chemistry (22.09.2016)
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High-throughput Analysis of Synaptic Activity in Electrically Stimulated Neuronal Cultures
Van Dyck, Michiel, Mishra, Rajiv K., Pestana, Francisco, Verstraelen, Peter, Lavreysen, Hilde, Pita-Almenar, Juan D., Kashikar, Nachiket D., De Vos, Winnok H.
Published in Neuroinformatics (Totowa, N.J.) (01.10.2021)
Published in Neuroinformatics (Totowa, N.J.) (01.10.2021)
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Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging
Andrés, José-Ignacio, Alcázar, Jesús, Cid, José María, De Angelis, Meri, Iturrino, Laura, Langlois, Xavier, Lavreysen, Hilde, Trabanco, Andrés A, Celen, Sofie, Bormans, Guy
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
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Journal Article
Discovery of 1‑Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)‑pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor
Cid, José María, Tresadern, Gary, Duvey, Guillaume, Lütjens, Robert, Finn, Terry, Rocher, Jean-Philippe, Poli, Sonia, Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, Linares, María Lourdes, Andrés, José Ignacio, Alcazar, Jesús, Alonso, José Manuel, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Ahnaou, Abdelah, Drinkenburg, Wilhelmus, Mackie, Claire, Pype, Stefan, Gallacher, David, Trabanco, Andrés A
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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Scaffold Hopping to Imidazo[1,2‑a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor
de Lucas, Ana I, Vega, Juan A, García Molina, Aránzazu, Linares, María Lourdes, Tresadern, Gary, Lavreysen, Hilde, Oehlrich, Daniel, Trabanco, Andrés A, Cid, José M
Published in ACS omega (07.09.2021)
Published in ACS omega (07.09.2021)
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JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist
Lavreysen, Hilde, Wouters, Ria, Bischoff, François, Nóbrega Pereira, Sandrina, Langlois, Xavier, Blokland, Saskia, Somers, Marijke, Dillen, Lieve, Lesage, Anne S.J.
Published in Neuropharmacology (01.12.2004)
Published in Neuropharmacology (01.12.2004)
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[3H]R214127: A Novel High-Affinity Radioligand for the mGlu1 Receptor Reveals a Common Binding Site Shared by Multiple Allosteric Antagonists
Lavreysen, Hilde, Janssen, Cor, Bischoff, François, Langlois, Xavier, Leysen, Josée E, Lesage, Anne S J
Published in Molecular pharmacology (01.05.2003)
Published in Molecular pharmacology (01.05.2003)
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Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative autoradiographic study using [ 3H]R214127
Lavreysen, Hilde, Pereira, Sandrina Nóbrega, Leysen, Joseé E, Langlois, Xavier, Lesage, Anne S.J
Published in Neuropharmacology (01.04.2004)
Published in Neuropharmacology (01.04.2004)
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321. Watching Synapses in Action: From Assaying Synaptic Function to Drug Discovery
Kashikar, Nachiket, Kemp, John, Lavreysen, Hilde
Published in Biological psychiatry (1969) (15.05.2017)
Published in Biological psychiatry (1969) (15.05.2017)
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Journal Article
Supersensitivity of Human Metabotropic Glutamate 1a Receptor Signaling in L929sA Cells
Lavreysen, Hilde, Le Poul, Emmanuel, Van Gompel, Paul, Dillen, Lieve, Leysen, Josée E, Lesage, Anne S J
Published in Molecular pharmacology (01.05.2002)
Published in Molecular pharmacology (01.05.2002)
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Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2–positive allosteric modulator JNJ‐46356479 and levetiracetam in the mouse 6‐Hz (44‐mA) model
Metcalf, Cameron S., Klein, Brian D., Smith, Misty D., Ceusters, Marc, Lavreysen, Hilde, Pype, Stefan, Van Osselaer, Nancy, Twyman, Roy, White, H. Steve
Published in Epilepsia (Copenhagen) (01.03.2018)
Published in Epilepsia (Copenhagen) (01.03.2018)
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Constitutive activity of the metabotropic glutamate receptor 2 explored with a whole-cell label-free biosensor
Doornbos, Maarten L.J., Van der Linden, Ilse, Vereyken, Liesbeth, Tresadern, Gary, IJzerman, Adriaan P., Lavreysen, Hilde, Heitman, Laura H.
Published in Biochemical pharmacology (01.06.2018)
Published in Biochemical pharmacology (01.06.2018)
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Journal Article
Discovery and Kinetic Profiling of 7‑Aryl-1,2,4-triazolo[4,3‑a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2
Doornbos, Maarten L. J, Cid, José María, Haubrich, Jordi, Nunes, Alexandro, van de Sande, Jasper W, Vermond, Sophie C, Mulder-Krieger, Thea, Trabanco, Andrés A, Ahnaou, Abdellah, Drinkenburg, Wilhelmus H, Lavreysen, Hilde, Heitman, Laura H, IJzerman, Adriaan P, Tresadern, Gary
Published in Journal of medicinal chemistry (10.08.2017)
Published in Journal of medicinal chemistry (10.08.2017)
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Synthesis, Evaluation, and Radio labeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging
Andres, Jose-Ignacio, Alcazar, Jesus, Maria Cid, Jose, De Angelis, Meri, Iturrino, Laura, Langlois, Xavier, Lavreysen, Hilde, Trabanco, Andres A., Celen, Sofie, Bormans, Guy
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
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