PBI-4050 Reduces Stellate Cell Activation and Liver Fibrosis through Modulation of Intracellular ATP Levels and the Liver Kinase B1/AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway
Grouix, Brigitte, Sarra-Bournet, Francois, Leduc, Martin, Simard, Jean-Christophe, Hince, Kathy, Geerts, Lilianne, Blais, Alexandra, Gervais, Liette, Laverdure, Alexandre, Felton, Alexandra, Richard, Jonathan, Ouboudinar, Jugurtha, Gagnon, William, Leblond, François A, Laurin, Pierre, Gagnon, Lyne
Published in The Journal of pharmacology and experimental therapeutics (01.10.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2018)
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Journal Article
Design and Synthesis of New 1,3,5-Trisubstituted Triazines for the Treatment of Cancer and Inflammation
Zacharie, Boulos, Abbott, Shaun D, Duceppe, Jean-Simon, Gagnon, Lyne, Grouix, Brigitte, Geerts, Lilianne, Gervais, Liette, Sarra-Bournet, François, Perron, Valérie, Wilb, Nicole, Penney, Christopher L, Laurin, Pierre
Published in ChemistryOpen (Weinheim) (01.09.2018)
Published in ChemistryOpen (Weinheim) (01.09.2018)
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Journal Article
Phase 2 clinical trial of PBI-4050 in patients with idiopathic pulmonary fibrosis
Khalil, Nasreen, Manganas, Helene, Ryerson, Christopher J, Shapera, Shane, Cantin, Andre M, Hernandez, Paul, Turcotte, Eric E, Parker, Joseph M, Moran, John E, Albert, Gary R, Sawtell, Renata, Hagerimana, Aline, Laurin, Pierre, Gagnon, Lyne, Cesari, Frank, Kolb, Martin
Published in The European respiratory journal (01.03.2019)
Published in The European respiratory journal (01.03.2019)
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Journal Article
A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84
Gagnon, Lyne, Leduc, Martin, Thibodeau, Jean-Francois, Zhang, Ming-Zhi, Grouix, Brigitte, Sarra-Bournet, Francois, Gagnon, William, Hince, Kathy, Tremblay, Mikaël, Geerts, Lilianne, Kennedy, Christopher R J, Hébert, Richard L, Gutsol, Alex, Holterman, Chet E, Kamto, Eldjonai, Gervais, Liette, Ouboudinar, Jugurtha, Richard, Jonathan, Felton, Alexandra, Laverdure, Alexandre, Simard, Jean-Christophe, Létourneau, Sylvie, Cloutier, Marie-Pier, Leblond, Francois A, Abbott, Shaun D, Penney, Christopher, Duceppe, Jean-Simon, Zacharie, Boulos, Dupuis, Jocelyn, Calderone, Angelino, Nguyen, Quang T, Harris, Raymond C, Laurin, Pierre
Published in The American journal of pathology (01.05.2018)
Published in The American journal of pathology (01.05.2018)
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Journal Article
Plasminogen replacement therapy for the treatment of children and adults with congenital plasminogen deficiency
Shapiro, Amy D., Nakar, Charles, Parker, Joseph M., Albert, Gary R., Moran, John E., Thibaudeau, Karen, Thukral, Neelam, Hardesty, Brandon M., Laurin, Pierre, Sandset, Per Morten
Published in Blood (22.03.2018)
Published in Blood (22.03.2018)
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Journal Article
SP345ACTIVATION OF THE FREE-FATTY ACID RECEPTOR GPR40 IMPROVES ANEMIA IN MOUSE MODELS OF KIDNEY DISEASE VIA A NOVEL EPO-INDEPENDENT MECHANISM OF ACTION
Gagnon, Lyne, Thibodeau, Jean-Francois, Holterman, Chet, Laurin, Pierre, Hébert, Richard, Kennedy, Christopher, Grouix, Brigitte
Published in Nephrology, dialysis, transplantation (01.06.2019)
Published in Nephrology, dialysis, transplantation (01.06.2019)
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Journal Article
PBI-4050 reduces pulmonary hypertension, lung fibrosis, and right ventricular dysfunction in heart failure
Nguyen, Quang T, Nsaibia, Mohamed J, Sirois, Martin G, Calderone, Angelino, Tardif, Jean-Claude, Fen Shi, Yan, Ruiz, Matthieu, Daneault, Caroline, Gagnon, Lyne, Grouix, Brigitte, Laurin, Pierre, Dupuis, Jocelyn
Published in Cardiovascular research (01.01.2020)
Published in Cardiovascular research (01.01.2020)
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Journal Article
SP436PBI-4050 IMPROVES METABOLIC REGULATION AND DIABETIC NEPHROPATHY THROUGH REDUCTION OF ER STRESS, PRO-INFLAMMATORY/FIBROTIC MARKERS, GALECTIN-3 EXPRESSION AND INFLAMMATORY CELL INFILTRATION IN OB/OB MOUSE MODEL
Gagnon, Lyne, Simard, Jean-Christophe, Cloutier, Marie-Pier, Laverdure, Alexandre, Richard, Jonathan, Gervais, Liette, Felton, Alexandra, Laurin, Pierre, Grouix, Brigitte
Published in Nephrology, dialysis, transplantation (01.06.2019)
Published in Nephrology, dialysis, transplantation (01.06.2019)
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Journal Article
Fourteen-Day Evolution of COVID-19 Symptoms during the Third Wave in Nonvaccinated Subjects and Effects of Hesperidin Therapy: A Randomized, Double-Blinded, Placebo-Controlled Study
Dupuis, Jocelyn, Laurin, Pierre, Tardif, Jean-Claude, Hausermann, Leslie, Rosa, Camille, Guertin, Marie-Claude, Thibaudeau, Karen, Gagnon, Lyne, Cesari, Frank, Robitaille, Martin, Moran, John E.
