Redox Modification of Nuclear Actin by MICAL-2 Regulates SRF Signaling
Lundquist, Mark R., Storaska, Andrew J., Liu, Ting-Chun, Larsen, Scott D., Evans, Todd, Neubig, Richard R., Jaffrey, Samie R.
Published in Cell (30.01.2014)
Published in Cell (30.01.2014)
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Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence
Zheng, Huiqing, Colvin, Christopher J, Johnson, Benjamin K, Kirchhoff, Paul D, Wilson, Michael, Jorgensen-Muga, Katriana, Larsen, Scott D, Abramovitch, Robert B
Published in Nature chemical biology (01.02.2017)
Published in Nature chemical biology (01.02.2017)
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Journal Article
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells
Chefetz, Ilana, Grimley, Edward, Yang, Kun, Hong, Linda, Vinogradova, Ekaterina V., Suciu, Radu, Kovalenko, Ilya, Karnak, David, Morgan, Cynthia A., Chtcherbinine, Mikhail, Buchman, Cameron, Huddle, Brandt, Barraza, Scott, Morgan, Meredith, Bernstein, Kara A., Yoon, Euisik, Lombard, David B., Bild, Andrea, Mehta, Geeta, Romero, Iris, Chiang, Chun-Yi, Landen, Charles, Cravatt, Benjamin, Hurley, Thomas D., Larsen, Scott D., Buckanovich, Ronald J.
Published in Cell reports (Cambridge) (12.03.2019)
Published in Cell reports (Cambridge) (12.03.2019)
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Novel inhibitors of Staphylococcus aureus virulence gene expression and biofilm formation
Ma, Yibao, Xu, Yuanxi, Yestrepsky, Bryan D, Sorenson, Roderick J, Chen, Meng, Larsen, Scott D, Sun, Hongmin
Published in PloS one (15.10.2012)
Published in PloS one (15.10.2012)
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Journal Article
Physicochemical properties and formulation development of a novel compound inhibiting Staphylococcus aureus biofilm formation
Wang, Nan, Qi, Feng, Yu, Haqing, Yestrepsky, Bryan D, Larsen, Scott D, Shi, Honglan, Ji, Juan, Anderson, David W, Li, Hao, Sun, Hongmin
Published in PloS one (08.02.2021)
Published in PloS one (08.02.2021)
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Journal Article
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy
Huddle, Brandt C, Grimley, Edward, Buchman, Cameron D, Chtcherbinine, Mikhail, Debnath, Bikash, Mehta, Pooja, Yang, Kun, Morgan, Cynthia A, Li, Siwei, Felton, Jeremy, Sun, Duxin, Mehta, Geeta, Neamati, Nouri, Buckanovich, Ronald J, Hurley, Thomas D, Larsen, Scott D
Published in Journal of medicinal chemistry (11.10.2018)
Published in Journal of medicinal chemistry (11.10.2018)
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Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis
Sisson, Thomas H, Ajayi, Iyabode O, Subbotina, Natalya, Dodi, Amos E, Rodansky, Eva S, Chibucos, Lauren N, Kim, Kevin K, Keshamouni, Venkateshwar G, White, Eric S, Zhou, Yong, Higgins, Peter D.R, Larsen, Scott D, Neubig, Richard R, Horowitz, Jeffrey C
Published in The American journal of pathology (01.04.2015)
Published in The American journal of pathology (01.04.2015)
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Journal Article
Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts
Johnson, Laura A, Rodansky, Eva S, Haak, Andrew J, Larsen, Scott D, Neubig, Richard R, Higgins, Peter D R
Published in Inflammatory bowel diseases (01.01.2014)
Published in Inflammatory bowel diseases (01.01.2014)
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Journal Article
X‑ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases
Báez-Santos, Yahira M, Barraza, Scott J, Wilson, Michael W, Agius, Michael P, Mielech, Anna M, Davis, Nicole M, Baker, Susan C, Larsen, Scott D, Mesecar, Andrew D
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
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Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease
Beck, Michael W., Derrick, Jeffrey S., Kerr, Richard A., Oh, Shin Bi, Cho, Woo Jong, Lee, Shin Jung C., Ji, Yonghwan, Han, Jiyeon, Tehrani, Zahra Aliakbar, Suh, Nayoung, Kim, Sujeong, Larsen, Scott D., Kim, Kwang S., Lee, Joo-Yong, Ruotolo, Brandon T., Lim, Mi Hee
Published in Nature communications (13.10.2016)
Published in Nature communications (13.10.2016)
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Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents
Bell, Jessica L., Haak, Andrew J., Wade, Susan M., Kirchhoff, Paul D., Neubig, Richard R., Larsen, Scott D.
