Lecanemab, Aducanumab, and Gantenerumab — Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer’s Disease
Söderberg, Linda, Johannesson, Malin, Nygren, Patrik, Laudon, Hanna, Eriksson, Fredrik, Osswald, Gunilla, Möller, Christer, Lannfelt, Lars
Published in Neurotherapeutics (01.01.2023)
Published in Neurotherapeutics (01.01.2023)
Get full text
Journal Article
The Amyloid-β Pathway in Alzheimer’s Disease
Hampel, Harald, Hardy, John, Blennow, Kaj, Chen, Christopher, Perry, George, Kim, Seung Hyun, Villemagne, Victor L., Aisen, Paul, Vendruscolo, Michele, Iwatsubo, Takeshi, Masters, Colin L., Cho, Min, Lannfelt, Lars, Cummings, Jeffrey L., Vergallo, Andrea
Published in Molecular psychiatry (01.10.2021)
Published in Molecular psychiatry (01.10.2021)
Get full text
Journal Article
Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
Sardar Sinha, Maitrayee, Ansell-Schultz, Anna, Civitelli, Livia, Hildesjö, Camilla, Larsson, Max, Lannfelt, Lars, Ingelsson, Martin, Hallbeck, Martin
Published in Acta neuropathologica (01.07.2018)
Published in Acta neuropathologica (01.07.2018)
Get full text
Journal Article
A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody
Swanson, Chad J, Zhang, Yong, Dhadda, Shobha, Wang, Jinping, Kaplow, June, Lai, Robert Y K, Lannfelt, Lars, Bradley, Heather, Rabe, Martin, Koyama, Akihiko, Reyderman, Larisa, Berry, Donald A, Berry, Scott, Gordon, Robert, Kramer, Lynn D, Cummings, Jeffrey L
Published in Alzheimer's research & therapy (17.04.2021)
Published in Alzheimer's research & therapy (17.04.2021)
Get full text
Journal Article
Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease
Sehlin, Dag, Fang, Xiaotian T., Cato, Linda, Antoni, Gunnar, Lannfelt, Lars, Syvänen, Stina
Published in Nature communications (19.02.2016)
Published in Nature communications (19.02.2016)
Get full text
Journal Article
Serial propagation of distinct strains of Aβ prions from Alzheimer’s disease patients
Watts, Joel C., Condello, Carlo, Stöhr, Jan, Oehler, Abby, Lee, Joanne, DeArmond, Stephen J., Lannfelt, Lars, Ingelsson, Martin, Giles, Kurt, Prusiner, Stanley B.
Published in Proceedings of the National Academy of Sciences - PNAS (15.07.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (15.07.2014)
Get full text
Journal Article
Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals
Danielsson, Marcus, Halvardson, Jonatan, Davies, Hanna, Torabi Moghadam, Behrooz, Mattisson, Jonas, Rychlicka-Buniowska, Edyta, Jaszczyński, Janusz, Heintz, Julia, Lannfelt, Lars, Giedraitis, Vilmantas, Ingelsson, Martin, Dumanski, Jan P, Forsberg, Lars A
Published in European journal of human genetics : EJHG (01.03.2020)
Published in European journal of human genetics : EJHG (01.03.2020)
Get full text
Journal Article
Vascular Risk Factors and Dementia: 40-Year Follow-Up of a Population-Based Cohort
Rönnemaa, Elina, Zethelius, Björn, Lannfelt, Lars, Kilander, Lena
Published in Dementia and geriatric cognitive disorders (01.01.2011)
Published in Dementia and geriatric cognitive disorders (01.01.2011)
Get full text
Journal Article
The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death
Söllvander, Sofia, Nikitidou, Elisabeth, Gallasch, Linn, Zyśk, Marlena, Söderberg, Linda, Sehlin, Dag, Lannfelt, Lars, Erlandsson, Anna
Published in Journal of neuroinflammation (28.03.2018)
Published in Journal of neuroinflammation (28.03.2018)
Get full text
Journal Article
Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease
