Phase Ib Study of Glasdegib, a Hedgehog Pathway Inhibitor, in Combination with Standard Chemotherapy in Patients with AML or High-Risk MDS
Savona, Michael R, Pollyea, Daniel A, Stock, Wendy, Oehler, Vivian G, Schroeder, Mark A, Lancet, Jeffrey, McCloskey, James, Kantarjian, Hagop M, Ma, Weidong Wendy, Shaik, M Naveed, Laird, A Douglas, Zeremski, Mirjana, O'Connell, Ashleigh, Chan, Geoffrey, Cortes, Jorge E
Published in Clinical cancer research (15.05.2018)
Published in Clinical cancer research (15.05.2018)
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Glasdegib in combination with cytarabine and daunorubicin in patients with AML or high‐risk MDS: Phase 2 study results
Cortes, Jorge E., Douglas Smith, B., Wang, Eunice S., Merchant, Akil, Oehler, Vivian G., Arellano, Martha, DeAngelo, Daniel J., Pollyea, Daniel A., Sekeres, Mikkael A., Robak, Tadeusz, Ma, Weidong Wendy, Zeremski, Mirjana, Naveed Shaik, M., Douglas Laird, A., O'Connell, Ashleigh, Chan, Geoffrey, Schroeder, Mark A.
Published in American journal of hematology (01.11.2018)
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Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth
Yakes, F Michael, Chen, Jason, Tan, Jenny, Yamaguchi, Kyoko, Shi, Yongchang, Yu, Peiwen, Qian, Fawn, Chu, Felix, Bentzien, Frauke, Cancilla, Belinda, Orf, Jessica, You, Andrew, Laird, A Douglas, Engst, Stefan, Lee, Lillian, Lesch, Justin, Chou, Yu-Chien, Joly, Alison H
Published in Molecular cancer therapeutics (01.12.2011)
Published in Molecular cancer therapeutics (01.12.2011)
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Inotuzumab Ozogamicin for Relapsed/Refractory Acute Lymphoblastic Leukemia in the INO-VATE Trial: CD22 Pharmacodynamics, Efficacy, and Safety by Baseline CD22
Kantarjian, Hagop M, Stock, Wendy, Cassaday, Ryan D, DeAngelo, Daniel J, Jabbour, Elias, O'Brien, Susan M, Stelljes, Matthias, Wang, Tao, Paccagnella, M Luisa, Nguyen, Kevin, Sleight, Barbara, Vandendries, Erik, Neuhof, Alexander, Laird, A Douglas, Advani, Anjali S
Published in Clinical cancer research (15.05.2021)
Published in Clinical cancer research (15.05.2021)
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Determinants of Response to Talazoparib in Patients with HER2-Negative, Germline BRCA1/2-Mutated Breast Cancer
Blum, Joanne L, Laird, A Douglas, Litton, Jennifer K, Rugo, Hope S, Ettl, Johannes, Hurvitz, Sara A, Martin, Miguel, Roché, Henri H, Lee, Kyung-Hun, Goodwin, Annabel, Chen, Ying, Lanzalone, Silvana, Chelliserry, Jijumon, Czibere, Akos, Hopkins, Julia F, Albacker, Lee A, Mina, Lida A
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Published in Clinical cancer research (01.04.2022)
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Inotuzumab ozogamicin in adults with relapsed or refractory CD22-positive acute lymphoblastic leukemia: a phase 1/2 study
DeAngelo, Daniel J., Stock, Wendy, Stein, Anthony S., Shustov, Andrei, Liedtke, Michaela, Schiffer, Charles A., Vandendries, Erik, Liau, Katherine, Ananthakrishnan, Revathi, Boni, Joseph, Laird, A. Douglas, Fostvedt, Luke, Kantarjian, Hagop M., Advani, Anjali S.
