Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis
Bäurle, Stefan, Nagel, Jens, Peters, Olaf, Bräuer, Nico, ter Laak, Antonius, Preusse, Cornelia, Rottmann, Antje, Heldmann, Dieter, Bothe, Ulrich, Blume, Thorsten, Zorn, Ludwig, Walter, Daryl, Zollner, Thomas M, Steinmeyer, Andreas, Langer, Gernot
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A
Friberg, Anders, Rehwinkel, Hartmut, Nguyen, Duy, Pütter, Vera, Quanz, Maria, Weiske, Jörg, Eberspächer, Uwe, Heisler, Iring, Langer, Gernot
Published in ACS omega (09.06.2020)
Published in ACS omega (09.06.2020)
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The Cochaperone Bag-1L Enhances Androgen Receptor Action via Interaction with the NH2-Terminal Region of the Receptor
Shatkina, Liubov, Mink, Sigrun, Rogatsch, Hermann, Klocker, Helmut, Langer, Gernot, Nestl, Andrea, Cato, Andrew C. B.
Published in Molecular and Cellular Biology (01.10.2003)
Published in Molecular and Cellular Biology (01.10.2003)
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Journal Article
G Protein-Coupled Receptor 30 Localizes to the Endoplasmic Reticulum and Is Not Activated by Estradiol
Otto, Christiane, Rohde-Schulz, Beate, Schwarz, Gilda, Fuchs, Iris, Klewer, Mario, Brittain, Dominic, Langer, Gernot, Bader, Benjamin, Prelle, Katja, Nubbemeyer, Reinhard, Fritzemeier, Karl-Heinrich
Published in Endocrinology (Philadelphia) (01.10.2008)
Published in Endocrinology (Philadelphia) (01.10.2008)
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Journal Article
A critical review of fundamental controversies in the field of GPR30 research
Langer, Gernot, Bader, Benjamin, Meoli, Luca, Isensee, Jörg, Delbeck, Martina, Noppinger, Patricia Ruiz, Otto, Christiane
Published in Steroids (01.08.2010)
Published in Steroids (01.08.2010)
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Conference Proceeding
Discovery and In Vitro Characterization of BAY 2686013, an Allosteric Small Molecule Antagonist of the Human Pituitary Adenylate Cyclase-Activating Polypeptide Receptor
Langer, Gernot, Scott, John, Lind, Christoffer, Otto, Christiane, Bothe, Ulrich, Laux-Biehlmann, Alexis, Müller, Jörg, le Roy, Beau, Irlbacher, Horst, Nowak-Reppel, Katrin, Schlüter, Anne, Davenport, Adam J, Slack, Mark, Bäurle, Stefan
Published in Molecular pharmacology (01.09.2023)
Published in Molecular pharmacology (01.09.2023)
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Journal Article
Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women
Panknin, Olaf, Wagenfeld, Andrea, Bone, Wilhelm, Bender, Eckhard, Nowak-Reppel, Katrin, Fernández-Montalván, Amaury E, Nubbemeyer, Reinhard, Bäurle, Stefan, Ring, Sven, Schmees, Norbert, Prien, Olaf, Schäfer, Martina, Friedrich, Christian, Zollner, Thomas M, Steinmeyer, Andreas, Mueller, Thomas, Langer, Gernot
Published in Journal of medicinal chemistry (22.10.2020)
Published in Journal of medicinal chemistry (22.10.2020)
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Journal Article
Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo
Wortmann, Lars, Lindenthal, Bernhard, Muhn, Peter, Walter, Alexander, Nubbemeyer, Reinhard, Heldmann, Dieter, Sobek, Lothar, Morandi, Federica, Schrey, Anna K, Moosmayer, Dieter, Günther, Judith, Kuhnke, Joachim, Koppitz, Marcus, Lücking, Ulrich, Röhn, Ulrike, Schäfer, Martina, Nowak-Reppel, Katrin, Kühne, Ronald, Weinmann, Hilmar, Langer, Gernot
Published in Journal of medicinal chemistry (27.11.2019)
Published in Journal of medicinal chemistry (27.11.2019)
