Search Results - "LAMBING Joseph" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-( N, N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-( N, N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

by Zhang, Penglie, Huang, Wenrong, Wang, Lingyan, Bao, Liang, Jia, Zhaozhong J., Bauer, Shawn M., Goldman, Erick A., Probst, Gary D., Song, Yonghong, Su, Ting, Fan, Jingmei, Wu, Yanhong, Li, Wenhao, Woolfrey, John, Sinha, Uma, Wong, Paul W., Edwards, Susan T., Arfsten, Ann E., Clizbe, Lane A., Kanter, James, Pandey, Anjali, Park, Gary, Hutchaleelaha, Athiwat, Lambing, Joseph L., Hollenbach, Stanley J., Scarborough, Robert M., Zhu, Bing-Yan
Published in Bioorganic & medicinal chemistry letters (15.04.2009)

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Journal Article

ABSENCE OF QTC PROLONGATION WITH BETRIXABAN: A RANDOMIZED, DOUBLE-BLIND, PLACEBO- AND POSITIVE-CONTROLLED THOROUGH ECG STUDY

ABSENCE OF QTC PROLONGATION WITH BETRIXABAN: A RANDOMIZED, DOUBLE-BLIND, PLACEBO- AND POSITIVE-CONTROLLED THOROUGH ECG STUDY

by Sinha, Uma, Morganroth, Joel, Gretler, Daniel D, Hollenbach, Stanley J, Lambing, Joseph L
Published in Journal of the American College of Cardiology (12.03.2013)

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Journal Article

Absence of QTc prolongation with betrixaban: a randomized, double-blind, placebo- and positive-controlled thorough ECG study

Absence of QTc prolongation with betrixaban: a randomized, double-blind, placebo- and positive-controlled thorough ECG study

by Morganroth, Joel, Gretler, Daniel D, Hollenbach, Stanley J, Lambing, Joseph L, Sinha, Uma
Published in Expert opinion on pharmacotherapy (01.01.2013)

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Identification of Orally Active, Potent, and Selective 4-Piperazinylquinazolines as Antagonists of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase Family

Identification of Orally Active, Potent, and Selective 4-Piperazinylquinazolines as Antagonists of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase Family

by Pandey, Anjali, Volkots, Deborah L, Seroogy, Joseph M, Rose, Jack W, Yu, Jin-Chen, Lambing, Joseph L, Hutchaleelaha, Athiwat, Hollenbach, Stanley J, Abe, Keith, Giese, Neill A, Scarborough, Robert M
Published in Journal of medicinal chemistry (15.08.2002)

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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 3: Design, synthesis and sar of orally bioavailable benzamidine-P4 inhibitors

1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 3: Design, synthesis and sar of orally bioavailable benzamidine-P4 inhibitors

by JIA, Zhaozhong J, YANHONG WU, HOLLENNBACH, Stanley J, LAMBING, Joseph L, SCARBOROUGH, Robert M, ZHU, Bing-Yan, WENRONG HUANG, PENGLIE ZHANG, YONGHONG SONG, WOOLFREY, John, SINHA, Uma, ARFSTEN, Ann E, EDWARDS, Susan T, HUTCHALEELAHA, Athiwat
Published in Bioorganic & medicinal chemistry letters (08.03.2004)

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Journal Article

Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy: A Clinical Trial

Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy: A Clinical Trial

by Heitner, Stephen B, Jacoby, Daniel, Lester, Steven J, Owens, Anjali, Wang, Andrew, Zhang, David, Lambing, Joseph, Lee, June, Semigran, Marc, Sehnert, Amy J
Published in Annals of internal medicine (04.06.2019)

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Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs

Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs

by PENGLIE ZHANG, LIANG BAO, LAMBING, Joseph L, HOLLENBACH, Stanley J, SCARBOROUGH, Robert M, ZHU, Bing-Yan, ZUCKETT, Jingmei F, GOLDMAN, Erick A, JIA, Zhaozhong J, ARFSTEN, Ann, EDWARDS, Susan, SINHA, Uma, HUTCHALEELAHA, Athiwat, PARK, Gary
Published in Bioorganic & medicinal chemistry letters (23.02.2004)

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Journal Article

Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity

Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity

by PENGLIE ZHANG, LIANG BAO, HOLLENBACH, Stanley J, SCARBOROUGH, Robert M, ZHU, Bing-Yan, ZUCKETT, Jingmei F, JIA, Zhaozhong J, WOOLFREY, John, ARFSTEN, Ann, EDWARDS, Susan, SINHA, Uma, HUTCHALEELAHA, Athiwat, LAMBING, Joseph L
Published in Bioorganic & medicinal chemistry letters (23.02.2004)

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Journal Article

Discovery of Novel 2,8-Diazaspiro[4.5]decanes as Orally Active Glycoprotein IIb-IIIa Antagonists

Discovery of Novel 2,8-Diazaspiro[4.5]decanes as Orally Active Glycoprotein IIb-IIIa Antagonists

by Mehrotra, Mukund M., Heath, Julie A., Smyth, Mark S., Pandey, Anjali, Rose, Jack W., Seroogy, Joseph M., Volkots, Deborah L., Nannizzi-Alaimo, Lisa, Park, Gary L., Lambing, Joseph L., Hollenbach, Stanley J., Scarborough, Robert M.
Published in Journal of medicinal chemistry (08.04.2004)