Published in Blood advances (27.06.2017)
Published in Blood advances (27.06.2017)
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Cabozantinib in chemotherapy-pretreated metastatic castration-resistant prostate cancer: results of a phase II nonrandomized expansion study
Smith, Matthew R, Sweeney, Christopher J, Corn, Paul G, Rathkopf, Dana E, Smith, David C, Hussain, Maha, George, Daniel J, Higano, Celestia S, Harzstark, Andrea L, Sartor, A Oliver, Vogelzang, Nicholas J, Gordon, Michael S, de Bono, Johann S, Haas, Naomi B, Logothetis, Christopher J, Elfiky, Aymen, Scheffold, Christian, Laird, A Douglas, Schimmoller, Frauke, Basch, Ethan M, Scher, Howard I
Published in Journal of clinical oncology (20.10.2014)
Published in Journal of clinical oncology (20.10.2014)
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In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
MENDEL, Dirk B, LAIRD, A. Douglas, MURRAY, Lesley J, CARVER, Jeremy, CHAN, Emily, MOSS, Katherine G, HAZNEDAR, Joshua Ö, SUKBUNTHERNG, Juthamas, BLAKE, Robert A, LI SUN, CHO TANG, MILLER, Todd, XIAOHUA XIN, SHIRAZIAN, Sheri, MCMAHON, Gerald, CHERRINGTON, Julie M, LOUIE, Sharianne G, CHRISTENSEN, James G, GUANGMIN LI, SCHRECK, Randall E, ABRAMS, Tinya J, NGAI, Theresa J, LEE, Leslie B
Published in Clinical cancer research (2003)
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Published in Clinical cancer research (2003)
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The Selective PI3K Inhibitor XL147 (SAR245408) Inhibits Tumor Growth and Survival and Potentiates the Activity of Chemotherapeutic Agents in Preclinical Tumor Models
Foster, Paul, Yamaguchi, Kyoko, Hsu, Pin P, Qian, Fawn, Du, Xiangnan, Wu, Jianming, Won, Kwang-Ai, Yu, Peiwen, Jaeger, Christopher T, Zhang, Wentao, Marlowe, Charles K, Keast, Paul, Abulafia, Wendy, Chen, Jason, Young, Jenny, Plonowski, Artur, Yakes, F Michael, Chu, Felix, Engell, Kelly, Bentzien, Frauke, Lam, Sanh T, Dale, Stephanie, Yturralde, Olivia, Matthews, David J, Lamb, Peter, Laird, A Douglas
Published in Molecular cancer therapeutics (01.04.2015)
Published in Molecular cancer therapeutics (01.04.2015)
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Avelumab in Combination Regimens for Relapsed/Refractory DLBCL: Results from the Phase Ib JAVELIN DLBCL Study
Hawkes, Eliza A., Phillips, Tycel, Budde, Lihua Elizabeth, Santoro, Armando, Saba, Nakhle S., Roncolato, Fernando, Gregory, Gareth P., Verhoef, Gregor, Offner, Fritz, Quero, Cristina, Radford, John, Giannopoulos, Krzysztof, Stevens, Don, Thall, Aron, Huang, Bo, Laird, A. Douglas, Sandner, Robin, Ansell, Stephen M.
Published in Targeted oncology (01.11.2021)
Published in Targeted oncology (01.11.2021)
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The design, synthesis, and biological evaluation of PIM kinase inhibitors
Tsuhako, Amy Lew, Brown, David S., Koltun, Elena S., Aay, Naing, Arcalas, Arlyn, Chan, Vicky, Du, Hongwang, Engst, Stefan, Franzini, Maurizio, Galan, Adam, Huang, Ping, Johnston, Stuart, Kane, Brian, Kim, Moon H., Douglas Laird, A., Lin, Rui, Mock, Lillian, Ngan, Iris, Pack, Michael, Stott, Gordon, Stout, Thomas J., Yu, Peiwen, Zaharia, Cristiana, Zhang, Wentao, Zhou, Peiwen, Nuss, John M., Kearney, Patrick C., Xu, Wei
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
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Genomic analysis of advanced breast cancer tumors from talazoparib-treated gBRCA1/2mut carriers in the ABRAZO study
Turner, Nicholas C., Laird, A. Douglas, Telli, Melinda L., Rugo, Hope S., Mailliez, Audrey, Ettl, Johannes, Grischke, Eva-Maria, Mina, Lida A., Balmaña, Judith, Fasching, Peter A., Hurvitz, Sara A., Hopkins, Julia F., Albacker, Lee A., Chelliserry, Jijumon, Chen, Ying, Conte, Umberto, Wardley, Andrew M., Robson, Mark E.
