The phosphoinositide 3′-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
Hoellenriegel, Julia, Meadows, Sarah A., Sivina, Mariela, Wierda, William G., Kantarjian, Hagop, Keating, Michael J., Giese, Neill, O'Brien, Susan, Yu, Albert, Miller, Langdon L., Lannutti, Brian J., Burger, Jan A.
Published in Blood (29.09.2011)
Published in Blood (29.09.2011)
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Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia
Brown, Jennifer R., Byrd, John C., Coutre, Steven E., Benson, Don M., Flinn, Ian W., Wagner-Johnston, Nina D., Spurgeon, Stephen E., Kahl, Brad S., Bello, Celeste, Webb, Heather K., Johnson, Dave M., Peterman, Sissy, Li, Daniel, Jahn, Thomas M., Lannutti, Brian J., Ulrich, Roger G., Yu, Albert S., Miller, Langdon L., Furman, Richard R.
Published in Blood (29.05.2014)
Published in Blood (29.05.2014)
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The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia
Herman, Sarah E M, Montraveta, Arnau, Niemann, Carsten U, Mora-Jensen, Helena, Gulrajani, Michael, Krantz, Fanny, Mantel, Rose, Smith, Lisa L, McClanahan, Fabienne, Harrington, Bonnie K, Colomer, Dolors, Covey, Todd, Byrd, John C, Izumi, Raquel, Kaptein, Allard, Ulrich, Roger, Johnson, Amy J, Lannutti, Brian J, Wiestner, Adrian, Woyach, Jennifer A
Published in Clinical cancer research (01.06.2017)
Published in Clinical cancer research (01.06.2017)
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ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient–derived xenograft mouse models
Vaisitti, Tiziana, Arruga, Francesca, Vitale, Nicoletta, Lee, Thanh-Trang, Ko, Mira, Chadburn, Amy, Braggio, Esteban, Di Napoli, Arianna, Iannello, Andrea, Allan, John N., Miller, Langdon L., Lannutti, Brian J., Furman, Richard R., Jessen, Katti A., Deaglio, Silvia
Published in Blood (17.06.2021)
Published in Blood (17.06.2021)
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The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells
Fiorcari, Stefania, Brown, Wells S, McIntyre, Bradley W, Estrov, Zeev, Maffei, Rossana, O'Brien, Susan, Sivina, Mariela, Hoellenriegel, Julia, Wierda, William G, Keating, Michael J, Ding, Wei, Kay, Neil E, Lannutti, Brian J, Marasca, Roberto, Burger, Jan A
Published in PloS one (23.12.2013)
Published in PloS one (23.12.2013)
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PI3Kδ inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma
Meadows, Sarah A., Vega, Francisco, Kashishian, Adam, Johnson, Dave, Diehl, Volker, Miller, Langdon L., Younes, Anas, Lannutti, Brian J.
Published in Blood (23.02.2012)
Published in Blood (23.02.2012)
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Journal Article
CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
Lannutti, Brian J., Meadows, Sarah A., Herman, Sarah E.M., Kashishian, Adam, Steiner, Bart, Johnson, Amy J., Byrd, John C., Tyner, Jeffrey W., Loriaux, Marc M., Deininger, Mike, Druker, Brian J., Puri, Kamal D., Ulrich, Roger G., Giese, Neill A.
Published in Blood (13.01.2011)
Published in Blood (13.01.2011)
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Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
Herman, Sarah E.M., Gordon, Amber L., Wagner, Amy J., Heerema, Nyla A., Zhao, Weiqiang, Flynn, Joseph M., Jones, Jeffrey, Andritsos, Leslie, Puri, Kamal D., Lannutti, Brian J., Giese, Neill A., Zhang, Xiaoli, Wei, Lai, Byrd, John C., Johnson, Amy J.
Published in Blood (23.09.2010)
Published in Blood (23.09.2010)
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Targeting Nonclassical Oncogenes for Therapy in T-ALL
Subramaniam, Prem S., Whye, Dosh W., Efimenko, Evgeni, Chen, Jianchung, Tosello, Valeria, De Keersmaecker, Kim, Kashishian, Adam, Thompson, Mary Ann, Castillo, Mireia, Cordon-Cardo, Carlos, Davé, Utpal P., Ferrando, Adolfo, Lannutti, Brian J., Diacovo, Thomas G.
