Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor
Han, Yongxin, Belley, Michel, Bayly, Christopher I., Colucci, John, Dufresne, Claude, Giroux, Andre, Lau, Cheuk K., Leblanc, Yves, McKay, Daniel, Therien, Michel, Wilson, Marie-Claire, Skorey, Kathryn, Chan, Chi-Chung, Scapin, Giovana, Kennedy, Brian P.
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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The Structural Basis for the Selectivity of Benzotriazole Inhibitors of PTP1B
Scapin, Giovanna, Patel, Sangita B, Becker, Joseph W, Wang, Qingping, Desponts, Caroline, Waddleton, Deena, Skorey, Kathryn, Cromlish, Wanda, Bayly, Christopher, Therien, Michel, Gauthier, Jacques Yves, Li, Chun Sing, Lau, Cheuk K, Ramachandran, Chidambaram, Kennedy, Brian P, Asante-Appiah, Ernest
Published in Biochemistry (Easton) (07.10.2003)
Published in Biochemistry (Easton) (07.10.2003)
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Difluoroethylamines as an amide isostere in inhibitors of cathepsin K
Isabel, Elise, Mellon, Christophe, Boyd, Michael J., Chauret, Nathalie, Deschênes, Denis, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Khougaz, Karine, Lau, Cheuk K., Léger, Serge, Levorse, Dorothy A., Li, Chun Sing, Massé, Frédéric, David Percival, M., Roy, Bruno, Scheigetz, John, Thérien, Michel, Truong, Vouy Linh, Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Cameron Black, W.
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
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The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor
Isabel, Elise, Bateman, Kevin P., Chauret, Nathalie, Cromlish, Wanda, Desmarais, Sylvie, Duong, Le T., Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Lamontagne, Sonia, Lau, Cheuk K., Léger, Serge, LeRiche, Tammy, Lévesque, Jean-François, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Mellon, Christophe, Nicoll-Griffith, Deborah A., Oballa, Renata M., Percival, M. David, Riendeau, Denis, Robichaud, Joël, Rodan, Gideon A., Rodan, Sevgi B., Seto, Carmai, Thérien, Michel, Truong, Vouy Linh, Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Black, W. Cameron
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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The C3a receptor antagonist SB 290157 has agonist activity
Mathieu, Marie-Claude, Sawyer, Nicole, Greig, Gillian M., Hamel, Martine, Kargman, Stacia, Ducharme, Yves, Lau, Cheuk K., Friesen, Richard W., O’Neill, Gary P., Gervais, Francois G., Therien, Alex G.
Published in Immunology Letters (15.09.2005)
Published in Immunology Letters (15.09.2005)
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Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors
LOU, Cheuk K, BAYLY, Christopher I, QINGPING WANG, SKOREY, Kathryn, WADDLETON, Deena, PAYETTE, Paul, RAMACHANDRAN, Chidambaram, KENNEDY, Brian P, SCAPIN, Giovana, GAUTHIER, Jacques Yves, CHUN SING LI, THERIEN, Michel, ASANTE-APPIAH, Ernest, CROMLISH, Wanda, BOIE, Yves, FORGHANI, Farnaz, DESMARAIS, Sylvie
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
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Pyridazinones as selective cyclooxygenase-2 inhibitors
Li, Chun Sing, Brideau, Christine, Chan, Chi Chung, Savoie, Chantal, Claveau, David, Charleson, Stella, Gordon, Robert, Greig, Gillian, Gauthier, Jacques Yves, Lau, Cheuk K, Riendeau, Denis, Thérien, Michel, Wong, Elizabeth, Prasit, Petpiboon
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
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Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme
THERIEN, Michel, SKOREY, Kathryn, ZAMBONI, Robert, CHUN SING LI, LAU, Cheuk K, LERICHE, Tammy, VOUY LINH TRUONG, WADDLETON, Deena, RAMACHANDRAN, Chidambaram
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
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Cyclooxygenase-2 Inhibitors. Synthesis and Pharmacological Activities of 5-Methanesulfonamido-1-indanone Derivatives
Li, Chun-Sing, Black, W. Cameron, Chan, Chi-Chung, Ford-Hutchinson, Anthony W, Gauthier, Jacques-Yves, Gordon, Robert, Guay, Daniel, Kargman, Stacia, Lau, Cheuk K
Published in Journal of medicinal chemistry (01.12.1995)
Published in Journal of medicinal chemistry (01.12.1995)
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Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase
Lau, Cheuk K, Belanger, Patrice C, Dufresne, Claude, Scheigetz, John, Therien, Michel, Fitzsimmons, Brian, Young, Robert N, Ford-Hutchinson, Anthony W, Riendeau, Denis
Published in Journal of medicinal chemistry (01.04.1992)
Published in Journal of medicinal chemistry (01.04.1992)
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Reductive deoxygenation of aryl aldehydes and ketones by tert-butylamine-borane and aluminum chloride
Lau, Cheuk K, Tardif, Sylvie, Dufresne, Claude, Scheigetz, John
Published in Journal of organic chemistry (01.01.1989)
Published in Journal of organic chemistry (01.01.1989)
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Total synthesis of LTB4 and analogs
Guindon, Yvan, Delorme, Daniel, Lau, Cheuk K, Zamboni, Robert
Published in Journal of organic chemistry (01.01.1988)
Published in Journal of organic chemistry (01.01.1988)
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Reactions of 2-phenyl-4H-1,3,2-benzodioxaborin, a stable ortho-quinone methide precursor
Chambers, Jeffrey D, Crawford, Jason, Williams, Haydn W. R, Dufresne, Claude, Scheigetz, John, Bernstein, Michael A, Lau, Cheuk K
Published in Canadian journal of chemistry (01.06.1992)
Published in Canadian journal of chemistry (01.06.1992)
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ortho-Specific alkylation of phenols via 1,3,2-benzodioxaborins
Lau, Cheuk K, Williams, Haydn W.R, Tardiff, Sylvie, Dufresne, Claude, Scheigetz, John, Bélanger, Patrice C
Published in Canadian journal of chemistry (01.09.1989)
Published in Canadian journal of chemistry (01.09.1989)
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Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224
Lau, Cheuk K, Belanger, Patrice C, Scheigetz, John, Dufresne, Claude, Williams, Haydn W. R, Maycock, Alan L, Guindon, Yvan, Bach, Thomas, Dallob, Aimee L
Published in Journal of medicinal chemistry (01.06.1989)
Published in Journal of medicinal chemistry (01.06.1989)
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Syntheses of quinolines, dihydro- and tetrahydroquinolines via ortho-quinone methide imine intermediate
Wiebe, Jennifer M., Caillé, Alain S., Trimble, Laird, Lau, Cheuk K.
Published in Tetrahedron (02.09.1996)
Published in Tetrahedron (02.09.1996)
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