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Journal Article

N, N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors

N, N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors

by JIA, Zhaozhong J, TING SU, WENRONG HUANG, WOOLFREY, John, SINHA, Uma, ARFSTEN, Ann E, HUTCHALEELAHA, Athiwat, HOLLENBACH, Stanley J, LAMBING, Joseph L, SCARBOROUGH, Robert M, ZHU, Bing-Yan, ZUCKETT, Jingmei F, YANHONG WU, GOLDMAN, Erick A, WENHAO LI, PENGLIE ZHANG, CLIZBE, Lane A, YONGHONG SONG, BAUER, Shawn M
Published in Bioorganic & medicinal chemistry letters (03.05.2004)

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Journal Article

Metabolism and Disposition of Betrixaban and Its Lack of Interaction with Major CYP Enzymes

Metabolism and Disposition of Betrixaban and Its Lack of Interaction with Major CYP Enzymes

by Hutchaleelaha, Athiwat, Ye, Christine, Song, Yonghong, Lorenz, Todd, Gretler, Daniel, Lambing, Joseph L
Published in Blood (16.11.2012)

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Journal Article

비대성 심근병증의 치료에서 사용하기 위한 마바캄텐

비대성 심근병증의 치료에서 사용하기 위한 마바캄텐

by LAMBING JOSEPH, SEMIGRAN MARC J, LEE JUNE H, EVANCHIK MARC, GREEN ERIC
Year of Publication 06.04.2020

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Patent

1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors

1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors

by Jia, Zhaozhong J., Wu, Yanhong, Huang, Wenrong, Zhang, Penglie, Song, Yonghong, Woolfrey, John, Sinha, Uma, Arfsten, Ann E., Edwards, Susan T., Hutchaleelaha, Athiwat, Hollennbach, Stanley J., Lambing, Joseph L., Scarborough, Robert M., Zhu, Bing-Yan
Published in Bioorganic & medicinal chemistry letters (01.03.2004)

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Journal Article

미오신 조절제를 사용한 치료 방법

미오신 조절제를 사용한 치료 방법

by MCDOWELL ROBERT, LAMBING JOSEPH, MEALIFFE MATTHEW EDWARDS, LI WANYING, MA GRACE YANFEI, FANG LIANG, AUBELE DANIELLE L, ZHANG DAVID, SEHNERT AMY, DEL RIO CARLOS L, LAMPL KATHY L, SEHL LOUIS CHARLES, CARLSON TIMOTHY, FERNANDES SARAH, SEMIGRAN MARC J, HENZE MARCUS PATRICK, NISSEN STEVE, DESAI MILIND Y, EDELBERG JAY M, KANE BRIAN EDMUND
Year of Publication 12.08.2022

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Patent

Abstract 16466: EXPLORER-HCM: Phase 3 Randomized, Multi-Center, Double-Blind, Placebo-Controlled Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Abstract 16466: EXPLORER-HCM: Phase 3 Randomized, Multi-Center, Double-Blind, Placebo-Controlled Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy

by Olivotto, Iacopo, Ho, Carolyn, Jacoby, Daniel, Lester, Steven, Roe, Matthew, Wang, Andrew, Tamby, Jean-Francois, Lambing, Joseph, Lee, June, Zhang, David, Sehnert, Amy, Heitner, Stephen
Published in Circulation (New York, N.Y.) (06.11.2018)

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Journal Article

Abstract 16842: Obstructive Hypertrophic Cardiomyopathy: Initial Single Ascending Dose Data in Healthy Volunteers and Patients

Abstract 16842: Obstructive Hypertrophic Cardiomyopathy: Initial Single Ascending Dose Data in Healthy Volunteers and Patients

by Maron, Martin, Ashley, Euan, Blok, Thomas, Evanchik, Marc, Lambing, Joseph, Lester, Steven, Mahaffey, Kenneth, Markova, Svetlana, Owens, Anjali, Ritter, James, Wang, Andrew, Fox, Jonathan
Published in Circulation (New York, N.Y.) (11.11.2016)

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Journal Article

Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido )-5-metho xybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido )-5-metho xybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

by Zhang, Penglie, Huang, Wenrong, Wang, Lingyan, Bao, Liang, Jia, Zhaozhong J, Bauer, Shawn M, Goldman, Erick A, Probst, Gary D, Song, Yonghong, Su, Ting, Fan, Jingmei, Wu, Yanhong, Li, Wenhao, Woolfrey, John, Sinha, Uma, Wong, Paul W, Edwards, Susan T, Arfsten, Ann E, Clizbe, Lane A, Kanter, James, Pandey, Anjali, Park, Gary, Hutchaleelaha, Athiwat, Lambing, Joseph L, Hollenbach, Stanley J, Scarborough, Robert M, Zhu, Bing-Yan
Published in Bioorganic & medicinal chemistry letters (01.04.2009)

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Journal Article

Treatment of HCM with pyrimidinedione compounds

Treatment of HCM with pyrimidinedione compounds

by ZHANG, David, CARLSON, Timothy, LAMBING, Joseph, LEE, June H, SEMIGRAN, Marc J, GREEN, Eric, EVANCHIK, Marc
Year of Publication 27.06.2024

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Patent

Mavacamten for use in the treatment of hypertrophic cardiomyopathy

Mavacamten for use in the treatment of hypertrophic cardiomyopathy

by ZHANG, David, CARLSON, Timothy, LAMBING, Joseph, LEE, June H, SEMIGRAN, Marc J, GREEN, Eric, EVANCHIK, Marc
Year of Publication 07.03.2024

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Patent

TREATMENT OF HCM WITH PYRIMIDINEDIONE COMPOUNDS

TREATMENT OF HCM WITH PYRIMIDINEDIONE COMPOUNDS

by Carlson, Timothy, Lee, June H, Lambing, Joseph, Evanchik, Marc, Green, Eric, Semigran, Marc J, Zhang, David
Year of Publication 06.10.2022

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Patent