Published in Cancer cell (17.04.2012)
Published in Cancer cell (17.04.2012)
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The antibody drug conjugate VLS-101 targeting ROR1 is effective in CAR T-resistant mantle cell lymphoma
Jiang, Vivian Changying, Liu, Yang, Jordan, Alexa, McIntosh, Joseph, Li, Yijing, Che, Yuxuan, Jessen, Katti A., Lannutti, Brian J., Wang, Michael
Published in Journal of hematology and oncology (28.08.2021)
Published in Journal of hematology and oncology (28.08.2021)
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Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia
Davids, Matthew S., Deng, Jing, Wiestner, Adrian, Lannutti, Brian J., Wang, Lili, Wu, Catherine J., Wilson, Wyndham H., Brown, Jennifer R., Letai, Anthony
Published in Blood (25.10.2012)
Published in Blood (25.10.2012)
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Combined BTK and PI3Kδ Inhibition with Acalabrutinib and ACP-319 Improves Survival and Tumor Control in CLL Mouse Model
Niemann, Carsten U, Mora-Jensen, Helena I, Dadashian, Eman L, Krantz, Fanny, Covey, Todd, Chen, Shih-Shih, Chiorazzi, Nicholas, Izumi, Raquel, Ulrich, Roger, Lannutti, Brian J, Wiestner, Adrian, Herman, Sarah E M
Published in Clinical cancer research (01.10.2017)
Published in Clinical cancer research (01.10.2017)
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Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia
Byrd, John C, Harrington, Bonnie, O’Brien, Susan, Jones, Jeffrey A, Schuh, Anna, Devereux, Steve, Chaves, Jorge, Wierda, William G, Awan, Farrukh T, Brown, Jennifer R, Hillmen, Peter, Stephens, Deborah M, Ghia, Paolo, Barrientos, Jacqueline C, Pagel, John M, Woyach, Jennifer, Johnson, Dave, Huang, Jane, Wang, Xiaolin, Kaptein, Allard, Lannutti, Brian J, Covey, Todd, Fardis, Maria, McGreivy, Jesse, Hamdy, Ahmed, Rothbaum, Wayne, Izumi, Raquel, Diacovo, Thomas G, Johnson, Amy J, Furman, Richard R
Published in The New England journal of medicine (28.01.2016)
Published in The New England journal of medicine (28.01.2016)
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The role of phosphatidylinositol 3-kinase-δ in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia
Herman, Sarah E.M., Lapalombella, Rosa, Gordon, Amber L., Ramanunni, Asha, Blum, Kristie A., Jones, Jeffrey, Zhang, Xiaoli, Lannutti, Brian J., Puri, Kamal D., Muthusamy, Natarajan, Byrd, John C., Johnson, Amy J.
Published in Blood (21.04.2011)
Published in Blood (21.04.2011)
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Tetraspanin CD37 Directly Mediates Transduction of Survival and Apoptotic Signals
Lapalombella, Rosa, Yeh, Yuh-Ying, Wang, Liwen, Ramanunni, Asha, Rafiq, Sarwish, Jha, Shruti, Staubli, Justin, Lucas, David M., Mani, Rajeswaran, Herman, Sarah E.M., Johnson, Amy J., Lozanski, Arletta, Andritsos, Leslie, Jones, Jeffrey, Flynn, Joseph M., Lannutti, Brian, Thompson, Peter, Algate, Paul, Stromatt, Scott, Jarjoura, David, Mo, Xiaokui, Wang, Dasheng, Chen, Ching-Shih, Lozanski, Gerard, Heerema, Nyla A., Tridandapani, Susheela, Freitas, Michael A., Muthusamy, Natarajan, Byrd, John C.
Published in Cancer cell (15.05.2012)
Published in Cancer cell (15.05.2012)
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PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML
Goodwin, Charles B, Li, Xing Jun, Mali, Raghuveer S., Chan, Gordon, Kang, Michelle, Liu, Ziyue, Vanhaesebroeck, Bart, Neel, Benjamin G., Loh, Mignon L., Lannutti, Brian J., Kapur, Reuben, Chan, Rebecca J.
Published in Blood (01.05.2014)
Published in Blood (01.05.2014)
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Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption
Shugg, Ryan P P, Thomson, Ashley, Tanabe, Natsuko, Kashishian, Adam, Steiner, Bart H, Puri, Kamal D, Pereverzev, Alexey, Lannutti, Brian J, Jirik, Frank R, Dixon, S Jeffrey, Sims, Stephen M
Published in The Journal of biological chemistry (06.12.2013)
Published in The Journal of biological chemistry (06.12.2013)
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Journal Article
The phosphatidylinositol 3‐kinases (PI3K) inhibitor GS‐1101 synergistically potentiates histone deacetylase inhibitor‐induced proliferation inhibition and apoptosis through the inactivation of PI3K and extracellular signal‐regulated kinase pathways
Bodo, Juraj, Zhao, Xiaoxian, Sharma, Arishya, Hill, Brian T., Portell, Craig A., Lannutti, Brian J., Almasan, Alexandru, Hsi, Eric D.
Published in British journal of haematology (01.10.2013)
Published in British journal of haematology (01.10.2013)
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Journal Article
Incomplete restoration of Mpl expression in the mpl−/− mouse produces partial correction of the stem cell–repopulating defect and paradoxical thrombocytosis
Lannutti, Brian J., Epp, Angela, Roy, Jacqueline, Chen, Junmei, Josephson, Neil C.
Published in Blood (19.02.2009)
Published in Blood (19.02.2009)
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