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
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Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury
Haak, Andrew J, Tsou, Pei-Suen, Amin, Mohammad A, Ruth, Jeffrey H, Campbell, Phillip, Fox, David A, Khanna, Dinesh, Larsen, Scott D, Neubig, Richard R
Published in The Journal of pharmacology and experimental therapeutics (01.06.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2014)
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Journal Article
Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes
Dumas, Megan E., Chen, Geng-Yuan, Kendrick, Nicole D., Xu, George, Larsen, Scott D., Jana, Somnath, Waterson, Alex G., Bauer, Joshua A., Hancock, William, Sulikowski, Gary A., Ohi, Ryoma
Published in Bioorganic & medicinal chemistry letters (15.01.2019)
Published in Bioorganic & medicinal chemistry letters (15.01.2019)
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5‑Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma
Kahl, Dylan J, Hutchings, Kim M, Lisabeth, Erika Mathes, Haak, Andrew J, Leipprandt, Jeffrey R, Dexheimer, Thomas, Khanna, Dinesh, Tsou, Pei-Suen, Campbell, Phillip L, Fox, David A, Wen, Bo, Sun, Duxin, Bailie, Marc, Neubig, Richard R, Larsen, Scott D
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis
Yu-Wai-Man, Cynthia, Spencer-Dene, Bradley, Lee, Richard M. H., Hutchings, Kim, Lisabeth, Erika M., Treisman, Richard, Bailly, Maryse, Larsen, Scott D., Neubig, Richard R., Khaw, Peng T.
Published in Scientific reports (31.03.2017)
Published in Scientific reports (31.03.2017)
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Diterpenoids from Gutierrezia sarothrae and G. microcephala: Chemical diversity, chemophenetics and implications to toxicity in grazing livestock
Gardner, Dale R., Cook, Daniel, Larsen, Scott W., Stonecipher, Clinton A., Johnson, Robert
Published in Phytochemistry (Oxford) (01.10.2020)
Published in Phytochemistry (Oxford) (01.10.2020)
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Journal Article
Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors
Waldschmidt, Helen V, Homan, Kristoff T, Cruz-Rodríguez, Osvaldo, Cato, Marilyn C, Waninger-Saroni, Jessica, Larimore, Kelly M, Cannavo, Alessandro, Song, Jianliang, Cheung, Joseph Y, Kirchhoff, Paul D, Koch, Walter J, Tesmer, John J. G, Larsen, Scott D
Published in Journal of medicinal chemistry (28.04.2016)
Published in Journal of medicinal chemistry (28.04.2016)
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Development of substituted benzimidazoles as inhibitors of human aldehyde dehydrogenase 1A isoenzymes
Takahashi, Cyrus, Chtcherbinine, Mikhail, Huddle, Brandt C., Wilson, Michael W., Emmel, Timothy, Hohlman, Robert M., McGonigal, Stacy, Buckanovich, Ronald J., Larsen, Scott D., Hurley, Thomas D.
Published in Chemico-biological interactions (01.03.2024)
Published in Chemico-biological interactions (01.03.2024)
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