Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes
Graaf, Chris de, Donnelly, Dan, Wootten, Denise, Lau, Jesper, Sexton, Patrick M, Miller, Laurence J, Ahn, Jung-Mo, Liao, Jiayu, Fletcher, Madeleine M, Yang, Dehua, Brown, Alastair J H, Zhou, Caihong, Deng, Jiejie, Wang, Ming-Wei
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Published in Pharmacological reviews (01.10.2016)
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Structure of the human glucagon class B G-protein-coupled receptor
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Published in Nature (London) (25.07.2013)
Published in Nature (London) (25.07.2013)
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Structure of the full-length glucagon class B G-protein-coupled receptor
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Published in Nature (London) (08.06.2017)
Published in Nature (London) (08.06.2017)
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Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: Translational difficulties and pitfalls
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Published in PloS one (04.03.2022)
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Long acting analogue of the calcitonin gene-related peptide induces positive metabolic effects and secretion of the glucagon-like peptide-1
Nilsson, Cecilia, Hansen, Thomas Kruse, Rosenquist, Christian, Hartmann, Bolette, Kodra, János T., Lau, Jesper F., Clausen, Trine Ryberg, Raun, Kirsten, Sams, Anette
Published in European journal of pharmacology (15.02.2016)
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214-LB: Activating and Disrupting the Liver–Alpha-Cell Axis Respectively Enhances and Impairs Amino Acid Metabolism and Alpha-Cell Growth
CHRISTENSEN, EMILIE E., GALSGAARD, KATRINE D., JOHANSEN, CHRISTIAN D., TRAMMELL, SAMUEL, BOMHOLT, ANNA B., HUNT, JENNA, KRUSE, THOMAS, LAU, JESPER F., GREVENGOED, TRISHA, HOLST, JENS J., WEWER ALBRECHTSEN, NICOLAI J.
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Published in Diabetes (New York, N.Y.) (01.06.2022)
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1332-P: Increased and Decreased Glucagon Receptor Signaling Respectively Enhances and Impairs Triglyceride Metabolism Acutely and Chronically
GALSGAARD, KATRINE D., CHRISTENSEN, EMILIE E., BOMHOLT, ANNA B., HUNT, JENNA, KRUSE, THOMAS, LAU, JESPER F., CHRISTOFFERSEN, CHRISTINA, HOLST, JENS J., WEWER ALBRECHTSEN, NICOLAI J.
Published in Diabetes (New York, N.Y.) (01.06.2022)
Published in Diabetes (New York, N.Y.) (01.06.2022)
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Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice
Galsgaard, Katrine D, Elmelund, Emilie, Johansen, Christian D, Bomholt, Anna B, Kizilkaya, Hüsün S, Ceutz, Frederik, Hunt, Jenna E, Kissow, Hannelouise, Winther-Sørensen, Marie, Sørensen, Charlotte M, Kruse, Thomas, Lau, Jesper F, Rosenkilde, Mette M, Ørskov, Cathrine, Christoffersen, Christina, Holst, Jens J, Wewer Albrechtsen, Nicolai J
Published in Molecular metabolism (Germany) (01.12.2022)
Published in Molecular metabolism (Germany) (01.12.2022)
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Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells
Elmelund, Emilie, Galsgaard, Katrine D., Johansen, Christian D., Trammell, Samuel A.J., Bomholt, Anna B., Winther-Sørensen, Marie, Hunt, Jenna E., Sørensen, Charlotte M., Kruse, Thomas, Lau, Jesper F., Grevengoed, Trisha J., Holst, Jens J., Wewer Albrechtsen, Nicolai J.
Published in iScience (18.11.2022)
Published in iScience (18.11.2022)
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Small-molecule agonists for the glucagon-like peptide 1 receptor
Knudsen, Lotte Bjerre, Kiel, Dan, Teng, Min, Behrens, Carsten, Bhumralkar, Dilip, Kodra, János T, Holst, Jens J, Jeppesen, Claus B, Johnson, Michael D, de Jong, Johannes Cornelis, Jorgensen, Anker Steen, Kercher, Tim, Kostrowicki, Jarek, Madsen, Peter, Olesen, Preben H, Petersen, Jacob S, Poulsen, Fritz, Sidelmann, Ulla G, Sturis, Jeppe, Truesdale, Larry, May, John, Lau, Jesper
Published in Proceedings of the National Academy of Sciences - PNAS (16.01.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (16.01.2007)
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Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids
Garcia-Castillo, Maria Daniela, Chinnapen, Daniel J-F, Te Welscher, Yvonne M, Gonzalez, Rodrigo J, Softic, Samir, Pacheco, Michele, Mrsny, Randall J, Kahn, C Ronald, von Andrian, Ulrich H, Lau, Jesper, Pentelute, Bradley L, Lencer, Wayne I
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Published in eLife (31.05.2018)
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Identification and in Vivo and in Vitro Characterization of Long Acting and Melanocortin 4 Receptor (MC4-R) Selective α-Melanocyte-Stimulating Hormone (α-MSH) Analogues
Conde-Frieboes, Kilian, Thøgersen, Henning, Lau, Jesper F, Sensfuss, Ulrich, Hansen, Thomas K, Christensen, Leif, Spetzler, Jane, Olsen, Helle B, Nilsson, Cecilia, Raun, Kirsten, Dahl, Kirsten, Hansen, Birgit S, Wulff, Birgitte S
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Published in Journal of medicinal chemistry (08.03.2012)
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Discovery and SAR of a Novel Selective and Orally Bioavailable Nonpeptide Classical Competitive Inhibitor Class of Protein-Tyrosine Phosphatase 1B
Andersen, Henrik Sune, Olsen, Ole H, Iversen, Lars F, Sørensen, Anette L. P, Mortensen, Steen B, Christensen, Michael S, Branner, Sven, Hansen, Thomas K, Lau, Jesper F, Jeppesen, Lone, Moran, Edmond J, Su, Jing, Bakir, Farid, Judge, Luke, Shahbaz, Manou, Collins, Tassie, Vo, Todd, Newman, Michael J, Ripka, William C, Møller, Niels Peter H
Published in Journal of medicinal chemistry (26.09.2002)
Published in Journal of medicinal chemistry (26.09.2002)
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Optimization of Alkylidene Hydrazide Based Human Glucagon Receptor Antagonists. Discovery of the Highly Potent and Orally Available 3-Cyano-4-hydroxybenzoic Acid [1-(2,3,5,6-Tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide
Madsen, Peter, Ling, Anthony, Plewe, Michael, Sams, Christian K, Knudsen, Lotte B, Sidelmann, Ulla G, Ynddal, Lars, Brand, Christian L, Andersen, Birgitte, Murphy, Douglas, Teng, Min, Truesdale, Larry, Kiel, Dan, May, John, Kuki, Atsuo, Shi, Shenghua, Johnson, Michael D, Teston, Kimberly Ann, Feng, Jun, Lakis, James, Anderes, Kenna, Gregor, Vlad, Lau, Jesper
Published in Journal of medicinal chemistry (19.12.2002)
Published in Journal of medicinal chemistry (19.12.2002)
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Sequential functionalisation of bis-protected tetrathiafulvalene-dithiolates
Simonsen, KB, Svenstrup, N, Lau, J, Simonsen, O, Mork, P, Kristensen, GJ, Becher, J
Published in Synthesis (Stuttgart) (01.03.1996)
Published in Synthesis (Stuttgart) (01.03.1996)
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