The Targets of Currently Used Antibacterial Agents: Lessons for Drug Discovery
LANGE, Roland P, LOCHER, Hans H, WYSS, Pierre C, THEN, Rudolf L
Published in Current pharmaceutical design (01.10.2007)
Published in Current pharmaceutical design (01.10.2007)
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Journal Article
The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms
Mac Sweeney, Aengus, Chambovey, Alain, Wicki, Micha, Müller, Manon, Artico, Nadia, Lange, Roland, Bijelic, Aleksandar, Breibeck, Joscha, Rompel, Annette
Published in PloS one (27.06.2018)
Published in PloS one (27.06.2018)
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Journal Article
Genetic Analysis and Functional Characterization of the Streptococcus pneumoniae vic Operon
WAGNER, Christian, DE SAIZIEU, Antoine, SCHÖNFELD, Hans-Joachim, KAMBER, Markus, LANGE, Roland, THOMPSON, Charles J, PAGE, Malcolm G
Published in Infection and Immunity (01.11.2002)
Published in Infection and Immunity (01.11.2002)
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Journal Article
Identification and characterization of stationary phase inducible genes in Escherichia coli
Weichart, Dieter, Lange, Roland, Henneberg, Nicola, Hengge-Aronis, Regine
Published in Molecular microbiology (01.10.1993)
Published in Molecular microbiology (01.10.1993)
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Journal Article
TnTIN and TnTAP: Mini-Transposons for Site-Specific Proteolysis in vivo
Ehrmann, Michael, Bolek, Petra, Mondigler, Martin, Boyd, Dana, Lange, Roland
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.1997)
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Journal Article
Identification of SARS-CoV-2 Mpro inhibitors through deep reinforcement learning for de novo drug design and computational chemistry approaches
Hazemann, Julien, Kimmerlin, Thierry, Lange, Roland, Sweeney, Aengus Mac, Bourquin, Geoffroy, Ritz, Daniel, Czodrowski, Paul
Published in MedChemComm (19.06.2024)
Published in MedChemComm (19.06.2024)
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Journal Article
Identification of SARS-CoV-2 Mpro inhibitors through deep reinforcement learning for drug design and computational chemistry approaches
Hazemann, Julien, Kimmerlin, Thierry, Lange, Roland, Sweeney, Aengus Mac, Bourquin, Geoffroy, Ritz, Daniel, Czodrowski, Paul
Published in RSC medicinal chemistry (19.06.2024)
Published in RSC medicinal chemistry (19.06.2024)
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Journal Article
Fragment‐based screening targeting an open form of the SARS‐CoV‐2 main protease binding pocket
Huang, Chia-Ying, Metz, Alexander, Lange, Roland, Artico, Nadia, Potot, Céline, Hazemann, Julien, Müller, Manon, Dos Santos, Marina, Chambovey, Alain, Ritz, Daniel, Eris, Deniz, Meyer, Solange, Bourquin, Geoffroy, Sharpe, May, Mac Sweeney, Aengus
Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2024)
Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2024)
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Journal Article
Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria
Surivet, Jean-Philippe, Panchaud, Philippe, Specklin, Jean-Luc, Diethelm, Stefan, Blumstein, Anne-Catherine, Gauvin, Jean-Christophe, Jacob, Loïc, Masse, Florence, Mathieu, Gaëlle, Mirre, Azely, Schmitt, Christine, Lange, Roland, Tidten-Luksch, Naomi, Gnerre, Carmela, Seeland, Swen, Herrmann, Charlyse, Seiler, Peter, Enderlin-Paput, Michel, Mac Sweeney, Aengus, Wicki, Micha, Hubschwerlen, Christian, Ritz, Daniel, Rueedi, Georg
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
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Journal Article
Optimization of LpxC Inhibitor Lead Compounds Focusing on Efficacy and Formulation for High Dose Intravenous Administration
Panchaud, Philippe, Surivet, Jean-Philippe, Diethelm, Stefan, Blumstein, Anne-Catherine, Gauvin, Jean-Christophe, Jacob, Loïc, Masse, Florence, Mathieu, Gaëlle, Mirre, Azely, Schmitt, Christine, Enderlin-Paput, Michel, Lange, Roland, Gnerre, Carmela, Seeland, Swen, Herrmann, Charlyse, Locher, Hans H, Seiler, Peter, Ritz, Daniel, Rueedi, Georg
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
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Journal Article
The Crystal Structure of E. coli 1-Deoxy- d-xylulose-5-phosphate Reductoisomerase in a Ternary Complex with the Antimalarial Compound Fosmidomycin and NADPH Reveals a Tight-binding Closed Enzyme Conformation
Mac Sweeney, Aengus, Lange, Roland, Fernandes, Roberta P.M., Schulz, Henk, Dale, Glenn E., Douangamath, Alice, Proteau, Philip J., Oefner, Christian
Published in Journal of molecular biology (07.01.2005)
Published in Journal of molecular biology (07.01.2005)
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Journal Article
Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity
Surivet, Jean-Philippe, Lange, Roland, Hubschwerlen, Christian, Keck, Wolfgang, Specklin, Jean-Luc, Ritz, Daniel, Bur, Daniel, Locher, Hans, Seiler, Peter, Strasser, Daniel Stefan, Prade, Lars, Kohl, Christopher, Schmitt, Christine, Chapoux, Gaëlle, Ilhan, Eser, Ekambaram, Nadia, Athanasiou, Alcibiade, Knezevic, Andreja, Sabato, Daniela, Chambovey, Alain, Gaertner, Mika, Enderlin, Michel, Boehme, Maria, Sippel, Virginie, Wyss, Pierre
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
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Journal Article
Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide
de Saizieu, A, Gardès, C, Flint, N, Wagner, C, Kamber, M, Mitchell, T J, Keck, W, Amrein, K E, Lange, R
Published in Journal of bacteriology (01.09.2000)
Published in Journal of bacteriology (01.09.2000)
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Journal Article
Domain organization and molecular characterization of 13 two-component systems identified by genome sequencing of Streptococcus pneumoniae
Lange, Roland, Wagner, Christian, de Saizieu, Antoine, Flint, Nicholas, Molnos, Juliette, Stieger, Martin, Caspers, Patrick, Kamber, Markus, Keck, Wolfgang, Amrein, Kurt E
Published in Gene (03.09.1999)
Published in Gene (03.09.1999)
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