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Industrial Synthesis of the Key Precursor in the Synthesis of the Anti-Influenza Drug Oseltamivir Phosphate (Ro 64-0796/002, GS-4104-02): Ethyl (3R,4S,5S)-4,5-epoxy-3-(1-ethyl-propoxy)-cyclohex-1-ene-1-carboxylate

Industrial Synthesis of the Key Precursor in the Synthesis of the Anti-Influenza Drug Oseltamivir Phosphate (Ro 64-0796/002, GS-4104-02): Ethyl (3R,4S,5S)-4,5-epoxy-3-(1-ethyl-propoxy)-cyclohex-1-ene-1-carboxylate

by Federspiel, Muriel, Fischer, Rolf, Hennig, Michael, Mair, Hans-Jürgen, Oberhauser, Thomas, Rimmler, Gösta, Albiez, Thomas, Bruhin, Jürg, Estermann, Heinrich, Gandert, Carsten, Göckel, Volker, Götzö, Stephan, Hoffmann, Ursula, Huber, Gabriel, Janatsch, Günter, Lauper, Stephan, Röckel-Stäbler, Odette, Trussardi, Rene, Zwahlen, Andreas G
Published in Organic process research & development (01.07.1999)

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Journal Article

PROPANE-1-SULFONIC ACID 3-5-4-CHLORO-PHENYL-1H-PYRROLO23-BPYRIDINE-3-CARBONYL-24-DIFLUORO-PHENYL-AMIDE COMPOSITIONS AND USES THEREOF

PROPANE-1-SULFONIC ACID 3-5-4-CHLORO-PHENYL-1H-PYRROLO23-BPYRIDINE-3-CARBONYL-24-DIFLUORO-PHENYL-AMIDE COMPOSITIONS AND USES THEREOF

by VISOR GARY CONARD, GO ZENAIDA, DIODONE RALPH, WYTTENBACH NICOLE, MAIR HANS JUERGEN, SHAH NAVNIT HARGOVINDAS, LAUPER STEPHAN, IYER RAMAN MAHADEVAN, DESAI DIPEN, IBRAHIM PRABHA N, WIERS FRANK, SANDHU HARPREET K, PUDEWELL JOHANNES
Year of Publication 26.05.2017

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Patent

PROPANE-1-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE COMPOSITIONS AND USES THEREOF

PROPANE-1-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE COMPOSITIONS AND USES THEREOF

by LAUPER STEPHAN, WIERS FRANK, DIODONE RALPH, MAIR HANS JUERGEN, PUDEWELL JOHANNES
Year of Publication 13.09.2012

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Patent

PROPANE-1-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE COMPOSITIONS AND USES THEREOF

PROPANE-1-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE COMPOSITIONS AND USES THEREOF

by VISOR GARY CONARD, GO ZENAIDA, DIODONE RALPH, WYTTENBACH NICOLE, MAIR HANS JUERGEN, SHAH NAVNIT HARGOVINDAS, LAUPER STEPHAN, IYER RAMAN MAHADEVAN, DESAI DIPEN, IBRAHIM PRABHA N, WIERS FRANK, SANDHU HARPREET K, PUDEWELL JOHANNES
Year of Publication 17.01.2012

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Patent

PROPANE- I-SULFONIC ACID {3- (4-CHLORO-PHENYL)-1H-PYRROLO [2, 3-B] PYRIDINE-3-CARCONYL] -2, 4-DIFLUORO-PHENYL} -AMIDE COMPOSITIONS AND USES THEREOF

PROPANE- I-SULFONIC ACID {3- (4-CHLORO-PHENYL)-1H-PYRROLO [2, 3-B] PYRIDINE-3-CARCONYL] -2, 4-DIFLUORO-PHENYL} -AMIDE COMPOSITIONS AND USES THEREOF

by MAIR, HANS-JUERGEN, WIERS, FRANK, NAVNIT H. SHAH, LAUPER, STEPHAN, ZENAIDA GO, IBRAHIM, PRABHA N, DIODONE, RALPH, GARY VISOR, JOHANNES PUDEWELL, IYER, RAMAN MAHADEVAN, SANDHU, HARPREET K, DESAI, DIPEN, WYTTENBACH, NICOLE
Year of Publication 25.11.2019

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Patent

COMPOSITIONS AND USES THEREOF

COMPOSITIONS AND USES THEREOF

by Go, Zenaida, Lauper, Stephan, Pudewell, Johannes, Desai, Dipen, Visor, Gary, Ibrahim, Prabha N, Diodone, Ralph, Wyttenbach, Nicole, Shah, Navnit H, Iyer, Raman, Sandhu, Harpreet K, Wierschem, Frank, Mair, Hans-Juergen
Year of Publication 08.08.2019

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Patent

PROPANE-I-SULFONIC ACID {3- [5- (4- CHLORO-PHENYL) -1H-PYRROLO [2, 3-B} PYRIDINE-3-CARBONYL] -2, 4-DIFLUORO-PHENYL} -AMIDE COMPOSITIONS AND USES THEREOF

