Adaptive mutability of colorectal cancers in response to targeted therapies
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Published in Science (American Association for the Advancement of Science) (20.12.2019)
Published in Science (American Association for the Advancement of Science) (20.12.2019)
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High-dose vitamin C enhances cancer immunotherapy
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Published in Science translational medicine (26.02.2020)
Published in Science translational medicine (26.02.2020)
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Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
Siravegna, Giulia, Mussolin, Benedetta, Buscarino, Michela, Corti, Giorgio, Cassingena, Andrea, Crisafulli, Giovanni, Ponzetti, Agostino, Cremolini, Chiara, Amatu, Alessio, Lauricella, Calogero, Lamba, Simona, Hobor, Sebastijan, Avallone, Antonio, Valtorta, Emanuele, Rospo, Giuseppe, Medico, Enzo, Motta, Valentina, Antoniotti, Carlotta, Tatangelo, Fabiana, Bellosillo, Beatriz, Veronese, Silvio, Budillon, Alfredo, Montagut, Clara, Racca, Patrizia, Marsoni, Silvia, Falcone, Alfredo, Corcoran, Ryan B, Di Nicolantonio, Federica, Loupakis, Fotios, Siena, Salvatore, Sartore-Bianchi, Andrea, Bardelli, Alberto
Published in Nature medicine (01.07.2015)
Published in Nature medicine (01.07.2015)
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The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets
Medico, Enzo, Russo, Mariangela, Picco, Gabriele, Cancelliere, Carlotta, Valtorta, Emanuele, Corti, Giorgio, Buscarino, Michela, Isella, Claudio, Lamba, Simona, Martinoglio, Barbara, Veronese, Silvio, Siena, Salvatore, Sartore-Bianchi, Andrea, Beccuti, Marco, Mottolese, Marcella, Linnebacher, Michael, Cordero, Francesca, Di Nicolantonio, Federica, Bardelli, Alberto
Published in Nature communications (30.04.2015)
Published in Nature communications (30.04.2015)
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Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer
Misale, Sandra, Arena, Sabrina, Lamba, Simona, Siravegna, Giulia, Lallo, Alice, Hobor, Sebastijan, Russo, Mariangela, Buscarino, Michela, Lazzari, Luca, Sartore-Bianchi, Andrea, Bencardino, Katia, Amatu, Alessio, Lauricella, Calogero, Valtorta, Emanuele, Siena, Salvatore, Di Nicolantonio, Federica, Bardelli, Alberto
Published in Science translational medicine (19.02.2014)
Published in Science translational medicine (19.02.2014)
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Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature
Gilles, Maud-Emmanuelle, Maione, Federica, Cossutta, Mélissande, Carpentier, Gilles, Caruana, Laure, Di Maria, Silvia, Houppe, Claire, Destouches, Damien, Shchors, Ksenya, Prochasson, Christopher, Mongelard, Fabien, Lamba, Simona, Bardelli, Alberto, Bouvet, Philippe, Couvelard, Anne, Courty, José, Giraudo, Enrico, Cascone, Ilaria
Published in Cancer research (Chicago, Ill.) (15.12.2016)
Published in Cancer research (Chicago, Ill.) (15.12.2016)
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Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer
Sartore-Bianchi, Andrea, Di Nicolantonio, Federica, Nichelatti, Michele, Molinari, Francesca, De Dosso, Sara, Saletti, Piercarlo, Martini, Miriam, Cipani, Tiziana, Marrapese, Giovanna, Mazzucchelli, Luca, Lamba, Simona, Veronese, Silvio, Frattini, Milo, Bardelli, Alberto, Siena, Salvatore
Published in PloS one (02.10.2009)
Published in PloS one (02.10.2009)
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Erratum: Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
