Search Results - "LAINCHBURY, MICHAEL" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Structure-Based Optimization of a Series of Covalent, Cell Active Bfl‑1 Inhibitors

Structure-Based Optimization of a Series of Covalent, Cell Active Bfl‑1 Inhibitors

by Lucas, Simon C. C., Blackwell, J. Henry, Börjesson, Ulf, Hargreaves, David, Milbradt, Alexander G., Bostock, Mark J., Ahmed, Samiyah, Beaumont, Kevin, Cheung, Tony, Demanze, Sylvain, Gohlke, Andrea, Guerot, Carine, Haider, Afreen, Kantae, Vasudev, Kauffman, Gregory W., Kinzel, Olaf, Kupcova, Lea, Lainchbury, Michael D., Lamb, Michelle L., Leon, Leonardo, Palisse, Adeline, Sacchetto, Claudia, Storer, R. Ian, Su, Nancy, Thomson, Clare, Vales, John, Chen, Yunhua, Hu, Xiaolong
Published in Journal of medicinal chemistry (26.09.2024)

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Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation

Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation

by Hanan, Emily J, Eigenbrot, Charles, Bryan, Marian C, Burdick, Daniel J, Chan, Bryan K, Chen, Yuan, Dotson, Jennafer, Heald, Robert A, Jackson, Philip S, La, Hank, Lainchbury, Michael D, Malek, Shiva, Purkey, Hans E, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen M, Sideris, Steve, Tam, Christine, Wang, Shumei, Yeap, Siew Kuen, Yen, Ivana, Yin, Jianping, Yu, Christine, Zilberleyb, Inna, Heffron, Timothy P
Published in Journal of medicinal chemistry (11.12.2014)

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Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor

Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor

by Chan, Bryan K, Hanan, Emily J, Bowman, Krista K, Bryan, Marian C, Burdick, Daniel, Chan, Emily, Chen, Yuan, Clausen, Saundra, Dela Vega, Trisha, Dotson, Jennafer, Eigenbrot, Charles, Elliott, Richard L, Heald, Robert A, Jackson, Philip S, Knight, Jamie D, La, Hank, Lainchbury, Michael D, Malek, Shiva, Purkey, Hans E, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen M, Sideris, Steve, Shao, Lily, Wang, Shumei, Yeap, Siew Kuen, Yen, Ivana, Yu, Christine, Heffron, Timothy P
Published in Journal of medicinal chemistry (13.10.2016)

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A Protecting Group Free Synthesis of (±)-Neostenine via the [5 + 2] Photocycloaddition of Maleimides

A Protecting Group Free Synthesis of (±)-Neostenine via the [5 + 2] Photocycloaddition of Maleimides

by Lainchbury, Michael D, Medley, Marcus I, Taylor, Piers M, Hirst, Paul, Dohle, Wolfgang, Booker-Milburn, Kevin I
Published in Journal of organic chemistry (05.09.2008)

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Checkpoint kinase inhibitors: a patent review (2009 - 2010)

Checkpoint kinase inhibitors: a patent review (2009 - 2010)

by Lainchbury, Michael, Collins, Ian
Published in Expert opinion on therapeutic patents (01.08.2011)

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Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study

Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study

by Heald, Robert, Bowman, Krista K, Bryan, Marian C, Burdick, Daniel, Chan, Bryan, Chan, Emily, Chen, Yuan, Clausen, Saundra, Dominguez-Fernandez, Belen, Eigenbrot, Charles, Elliott, Richard, Hanan, Emily J, Jackson, Philip, Knight, Jamie, La, Hank, Lainchbury, Michael, Malek, Shiva, Mann, Sam, Merchant, Mark, Mortara, Kyle, Purkey, Hans, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen, Sideris, Steve, Shao, Lily, Wang, Shumei, Yeap, Kuen, Yen, Ivana, Yu, Christine, Heffron, Timothy P
Published in Journal of medicinal chemistry (25.11.2015)

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Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1

Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1

by Tellis, John C, Wei, BinQing, Siu, Michael, An, Le, Chan, Grace Kayan, Chen, Yong, Du, Xiangnan, Gazzard, Lewis, Hu, Baihua, Kiefer, James, Kakiuchi-Kiyota, Satoko, Lainchbury, Michael, Linehan, Jonathan L, Luo, Xifeng, Malhotra, Sushant, Mendonca, Rohan, Pang, Jodie, Ran, Yinqing, Sethuraman, Vijay, Seward, Eileen, Sneeringer, Chris, Su, Dian, Wang, Weiru, Wu, Ping, Moffat, John G, Heffron, Timothy P, Choo, Edna F, Chan, Bryan K
Published in ACS medicinal chemistry letters (12.09.2024)

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The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eμ-MYC driven B-cell lymphoma

The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eμ-MYC driven B-cell lymphoma

by Walton, Mike I., Eve, Paul D., Hayes, Angela, Henley, Alan T., Valenti, Melanie R., De Haven Brandon, Alexis K., Box, Gary, Boxall, Kathy J., Tall, Matthew, Swales, Karen, Matthews, Thomas P., McHardy, Tatiana, Lainchbury, Michael, Osborne, James, Hunter, Jill E., Perkins, Neil D., Aherne, G. Wynne, Reader, John C., Raynaud, Florence I., Eccles, Suzanne A., Collins, Ian, Garrett, Michelle D.
Published in Oncotarget (19.01.2016)