PROPANE-I-SULFONIC ACID {3- [5- (4- CHLORO-PHENYL) -1H-PYRROLO [2, 3-B} PYRIDINE-3-CARBONYL] -2, 4-DIFLUORO-PHENYL} -AMIDE COMPOSITIONS AND USES THEREOF

by LAUPER, Stephan, GO, Zenaida, WYTTENBACH, Nicole, PUDEWELL, Johannes, IYER, Raman Mahadevan, IBRAHIM, Prabha N, VISOR, Gary Conard, DESAI, Dipen, WIERS, Frank, SHAH, Navnit Hargovindas, SANDHU, Harpreet, K, DIODONE, Ralph, MAIR, Hans-Juergen
Year of Publication 10.01.2018

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Patent

Compositions and uses thereof

Compositions and uses thereof

by Sandhu Harpreet K, Diodone Ralph, Ibrahim Prabha N, Desai Dipen, Go Zenaida, Visor Gary, Mair Hans-Juergen, Shah Navnit H, Wierschem Frank, Iyer Raman, Wyttenbach Nicole, Pudewell Johannes, Lauper Stephan
Year of Publication 30.05.2017

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Patent

PROPANE-I-SULFONIC ACID {3- [5-(4-CHLORO-PHENYL) -1H -PYRROLO [2, 3-B] PYRIDINE-3-CARBONYL] -2,4 DIFLUORO-PHENYL} - AMIDE COMPOSITIONS AND USES THEREOF

PROPANE-I-SULFONIC ACID {3- [5-(4-CHLORO-PHENYL) -1H -PYRROLO [2, 3-B] PYRIDINE-3-CARBONYL] -2,4 DIFLUORO-PHENYL} - AMIDE COMPOSITIONS AND USES THEREOF

by MAIR, HANS-JUERGEN, WIERS, FRANK, VISOR, GARY CONARD, LAUPER, STEPHAN, DIODONE, RALPH, IBRAHIM, PRABHA N, SHAH, NAVNIT HARGOVINDAS, PUDEWELL, JOHANNES, GO, ZENAIDA, IYER, RAMAN MAHADEVAN, SANDHU, HARPREET K, DESAI, DIPEN, WYTTENBACH, NICOLE
Year of Publication 15.03.2017

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Patent

Propane- I-sulfonic acid {3- [5- (4 -chloro-phenyl) -1H-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof

Propane- I-sulfonic acid {3- [5- (4 -chloro-phenyl) -1H-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof

by Go, Zenaida, Lauper, Stephan, Pudewell, Johannes, Desai, Dipen, Ibrahim, Prabha N, Diodone, Ralph, Iyer, Raman Mahadevan, Visor, Gary Conard, Wyttenbach, Nicole, Shah, Navnit Hargovindas, Sandhu, Harpreet K, Wierschem, Frank, Mair, Hans-Juergen
Year of Publication 23.02.2017

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Patent

COMPOSITIONS AND USES THEREOF

COMPOSITIONS AND USES THEREOF

by Sandhu Harpreet K, Diodone Ralph, Ibrahim Prabha N, Desai Dipen, Go Zenaida, Visor Gary, Mair Hans-Juergen, Shah Navnit H, Wierschem Frank, Iyer Raman, Wyttenbach Nicole, Pudewell Johannes, Lauper Stephan
Year of Publication 08.12.2016

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Patent

PROPANE-I-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE COMPOSITIONS AND USES THEREOF

PROPANE-I-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE COMPOSITIONS AND USES THEREOF

by IBRAHIM, Prabha, N, LAUPER, Stephan, GO, Zenaida, WYTTENBACH, Nicole, VISOR, Gary, Conard, PUDEWELL, Johannes, SHAH, Navnit, Hargovindas, DESAI, Dipen, IYER, Raman, Mahadevan, WIERS, Frank, SANDHU, Harpreet, K, DIODONE, Ralph, MAIR, Hans-Juergen
Year of Publication 28.10.2016

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Patent

Compositions and uses thereof

Compositions and uses thereof

by Sandhu Harpreet K, Diodone Ralph, Ibrahim Prabha N, Desai Dipen, Go Zenaida, Visor Gary, Mair Hans-Juergen, Shah Navnit H, Wierschem Frank, Iyer Raman, Wyttenbach Nicole, Pudewell Johannes, Lauper Stephan
Year of Publication 20.09.2016

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Patent

dispersão sólida, formulação, composição e comprimido compreendendo {3-[5-(4-cloro-fenil)-1h-pirrol[2,3-b]piridina-3-carbonil]-2,4-diflúor-fenil}-amida do ácido propano-1-sulfônico

dispersão sólida, formulação, composição e comprimido compreendendo {3-[5-(4-cloro-fenil)-1h-pirrol[2,3-b]piridina-3-carbonil]-2,4-diflúor-fenil}-amida do ácido propano-1-sulfônico

by Harpreet K.Sandhu, Ralph Diodone, Frank Wierschem, Raman Mahadevan Iyer, Dipen Desai, Navnit Hargovindas Shah, Zenaida Go, Stephan Lauper, Johannes Pudewell, Prabha N.Ibrahim, Nicole Wyttenbach, Hans-Juergen Mair, Gary Conard Visor
Year of Publication 25.05.2021

