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Published in Journal of medicinal chemistry (23.04.2015)
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Kinamycins A and C, bacterial metabolites that contain an unusual diazo group, as potential new anticancer agents: antiproliferative and cell cycle effects
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The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)‑2-(3-((E)‑4-(((cis)‑2,6-Dimethylmorpholino)methyl)styryl)‑1H‑indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent
Sampson, Peter B., Liu, Yong, Forrest, Bryan, Cumming, Graham, Li, Sze-Wan, Patel, Narendra Kumar, Edwards, Louise, Laufer, Radoslaw, Feher, Miklos, Ban, Fuqiang, Awrey, Donald E., Mao, Guodong, Plotnikova, Olga, Hodgson, Richard, Beletskaya, Irina, Mason, Jacqueline M., Luo, Xunyi, Nadeem, Vincent, Wei, Xin, Kiarash, Reza, Madeira, Brian, Huang, Ping, Mak, Tak W., Pan, Guohua, Pauls, Henry W.
Published in Journal of medicinal chemistry (08.01.2015)
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The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1 R ,2 S )-2-(3-(( E )-4-((( cis )-2,6-Dimethylmorpholino)methyl)styryl)-1 H -indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent
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NG GRACE, LANG YUNHUI, LAUFER RADOSLAW, PAULS HEINZ W, LI SZE WAN, LIU YONG, SAMPSON PETER BRENT, PATEL NARENDRA KUMAR B
Year of Publication 02.01.2024
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Published in ACS medicinal chemistry letters (14.07.2016)
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Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3′-indolin]-2′-ones as potent PLK4 inhibitors with oral antitumor efficacy
Li, Sze-Wan, Liu, Yong, Sampson, Peter B., Patel, Narendra Kumar, Forrest, Bryan T., Edwards, Louise, Laufer, Radoslaw, Feher, Miklos, Ban, Fuqiang, Awrey, Donald E., Hodgson, Richard, Beletskaya, Irina, Mao, Guodong, Mason, Jacqueline M., Wei, Xin, Luo, Xunyi, Kiarash, Reza, Green, Erin, Mak, Tak W., Pan, Guohua, Pauls, Henry W.
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Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK
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The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents
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Published in Journal of medicinal chemistry (08.01.2015)
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The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1 H -indazole-5-carboxamides as Anticancer Agents
Liu, Yong, Lang, Yunhui, Patel, Narendra Kumar, Ng, Grace, Laufer, Radoslaw, Li, Sze-Wan, Edwards, Louise, Forrest, Bryan, Sampson, Peter B., Feher, Miklos, Ban, Fuqiang, Awrey, Donald E., Beletskaya, Irina, Mao, Guodong, Hodgson, Richard, Plotnikova, Olga, Qiu, Wei, Chirgadze, Nickolay Y., Mason, Jacqueline M., Wei, Xin, Lin, Dan Chi-Chia, Che, Yi, Kiarash, Reza, Madeira, Brian, Fletcher, Graham C., Mak, Tak W., Bray, Mark R., Pauls, Henry W.
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Published in Journal of medicinal chemistry (23.04.2015)
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One-Pot Friedlander Quinoline Synthesis: Scope and Limitations
Li, An-Hu, Beard, David J., Coate, Heather, Honda, Ayako, Kadalbajoo, Mridula, Kleinberg, Andrew, Laufer, Radoslaw, Mulvihill, Kristen M., Nigro, Anthony, Rastogi, Pawan, Sherman, Dan, Siu, Kam W., Steinig, Arno G., Wang, Ti, Werner, Doug, Crew, Andrew P., Mulvihill, Mark J.
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Published in Synthesis (Stuttgart) (01.05.2010)
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