Siravegna, Giulia, Mussolin, Benedetta, Buscarino, Michela, Corti, Giorgio, Cassingena, Andrea, Crisafulli, Giovanni, Ponzetti, Agostino, Cremolini, Chiara, Amatu, Alessio, Lauricella, Calogero, Lamba, Simona, Hobor, Sebastijan, Avallone, Antonio, Valtorta, Emanuele, Rospo, Giuseppe, Medico, Enzo, Motta, Valentina, Antoniotti, Carlotta, Tatangelo, Fabiana, Bellosillo, Beatriz, Veronese, Silvio, Budillon, Alfredo, Montagut, Clara, Racca, Patrizia, Marsoni, Silvia, Falcone, Alfredo, Corcoran, Ryan B, Di Nicolantonio, Federica, Loupakis, Fotios, Siena, Salvatore, Sartore-Bianchi, Andrea, Bardelli, Alberto
Published in Nature medicine (01.07.2015)
Published in Nature medicine (01.07.2015)
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The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone
Molenaar, Remco J, Verbaan, Dagmar, Lamba, Simona, Zanon, Carlo, Jeuken, Judith W M, Boots-Sprenger, Sandra H E, Wesseling, Pieter, Hulsebos, Theo J M, Troost, Dirk, van Tilborg, Angela A, Leenstra, Sieger, Vandertop, W Peter, Bardelli, Alberto, van Noorden, Cornelis J F, Bleeker, Fonnet E
Published in Neuro-oncology (Charlottesville, Va.) (01.09.2014)
Published in Neuro-oncology (Charlottesville, Va.) (01.09.2014)
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KRAS gene amplification in colorectal cancer and impact on response to EGFR‐targeted therapy
Valtorta, Emanuele, Misale, Sandra, Sartore‐Bianchi, Andrea, Nagtegaal, Iris D., Paraf, François, Lauricella, Calogero, Dimartino, Valentina, Hobor, Sebastijan, Jacobs, Bart, Ercolani, Cristiana, Lamba, Simona, Scala, Elisa, Veronese, Silvio, Laurent‐Puig, Pierre, Siena, Salvatore, Tejpar, Sabine, Mottolese, Marcella, Punt, Cornelis J.A., Gambacorta, Marcello, Bardelli, Alberto, Nicolantonio, Federica
Published in International journal of cancer (01.09.2013)
Published in International journal of cancer (01.09.2013)
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RAF Suppression Synergizes with MEK Inhibition in KRAS Mutant Cancer Cells
Lamba, Simona, Russo, Mariangela, Sun, Chong, Lazzari, Luca, Cancelliere, Carlotta, Grernrum, Wipawadee, Lieftink, Cor, Bernards, Rene, Di Nicolantonio, Federica, Bardelli, Alberto
Published in Cell reports (Cambridge) (11.09.2014)
Published in Cell reports (Cambridge) (11.09.2014)
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Dual VEGFA/BRAF targeting boosts PD‐1 blockade in melanoma through GM‐CSF‐mediated infiltration of M1 macrophages
Comunanza, Valentina, Gigliotti, Chiara, Lamba, Simona, Doronzo, Gabriella, Vallariello, Edoardo, Martin, Valentina, Isella, Claudio, Medico, Enzo, Bardelli, Alberto, Sangiolo, Dario, Di Nicolantonio, Federica, Bussolino, Federico
Published in Molecular oncology (01.08.2023)
Published in Molecular oncology (01.08.2023)
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Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer
Rospo, Giuseppe, Chilà, Rosaria, Matafora, Vittoria, Basso, Veronica, Lamba, Simona, Bartolini, Alice, Bachi, Angela, Di Nicolantonio, Federica, Mondino, Anna, Germano, Giovanni, Bardelli, Alberto
Published in Genome medicine (19.01.2024)
Published in Genome medicine (19.01.2024)
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Preclinical efficacy of carfilzomib in BRAF‐mutant colorectal cancer models
Maione, Federica, Oddo, Daniele, Galvagno, Federica, Falcomatà, Chiara, Pandini, Marta, Macagno, Marco, Pessei, Valeria, Barault, Ludovic, Gigliotti, Chiara, Mira, Alessia, Corti, Giorgio, Lamba, Simona, Riganti, Chiara, Castella, Barbara, Massaia, Massimo, Rad, Roland, Saur, Dieter, Bardelli, Alberto, Di Nicolantonio, Federica
Published in Molecular oncology (01.06.2024)
