Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties
Flynn, Bernard L, Gill, Gurmit S, Grobelny, Damian W, Chaplin, Jason H, Paul, Dharam, Leske, Annabell F, Lavranos, Tina C, Chalmers, David K, Charman, Susan A, Kostewicz, Edmund, Shackleford, David M, Morizzi, Julia, Hamel, Ernest, Jung, M. Katherine, Kremmidiotis, Gabriel
Published in Journal of medicinal chemistry (08.09.2011)
Published in Journal of medicinal chemistry (08.09.2011)
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Journal Article
BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy
Kremmidiotis, Gabriel, Leske, Annabell F, Lavranos, Tina C, Beaumont, Donna, Gasic, Jelena, Hall, Allison, O'Callaghan, Michael, Matthews, Clayton A, Flynn, Bernard
Published in Molecular cancer therapeutics (01.06.2010)
Published in Molecular cancer therapeutics (01.06.2010)
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Phase I study of BNC105P, carboplatin and gemcitabine in partially platinum-sensitive ovarian cancer patients in first or second relapse (ANZGOG-1103)
Lindemann, Kristina, Beale, Philip J., Rossi, Emma, Goh, Jeff C., Vaughan, Michelle M., Tenney, Meaghan E., Martyn, Julie K., Sommeijer, Dirkje, Iglesias, Jose L., Kremmidiotis, Gabriel, Simpson, Jeremy, Doolin, Elizabeth, Lavranos, Tina C., Leske, Annabell, Veillard, Anneso S., Espinoza, David, Stockler, Martin R., Rischin, Danny
Published in Cancer chemotherapy and pharmacology (01.01.2019)
Published in Cancer chemotherapy and pharmacology (01.01.2019)
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The Combination of Metformin and Valproic Acid Has a Greater Anti-tumoral Effect on Prostate Cancer Growth In Vivo than Either Drug Alone
Tran, Linh N K, Kichenadasse, Ganessan, Morel, Katherine L, Lavranos, Tina C, Klebe, Sonja, Lower, Karen M, Ormsby, Rebecca J, Elliot, David J, Sykes, Pamela J
Published in In vivo (Athens) (01.01.2019)
Published in In vivo (Athens) (01.01.2019)
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Journal Article
The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer
Inglis, Daniel J, Lavranos, Tina C, Beaumont, Donna M, Leske, Annabell F, Brown, Chloe K, Hall, Allison J, Kremmidiotis, Gabriel
Published in Cancer biology & therapy (01.01.2014)
Published in Cancer biology & therapy (01.01.2014)
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Circulating tumour cell RNA characterisation from colorectal cancer patient blood after inertial microfluidic enrichment
Winter, Marnie, Cai, Zhen, Winkler, Katharina, Georgiou, Kristen, Inglis, Daniel, Lavranos, Tina, Rezaei, Meysam, Warkiani, Majid, Thierry, Benjamin
Published in MethodsX (01.01.2019)
Published in MethodsX (01.01.2019)
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Journal Article
Discovery and validation of drug targets for tumour angiogenesis
Kremmidiotis, Gabriel, Lavranos, Tina C
Published in Expert opinion on therapeutic targets (01.04.2005)
Published in Expert opinion on therapeutic targets (01.04.2005)
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Abstract 4982: BNC105 induces tumor micro-environment changes which enhance the efficacy of checkpoint inhibitor therapy in preclinical models
Inglis, Daniel J., Beaumont, Donna M., Leske, Annabell F., Scherer, Michaela A., Lavranos, Tina C.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 3910: Characterization of BNC101 a human specific monoclonal antibody targeting the GPCR LGR5: First-in-human evidence of target engagement
Inglis, Daniel J., Licari, John, Georgiou, Kristen R., Wittwer, Nicole L., Hamilton, Ross W., Beaumont, Donna M., Scherer, Michaela A., Lavranos, Tina C.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract 1881: The microtubule-disrupting drug BNC105 is a potent inducer of apoptosis in AML patient samples
Inglis, Daniel J., Casolari, Debora A., Nguyen, Tran, Beaumont, Donna M., Wittwer, Nicole L., Ross, David, D'Andrea, Richard, Lavranos, Tina C.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Evidence for ovarian granulosa stem cells: telomerase activity and localization of the telomerase ribonucleic acid component in bovine ovarian follicles
Lavranos, T.C, Mathis, J.M, Latham, S.E, Kalionis, B, Shay, J.W, Rodgers, R.J
Published in Biology of reproduction (01.08.1999)
Published in Biology of reproduction (01.08.1999)
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Abstract B92: The tubulin-targeting agent BNC105 potentiates the efficacy of immune checkpoint inhibitors in preclinical models of colorectal cancer
Lavranos, Tina C., Beaumont, Donna, Inglis, Daniel, Scherer, Michaela, Hawkins, Chloe, Leske, Annabell F., Kremmidiotis, Gabriel
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Abstract 4115: BNC420 is a novel VEGFR3 selective inhibitor, which unlike the pan-VEGFR inhibitor Sunitinib, suppresses lymphatic metastasis in a model of metastatic melanoma
Leske, Annabell, Lavranos, Tina, Beaumont, Donna, Brown, Chloe, Paul, Darham, Inglis, Daniel, Scherer, Michaela, Harvey, Andrew, Kremmidiotis, Gabriel
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract B174: Complementary activity of the vascular disruption agent BNC105 and the hypoxia-activated prodrug evofosfamide (TH-302) in suppressing the growth of preclinical renal and breast solid tumors
Lavranos, Tina C., Inglis, Daniel, Beaumont, Donna, Leske, Annabell F., Hawkins, Chloe, Scherer, Michaela, Hart, Charles, Sun, Jessica, Elenbaas, Brian, Kremmidiotis, Gabriel
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Abstract B67: Induction of tumor hypoxia synergises with inhibitors of tumor metabolic and angiogenic adaptive responses to suppress tumor growth and enhance host survival
Inglis, Daniel J., Lavranos, Tina C., Beaumont, Donna M., Leske, Annabell F., Brown, Chloe K., Kremmidiotis, Gabriel
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Abstract 4039: Harnessing the tumor adaptive response to hypoxia to identify novel combinations of the vascular disrupting agent BNC105 with targeted therapeutics
Lavranos, Tina C., Inglis, Daniel J., Beaumont, Donna M., Leske, Annabell F., Brown, Chloe K., Kremmidiotis, Gabriel
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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