A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants
Schenkel, Laurie B., Molina, Jennifer R., Swinger, Kerren K., Abo, Ryan, Blackwell, Danielle J., Lu, Alvin Z., Cheung, Anne E., Church, W. David, Kunii, Kaiko, Kuplast-Barr, Kristy G., Majer, Christina R., Minissale, Elena, Mo, Jan-Rung, Niepel, Mario, Reik, Christopher, Ren, Yue, Vasbinder, Melissa M., Wigle, Tim J., Richon, Victoria M., Keilhack, Heike, Kuntz, Kevin W.
Published in Cell chemical biology (19.08.2021)
Published in Cell chemical biology (19.08.2021)
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In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement
Wigle, Tim J, Blackwell, Danielle J, Schenkel, Laurie B, Ren, Yue, Church, W David, Desai, Hetvi J, Swinger, Kerren K, Santospago, Andrew G, Majer, Christina R, Lu, Alvin Z, Niepel, Mario, Perl, Nicholas R, Vasbinder, Melissa M, Keilhack, Heike, Kuntz, Kevin W
Published in Cell chemical biology (16.07.2020)
Published in Cell chemical biology (16.07.2020)
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Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity
Schenkel, Laurie B, Olivieri, Philip R, Boezio, Alessandro A, Deak, Holly L, Emkey, Renee, Graceffa, Russell F, Gunaydin, Hakan, Guzman-Perez, Angel, Lee, Josie H, Teffera, Yohannes, Wang, Weiya, Youngblood, Beth D, Yu, Violeta L, Zhang, Maosheng, Gavva, Narender R, Lehto, Sonya G, Geuns-Meyer, Stephanie
Published in Journal of medicinal chemistry (24.03.2016)
Published in Journal of medicinal chemistry (24.03.2016)
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Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors
DiMauro, Erin F, Altmann, Stephen, Berry, Loren M, Bregman, Howard, Chakka, Nagasree, Chu-Moyer, Margaret, Bojic, Elma Feric, Foti, Robert S, Fremeau, Robert, Gao, Hua, Gunaydin, Hakan, Guzman-Perez, Angel, Hall, Brian E, Huang, Hongbing, Jarosh, Michael, Kornecook, Thomas, Lee, Josie, Ligutti, Joseph, Liu, Dong, Moyer, Bryan D, Ortuno, Daniel, Rose, Paul E, Schenkel, Laurie B, Taborn, Kristin, Wang, Jean, Wang, Yan, Yu, Violeta, Weiss, Matthew M
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
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Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule
Wigle, Tim J., Ren, Yue, Molina, Jennifer R., Blackwell, Danielle J., Schenkel, Laurie B., Swinger, Kerren K., Kuplast‐Barr, Kristy, Majer, Christina R., Church, W. David, Lu, Alvin Z., Mo, Jason, Abo, Ryan, Cheung, Anne, Dorsey, Bryan W., Niepel, Mario, Perl, Nicholas R., Vasbinder, Melissa M., Keilhack, Heike, Kuntz, Kevin W.
