ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43
Stoica, Radu, De Vos, Kurt J., Paillusson, Sébastien, Mueller, Sarah, Sancho, Rosa M., Lau, Kwok-Fai, Vizcay-Barrena, Gema, Lin, Wen-Lang, Xu, Ya-Fei, Lewis, Jada, Dickson, Dennis W., Petrucelli, Leonard, Mitchell, Jacqueline C., Shaw, Christopher E., Miller, Christopher C. J.
Published in Nature communications (03.06.2014)
Published in Nature communications (03.06.2014)
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Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models
Chen, Zhefan Stephen, Li, Li, Peng, Shaohong, Chen, Francis M, Zhang, Qian, An, Ying, Lin, Xiao, Li, Wen, Koon, Alex Chun, Chan, Ting‐Fung, Lau, Kwok‐Fai, Ngo, Jacky Chi Ki, Wong, Wing Tak, Kwan, Kin Ming, Chan, Ho Yin Edwin
Published in EMBO reports (01.09.2018)
Published in EMBO reports (01.09.2018)
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Familial ataxia, tremor, and dementia in a polish family with a novel mutation in the CCDC88C gene
Leńska‐Mieciek, Marta, Charzewska, Agnieszka, Królicki, Leszek, Hoffman‐Zacharska, Dorota, Chen, Zhefan Stephen, Lau, Kwok‐Fai, Chan, Ho Yin Edwin, Gambin, Tomasz, Fiszer, Urszula
Published in Movement disorders (01.01.2019)
Published in Movement disorders (01.01.2019)
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Insulin stimulates atypical protein kinase C‐mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6‐Rac1 signaling
Chau, Dennis Dik‐Long, Li, Wen, Chan, Wai Wa Ray, Sun, Jacquelyne Ka‐Li, Zhai, Yuqi, Chow, Hei‐Man, Lau, Kwok‐Fai
Published in The FASEB journal (01.11.2022)
Published in The FASEB journal (01.11.2022)
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CAG expansion induces nucleolar stress in polyglutamine diseases
Tsoi, Ho, Lau, Terrence Chi-Kong, Tsang, Suk-Ying, Lau, Kwok-Fai, Chan, Ho Yin Edwin
Published in Proceedings of the National Academy of Sciences - PNAS (14.08.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (14.08.2012)
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FE65: a hub for neurodevelopment
Zhai, Yuqi, Ng, Laura Lok-Haang, Chau, Dennis Dik-Long, Lau, Kwok-Fai
Published in Neural regeneration research (01.09.2024)
Published in Neural regeneration research (01.09.2024)
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The lysosomal protein cathepsin L is a progranulin protease
Lee, Chris W, Stankowski, Jeannette N, Chew, Jeannie, Cook, Casey N, Lam, Ying-Wai, Almeida, Sandra, Carlomagno, Yari, Lau, Kwok-Fai, Prudencio, Mercedes, Gao, Fen-Biao, Bogyo, Matthew, Dickson, Dennis W, Petrucelli, Leonard
Published in Molecular neurodegeneration (25.07.2017)
Published in Molecular neurodegeneration (25.07.2017)
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Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content
De Vos, Kurt J., Chapman, Anna L., Tennant, Maria E., Manser, Catherine, Tudor, Elizabeth L., Lau, Kwok-Fai, Brownlees, Janet, Ackerley, Steven, Shaw, Pamela J., McLoughlin, Declan M., Shaw, Christopher E., Leigh, P. Nigel, Miller, Christopher C.J., Grierson, Andrew J.
Published in Human molecular genetics (15.11.2007)
Published in Human molecular genetics (15.11.2007)
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Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35
Chau, Dennis Dik-Long, Yung, Kristen Wing-Yu, Chan, William Wai-Lun, An, Ying, Hao, Yan, Chan, Ho-Yin Edwin, Ngo, Jacky Chi-Ki, Lau, Kwok-Fai
Published in The FASEB journal (01.11.2019)
Published in The FASEB journal (01.11.2019)
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Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease
Iyaswamy, Ashok, Thakur, Abhimanyu, Guan, Xin-Jie, Krishnamoorthi, Senthilkumar, Fung, Tsz Yan, Lu, Kejia, Gaurav, Isha, Yang, Zhijun, Su, Cheng-Fu, Lau, Kwok-Fai, Zhang, Kui, Ng, Roy Chun-Laam, Lian, Qizhou, Cheung, King-Ho, Ye, Keqiang, Chen, Huanhuan Joyce, Li, Min
Published in Signal transduction and targeted therapy (23.10.2023)
Published in Signal transduction and targeted therapy (23.10.2023)
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Amyloid Precursor Protein Is Associated with Aggressive Behavior in Nonluminal Breast Cancers
Tsang, Julia Y.S., Lee, Michelle A., Ni, Yun‐Bi, Chan, Siu‐Ki, Cheung, Sai‐Yin, Chan, Wai‐Wa, Lau, Kwok‐Fai, Tse, Gary M.K.
Published in The oncologist (Dayton, Ohio) (01.11.2018)
Published in The oncologist (Dayton, Ohio) (01.11.2018)
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AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models
Hong, Huiling, Koon, Alex Chun, Chen, Zhefan Stephen, Wei, Yuming, An, Ying, Li, Wen, Lau, Matthew Ho Yan, Lau, Kwok-Fai, Ngo, Jacky Chi Ki, Wong, Chun-Ho, Au-Yeung, Ho Yu, Zimmerman, Steven C., Chan, Ho Yin Edwin
Published in The Journal of biological chemistry (22.02.2019)
Published in The Journal of biological chemistry (22.02.2019)
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Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627
Ng, Andy Ka-Leung, Chan, Wai-Hon, Choi, Sze-Ting, Lam, Mandy Ka-Han, Lau, Kwok-Fai, Chan, Paul Kay-Sheung, Au, Shannon Wing-Ngor, Fodor, Ervin, Shaw, Pang-Chui
Published in PloS one (03.05.2012)
Published in PloS one (03.05.2012)
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Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65
Chow, Wan Ning Vanessa, Luk, Hon Wing, Chan, Ho Yin Edwin, Lau, Kwok-Fai
Published in Biochemical journal (01.05.2012)
Published in Biochemical journal (01.05.2012)
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