Published in NPJ breast cancer (06.10.2023)
Published in NPJ breast cancer (06.10.2023)
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Contribution of individual targets to the antitumor efficacy of the multitargeted receptor tyrosine kinase inhibitor SU11248
Potapova, Olga, Laird, A Douglas, Nannini, Michelle A, Barone, Angela, Li, Guangmin, Moss, Katherine G, Cherrington, Julie M, Mendel, Dirk B
Published in Molecular cancer therapeutics (01.05.2006)
Published in Molecular cancer therapeutics (01.05.2006)
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Randomized comparison of low dose cytarabine with or without glasdegib in patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome
Cortes, Jorge E., Heidel, Florian H., Hellmann, Andrzej, Fiedler, Walter, Smith, B. Douglas, Robak, Tadeusz, Montesinos, Pau, Pollyea, Daniel A., DesJardins, Pierre, Ottmann, Oliver, Ma, Weidong Wendy, Shaik, M. Naveed, Laird, A. Douglas, Zeremski, Mirjana, O’Connell, Ashleigh, Chan, Geoffrey, Heuser, Michael
Published in Leukemia (01.02.2019)
Published in Leukemia (01.02.2019)
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Talazoparib monotherapy in metastatic castration-resistant prostate cancer with DNA repair alterations (TALAPRO-1): an open-label, phase 2 trial
de Bono, Johann S, Mehra, Niven, Scagliotti, Giorgio V, Castro, Elena, Dorff, Tanya, Stirling, Adam, Stenzl, Arnulf, Fleming, Mark T, Higano, Celestia S, Saad, Fred, Buttigliero, Consuelo, van Oort, Inge M, Laird, A Douglas, Mata, Marielena, Chen, Hsiang-Chun, Healy, Cynthia G, Czibere, Akos, Fizazi, Karim
Published in The lancet oncology (01.09.2021)
Published in The lancet oncology (01.09.2021)
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SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity
Patyna, Shem, Laird, A Douglas, Mendel, Dirk B, O'farrell, Anne-Marie, Liang, Chris, Guan, Huiping, Vojkovsky, Tomas, Vasile, Stefan, Wang, Xueyan, Chen, Jeffrey, Grazzini, Maren, Yang, Cheng Y, Haznedar, Joshua O, Sukbuntherng, Juthamas, Zhong, Wei-Zhu, Cherrington, Julie M, Hu-Lowe, Dana
Published in Molecular cancer therapeutics (01.07.2006)
Published in Molecular cancer therapeutics (01.07.2006)
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Inhibition of the T790M Gatekeeper Mutant of the Epidermal Growth Factor Receptor by EXEL-7647
GENDREAU, Steven B, VENTURA, Richard, JACKMAN, Lisa, YONGCHANG SHI, PEIWEN YU, JING WANG, AFTAB, Dana T, JAEGER, Christopher T, MEYER, Stephanie M, DE COSTA, Anushka, ENGELL, Kelly, CHEN, Jason, KEAST, Paul, MARTINI, Jean-Francois, JOLY, Alison H, LAIRD, A. Douglas, YAKES, F. Michael, WENTAO ZHANG, BENTZIEN, Frauke, CANCILLA, Belinda, LUTMAN, Jeffery, CHU, Felix
Published in Clinical cancer research (15.06.2007)
Published in Clinical cancer research (15.06.2007)
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Small molecule tyrosine kinase inhibitors: clinical development of anticancer agents
Laird, A Douglas, Cherrington, Julie M
Published in Expert opinion on investigational drugs (01.01.2003)
Published in Expert opinion on investigational drugs (01.01.2003)
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Hair Depigmentation Is a Biological Readout for Pharmacological Inhibition of KIT in Mice and Humans
Moss, Katherine G, Toner, Guy C, Cherrington, Julie M, Mendel, Dirk B, Laird, A Douglas
Published in The Journal of pharmacology and experimental therapeutics (01.11.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2003)
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First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial
Fizazi, Karim, Azad, Arun A., Matsubara, Nobuaki, Carles, Joan, Fay, Andre P., De Giorgi, Ugo, Joung, Jae Young, Fong, Peter C. C., Voog, Eric, Jones, Robert J., Shore, Neal D., Dunshee, Curtis, Zschäbitz, Stefanie, Oldenburg, Jan, Ye, Dingwei, Lin, Xun, Healy, Cynthia G., Di Santo, Nicola, Laird, A. Douglas, Zohren, Fabian, Agarwal, Neeraj
Published in Nature medicine (2024)
Published in Nature medicine (2024)
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