NMR line-broadening and transferred NOESY as a medicinal chemistry tool for studying inhibitors of the hepatitis C virus NS3 protease domain
LaPlante, Steven R, Aubry, Norman, Bonneau, Pierre R, Kukolj, George, Lamarre, Daniel, Lefebvre, Sylvain, Li, Hong, Llinàs-Brunet, Montse, Plouffe, Céline, Cameron, Dale R
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
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Journal Article
Changes in drug 13C NMR chemical shifts as a tool for monitoring interactions with DNA
Boudreau, Eilis A., Pelczer, István, Borer, Philip N., Heffron, Gregory J., LaPlante, Steven R.
Published in Biophysical chemistry (01.06.2004)
Published in Biophysical chemistry (01.06.2004)
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Journal Article
Solution Structure of Substrate-based Ligands When Bound to Hepatitis C Virus NS3 Protease Domain
LaPlante, S R, Cameron, D R, Aubry, N, Lefebvre, S, Kukolj, G, Maurice, R, Thibeault, D, Lamarre, D, Llinàs-Brunet, M
Published in The Journal of biological chemistry (25.06.1999)
Published in The Journal of biological chemistry (25.06.1999)
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Journal Article
Evidence of a Conformational Change in the Human Cytomegalovirus Protease upon Binding of Peptidyl-Activated Carbonyl Inhibitors
Bonneau, Pierre R, Grand-Maître, Chantal, Greenwood, Daniel J, Lagacé, Lisette, LaPlante, Steven R, Massariol, Marie-Josée, Ogilvie, William W, O'Meara, Jeff A, Kawai, Stephen H
Published in Biochemistry (Easton) (14.10.1997)
Published in Biochemistry (Easton) (14.10.1997)
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Journal Article
Sodium Tetraphenylborate Displays Selective Bactericidal Activity against Neisseria meningitidis and N. gonorrhoeae and Is Effective at Reducing Bacterial Infection Load
Bernet, Eve, Lebughe, Marthe, Vincent, Antony T, Haghdoost, Mohammad Mehdi, Golbaghi, Golara, Laplante, Steven, Castonguay, Annie, Veyrier, Frederic J
Published in Antimicrobial agents and chemotherapy (20.01.2021)
Published in Antimicrobial agents and chemotherapy (20.01.2021)
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Journal Article
Repurposing Drugs and Synergistic Combinations as Potential Therapies for Inhibiting SARS-CoV-2 and Coronavirus Replication
Boulon, Richard, Mazeaud, Clément, Farahani, Majid D., Broquière, Mathilde, Iddir, Mustapha, Charpentier, Tania, Anton, Anaïs, Ayotte, Yann, Woo, Simon, Lamarre, Alain, Chatel-Chaix, Laurent, LaPlante, Steven R.
Published in ACS pharmacology & translational science (05.11.2024)
Published in ACS pharmacology & translational science (05.11.2024)
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Journal Article
Arylboronic acids as safe and specific human butyrylcholinesterase inhibitors
Mendes dos Santos, Eduardo, do Amaral e Silva, Nayane Abreu, Gonçalves, Karina Godarth, Vale, André Alvares Marques, de Azevedo-Santos, Ana Paula Silva, França, Tanos Celmar Costa, LaPlante, Steven R., Resende, Jackson Antonio Lamounier Camargos, Romeiro, Nelilma Correia, Lima, Josélia Alencar, Martins, Daniela de Luna, Nascimento, Maria do Desterro Soares Brandão
Published in Journal of molecular structure (15.10.2023)
Published in Journal of molecular structure (15.10.2023)
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Journal Article
Fatty acid mimetic PBI-4547 restores metabolic homeostasis via GPR84 in mice with non-alcoholic fatty liver disease
Simard, Jean-Christophe, Thibodeau, Jean-François, Leduc, Martin, Tremblay, Mikael, Laverdure, Alexandre, Sarra-Bournet, François, Gagnon, William, Ouboudinar, Jugurtha, Gervais, Liette, Felton, Alexandra, Letourneau, Sylvie, Geerts, Lilianne, Cloutier, Marie-Pier, Hince, Kathy, Corpuz, Ramon, Blais, Alexandra, Quintela, Vanessa Marques, Duceppe, Jean-Simon, Abbott, Shaun D., Blais, Amélie, Zacharie, Boulos, Laurin, Pierre, Laplante, Steven R., Kennedy, Christopher R. J., Hébert, Richard L., Leblond, François A., Grouix, Brigitte, Gagnon, Lyne
Published in Scientific reports (29.07.2020)
Published in Scientific reports (29.07.2020)
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Journal Article
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV‑1
Fader, Lee D, Malenfant, Eric, Parisien, Mathieu, Carson, Rebekah, Bilodeau, François, Landry, Serge, Pesant, Marc, Brochu, Christian, Morin, Sébastien, Chabot, Catherine, Halmos, Ted, Bousquet, Yves, Bailey, Murray D, Kawai, Stephen H, Coulombe, René, LaPlante, Steven, Jakalian, Araz, Bhardwaj, Punit K, Wernic, Dominik, Schroeder, Patricia, Amad, Ma’an, Edwards, Paul, Garneau, Michel, Duan, Jianmin, Cordingley, Michael, Bethell, Richard, Mason, Stephen W, Bös, Michael, Bonneau, Pierre, Poupart, Marc-André, Faucher, Anne-Marie, Simoneau, Bruno, Fenwick, Craig, Yoakim, Christiane, Tsantrizos, Youla
Published in ACS medicinal chemistry letters (10.04.2014)
Published in ACS medicinal chemistry letters (10.04.2014)
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Journal Article
Human Cytomegalovirus Protease Complexes Its Substrate Recognition Sequences in an Extended Peptide Conformation
LaPlante, Steven R, Aubry, Norman, Bonneau, Pierre R, Cameron, Dale R, Lagacé, Lisette, Massariol, Marie-Josée, Montpetit, Hélène, Plouffe, Céline, Kawai, Stephen H, Fulton, Bruce D, Chen, Zhigang, Ni, Feng
Published in Biochemistry (Easton) (07.07.1998)
Published in Biochemistry (Easton) (07.07.1998)
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Journal Article
The Conformation of a Peptidyl Methyl Ketone Inhibitor Bound to the Human Cytomegalovirus Protease
LaPlante, Steven R., Cameron, Dale R., Aubry, Norman, Bonneau, Pierre R., Déziel, Robert, Grand-Maître, Chantal, Ogilvie, William W., Kawai, Stephen H.