Published in Evidence-based complementary and alternative medicine (2022)
Published in Evidence-based complementary and alternative medicine (2022)
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Journal Article
THU-078-PBI-4050 inhibits hepatic stellate cell activation, restores autophagy, and reduces CCl4-induced liver fibrosis
Grouix, Brigitte, Sarra-Bournet, François, Geerts, Lilianne, Hince, Kathy, Tremblay, Mikaël, Felton, Alexandra, Blais, Alexandra, Ouboudinar, Jugurtha, Simard, Jean-Christophe, Laurin, Pierre, Gagnon, Lyne
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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Journal Article
FRI-097-PBI-4050 treatment decreases sepsis-induced liver injury in mice
Thibodeau, Jean-François, Grouix, Brigitte, Simard, Jean-Christophe, Holterman, Chet, Gutsol, Alex, Blais, Alexandra, Laverdure, Alexandre, Hébert, Richard, Leblond, François, Laurin, Pierre, Kennedy, Chris, Gagnon, Lyne
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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Journal Article
PS-134-Oral treatment with PBI-4547 promotes beta-oxidation and energy expenditure, and reverses liver damage and white adipose tissue fibrosis in high-fat diet and ob/ob mouse models of NAFLD
Grouix, Brigitte, Laverdure, Alexandre, Sarra-Bournet, François, Tremblay, Mikaël, Cloutier, Marie-Pier, Gervais, Liette, Richard, Jonathan, Felton, Alexandra, Laurin, Pierre, Gagnon, Lyne
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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Journal Article
PBI-4547 Prevents Progression of Prediabetic Condition to Type 1 Diabetes in NOD Mice
LEBLOND, FRANÇOIS A., HINCE, KATHY, SARRA-BOURNET, FRANÇOIS, GAGNON, WILLIAM, TREMBLAY, MIKAËL, CLOUTIER, MARIE-PIER, LÉTOURNEAU, SYLVIE, SIMARD, JEAN-CHRISTOPHE, LEDUC, MARTIN, GROUIX, BRIGITTE, LAURIN, PIERRE, GAGNON, LYNE
Published in Diabetes (New York, N.Y.) (01.07.2018)
Published in Diabetes (New York, N.Y.) (01.07.2018)
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Journal Article
PBI-4547 Improves Glucose Metabolism and Insulin Resistance, and Reduces Liver Damage in a High-Fat Diet Mouse Model of Obesity and Metabolic Syndrome
LEDUC, MARTIN, GROUIX, BRIGITTE, TREMBLAY, MIKAËL, GERVAIS, LIETTE, SARRA-BOURNET, FRANÇOIS, FELTON, ALEXANDRA, SIMARD, JEAN-CHRISTOPHE, LEBLOND, FRANÇOIS A., LAURIN, PIERRE, GAGNON, LYNE
Published in Diabetes (New York, N.Y.) (01.07.2018)
Published in Diabetes (New York, N.Y.) (01.07.2018)
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Journal Article
PBI-4050 Improves Metabolic Regulation and Diabetic Nephropathy through Reduction of ER Stress, Pro-Inflammatory/Fibrotic Markers, Galectin-3 Expression, and Inflammatory Cell Infiltration in ob/ob Mouse Model
SIMARD, JEAN-CHRISTOPHE, CLOUTIER, MARIE-PIER, LAVERDURE, ALEXANDRE, RICHARD, JONATHAN, GERVAIS, LIETTE, FELTON, ALEXANDRA, GROUIX, BRIGITTE, LAURIN, PIERRE, LEDUC, MARTIN, LEBLOND, FRANÇOIS A., GAGNON, LYNE
Published in Diabetes (New York, N.Y.) (01.07.2018)
Published in Diabetes (New York, N.Y.) (01.07.2018)
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Journal Article
PBI-4547 Reverses Diabetes and Metabolic Syndrome through Regulation of Lipid/Glucose Metabolism, ß-Oxidation and Fibrosis in Liver, and White Adipose Tissue in ob/ob Mice
GAGNON, LYNE, LAVERDURE, ALEXANDRE, SARRA-BOURNET, FRANÇOIS, CLOUTIER, MARIE-PIER, FELTON, ALEXANDRA, TREMBLAY, MIKAËL, RICHARD, JONATHAN, GERVAIS, LIETTE, LAURIN, PIERRE, LEBLOND, FRANÇOIS A., GROUIX, BRIGITTE
Published in Diabetes (New York, N.Y.) (01.07.2018)
Published in Diabetes (New York, N.Y.) (01.07.2018)
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Journal Article