Challenge of Atropisomerism in Drug Discovery
Clayden, Jonathan, Moran, Wesley J, Edwards, Paul J, LaPlante, Steven R
Published in Angewandte Chemie (International ed.) (01.01.2009)
Published in Angewandte Chemie (International ed.) (01.01.2009)
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Drug Self-Aggregation into Nano-Entities Has the Potential to Induce Immune Responses
Shahout, Fatma, Vanharen, Marion, Saafane, Abdelaziz, Gillard, James, Girard, Denis, LaPlante, Steven R.
Published in Molecular pharmaceutics (07.08.2023)
Published in Molecular pharmaceutics (07.08.2023)
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Journal Article
Revealing Atropisomer Axial Chirality in Drug Discovery
LaPlante, Steven R., Edwards, Paul J., Fader, Lee D., Jakalian, Araz, Hucke, Oliver
Published in ChemMedChem (07.03.2011)
Published in ChemMedChem (07.03.2011)
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Journal Article
Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy
Mistretta, Maxime, Cimino, Mena, Campagne, Pascal, Volant, Stevenn, Kornobis, Etienne, Hebert, Olivier, Rochais, Christophe, Dallemagne, Patrick, Lecoutey, Cédric, Tisnerat, Camille, Lepailleur, Alban, Ayotte, Yann, LaPlante, Steven R., Gangneux, Nicolas, Záhorszká, Monika, Korduláková, Jana, Vichier-Guerre, Sophie, Bonhomme, Frédéric, Pokorny, Laura, Albert, Marvin, Tinevez, Jean-Yves, Manina, Giulia
Published in Nature communications (16.05.2024)
Published in Nature communications (16.05.2024)
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Journal Article
The Search for Antidotes Against Ricin
Botelho, Fernanda Diniz, Franca, Tanos Celmar Costa, LaPlante, Steven R
Published in Mini reviews in medicinal chemistry (23.01.2024)
Published in Mini reviews in medicinal chemistry (23.01.2024)
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Journal Article
Exposing Small-Molecule Nanoentities by a Nuclear Magnetic Resonance Relaxation Assay
Ayotte, Yann, Marando, Victoria M, Vaillancourt, Louis, Bouchard, Patricia, Heffron, Gregory, Coote, Paul W, Larda, Sacha T, LaPlante, Steven R
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
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Journal Article
Fragment‐Based Phenotypic Lead Discovery: Cell‐Based Assay to Target Leishmaniasis
Ayotte, Yann, Bilodeau, François, Descoteaux, Albert, LaPlante, Steven R.
Published in ChemMedChem (18.07.2018)
Published in ChemMedChem (18.07.2018)
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Journal Article
Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings
Fnaiche, Ahmed, Mélin, Léa, Suárez, Narjara González, Paquin, Alexis, Vu, Victoria, Li, Fengling, Allali-Hassani, Abdellah, Bolotokova, Albina, Allemand, Frédéric, Gelin, Muriel, Cotelle, Philippe, Woo, Simon, LaPlante, Steven R., Barsyte-Lovejoy, Dalia, Santhakumar, Vijayaratnam, Vedadi, Masoud, Guichou, Jean-François, Annabi, Borhane, Gagnon, Alexandre
Published in Bioorganic & medicinal chemistry letters (15.10.2023)
Published in Bioorganic & medicinal chemistry letters (15.10.2023)
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Journal Article
NMR spectroscopy can help accelerate antiviral drug discovery programs
LaPlante, Steven R., Coric, Pascale, Bouaziz, Serge, França, Tanos C.C.
Published in Microbes and infection (01.09.2024)
Published in Microbes and infection (01.09.2024)
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Journal Article
Synthesis of a thiophene-based fluorinated library applied to fragment-based drug discovery via19F NMR with confirmed binding to mutant HRASG12V
Bendahan, David, Franca, Tanos C C, Amiens, Kathleen C, Ayotte, Yann, gione, Pat, LaPlante, Steven R
Published in New journal of chemistry (21.10.2024)
Published in New journal of chemistry (21.10.2024)
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Journal Article
A Multi-epitope Vaccine Candidate Against Bolivian Hemorrhagic fever Caused by Machupo Virus
Ali, Zeeshan, Cardoza, Jyothsna Volisha, Basak, Srijita, Narsaria, Utkarsh, Bhattacharjee, Surjit, G., Unnati Meher, Isaac, Samuel Paul, Franca, Tanos C. C., LaPlante, Steven R., George, Sudhan S.
Published in Applied biochemistry and biotechnology (01.04.2024)
Published in Applied biochemistry and biotechnology (01.04.2024)
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Journal Article
Compound Aggregation in Drug Discovery: Implementing a Practical NMR Assay for Medicinal Chemists
LaPlante, Steven R, Carson, Rebekah, Gillard, James, Aubry, Norman, Coulombe, René, Bordeleau, Sylvain, Bonneau, Pierre, Little, Michael, O’Meara, Jeff, Beaulieu, Pierre L
Published in Journal of medicinal chemistry (27.06.2013)
Published in Journal of medicinal chemistry (27.06.2013)
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Journal Article
Fragment-Based Phenotypic Lead Discovery To Identify New Drug Seeds That Target Infectious Diseases
Ayotte, Yann, Bernet, Eve, Bilodeau, François, Cimino, Mena, Gagnon, Dominic, Lebughe, Marthe, Mistretta, Maxime, Ogadinma, Paul, Ouali, Sarah-Lisa, Sow, Aïssatou Aïcha, Chatel-Chaix, Laurent, Descoteaux, Albert, Manina, Giulia, Richard, Dave, Veyrier, Frédéric, LaPlante, Steven R
Published in ACS chemical biology (19.11.2021)
Published in ACS chemical biology (19.11.2021)
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Journal Article
Probing the free-state solution behavior of drugs and their tendencies to self-aggregate into nano-entities
LaPlante, Steven R., Roux, Valérie, Shahout, Fatma, LaPlante, Gabriela, Woo, Simon, Denk, Maria M., Larda, Sacha T., Ayotte, Yann
Published in Nature protocols (01.11.2021)
Published in Nature protocols (01.11.2021)
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Journal Article
Robust Strategy for Hit-to-Lead Discovery: NMR for SAR
Larda, Sacha T., Ayotte, Yann, Denk, Maria M., Coote, Paul, Heffron, Gregory, Bendahan, David, Shahout, Fatma, Girard, Nicolas, Iddir, Mustapha, Bouchard, Patricia, Bilodeau, Francois, Woo, Simon, Farmer, Luc J., LaPlante, Steven R.
Published in Journal of medicinal chemistry (12.10.2023)
Published in Journal of medicinal chemistry (12.10.2023)
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