Published in Angewandte Chemie International Edition (16.10.1998)
Published in Angewandte Chemie International Edition (16.10.1998)
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Journal Article
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
Lamarre, Daniel, Anderson, Paul C, Bailey, Murray, Beaulieu, Pierre, Bolger, Gordon, Bonneau, Pierre, Bös, Michael, Cameron, Dale R, Cartier, Mireille, Cordingley, Michael G, Faucher, Anne-Marie, Goudreau, Nathalie, Kawai, Stephen H, Kukolj, George, Lagacé, Lisette, LaPlante, Steven R, Narjes, Hans, Poupart, Marc-André, Rancourt, Jean, Sentjens, Roel E, St George, Roger, Simoneau, Bruno, Steinmann, Gerhard, Thibeault, Diane, Tsantrizos, Youla S, Weldon, Steven M, Yong, Chan-Loi, Llinàs-Brunet, Montse
Published in Nature (13.11.2003)
Published in Nature (13.11.2003)
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Journal Article
Discovery of the First Thumb Pocket 1 NS5B Polymerase Inhibitor (BILB 1941) with Demonstrated Antiviral Activity in Patients Chronically Infected with Genotype 1 Hepatitis C Virus (HCV)
Beaulieu, Pierre L, Bös, Michael, Cordingley, Michael G, Chabot, Catherine, Fazal, Gulrez, Garneau, Michel, Gillard, James R, Jolicoeur, Eric, LaPlante, Steven, McKercher, Ginette, Poirier, Martin, Poupart, Marc-André, Tsantrizos, Youla S, Duan, Jianmin, Kukolj, George
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Journal Article
Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity
Beaulieu, Pierre L., Bolger, Gordon, Deon, Dan, Duplessis, Martin, Fazal, Gulrez, Gagnon, Alexandre, Garneau, Michel, LaPlante, Steven, Stammers, Timothy, Kukolj, George, Duan, Jianmin
Published in Bioorganic & medicinal chemistry letters (01.03.2015)
Published in Bioorganic & medicinal chemistry letters (01.03.2015)
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Journal Article
Peptides as Leads for Drug Discovery
Edwards, Paul J, LaPlante, Steven R
Published in Peptide Drug Discovery and Development (05.10.2011)
Published in Peptide Drug Discovery and Development (05.10.2011)
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Book Chapter
Searching for potential drugs against SARS-CoV-2 through virtual screening on several molecular targets
Almeida, Joyce S. F. D., Botelho, Fernanda D., de Souza, Felipe R., dos Santos, Marcelo C., Goncalves, Arlan da Silva, Rodrigues, Rodrigo L. B., Cardozo, Monique, Kitagawa, Daniel A. S., Vieira, Leandro A., Silva, Raphael S. F., Cavalcante, Samir F. A., Bastos, Leonardo da C., Nogueira, Mariana de O. T., de Santana, Priscila I. R., Brum, Juliana de O. C., Nepovimova, Eugenie, Kuca, Kamil, LaPlante, Steven R., Galante, Erick B. F., Franca, Tanos C. C.
Published in Journal of biomolecular structure & dynamics (08.01.2021)
Published in Journal of biomolecular structure & dynamics (08.01.2021)
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Journal Article
Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay
Stammers, Timothy A., Coulombe, René, Duplessis, Martin, Fazal, Gulrez, Gagnon, Alexandre, Garneau, Michel, Goulet, Sylvie, Jakalian, Araz, LaPlante, Steven, Rancourt, Jean, Thavonekham, Bounkham, Wernic, Dominik, Kukolj, George, Beaulieu, Pierre L.
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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Journal Article
Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors
O’Meara, Jeff A., Jakalian, Araz, LaPlante, Steven, Bonneau, Pierre R., Coulombe, René, Faucher, Anne-Marie, Guse, Ingrid, Landry, Serge, Racine, Jennifer, Simoneau, Bruno, Thavonekham, Bounkham, Yoakim, Christiane
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
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Journal Article
Benzimidazole Thumb Pocket I finger-loop inhibitors of HCV NS5B polymerase: Improved drug-like properties through C-2 SAR in three sub-series
Beaulieu, Pierre L., Dansereau, Nathalie, Duan, Jianmin, Garneau, Michel, Gillard, James, McKercher, Ginette, LaPlante, Steven, Lagacée, Lisette, Thauvette, Louise, Kukolj, George
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
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Journal Article