Published in Chembiochem : a European journal of chemical biology (15.06.2021)
Published in Chembiochem : a European journal of chemical biology (15.06.2021)
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Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines
PAYTON, Marc, BUSH, Tammy L, NHO NGUYEN, Hanh, OLIVIERI, Philip R, ROMERO, Karina, SCHENKEL, Laurie B, BAK, Annette, STANTON, Mary, DUSSAULT, Isabelle, PATEL, Vinod F, GEUNS-MEYER, Stephanie, RADINSKY, Robert, CHUNG, Grace, KENDALL, Richard L, ZIEGLER, Beth, EDEN, Patrick, MCELROY, Patricia, ROSS, Sandra, CEE, Victor J, DEAK, Holly L, HODOUS, Brian L
Published in Cancer research (Chicago, Ill.) (01.12.2010)
Published in Cancer research (Chicago, Ill.) (01.12.2010)
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Discovery of N‑(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), A Highly Selective, Orally Bioavailable Inhibitor of Aurora Kinases with Activity against Multidrug-Resistant Cancer Cell Lines
Geuns-Meyer, Stephanie, Cee, Victor J, Deak, Holly L, Du, Bingfan, Hodous, Brian L, Nguyen, Hanh Nho, Olivieri, Philip R, Schenkel, Laurie B, Vaida, Karina R, Andrews, Paul, Bak, Annette, Be, Xuhai, Beltran, Pedro J, Bush, Tammy L, Chaves, Mary K, Chung, Grace, Dai, Yang, Eden, Patrick, Hanestad, Kelly, Huang, Liyue, Lin, Min-Hwa Jasmine, Tang, Jin, Ziegler, Beth, Radinsky, Robert, Kendall, Richard, Patel, Vinod F, Payton, Marc
Published in Journal of medicinal chemistry (09.07.2015)
Published in Journal of medicinal chemistry (09.07.2015)
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New Air-Stable Catalysts for General and Efficient Suzuki−Miyaura Cross-Coupling Reactions of Heteroaryl Chlorides
Guram, Anil S, King, Anthony O, Allen, John G, Wang, Xianghong, Schenkel, Laurie B, Chan, Johann, Bunel, Emilio E, Faul, Margaret M, Larsen, Robert D, Martinelli, Michael J, Reider, Paul J
Published in Organic letters (27.04.2006)
Published in Organic letters (27.04.2006)
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Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors
Schenkel, Laurie B., DiMauro, Erin F., Nguyen, Hanh N., Chakka, Nagasree, Du, Bingfan, Foti, Robert S., Guzman-Perez, Angel, Jarosh, Michael, La, Daniel S., Ligutti, Joseph, Milgram, Benjamin C., Moyer, Bryan D., Peterson, Emily A., Roberts, John, Yu, Violeta L., Weiss, Matthew M.
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
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Synthesis of 4-Substituted Chlorophthalazines, Dihydrobenzoazepinediones, 2-Pyrazolylbenzoic Acid, and 2-Pyrazolylbenzohydrazide via 3-Substituted 3-Hydroxyisoindolin-1-ones
Nguyen, Hanh Nho, Cee, Victor J, Deak, Holly L, Du, Bingfan, Faber, Kathleen Panter, Gunaydin, Hakan, Hodous, Brian L, Hollis, Steven L, Krolikowski, Paul H, Olivieri, Philip R, Patel, Vinod F, Romero, Karina, Schenkel, Laurie B, Geuns-Meyer, Stephanie D
Published in Journal of organic chemistry (20.04.2012)
Published in Journal of organic chemistry (20.04.2012)
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Forced Self-Modification Assays as a Strategy to Screen MonoPARP Enzymes
Wigle, Tim J., Church, W. David, Majer, Christina R., Swinger, Kerren K., Aybar, Demet, Schenkel, Laurie B., Vasbinder, Melissa M., Brendes, Arne, Beck, Claudia, Prahm, Martin, Wegener, Dennis, Chang, Paul, Kuntz, Kevin W.