Khoonsari, Payam Emami, Häggmark, Anna, Lönnberg, Maria, Mikus, Maria, Kilander, Lena, Lannfelt, Lars, Bergquist, Jonas, Ingelsson, Martin, Nilsson, Peter, Kultima, Kim, Shevchenko, Ganna
Published in PloS one (07.03.2016)
Published in PloS one (07.03.2016)
Get full text
Journal Article
Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response
O'Callaghan, Paul, Li, Jin-Ping, Lannfelt, Lars, Lindahl, Ulf, Zhang, Xiao
Published in The Journal of biological chemistry (12.06.2015)
Published in The Journal of biological chemistry (12.06.2015)
Get full text
Journal Article
ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease
Nordström, Eva, Eriksson, Fredrik, Sigvardson, Jessica, Johannesson, Malin, Kasrayan, Alex, Jones-Kostalla, Martina, Appelkvist, Paulina, Söderberg, Linda, Nygren, Patrik, Blom, Magdalena, Rachalski, Adeline, Nordenankar, Karin, Zachrisson, Olof, Amandius, Ebba, Osswald, Gunilla, Moge, Mikael, Ingelsson, Martin, Bergström, Joakim, Lannfelt, Lars, Möller, Christer, Giorgetti, Marco, Fälting, Johanna
Published in Neurobiology of disease (01.12.2021)
Published in Neurobiology of disease (01.12.2021)
Get full text
Journal Article
Mosaic loss of chromosome Y in leukocytes matters
Forsberg, Lars A., Halvardson, Jonatan, Rychlicka-Buniowska, Edyta, Danielsson, Marcus, Moghadam, Behrooz Torabi, Mattisson, Jonas, Rasi, Chiara, Davies, Hanna, Lind, Lars, Giedraitis, Vilmantas, Lannfelt, Lars, Kilander, Lena, Ingelsson, Martin, Dumanski, Jan P.
Published in Nature genetics (01.01.2019)
Published in Nature genetics (01.01.2019)
Get full text
Journal Article
Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities
Söderberg, Linda, Johannesson, Malin, Gkanatsiou, Eleni, Nygren, Patrik, Fritz, Nicolas, Zachrisson, Olof, Rachalski, Adeline, Svensson, Anne-Sophie, Button, Emily, Dentoni, Giacomo, Osswald, Gunilla, Lannfelt, Lars, Möller, Christer
Published in Scientific reports (13.05.2024)
Published in Scientific reports (13.05.2024)
Get full text
Journal Article
Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice
Lindström, Veronica, Fagerqvist, Therese, Nordström, Eva, Eriksson, Fredrik, Lord, Anna, Tucker, Stina, Andersson, Jessica, Johannesson, Malin, Schell, Heinrich, Kahle, Philipp J, Möller, Christer, Gellerfors, Pär, Bergström, Joakim, Lannfelt, Lars, Ingelsson, Martin
Published in Neurobiology of disease (01.09.2014)
Published in Neurobiology of disease (01.09.2014)
Get full text
Journal Article
Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair ltp via NMDA-receptor activation
de Oliveira Diógenes Nogueira, Maria José, Dias, Raquel, Rombo, Diogo, Vicente Miranda, Hugo, Maiolino, Francesca, Guerreiro, Patrícia, Nasstrom, Thomas, Franquelim, Henri, Oliveira, Luís M.A., Castanho, Miguel, Lannfelt, Lars, Bergstrom, Joakim, Ingelsson, Martin, Quintas, Alexandre, Sebastião, Ana M, Lopes, Luisa, Outeiro, Tiago
Published in The Journal of neuroscience (22.08.2012)
Published in The Journal of neuroscience (22.08.2012)
Get full text
Journal Article
Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering
Sandberg, Anders, Luheshi, Leila M, Söllvander, Sofia, Pereira de Barros, Teresa, Macao, Bertil, Knowles, Tuomas P.J, Biverstål, Henrik, Lendel, Christofer, Ekholm-Petterson, Frida, Dubnovitsky, Anatoly, Lannfelt, Lars, Dobson, Christopher M, Härd, Torleif
Published in Proceedings of the National Academy of Sciences - PNAS (31.08.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (31.08.2010)
Get full text
Journal Article