PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies
Sen, Malabika, Kindsfather, Audrey, Danilova, Ludmila, Zhang, Feng, Colombo, Raffaele, LaPorte, Matthew G., Kurland, Brenda F., Huryn, Donna M., Wipf, Peter, Herman, James G.
Published in Epigenetics (02.07.2020)
Published in Epigenetics (02.07.2020)
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Journal Article
Radical [3 + 2]-Annulation of Divinylcyclopropanes: Rapid Synthesis of Complex Meloscine Analogs
Zhang, Hanmo, Jeon, Kyu Ok, Hay, E. Ben, Geib, Steven J, Curran, Dennis P, LaPorte, Matthew G
Published in Organic letters (03.01.2014)
Published in Organic letters (03.01.2014)
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Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators
Huryn, Donna M, Brodsky, Jeffrey L, Brummond, Kay M, Chambers, Peter G, Eyer, Benjamin, Ireland, Alex W, Kawasumi, Masaoki, LaPorte, Matthew G, Lloyd, Kayla, Manteau, Baptiste, Nghiem, Paul, Quade, Bettina, Seguin, Sandlin P, Wipf, Peter
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.2011)
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Journal Article
Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors
Nandi, Purbasha, DeVore, Kira, Wang, Feng, Li, Shan, Walker, Joel D., Truong, Thanh Tung, LaPorte, Matthew G., Wipf, Peter, Schlager, Heidi, McCleerey, John, Paquette, William, Columbres, Rod Carlo A., Gan, Taiping, Poh, Yu-Ping, Fromme, Petra, Flint, Andrew J., Wolf, Mark, Huryn, Donna M., Chou, Tsui-Fen, Chiu, Po-Lin
Published in Communications chemistry (09.08.2024)
Published in Communications chemistry (09.08.2024)
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Journal Article
Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway
Alverez, Celeste, Bulfer, Stacie L, Chakrasali, Ramappa, Chimenti, Michael. S, Deshaies, Raymond J, Green, Neal, Kelly, Mark, LaPorte, Matthew G, Lewis, Taber S, Liang, Mary, Moore, William J, Neitz, R. Jeffrey, Peshkov, Vsevolod A, Walters, Michael A, Zhang, Feng, Arkin, Michelle R, Wipf, Peter, Huryn, Donna M
Published in ACS medicinal chemistry letters (11.02.2016)
Published in ACS medicinal chemistry letters (11.02.2016)
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Journal Article
Diversity-oriented synthesis of a library of substituted tetrahydropyrones using oxidative carbon-hydrogen bond activation and click chemistry
Zaware, Nilesh, Laporte, Matthew G, Farid, Ramy, Liu, Lei, Wipf, Peter, Floreancig, Paul E
Published in Molecules (Basel, Switzerland) (02.05.2011)
Published in Molecules (Basel, Switzerland) (02.05.2011)
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Journal Article
Synthesis and in silico screening of a library of β-carboline-containing compounds
Brummond, Kay M, Goodell, John R, Laporte, Matthew G, Wang, Lirong, Xie, Xiang-Qun
Published in Beilstein journal of organic chemistry (10.07.2012)
Published in Beilstein journal of organic chemistry (10.07.2012)
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Journal Article
Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies
Condon, Stephen M, Mitsuuchi, Yasuhiro, Deng, Yijun, LaPorte, Matthew G, Rippin, Susan R, Haimowitz, Thomas, Alexander, Matthew D, Kumar, Pavan Tirunahari, Hendi, Mukta S, Lee, Yu-Hua, Benetatos, Christopher A, Yu, Guangyao, Kapoor, Gurpreet Singh, Neiman, Eric, Seipel, Martin E, Burns, Jennifer M, Graham, Martin A, McKinlay, Mark A, Li, Xiaochun, Wang, Jiawei, Shi, Yigong, Feltham, Rebecca, Bettjeman, Bodhi, Cumming, Mathew H, Vince, James E, Khan, Nufail, Silke, John, Day, Catherine L, Chunduru, Srinivas K
Published in Journal of medicinal chemistry (08.05.2014)
Published in Journal of medicinal chemistry (08.05.2014)
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Journal Article
Optimization of 1,2,4-Triazole-Based p97 Inhibitors for the Treatment of Cancer
LaPorte, Matthew G., Alverez, Celeste, Chatterley, Alexander, Kovaliov, Marina, Carder, Evan J., Houghton, Michael J., Lim, Chaemin, Miller, Eric R., Samankumara, Lalith P., Liang, Mary, Kerrigan, Kaylan, Yue, Zhizhou, Li, Shan, Tomaino, Francesca, Wang, Feng, Green, Neal, Stott, Gordon M., Srivastava, Apurva, Chou, Tsui-Fen, Wipf, Peter, Huryn, Donna M.