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Fragment screening at AstraZeneca: developing the next generation biophysics fragment set

Fragment screening at AstraZeneca: developing the next generation biophysics fragment set

by Lucas, Simon C. C, Börjesson, Ulf, Bostock, Mark J, Cuff, John, Edfeldt, Fredrik, Embrey, Kevin J, Eriksson, Per-Olof, Gohlke, Andrea, Gunnarson, Anders, Lainchbury, Michael, Milbradt, Alexander G, Moore, Rachel, Rawlins, Philip B, Sinclair, Ian, Stubbs, Christopher, Storer, R. Ian
Published in MedChemComm (21.09.2022)

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Journal Article

5-[[4-[[-2-]]-5--2-]]-2- 5-[[4-[[MORPHOLIN-2-YL]METHYLAMINO]-5-TRIFLUOROMETHYL-2-PYRIDYL]AMINO]PYRAZINE-2-CARBONITRILE AND THERAPEUTIC USES THEREOF

5-[[4-[[-2-]]-5--2-]]-2- 5-[[4-[[MORPHOLIN-2-YL]METHYLAMINO]-5-TRIFLUOROMETHYL-2-PYRIDYL]AMINO]PYRAZINE-2-CARBONITRILE AND THERAPEUTIC USES THEREOF

by LAINCHBURY MICHAEL, MATTHEWS THOMAS PETER, FARIA DA FONSECA MCHARDY TATIANA, OSBORNE JAMES, WALTON MICHAEL IAN, GARRETT MICHELLE DAWN, COLLINS IAN
Year of Publication 22.02.2024

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Patent

CCT244747 Is a Novel Potent and Selective CHK1 Inhibitor with Oral Efficacy Alone and in Combination with Genotoxic Anticancer Drugs

CCT244747 Is a Novel Potent and Selective CHK1 Inhibitor with Oral Efficacy Alone and in Combination with Genotoxic Anticancer Drugs

by WALTON, Mike I, EVE, Paul D, MATTHEWS, Thomas P, JAMIN, Yann, ROBINSON, Simon P, WYNNEAHERNE, G, READER, John C, CHESLER, Louis, RAYNAUD, Florence I, ECCLES, Suzanne A, COLLINS, Ian, GARRETT, Michelle D, HAYES, Angela, VALENTI, Melanie R, DE HAVEN BRANDON, Alexis K, BOX, Gary, HALLSWORTH, Albert, SMITH, Elizabeth L, BOXALL, Kathy J, LAINCHBURY, Michael
Published in Clinical cancer research (15.10.2012)

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Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1)

Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1)

by Chan, Bryan K, Seward, Eileen, Lainchbury, Michael, Brewer, Thomas F, An, Le, Blench, Toby, Cartwright, Matthew W, Chan, Grace Ka Yan, Choo, Edna F, Drummond, Jason, Elliott, Richard L, Gancia, Emanuela, Gazzard, Lewis, Hu, Baihua, Jones, Graham E, Luo, Xifeng, Madin, Andrew, Malhotra, Sushant, Moffat, John G, Pang, Jodie, Salphati, Laurent, Sneeringer, Christopher J, Stivala, Craig E, Wei, Binqing, Wang, Weiru, Wu, Ping, Heffron, Timothy P
Published in ACS medicinal chemistry letters (13.01.2022)

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5-[[4-[[-2-]]-5--2-]]-2- 5-[[4-[[MORPHOLIN-2-YL]METHYLAMINO]-5-TRIFLUOROMETHYL-2-PYRIDYL]AMINO]PYRAZINE-2-CARBONITRILE AND THERAPEUTIC USES THEREOF

5-[[4-[[-2-]]-5--2-]]-2- 5-[[4-[[MORPHOLIN-2-YL]METHYLAMINO]-5-TRIFLUOROMETHYL-2-PYRIDYL]AMINO]PYRAZINE-2-CARBONITRILE AND THERAPEUTIC USES THEREOF

by LAINCHBURY MICHAEL, MATTHEWS THOMAS PETER, FARIA DA FONSECA MCHARDY TATIANA, OSBORNE JAMES, WALTON MICHAEL IAN, GARRETT MICHELLE DAWN, COLLINS IAN
Year of Publication 11.11.2022

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Patent

Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)‑5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)

Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)‑5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)

by Osborne, James D, Matthews, Thomas P, McHardy, Tatiana, Proisy, Nicolas, Cheung, Kwai-Ming J, Lainchbury, Michael, Brown, Nathan, Walton, Michael I, Eve, Paul D, Boxall, Katherine J, Hayes, Angela, Henley, Alan T, Valenti, Melanie R, De Haven Brandon, Alexis K, Box, Gary, Jamin, Yann, Robinson, Simon P, Westwood, Isaac M, van Montfort, Rob L. M, Leonard, Philip M, Lamers, Marieke B. A. C, Reader, John C, Aherne, G. Wynne, Raynaud, Florence I, Eccles, Suzanne A, Garrett, Michelle D, Collins, Ian
Published in Journal of medicinal chemistry (09.06.2016)