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Patent

PROPANE-I-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE COMPOSITIONS AND USES THEREOF

PROPANE-I-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE COMPOSITIONS AND USES THEREOF

by MAIR, HANS-JUERGEN, WIERS, FRANK, PUDEWELL, JOHANNES, LAUPER, STEPHAN, DIODONE, RALPH
Year of Publication 19.09.2012

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Patent

PROPANE-I-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE COMPOSITIONS AND USES THEREOF

PROPANE-I-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE COMPOSITIONS AND USES THEREOF

by MAIR, HANS-JUERGEN, WIERS, FRANK, VISOR, GARY CONARD, LAUPER, STEPHAN, DIODONE, RALPH, IBRAHIM, PRABHA N, SHAH, NAVNIT HARGOVINDAS, GO, ZENAIDA, PUDEWELL, JOHANNES, IYER, RAMAN MAHADEVAN, SANDHU, HARPREET K, DESAI, DIPEN, WYTTENBACH, NICOLE
Year of Publication 29.02.2016

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Patent

PROPANE-I-SULFONIC ACID (3-(5-(4-CHLORO-PHENYL)-1H-PYRROLO(2,3-B)PYRIDINE-3-CARBONYL)-2,4-DIFLUORO-PHENYL)-AMIDE COMPOSITIONS AND USES THEREOF

PROPANE-I-SULFONIC ACID (3-(5-(4-CHLORO-PHENYL)-1H-PYRROLO(2,3-B)PYRIDINE-3-CARBONYL)-2,4-DIFLUORO-PHENYL)-AMIDE COMPOSITIONS AND USES THEREOF

by VISOR GARY CONARD, GO ZENAIDA, DIODONE RALPH, WYTTENBACH NICOLE, MAIR HANS-JUERGEN, SHAH NAVNIT HARGOVINDAS, LAUPER STEPHAN, IYER RAMAN MAHADEVAN, DESAI DIPEN, IBRAHIM PRABHA N, WIERS FRANK, SANDHU HARPREET K, PUDEWELL JOHANNES
Year of Publication 29.01.2016

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Patent

Propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide compositions and uses thereof

Propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide compositions and uses thereof

by VISOR GARY CONARD, GO ZENAIDA, DIODONE RALPH, WYTTENBACH NICOLE, MAIR HANS-JUERGEN, SHAH NAVNIT HARGOVINDAS, LAUPER STEPHAN, IYER RAMAN MAHADEVAN, DESAI DIPEN, IBRAHIM PRABHA N, WIERS FRANK, SANDHU HARPREET K, PUDEWELL JOHANNES
Year of Publication 13.01.2016

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Patent

PROPANE-I-SULFONIC ACID {3- [5- (4- CHLORO-PHENYL) -1H-PYRROLO [2, 3-B} PYRIDINE-3-CARBONYL] -2, 4-DIFLUORO-PHENYL} -AMIDE COMPOSITIONS AND USES THEREOF

PROPANE-I-SULFONIC ACID {3- [5- (4- CHLORO-PHENYL) -1H-PYRROLO [2, 3-B} PYRIDINE-3-CARBONYL] -2, 4-DIFLUORO-PHENYL} -AMIDE COMPOSITIONS AND USES THEREOF

by SANDHU, HARPREET, K, MAIR, HANS-JUERGEN, WIERS, FRANK, VISOR, GARY CONARD, LAUPER, STEPHAN, DIODONE, RALPH, IBRAHIM, PRABHA N, SHAH, NAVNIT HARGOVINDAS, GO, ZENAIDA, PUDEWELL, JOHANNES, IYER, RAMAN MAHADEVAN, DESAI, DIPEN, WYTTENBACH, NICOLE
Year of Publication 16.12.2015

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Patent

PROPAN-1-SULFONSYRE {3-[5-(4-CHLOR-PHENYL)-1H-PYRROL[2,3-B]PYRIDIN-3- CARBONYL]-2,4-DIFLUOR-PHENYL)-AMIDSAMMENSÆTNINGER OG ANVENDELSER DERAF

PROPAN-1-SULFONSYRE {3-[5-(4-CHLOR-PHENYL)-1H-PYRROL[2,3-B]PYRIDIN-3- CARBONYL]-2,4-DIFLUOR-PHENYL)-AMIDSAMMENSÆTNINGER OG ANVENDELSER DERAF

by IBRAHIM, PRABHA, N, SANDHU, HARPREET, K, MAIR, HANS-JUERGEN, IYER, RAMAN, MAHADEVAN, WIERS, FRANK, SHAH, NAVNIT, HARGOVINDAS, LAUPER, STEPHAN, DIODONE, RALPH, GO, ZENAIDA, PUDEWELL, JOHANNES, DESAI, DIPEN, VISOR, GARY, CONARD, WYTTENBACH, NICOLE
Year of Publication 14.12.2015

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Patent