Published in ACS medicinal chemistry letters (13.07.2023)
Published in ACS medicinal chemistry letters (13.07.2023)
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Journal Article
Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors
LaPorte, Matthew G., Wang, Zhuzhu, Colombo, Raffaele, Garzan, Atefeh, Peshkov, Vsevolod A., Liang, Mary, Johnston, Paul A., Schurdak, Mark E., Sen, Malabika, Camarco, Daniel P., Hua, Yun, Pollock, Netanya I., Lazo, John S., Grandis, Jennifer R., Wipf, Peter, Huryn, Donna M.
Published in Bioorganic & medicinal chemistry letters (01.08.2016)
Published in Bioorganic & medicinal chemistry letters (01.08.2016)
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Journal Article
Structure–Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97
Alverez, Celeste, Arkin, Michelle R, Bulfer, Stacie L, Colombo, Raffaele, Kovaliov, Marina, LaPorte, Matthew G, Lim, Chaemin, Liang, Mary, Moore, William J, Neitz, R. Jeffrey, Yan, Yongzhao, Yue, Zhizhou, Huryn, Donna M, Wipf, Peter
Published in ACS medicinal chemistry letters (10.12.2015)
Published in ACS medicinal chemistry letters (10.12.2015)
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Journal Article
Condensation reactions of guanidines with bis-electrophiles: formation of highly nitrogenous heterocycles
Arnold, David M., LaPorte, Matthew G., Anderson, Shelby M., Wipf, Peter
Published in Tetrahedron (09.09.2013)
Published in Tetrahedron (09.09.2013)
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Journal Article
A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site
Burnett, James C., Lim, Chaemin, Peyser, Brian D., Samankumara, Lalith P., Kovaliov, Marina, Colombo, Raffaele, Bulfer, Stacie L., LaPorte, Matthew G., Hermone, Ann R., McGrath, Connor F., Arkin, Michelle R., Gussio, Rick, Huryn, Donna M., Wipf, Peter
Published in Organic & biomolecular chemistry (16.05.2017)
Published in Organic & biomolecular chemistry (16.05.2017)
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Journal Article
Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97
LaPorte, Matthew G, Burnett, James C, Colombo, Raffaele, Bulfer, Stacie L, Alverez, Celeste, Chou, Tsui-Fen, Neitz, R. Jeffrey, Green, Neal, Moore, William J, Yue, Zhizhou, Li, Shan, Arkin, Michelle R, Wipf, Peter, Huryn, Donna M
Published in ACS medicinal chemistry letters (08.11.2018)
Published in ACS medicinal chemistry letters (08.11.2018)
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Journal Article
2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway
LaPorte, Matthew G., da Paz Lima, Dimas José, Zhang, Feng, Sen, Malabika, Grandis, Jennifer R., Camarco, Daniel, Hua, Yun, Johnston, Paul A., Lazo, John S., Resnick, Lynn O., Wipf, Peter, Huryn, Donna M.
Published in Bioorganic & medicinal chemistry letters (01.11.2014)
Published in Bioorganic & medicinal chemistry letters (01.11.2014)
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Journal Article
HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell lines
Johnston, Paul A, Sen, Malabika, Hua, Yun, Camarco, Daniel P, Shun, Tong Ying, Lazo, John S, Wilson, Gabriela Mustata, Resnick, Lynn O, LaPorte, Matthew G, Wipf, Peter, Huryn, Donna M, Grandis, Jennifer R
Published in Assay and drug development technologies (01.09.2015)
Published in Assay and drug development technologies (01.09.2015)
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Journal Article
Construction of a Spirooxindole Amide Library through Nitrile Hydrozirconation-Acylation-Cyclization Cascade
LaPorte, Matthew G, Tsegay, Sammi, Hong, Ki Bum, Lu, Chunliang, Fang, Cheng, Wang, Lirong, Xie, Xiang-Qun, Floreancig, Paul E
Published in ACS combinatorial science (08.07.2013)
Published in ACS combinatorial science (08.07.2013)
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Journal Article
Process Development and Synthesis of Birinapant: Large Scale Preparation and Acid-Mediated Dimerization of the Key Indole Intermediate
Deng, Yijun, Xie, Qiuzhe, LaPorte, Matthew G, Chasnoff, Anna T. A, Mortensen, Mark A, Patra, Debasis, Putrelo, Seth A, Antonovich, Robert S, Cao, Hong, Yan, Jun, Cooper, Arthur J, Rippin, Susan R, Alexander, Matthew D, Kumar, Pavan Tirunahari, Hendi, Mukta S, Lee, Yu-Hua, Haimowitz, Thomas, Condon, Stephen M
Published in Organic process research & development (19.02.2016)
Published in Organic process research & development (19.02.2016)
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