Published in Molecular oncology (01.06.2024)
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Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies
Russo, Mariangela, Lamba, Simona, Lorenzato, Annalisa, Sogari, Alberto, Corti, Giorgio, Rospo, Giuseppe, Mussolin, Benedetta, Montone, Monica, Lazzari, Luca, Arena, Sabrina, Oddo, Daniele, Linnebacher, Michael, Sartore-Bianchi, Andrea, Pietrantonio, Filippo, Siena, Salvatore, Di Nicolantonio, Federica, Bardelli, Alberto
Published in Nature communications (12.06.2018)
Published in Nature communications (12.06.2018)
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Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer
Oddo, Daniele, Siravegna, Giulia, Gloghini, Annunziata, Vernieri, Claudio, Mussolin, Benedetta, Morano, Federica, Crisafulli, Giovanni, Berenato, Rosa, Corti, Giorgio, Volpi, Chiara Costanza, Buscarino, Michela, Niger, Monica, Dunne, Philip D, Rospo, Giuseppe, Valtorta, Emanuele, Bartolini, Alice, Fucà, Giovanni, Lamba, Simona, Martinetti, Antonia, Di Bartolomeo, Maria, de Braud, Filippo, Bardelli, Alberto, Pietrantonio, Filippo, Di Nicolantonio, Federica
Published in British journal of cancer (25.07.2017)
Published in British journal of cancer (25.07.2017)
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DNA demethylation triggers cell free DNA release in colorectal cancer cells
Pessei, Valeria, Macagno, Marco, Mariella, Elisa, Congiusta, Noemi, Battaglieri, Vittorio, Battuello, Paolo, Viviani, Marco, Gionfriddo, Giulia, Lamba, Simona, Lorenzato, Annalisa, Oddo, Daniele, Idrees, Fariha, Cavaliere, Alessandro, Bartolini, Alice, Guarrera, Simonetta, Linnebacher, Michael, Monteonofrio, Laura, Cardone, Luca, Milella, Michele, Bertotti, Andrea, Soddu, Silvia, Grassi, Elena, Crisafulli, Giovanni, Bardelli, Alberto, Barault, Ludovic, Di Nicolantonio, Federica
Published in Genome medicine (09.10.2024)
Published in Genome medicine (09.10.2024)
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Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma
BALAKRISHNAN, Asha, BLEEKER, Fonnet E, LAMBA, Simona, RODOLFO, Monica, DANIOTTI, Maria, SCARPA, Aldo, VAN TILBORG, Angela A, LEENSTRA, Sieger, ZANON, Carlo, BARDELLI, Alberto
Published in Cancer research (Chicago, Ill.) (15.04.2007)
Published in Cancer research (Chicago, Ill.) (15.04.2007)
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Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses
Di Nicolantonio, Federica, Arena, Sabrina, Gallicchio, Margherita, Zecchin, Davide, Martini, Miriam, Flonta, Simona Emilia, Stella, Giulia Maria, Lamba, Simona, Cancelliere, Carlotta, Russo, Mariangela, Geuna, Massimo, Appendino, Giovanni, Fantozzi, Roberto, Medico, Enzo, Bardelli, Alberto
Published in Proceedings of the National Academy of Sciences - PNAS (30.12.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (30.12.2008)
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EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer
Amodio, Vito, Yaeger, Rona, Arcella, Pamela, Cancelliere, Carlotta, Lamba, Simona, Lorenzato, Annalisa, Arena, Sabrina, Montone, Monica, Mussolin, Benedetta, Bian, Yu, Whaley, Adele, Pinnelli, Marika, Murciano-Goroff, Yonina R., Vakiani, Efsevia, Valeri, Nicola, Liao, Wei-Li, Bhalkikar, Anuja, Thyparambil, Sheeno, Zhao, Hui-Yong, de Stanchina, Elisa, Marsoni, Silvia, Siena, Salvatore, Bertotti, Andrea, Trusolino, Livio, Li, Bob T., Rosen, Neal, Di Nicolantonio, Federica, Bardelli, Alberto, Misale, Sandra
Published in Cancer discovery (01.08.2020)
Published in Cancer discovery (01.08.2020)
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