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Journal Article

5-[[4-[[-2-]]-5--2-]]-2- 5-[[4-[[MORPHOLIN-2-YL]METHYLAMINO]-5-TRIFLUOROMETHYL-2-PYRIDYL]AMINO]PYRAZINE-2-CARBONITRILE AND THERAPEUTIC USES THEREOF

5-[[4-[[-2-]]-5--2-]]-2- 5-[[4-[[MORPHOLIN-2-YL]METHYLAMINO]-5-TRIFLUOROMETHYL-2-PYRIDYL]AMINO]PYRAZINE-2-CARBONITRILE AND THERAPEUTIC USES THEREOF

by LAINCHBURY MICHAEL, MATTHEWS THOMAS PETER, FARIA DA FONSECA MCHARDY TATIANA, OSBORNE JAMES, WALTON MICHAEL IAN, GARRETT MICHELLE DAWN, COLLINS IAN
Year of Publication 24.12.2021

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Patent

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR

by Bryan, Marian C, Burdick, Daniel J, Chan, Bryan K, Chen, Yuan, Clausen, Saundra, Dotson, Jennafer, Eigenbrot, Charles, Elliott, Richard, Hanan, Emily J, Heald, Robert, Jackson, Philip, La, Hank, Lainchbury, Michael, Malek, Shiva, Mann, Sam E, Purkey, Hans E, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen, Sideris, Steve, Wang, Shumei, Yen, Ivana, Yu, Christine, Heffron, Timothy P
Published in ACS medicinal chemistry letters (14.01.2016)

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Journal Article

5-[[4-[[-2-]]-5--2-]]-2- 5-[[4-[[MORPHOLIN-2-YL]METHYLAMINO]-5-TRIFLUOROMETHYL-2-PYRIDYL]AMINO]PYRAZINE-2-CARBONITRILE AND THERAPEUTIC USES THEREOF

5-[[4-[[-2-]]-5--2-]]-2- 5-[[4-[[MORPHOLIN-2-YL]METHYLAMINO]-5-TRIFLUOROMETHYL-2-PYRIDYL]AMINO]PYRAZINE-2-CARBONITRILE AND THERAPEUTIC USES THEREOF

by LAINCHBURY MICHAEL, MATTHEWS THOMAS PETER, FARIA DA FONSECA MCHARDY TATIANA, OSBORNE JAMES, WALTON MICHAEL IAN, GARRETT MICHELLE DAWN, COLLINS IAN
Year of Publication 30.04.2021

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Patent

Discovery of 3‑Alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as Selective, Orally Bioavailable CHK1 Inhibitors

Discovery of 3‑Alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as Selective, Orally Bioavailable CHK1 Inhibitors

by Lainchbury, Michael, Matthews, Thomas P, McHardy, Tatiana, Boxall, Kathy J, Walton, Michael I, Eve, Paul D, Hayes, Angela, Valenti, Melanie R, de Haven Brandon, Alexis K, Box, Gary, Aherne, G. Wynne, Reader, John C, Raynaud, Florence I, Eccles, Suzanne A, Garrett, Michelle D, Collins, Ian
Published in Journal of medicinal chemistry (26.11.2012)

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Journal Article

Correction to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study

Correction to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study

by Heald, Robert, Bowman, Krista K, Bryan, Marian C, Burdick, Daniel, Chan, Bryan, Chan, Emily, Chen, Yuan, Clausen, Saundra, Dominguez-Fernandez, Belen, Eigenbrot, Charles, Elliott, Richard, Hanan, Emily J, Jackson, Philip, Knight, Jamie, La, Hank, Lainchbury, Michael, Malek, Shiva, Mann, Sam, Merchant, Mark, Mortara, Kyle, Purkey, Hans, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen, Sideris, Steve, Shao, Lily, Wang, Shumei, Yeap, Kuen, Yen, Ivana, Yu, Christine, Heffron, Timothy P
Published in Journal of medicinal chemistry (24.03.2016)

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Journal Article

5-[[4-[[-2-]]-5--2-]]-2- 5-[[4-[[MORPHOLIN-2-YL]METHYLAMINO]-5-TRIFLUOROMETHYL-2-PYRIDYL]AMINO]PYRAZINE-2-CARBONITRILE AND THERAPEUTIC USES THEREOF

5-[[4-[[-2-]]-5--2-]]-2- 5-[[4-[[MORPHOLIN-2-YL]METHYLAMINO]-5-TRIFLUOROMETHYL-2-PYRIDYL]AMINO]PYRAZINE-2-CARBONITRILE AND THERAPEUTIC USES THEREOF

by LAINCHBURY MICHAEL, MATTHEWS THOMAS PETER, FARIA DA FONSECA MCHARDY TATIANA, OSBORNE JAMES, WALTON MICHAEL IAN, GARRETT MICHELLE DAWN, COLLINS IAN
Year of Publication 14.04.2020

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Patent

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