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Journal Article
푸로인다졸 유도체
PANKNIN OLAF, PILARI SABINE, SIEBENEICHER HOLGER, ROTTMANN ANTJE, LANGER GERNOT, SCHMIDT NICOLE, MIYATAKE ONDOZABAL HIDEKI, NUBBEMEYER REINHARD, SACHER FRANK, TER LAAK ANTONIUS, NOWAK REPPEL KATRIN, CERNECKA HANA
Year of Publication 25.08.2022
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Year of Publication 25.08.2022
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자궁내막증의 치료를 위한 GPR84의 억제제 및 길항제
OBENDORF MAIK, LANGER GERNOT, SACHER FRANK, OPPERMANN UDO, SHANG CATHERINE, MARTINEZ ESTRADA FERNANDO
Year of Publication 10.01.2020
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Year of Publication 10.01.2020
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SPIROINDOLINE DERIVATIVES FOR USE AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS
PANKNIN OLAF, RING SVEN, BAEURLE STEFAN, WAGENFELD ANDREA, LANGER GERNOT, NUBBEMEYER REINHARD, NOWAK REPPEL KATRIN
Year of Publication 14.12.2015
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Year of Publication 14.12.2015
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NOVEL BENZIMIDAZOLE DERIVATIVES AS EP4 ANTAGONISTS
KUHNKE JOACHIM, PETERS OLAF, ZORN LUDWIG, NAGEL JENS, LANGER GERNOT, KAULFUSS STEFAN, BLUME THORSTEN, TER LAAK ANTONIUS, BRAEUER NICO
Year of Publication 12.08.2015
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Year of Publication 12.08.2015
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FUROINDAZOLE DERIVATIVES AS ANTAGONISTS OR INHIBITORS OF GPR84
PANKNIN, Olaf, NUBBEMEYER, Reinhard, LANGER, Gernot, PILARI, Sabine, SACHER, Frank, NOWAK-REPPEL, Katrin, ROTTMANN, Antje, SIEBENEICHER, Holger
Year of Publication 18.07.2024
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Year of Publication 18.07.2024
Patent
FUROINDAZOLE DERIVATIVES AS ANTAGONISTS OR INHIBITORS OF GPR84
PANKNIN, Olaf, NUBBEMEYER, Reinhard, LANGER, Gernot, PILARI, Sabine, SACHER, Frank, NOWAK-REPPEL, Katrin, ROTTMANN, Antje, SIEBENEICHER, Holger
Year of Publication 06.03.2024
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Year of Publication 06.03.2024
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Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor
Schneikert, Jean, Hübner, Susanne, Langer, Gernot, Petri, Thomas, Jäättelä, Marja, Reed, Jennifer, Cato, Andrew C.B.
Published in The EMBO journal (01.12.2000)
Published in The EMBO journal (01.12.2000)
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Journal Article
BENZIMIDAZOLE DERIVATIVES AS EP4-LIGANDS
KOPPITZ, MARCUS, LANGER, GERNOT, PETERS, OLAF, BOTHE, ULRICH, NAGEL, JENS, BRAUER, NICO
Year of Publication 26.07.2022
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Year of Publication 26.07.2022
Patent
FUROINDAZOLE DERIVATIVES
PANKNIN, Olaf, SCHMIDT, Nicole, CERNECKA, Hana, NUBBEMEYER, Reinhard, PILARI, Sabine, LANGER, Gernot, TER LAAK, Antonius, SACHER, Frank, ROTTMANN, Antje, NOWAK-REPPEL, Katrin, SIEBENEICHER, Holger, MIYATAKE, ONDOZABAL, Hideki
Year of Publication 25.01.2024
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Year of Publication 25.01.2024
Patent
FUROINDAZOLE DERIVATIVES AS ANTAGONISTS OR INHIBITORS OF GPR84
PANKNIN, Olaf, NUBBEMEYER, Reinhard, LANGER, Gernot, PILARI, Sabine, SACHER, Frank, NOWAK-REPPEL, Katrin, ROTTMANN, Antje, SIEBENEICHER, Holger
Year of Publication 03.11.2022
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Year of Publication 03.11.2022
Patent