Published in SLAS discovery (01.03.2020)
Published in SLAS discovery (01.03.2020)
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Development of novel azabenzofuran TRPA1 antagonists as in vivo tools
Copeland, Katrina W., Boezio, Alessandro A., Cheung, Eugene, Lee, Josie, Olivieri, Philip, Schenkel, Laurie B., Wan, Qian, Wang, Weiya, Wells, Mary C., Youngblood, Beth, Gavva, Narender R., Lehto, Sonya G., Geuns-Meyer, Stephanie
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
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Discovery of Potent and Highly Selective Thienopyridine Janus Kinase 2 Inhibitors
Schenkel, Laurie B, Huang, Xin, Cheng, Alan, Deak, Holly L, Doherty, Elizabeth, Emkey, Renee, Gu, Yan, Gunaydin, Hakan, Kim, Joseph L, Lee, Josie, Loberg, Robert, Olivieri, Philip, Pistillo, Jeanne, Tang, Jin, Wan, Qian, Wang, Hui-Ling, Wang, Shen-Wu, Wells, Mary C, Wu, Bin, Yu, Violeta, Liu, Liqin, Geuns-Meyer, Stephanie
Published in Journal of medicinal chemistry (22.12.2011)
Published in Journal of medicinal chemistry (22.12.2011)
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Differential selectivity of JAK2 inhibitors in enzymatic and cellular settings
Yu, Violeta, Pistillo, Jeanne, Archibeque, Ivonne, Han Lee, Josie, Sun, Bee-Chun, Schenkel, Laurie B, Geuns-Meyer, Stephanie, Liu, Liqin, Emkey, Renee
Published in Experimental hematology (01.05.2013)
Published in Experimental hematology (01.05.2013)
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Journal Article
Selective Pharmaceutical Inhibition of PARP14 Mitigates Allergen-Induced IgE and Mucus Overproduction in a Mouse Model of Pulmonary Allergic Response
Eddie, Alex M, Chen, Kevin W, Schenkel, Laurie B, Swinger, Kerren K, Molina, Jennifer R, Kunii, Kaiko, Raybuck, Ariel L, Keilhack, Heike, Gibson-Corley, Katherine N, Niepel, Mario, Peebles, R Stokes, Boothby, Mark R, Cho, Sung Hoon
Published in ImmunoHorizons (11.07.2022)
Published in ImmunoHorizons (11.07.2022)
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Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats
Lehto, Sonya G, Weyer, Andy D, Youngblood, Beth D, Zhang, Maosheng, Yin, Ruoyuan, Wang, Weiya, Teffera, Yohannes, Cooke, Melanie, Stucky, Cheryl L, Schenkel, Laurie, Geuns-Meyer, Stephanie, Moyer, Bryan D, Wild, Kenneth D, Gavva, Narender R
Published in Molecular pain (2016)
Published in Molecular pain (2016)
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Journal Article
Discovery of a Potent, Selective, and Orally Bioavailable Pyridinyl-Pyrimidine Phthalazine Aurora Kinase Inhibitor
Cee, Victor J, Schenkel, Laurie B, Hodous, Brian L, Deak, Holly L, Nguyen, Hanh N, Olivieri, Philip R, Romero, Karina, Bak, Annette, Be, Xuhai, Bellon, Steve, Bush, Tammy L, Cheng, Alan C, Chung, Grace, Coats, Steve, Eden, Patrick M, Hanestad, Kelly, Gallant, Paul L, Gu, Yan, Huang, Xin, Kendall, Richard L, Lin, Min-Hwa Jasmine, Morrison, Michael J, Patel, Vinod F, Radinsky, Robert, Rose, Paul E, Ross, Sandra, Sun, Ji-Rong, Tang, Jin, Zhao, Huilin, Payton, Marc, Geuns-Meyer, Stephanie D
Published in Journal of medicinal chemistry (09.09.2010)
Published in Journal of medicinal chemistry (09.09.2010)
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Discovery of triazine-benzimidazoles as selective inhibitors of mTOR
Peterson, Emily A., Andrews, Paul S., Be, Xuhai, Boezio, Alessandro A., Bush, Tammy L., Cheng, Alan C., Coats, James R., Colletti, Adria E., Copeland, Katrina W., DuPont, Michelle, Graceffa, Russell, Grubinska, Barbara, Harmange, Jean-Christophe, Kim, Joseph L., Mullady, Erin L., Olivieri, Philip, Schenkel, Laurie B., Stanton, Mary K., Teffera, Yohannes, Whittington, Douglas A., Cai, Ti, La, Daniel S.
Published in Bioorganic & medicinal chemistry letters (01.04.2011)
Published in Bioorganic & medicinal chemistry letters (01.04.2011)
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